Viral hepatitis a+e

VIRAL HEPATITIS Dr Kamran Afzal Classified Microbiologist

HEPATITIS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

A “ Infectious” “ Serum” Viral hepatitis Enterically transmitted Parenterally transmitted F, G, TTV ? other E NANB B D C Viral Hepatitis - Historical Perspectives

[object Object],*linear, single strand; ** circular, double strand; *** circular, single strand Virus HAV HBV HCV HDV HEV DNA or RNA RNA* DNA** RNA* RNA*** RNA* Family Picornaviridae Hepadnaviridae Flaviviridae Deltavirus (genus) ? Envelope no yes yes yes no (Previously classified as a calicivirus)

Basic Features of Hepatitis Viruses Virus A B C D E Incubation Period* 4 (2-6) 8-12 (6-24) 6-9 (2-24) ? (2-10) 4-5 (2-9) Transmission fecal-oral parenteral parenteral parenteral fecal-oral * Weeks Chronic Infection No Yes Yes Yes No

CAUSES OF ACUTE HEPATITIS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

CAUSES OF CHRONIC HEPATITIS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

NATURE OF HAV ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

HAV CHARACTERS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

EPIDEMIOLOGY ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

TRANSMISSION ,[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

PATHOGENESIS ,[object Object],[object Object],[object Object],[object Object],[object Object]

PATHOLOGY ,[object Object],[object Object],[object Object],[object Object]

CLINICAL FINDINGS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

LABORATORY DIAGNOSIS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Fecal HAV Symptoms 0 1 2 3 4 5 6 12 24 Hepatitis A Infection Total anti-HAV Titer ALT IgM anti-HAV Months after exposure Typical Serological Course IgG anti-HAV

TREATMENT ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

PREVENTION ,[object Object],[object Object]

VACCINATION ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Vaccine Recommendations ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

HEPATITIS E VIRUS ,[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],EPIDEMIOLOGY

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],CLINICAL FEATURES

Symptoms ALT IgG anti-HEV IgM anti-HEV Virus in stool 0 1 2 3 4 5 6 7 8 9 10 11 12 13 Hepatitis E Virus Infection Typical Serologic Course Titer Weeks after Exposure

[object Object],[object Object],[object Object],PREVENTION AND CONTROL MEASURES

HEALTH EDUCATION MESSAGES ,[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Viral hepatitis a+e

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