Mitochondrial Shuttle Systems
Explain why NADH synthesized in the cytosol of liver cells and used for mitochondrial energy conversion generates 2.5 ATP per NADH, whereas NADH synthesize in muscle cell cytosol only generates 1.5 ATP per NADH?
Solution
NADH synthesized in the cytosol of liver cells and used for mitochondrial energy conversion generates 2.5 ATP per NADH, whereas NADH synthesized in muscle cell cytosol only generates 1.5 ATP per NADH.
In order to transfer electrons from NADH to glycerol 3-P dehydrogenase, 10 protons are transported from matrix to inter mitochondrial membrane where 4 protons are transported through complex 1, 4 protons through complex 3 and 2 protons through complex 4. And to make 1 ATP ,4 protons move from inter mitochondrial membrane to matrix by ATPase. Hence for NADH synthesized in the cytosol of liver cells, 10/4=2.5 ATP is generated.
For NADH synthesized in muscle cell cytosol 6 protons are transported, hence 6/4=1.5 ATP is generated. Since fewer protons are pumped, hence lesser ATP is generated.
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Mitochondrial Shuttle Systems Explain why NADH synthesized in the cyto.docx
1. Mitochondrial Shuttle Systems
Explain why NADH synthesized in the cytosol of liver cells and used for mitochondrial energy
conversion generates 2.5 ATP per NADH, whereas NADH synthesize in muscle cell cytosol only
generates 1.5 ATP per NADH?
Solution
NADH synthesized in the cytosol of liver cells and used for mitochondrial energy conversion
generates 2.5 ATP per NADH, whereas NADH synthesized in muscle cell cytosol only generates
1.5 ATP per NADH.
In order to transfer electrons from NADH to glycerol 3-P dehydrogenase, 10 protons are
transported from matrix to inter mitochondrial membrane where 4 protons are
transported through complex 1, 4 protons through complex 3 and 2 protons through
complex 4. And to make 1 ATP ,4 protons move from inter mitochondrial membrane to
matrix by ATPase. Hence for NADH synthesized in the cytosol of liver cells, 10/4=2.5 ATP
is generated.
For NADH synthesized in muscle cell cytosol 6 protons are transported, hence 6/4=1.5 ATP
is generated. Since fewer protons are pumped, hence lesser ATP is generated.
