5. Baby born dead Basically, these are the major risks that the mother and the baby exposed. Definitely, Lupus is a rare disease and it’s difficult to works with this because it’s not clearly what the cause of this disease is. Many scientists that work in HYPERLINK
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Rheumatic disease clinics of North America, believe that the principal cause of lupus can be a genetic component, but this is not completely clearly. Methodology: For this proposal will be to use animals first, animals like cats, because cats are very similar to the humans and also can have many babies from one birthing. So first have to ask for some permission like the vertebrates’ permissions to work with cats and then when have to work with humans ask for the respective permissions too. When I can have the cats I going to divide in three groups: the control group that going to be normal cats or cats without lupus; the experimental group that going to be pregnant cats with lupus and the third one going to be cats with lupus but not pregnant. That because I want to compare the behavior of the enzyme in this three groups; how this enzyme affects, if is positive or negative. So, after the enzyme is injected and being to working, I going to examine or monitoring each month the different groups. The monitoring is going to evaluate the behavior of the lupus, if the disease advances or control or minimizes, if the preeclampsia control and the hyperactive enzymes control and be normal. All these things going to be evaluate and when the babies born, have to evaluate how many lives, die or acquire Lupus Neonatal and also if the mother die or her disease advance. So, depend of my results after the pregnancy, I going to develop a treatment with less risk for the mother and develop a treatment to cure the lupus neonatal that the baby can get meanwhile the pregnancy, as I said. References: HYPERLINK
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Andrea L. Sestak, HYPERLINK
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Swapan K. Nath, HYPERLINK
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John B. Harley; HYPERLINK
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Rheumatic disease clinics of North America, ISSN 0889-857X, HYPERLINK
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Nº. 2, 2005 (Ejemplar dedicado a: Lupus eritematoso sistémico / HYPERLINK
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Murray B. Urowitz (ed. lit.)) , pags. 191-208 WOFSY D, SEAMAN WE: Successful Treatment of Autoimmunity in NZB/NZW F1 Mice with Monoclonal Antibody to L3T4. J Exp Med 1985, 161:378-391. Friedman EA, Rutherford JW. Pregnancy and lupus erythematosus. Obstet Gynecol 1956; 8: 601. Nossent HC, Swakk TJG. Systemic lupus erythematosus.VI Analysis of the interrelationship with pregnancy. J Rheumatol 1990; 17: 771. http://www.lupusresearchinstitute.org http://medicine.ucsf.edu/lupus RISE Program Lupus in Pregnant Women Karla Irenisse Velázquez Soto Biol. 3009