2. Ionisation: pKa Aggregation: Surface Activity
Our state of the art instrumentation delivers pKa values, We can measure Surface Tension, Critical Micelle
Distribution of Species plots, Buffer Capacity profile, ionic Concentrations, Total Surface Area and Air/Water partition
strength profiles and more using minimal sample co-efficient.
quantities.
Toxicity: Phospholipidosis
Lipophilicity: logP & logD
We have the facility to screen compounds for the potential
We have a number of techniques for measuring lipophilicity to induce phospholipidosis.
of compounds, including potentiometry, shake-flask and
HPLC-based methods that allow us to measure both
ionisable and neutral compounds. In combination with Screening Services: pKa, logD, PAMPA
ionisation data we provide full pH vs. logD profiles.
For fast but dependable PhysChem data in bulk we offer
high-throughput screening services.
Solubility: Kinetic, Equilibrium, Intrinsic,
pH vs. Solubility profiles
Expertise:
Our advanced solubility capabilities include measurement
of both kinetic and thermodynamic solubilities, as well as The scientists that run our analytical service are highly
supersaturation determination, excipient profiling and experienced in the measurement of physchem properties.
measurements in bio-relevant media. This information can In addition to receiving the requested results, our clients
bring great insights into the precipitation characteristics of also receive our expert assessment of the compound
a drug, and can help greatly in the understanding of physchem properties and the correlation between the
absorption properties and the effects of formulations. results obtained and any structural information
provided. This enables all our clients to benefit
from our data interpretation, not just
Dissolution: Simulated Intestinal Fluids simple numbers.
Using in-situ UV tools we can monitor the release of drug
into solution over time. Our capabilities include real-time
pH control in the vessel, and measurement in the presence
of excipients and bio-relevant buffer media including FaSSIF
& FeSSIF simulated intestinal fluids.
Solid State: XRPD, TGA, DSC, Raman
We partner with a leading solid-state expert who can apply
cutting edge solid state techniques to provide additional
evaluation of crystals obtained from any of our solution
chemistry assays.
3. Confidentiality and Security assured
We sign a non-disclosure agreement with all customers
before accepting samples for analysis.
As soon as we receive your samples and log them in, we will
place them in a locked safe, together with all confidential
documents. The safe contains an array of lockable drawers.
Each drawer contains samples from only one client.
Using Sirius’ Analytical services:
Traceability
• Visit the Analytical Service area on our website
All our assays follow documented, traceable, procedures in (http://www.sirius-analytical.com/analyticalservice/)
our state-of-the-art laboratories. Our laboratories are open • Follow the links for the analysis type of interest.
for customer audit visits. • Click the link to download a sample submittal form
• Send us your Non-Disclosure Agreement for review
and signature.
Custom Analysis • Send your sample with the completed questionnaire and
purchase order to the address on the submittal form.
If you have an application that requires precise real-time Please also email a copy to us in advance if possible.
pH control, in-situ UV detection, and state of the art • We will keep you fully updated on the progress of the
analysis tools, please contact us. We are happy to discuss work, from receipt of the sample to the issuing of the
custom projects using our instrumentation and expertise. final report.
4. Sirius Analytical
Riverside, Unit 12, Forest Row Business Park,
Forest Row, East Sussex, RH18 5DW, UK
Telephone: +44 (0) 1342 820720
Fax: +44 (0) 1342 820725
Email: sirius@sirius-analytical.com
web: www.sirius-analytical.com
