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Anesthesia for
Orthopedics surgery
Moderator :
Assoc. Prof Dr. Sujita Manandhar
Assist. Prof Dr. Pawan Kumar Hamal
Presenter : Dr. Krishna Dhakal
Learning objectives
• Describe general considerations and goals related to orthopedic
surgery
• Describe specific consideration associated with orthopedic
surgery ,their anesthetic implications and management
• Describe briefly about special orthopedic condition and their
anesthetic concerns
2/7/2019 2
Department of Anesthesiology and
Critical Care ,NAMS
• General consideration
1. Perioperative Goals
a) Pre op considerations
b) Intraoperative Goals
c) Post operative considerations
2. Age specific orthopedic conditions
3. Medical comorbidities
4. Co existing medications
2/7/2019 3
Department of Anesthesiology and Critical
Care ,NAMS
• Specific considerations
1. Positioning
2. Bone cement Implantation syndrome
3. Pneumatic Tourniquets
4. Fat embolism
5. Deep vein thrombosis and thromboembolism
6. Regional anesthesia and anticoagulation
2/7/2019
Department of Anesthesiology and Critical
Care ,NAMS
4
• Pre op considerations
1. Age
2. Co morbidities
3. Medications
4. Diagnostic studies
2/7/2019
Department of Anesthesiology and Critical
Care ,NAMS
5
Pre op considerations
• 1.Age of the patients
• Elderly
• Medical Conditions(MI,COPD,HTN CVD,DM)
• Anticoagulation therapy
• Renal dysfunctions
• Airway difficulties
• Osteoporesis
• Pediatrics
• Congenital deformities
• Undiagnosed muscular dystrophies
2/7/2019 6
Department of Anesthesiology and Critical
Care ,NAMS
Pre-op considerations
2. Comorbidities
• Trauma- stabilization
• Geriatric populations- HTN,CAD,CVD,COPD, osteoarthritis, RA
• Obesity-HTN,CAD,DM
3. Medications
• Steroids
• Opiods
• Antihypertensives
• NSAIDS
• Immunotherapy-Methotrexate
2/7/2019 7
Department of Anesthesiology and Critical
Care ,NAMS
Pre-op considerations
• Radiologic studies
• C-xray
• Xray –C spine-AP, lateral
• Cardiac studies
• ECG
• Echocardiography
• Labs
• CBC
• Platelets
• Renal functions,electrolytes
• Coagulation studies-
Anticogulation
medications,immunetherapy
2/7/2019 8
Department of Anesthesiology and Critical
Care ,NAMS
Choice of Anesthetic Technique
• Regional anesthesia vs General anesthesia
2/7/2019 9
Department of Anesthesiology and Critical
Care ,NAMS
Choice Of Anesthesia Technique contd..
Many orthopedic surgery because of localized peripheral sites led
themselves to RA techniques
Advantages of RA
• No or minimal airway manipulation
• Improved postoperative analgesia
• Decreased incidence of PONV
• Less respiratory and cardiac depression
• Reduced blood loss
• Decrease risk of DVT/Thromboembolism
2/7/2019
Department of Anesthesiology and Critical
Care ,NAMS
10
Upper Extremity Surgery
RA (+/- GA)
1. IRVA(Intravenous Regional Anesthesia)
• Advantage: simplicity of technique, rapid onset of action, controllable
duration of action and rapid return of function.
• Disadvantage: continuous use of tourniquet, the potential toxic effect
of the drug and lack of postoperative analgesia.
2. Brachial Plexus Block
3. Blockade of peripheral nerves
• Radial Nerve block.
• Median Nerve block.
• Ulnar Nerve block.
• Digital Nerves.
2/7/2019 11
Department of Anesthesiology and Critical
Care ,NAMS
Lower Extremity Surgery
• Can be completely performed under regional anesthesia
2/7/2019 12
Department of Anesthesiology and Critical
Care ,NAMS
Regional anesthesia technique for surgery of the
lower extremity
1. Hip
2. Knee
3. Lower leg
4. Ankle
5. Foot
• Spinal, epidural, lumbar plexus block.
• Spinal,epidural,3 in 1 block, femoral
sciatic block.
• Spinal, epidural, sciatic block, femoral-
sciatic block, sciatic and saphenous
block.
• Spinal, sciatic block
• Spinal, sciatic, ankle block, trans
metatarsal block.
2/7/2019 13
Department of Anesthesiology and Critical
Care ,NAMS
Intraoperative Goals
• Surgical anesthesia
 To provide optimal surgical operating conditions
 Appropriate depth of anesthesia
 Adequate pain control
• Optimize surgical exposure
 Neuromuscular blockade in GA
 Neuraxial anesthesia
 Peripheral nerve block
2/7/2019 14
Department of Anesthesiology and Critical
Care ,NAMS
Intraoperative Goals
• Proper positioning to Prevent stretch/compression nerve
injuries
• Prevent significant blood loss
may be reduced through
• proper positioning
• intraoperative blood salvage,
• induced hypotension,
• intraoperative hemodilution, and
2/7/2019
Department of Anesthesiology and Critical
Care ,NAMS
15
Post operative considerations
• Postoperative pain management
• Peripheral nerve blockade with or without catheter
• Opioids for breakthrough pain/multimodal analgesia
• NSAIDs and adjuvant analgesic medications
• Others
• ICU/Post op care
• Mechanical ventilation: if needed
2/7/2019 16
Department of Anesthesiology and Critical
Care ,NAMS
Specific Considerations
2/7/2019
Department of Anesthesiology and Critical
Care ,NAMS
17
Positioning
• Why positioning important??
1. Patient safety
2. Prevent nerve injuries
3. Enable iv access, ET Tube , catheter to remain patent
4. Enable proper monitor
5. Facilitates surgical approach
2/7/2019
Department of Anesthesiology and Critical
Care ,NAMS
18
Positioning
• Supine
• Lateral
• Prone
• Beach chair
• Fracture table
2/7/2019
Department of Anesthesiology and Critical
Care ,NAMS
19
Positioning contd..
• Supine
• Patient on back
• Arms on arm boards
• Arm < 90 degrees
• Arm is supinated ( palm up)
• Place padding under elbow if
able
• Arm tucked
• Check fingers
• Check IV lines and SpO2
probe
2/7/2019 20
Department of Anesthesiology and Critical
Care ,NAMS
Positioning contd..
 Lateral
 Body alignment
 Keep neck in neutral position
 Always place axillary roll
 Place padding between knees
 Place padding below lateral aspect
of dependent leg
 Position arms to parallel to one
another
 Place padding between arms or
place non-dependent arm on
padded surface
2/7/2019 21
Department of Anesthesiology and Critical
Care ,NAMS
Positioning contd…
• Prone
• Face down
• Head placement
• Head straight forward
• ET tube placement and
patency
• Check bilateral eyes/ears
for pressure points
• Head turned
• Check dependent eye/ear,
ETT placement
• Be aware of potential
vascular occlusion
2/7/2019 22
Department of Anesthesiology and Critical
Care ,NAMS
Positioning contd..
• Prone
 Arm placement
 Tucked – similar to supine
 Abducted
▪ Check neck rotation and arm
extension to avoid brachial
plexus injury
▪ Elbow are padded
 Chest rolls
 Iliac support
 Padding in placed under iliac crests
2/7/2019 23
Department of Anesthesiology and Critical
Care ,NAMS
Positioning contd..
Beach Chair
• Arms- supported to prevent
stretching of the brachial
plexus.
• Elastic stockings and active leg
compression devices - help
maintain venous return.
2/7/2019 24
Department of Anesthesiology and Critical
Care ,NAMS
Positioning contd..
• Fracture chair
• Maintenance of traction on the
fractured extremity, allowing
• manipulation for closed reduction
and fixation, and
• access to the fracture site for
radiography in several planes
• The ipsilateral arm is positioned on
an arm board or sling without
stretching the brachial plexus
• Gentiles protection
2/7/2019 25
Department of Anesthesiology and Critical
Care ,NAMS
Bone Cement Implantation Syndrome
• Bone cement Syndrome
Characterised by hypoxia , hypotension or both and or unexpected
loss of consciousness occurring at the time of cementation,
prosthesis insertion ,reduction of joint or occasionally, limb
tourniquet deflation in a patient undergoing cemented bone
surgery
• Bone cement-
Methyl methacrylate(MMA) an acrylic bone cement used during
arthroplastic procedures.
Donaldson et al 2009
2/7/2019 26
Department of Anesthesiology and Critical
Care ,NAMS
2/7/2019
Department of Anesthesiology and Critical
Care ,NAMS
27
•Clinical presentations
• Fever
• Hypoxia
• Hypotension
• Tachycardia
• Dysrhythmia
• Mental status change
• Dyspnea
• Decreased End tidal CO2
• Right ventricular failure and
cardiac arrest
2/7/2019 28
Department of Anesthesiology and Critical
Care ,NAMS
•Treatment strategies
1. Increasing FiO2 prior to cementing
2. Monitoring & maintaining hydration
3. Creating vent hole in the distal femur
4. High pressure lavage of femoral shaft to remove debris
5. Using cementless prosthesis
2/7/2019 29
Department of Anesthesiology and Critical
Care ,NAMS
2/7/2019 30
Department of Anesthesiology and Critical
Care ,NAMS
Pneumatic tourniquet
• To create bloodless field
• Not > 2 hours
• Prolonged inflation (>2hrs) leads
to
-transient muscle dysfunction
- rhabdomyolysis,
-nerve injuries
• 100 mmHg above systolic blood
pressure
2/7/2019 31
Department of Anesthesiology and Critical
Care ,NAMS
Pneumatic tourniquet
• Advantage
• Eliminate intraoperative
bleeding
• Disadvantages
• Neurologic effect
• Muscle change
• Systemic effects of the
tourniquet inflation
• Systemic effects of the
tourniquet release
2/7/2019 32
Department of Anesthesiology and Critical
Care ,NAMS
Pneumatic tourniquet
•Problems with inflation
• Pain
• Sympathetic stimulation:
Marked HTN, tachycardia, and diaphoresis
• Arterial thromboembolism, pulmonary embolism
• If prolonged >2 hour
Transient muscle dysfunction  rhabdomyolysis, permanent
nerve damage
• Folds or lines under tourniquet may cause bruising or pressure
necrosis of skin
2/7/2019 33
Department of Anesthesiology and Critical
Care ,NAMS
• Problems with deflation
• The good: decreases the tourniquet pain experienced
• Disadvantages
• Increase in blood level of: PaCo2, lactate, potassium: d/t washout of
accumulated waste
• Increase. in MV of spontaneously breathing patients
• Transient metabolic acidosis
• Core temperature decreases
2/7/2019 34
Department of Anesthesiology and Critical
Care ,NAMS
Prevention
• Select patients
• Wide, low-pressure cuff
• Apply the lowest pressure to prevent bleeding
• Limit time to 2 hours
• Set maximum pressure
-Arm 50-75 mmHg above systolic
-Leg 75-100 mmHg above systolic
• Doppler guided tourniquet pressure inflation
• Adequate padding underneath
2/7/2019 35
Department of Anesthesiology and Critical
Care ,NAMS
Fat Embolism Syndrome
• A well known complication of skeletal trauma and surgery
involving femoral medullary canal
• A physiologic response to fat within systemic circulation
• FES <2 - 22% , all long bone fracture
• Mortality rate - 10-20 %
• Presents within 72 hrs. following fracture of long bone,pelvis
with triad of – Dyspnea, confusion, petechiae
2/7/2019 36
Department of Anesthesiology and Critical
Care ,NAMS
2/7/2019
Department of Anesthesiology and Critical
Care ,NAMS
37
Clinical manifestations
• Neurologic: agitation, confusion,
stupor, coma
• Hematologic: thrombocytopenia,
prolonged CT
• Cutaneous: petechiae
(pathognomonic)
• Pulmonary: mild hypoxia, resp.
failure, ARDS (10%)
• CVS: persistent tachycardia,
hypotension
Dyspnea
Confusion Petechiae
2/7/2019 38
Department of Anesthesiology and Critical
Care ,NAMS
Gurd's Diagnosis of FES
• Major Features (at least one)
• Respiratory insufficiency: PaO2 <60
mm Hg, FiO2: 0.4
• Cerebral involvement: altered
mentation
• Petechial rash
• Minor Features (at least four)
• Pyrexia
• Tachycardia
• Retinal changes
• Jaundice
• Renal changes
• Laboratory Features
• Fat microglobulinemia
• Anemia
• Thrombocytopenia
• High ESR
Gurd AR, Wilson RI: The fat embolism syndrome. J Bone Joint Surg Br 56:408-416, 1974
2/7/2019 39
Department of Anesthesiology and Critical
Care ,NAMS
Schonfield index
• A score of >5 required for
the diagnosis of FES
Schonfeld SA, Ploysongsang Y, DiLisio R, et al: Fat embolism prophylaxis with corticosteroids: A prospective
study in high risk patients. Ann Int Med 99:438-443, 1983.
2/7/2019
40
How to diagnose FES under GA
• Decline in end tidal CO2
• Decline in arterial oxygen saturation
• Rise in pulmonary artery pressures
ECG
• Ischemic-appearing ST segment changes
• Right sided heart strain
2/7/2019 41
Department of Anesthesiology and Critical
Care ,NAMS
Treatment
Prophylactic
 Early stabilization of the fracture
Supportive
 Respiratory care
▪ O2 therapy (with CPAP ventilation - ARDS)
 Invasive monitoring
▪ Volume status, Inotrops
▪ Vasodilators for Pulmonary HTN
 High dose corticosteroid
2/7/2019 42
Department of Anesthesiology and Critical
Care ,NAMS
One of the leading causes of morbidity and mortality after
major orthopedic surgeries like THA, TKA, hip and pelvic
fracture surgeries.
• Incidence of DVT : 40-80% without prophylaxis
• Incidence pulmonary embolism is 20%(Fatality-1-3%)
• Major pathophysiological mechanism(Virchow’s Triad)
• Venous stasis
• Hypercoagulable state
• Endothelial damage
DVT And Thromboembolism
2/7/2019 43
Department of Anesthesiology and Critical
Care ,NAMS
DVT/Thromboembolism contd..
Risk Factors
• Obesity
• Age > 60 years
• Previous PE and DVT
• Cancer
• Procedure > 30 mins
• Use of tourniquet
• Lower extremities fracture
• Immobilization > 4 days
• Thrombophilia: mainly
hereditary eg. Factor V Leiden
(most common)
2/7/2019 44
Department of Anesthesiology and Critical
Care ,NAMS
Prevention
• Non-pharmacological
• Intermittent pneumatic compression
• TED stockings
• IVC filters: in patients C/I for anticoagulation
• Pharmacological
• Low dose heparin (UF)
• Warfarin
• LMWH
• Recent alternatives to:
• Fondaparinux
• Dabigatran
2/7/2019 45
Department of Anesthesiology and Critical
Care ,NAMS
•Treatment
• Anticoagulants OR Thrombolytics?
• Venous thrombi  Fibrin thrombi  anticoagulation for Prevention and treatment
• Severe, possibly fatal PE  Thrombolytics
WARFARIN
Blocking of Vit K dependent
coagulation factors
II, VII, IX, and X)
LMWH
inactivating thrombin and activated factor X
(factor Xa) through an antithrombin (AT)-
dependent mechanism
2/7/2019 46
Department of Anesthesiology and Critical
Care ,NAMS
Regional Anesthesia and anticoagulation
• Regional anesthesia and anticoagulation are important
considerations in orthopedic surgeries.
• A plan management for anticoagulant and anesthetic technique
must be taken for the specific patient under anticoagulation
2/7/2019 47
Department of Anesthesiology and Critical
Care ,NAMS
2/7/2019 48
Department of Anesthesiology and Critical
Care ,NAMS
2/7/2019 49
Department of Anesthesiology and Critical
Care ,NAMS
2/7/2019 50
Department of Anesthesiology and Critical
Care ,NAMS
Anesthetic considerations
Rheumatoid arthritis
2/7/2019 51
Department of Anesthesiology and Critical
Care ,NAMS
Osteoarthritis
• Anesthetic concrens
• Reduced joint movement
• Airway management
• IV access
• Spinal or epidural - difficult
• Positioning
• Concurrent analgesic therapy
2/7/2019 52
Department of Anesthesiology and Critical
Care ,NAMS
Ankylosing spondylitis
• Ankylosing spondylitis involves ossification of the axial ligaments
progressing from the sacral lumbar region cranially,
• Significant loss of spinal mobility
• Regional anesthesia may be difficult
• Reduced movement of C-spine and TMJ
• Thoracic spine movement restriction
• Difficulty in positioning
• Others:
• Aortic insufficiency, cardiac conduction defects, and pleural effusions.
2/7/2019 53
Department of Anesthesiology and Critical
Care ,NAMS
Anesthesia for spinal surgery
•Pathological condition requiring spine surgery are
– Spinal cord compression
– Herniation of an intervertebral disk
– Spinal deformities (scoliosis)
– Tumor or infection
– Vascular malformation
– Post traumatic stabilization
2/7/2019 54
Department of Anesthesiology and Critical
Care ,NAMS
Preoperative assessment
•Airway evaluation
•Respiratory evaluation
•Cardiovascular evaluation
•Neurological evaluation
2/7/2019 55
Department of Anesthesiology and Critical
Care ,NAMS
Monitoring
•Standard monitoring:
•NIBP, SPO2, HR, ECG, Capnograph, temperature
•Special monitoring:
•Invasive blood pressure, central venous pressure and urine output
2/7/2019 56
Department of Anesthesiology and Critical
Care ,NAMS
Problems associated with prone position in
Spine Surgery
1. Chest pressure - decreased chest compliance and impaired
respiration.
2. Abdominal pressure -inferior vena cava compression -
retrograde venous flow into the vertebral venous plexus -
resulting in epidural venous engorgement.
3. Peripheral nerve damage - as a result of excessive pressure or
traction.
4. Eyes, ears, nose, breast, and genitalia must be protected from
excessive pressure
2/7/2019 57
Department of Anesthesiology and Critical
Care ,NAMS
2/7/2019 58
Department of Anesthesiology and Critical
Care ,NAMS
Take home message
• Older age is a significant risk factor for poor outcome after
orthopedic surgery. They often have multiple comorbid
conditions that must be considered in the perioperative plan
• Proper positioning for orthopaedic procedures is paramount to
providing optimal surgical conditions, as well as avoiding
potential stretch and compression injuries.
• Fat embolism syndrome and bone cement implantation
syndrome - result in life threatening emergency thus
anticipation and management should be prompt
• Patients undergoing major orthopaedic are at high risk for
thromboembolic complications. Use of current pharmacologic
and mechanical methods of thromboprophylaxis is required
2/7/2019 59
Department of Anesthesiology and Critical
Care ,NAMS
Take home message
• Pneumatic tourniquets are often used to create a bloodless field but
also are associated with potential problems; hemodynamic changes,
pain, metabolic alterations, arterial thromboembolus, and even
pulmonary embolism
• Regional anaesthesia reduces perioperative complications compared
with GA, and may provide superior analgesia
• Regional anaesthesia and anticoagulation are important
considerations in orthopaedic surgeries. A plan management for
anticoagulant and anesthetic technique must be taken for the
specific patient under anticoagulation
2/7/2019 60
Department of Anesthesiology and Critical
Care ,NAMS
References
• Mikhail & Morgan’s Clinical Anesthesiology, 5th edition
• Barash, Paul G Cullen Clinical Anesthesia, 8th edition
• Ronald D. Miller Miller's Anesthesia , 7th edition
• American Society of Regional Anesthesia and Pain Medicine, Evidence-
Based Guidelines on regional anesthesia and anticoagulation,
3rd Edition
• Internet: www.asra.com/advisory-guidelines/article/4/interventional-
spine-and-pain-procedures-in-patients-on-antiplatelet-and-anticoa
2/7/2019 61
Department of Anesthesiology and Critical
Care ,NAMS
Thank You
2/7/2019 62
Department of Anesthesiology and Critical
Care ,NAMS

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Anesthesia for orthopedic surgery

  • 1. Anesthesia for Orthopedics surgery Moderator : Assoc. Prof Dr. Sujita Manandhar Assist. Prof Dr. Pawan Kumar Hamal Presenter : Dr. Krishna Dhakal
  • 2. Learning objectives • Describe general considerations and goals related to orthopedic surgery • Describe specific consideration associated with orthopedic surgery ,their anesthetic implications and management • Describe briefly about special orthopedic condition and their anesthetic concerns 2/7/2019 2 Department of Anesthesiology and Critical Care ,NAMS
  • 3. • General consideration 1. Perioperative Goals a) Pre op considerations b) Intraoperative Goals c) Post operative considerations 2. Age specific orthopedic conditions 3. Medical comorbidities 4. Co existing medications 2/7/2019 3 Department of Anesthesiology and Critical Care ,NAMS
  • 4. • Specific considerations 1. Positioning 2. Bone cement Implantation syndrome 3. Pneumatic Tourniquets 4. Fat embolism 5. Deep vein thrombosis and thromboembolism 6. Regional anesthesia and anticoagulation 2/7/2019 Department of Anesthesiology and Critical Care ,NAMS 4
  • 5. • Pre op considerations 1. Age 2. Co morbidities 3. Medications 4. Diagnostic studies 2/7/2019 Department of Anesthesiology and Critical Care ,NAMS 5
  • 6. Pre op considerations • 1.Age of the patients • Elderly • Medical Conditions(MI,COPD,HTN CVD,DM) • Anticoagulation therapy • Renal dysfunctions • Airway difficulties • Osteoporesis • Pediatrics • Congenital deformities • Undiagnosed muscular dystrophies 2/7/2019 6 Department of Anesthesiology and Critical Care ,NAMS
  • 7. Pre-op considerations 2. Comorbidities • Trauma- stabilization • Geriatric populations- HTN,CAD,CVD,COPD, osteoarthritis, RA • Obesity-HTN,CAD,DM 3. Medications • Steroids • Opiods • Antihypertensives • NSAIDS • Immunotherapy-Methotrexate 2/7/2019 7 Department of Anesthesiology and Critical Care ,NAMS
  • 8. Pre-op considerations • Radiologic studies • C-xray • Xray –C spine-AP, lateral • Cardiac studies • ECG • Echocardiography • Labs • CBC • Platelets • Renal functions,electrolytes • Coagulation studies- Anticogulation medications,immunetherapy 2/7/2019 8 Department of Anesthesiology and Critical Care ,NAMS
  • 9. Choice of Anesthetic Technique • Regional anesthesia vs General anesthesia 2/7/2019 9 Department of Anesthesiology and Critical Care ,NAMS
  • 10. Choice Of Anesthesia Technique contd.. Many orthopedic surgery because of localized peripheral sites led themselves to RA techniques Advantages of RA • No or minimal airway manipulation • Improved postoperative analgesia • Decreased incidence of PONV • Less respiratory and cardiac depression • Reduced blood loss • Decrease risk of DVT/Thromboembolism 2/7/2019 Department of Anesthesiology and Critical Care ,NAMS 10
  • 11. Upper Extremity Surgery RA (+/- GA) 1. IRVA(Intravenous Regional Anesthesia) • Advantage: simplicity of technique, rapid onset of action, controllable duration of action and rapid return of function. • Disadvantage: continuous use of tourniquet, the potential toxic effect of the drug and lack of postoperative analgesia. 2. Brachial Plexus Block 3. Blockade of peripheral nerves • Radial Nerve block. • Median Nerve block. • Ulnar Nerve block. • Digital Nerves. 2/7/2019 11 Department of Anesthesiology and Critical Care ,NAMS
  • 12. Lower Extremity Surgery • Can be completely performed under regional anesthesia 2/7/2019 12 Department of Anesthesiology and Critical Care ,NAMS
  • 13. Regional anesthesia technique for surgery of the lower extremity 1. Hip 2. Knee 3. Lower leg 4. Ankle 5. Foot • Spinal, epidural, lumbar plexus block. • Spinal,epidural,3 in 1 block, femoral sciatic block. • Spinal, epidural, sciatic block, femoral- sciatic block, sciatic and saphenous block. • Spinal, sciatic block • Spinal, sciatic, ankle block, trans metatarsal block. 2/7/2019 13 Department of Anesthesiology and Critical Care ,NAMS
  • 14. Intraoperative Goals • Surgical anesthesia  To provide optimal surgical operating conditions  Appropriate depth of anesthesia  Adequate pain control • Optimize surgical exposure  Neuromuscular blockade in GA  Neuraxial anesthesia  Peripheral nerve block 2/7/2019 14 Department of Anesthesiology and Critical Care ,NAMS
  • 15. Intraoperative Goals • Proper positioning to Prevent stretch/compression nerve injuries • Prevent significant blood loss may be reduced through • proper positioning • intraoperative blood salvage, • induced hypotension, • intraoperative hemodilution, and 2/7/2019 Department of Anesthesiology and Critical Care ,NAMS 15
  • 16. Post operative considerations • Postoperative pain management • Peripheral nerve blockade with or without catheter • Opioids for breakthrough pain/multimodal analgesia • NSAIDs and adjuvant analgesic medications • Others • ICU/Post op care • Mechanical ventilation: if needed 2/7/2019 16 Department of Anesthesiology and Critical Care ,NAMS
  • 17. Specific Considerations 2/7/2019 Department of Anesthesiology and Critical Care ,NAMS 17
  • 18. Positioning • Why positioning important?? 1. Patient safety 2. Prevent nerve injuries 3. Enable iv access, ET Tube , catheter to remain patent 4. Enable proper monitor 5. Facilitates surgical approach 2/7/2019 Department of Anesthesiology and Critical Care ,NAMS 18
  • 19. Positioning • Supine • Lateral • Prone • Beach chair • Fracture table 2/7/2019 Department of Anesthesiology and Critical Care ,NAMS 19
  • 20. Positioning contd.. • Supine • Patient on back • Arms on arm boards • Arm < 90 degrees • Arm is supinated ( palm up) • Place padding under elbow if able • Arm tucked • Check fingers • Check IV lines and SpO2 probe 2/7/2019 20 Department of Anesthesiology and Critical Care ,NAMS
  • 21. Positioning contd..  Lateral  Body alignment  Keep neck in neutral position  Always place axillary roll  Place padding between knees  Place padding below lateral aspect of dependent leg  Position arms to parallel to one another  Place padding between arms or place non-dependent arm on padded surface 2/7/2019 21 Department of Anesthesiology and Critical Care ,NAMS
  • 22. Positioning contd… • Prone • Face down • Head placement • Head straight forward • ET tube placement and patency • Check bilateral eyes/ears for pressure points • Head turned • Check dependent eye/ear, ETT placement • Be aware of potential vascular occlusion 2/7/2019 22 Department of Anesthesiology and Critical Care ,NAMS
  • 23. Positioning contd.. • Prone  Arm placement  Tucked – similar to supine  Abducted ▪ Check neck rotation and arm extension to avoid brachial plexus injury ▪ Elbow are padded  Chest rolls  Iliac support  Padding in placed under iliac crests 2/7/2019 23 Department of Anesthesiology and Critical Care ,NAMS
  • 24. Positioning contd.. Beach Chair • Arms- supported to prevent stretching of the brachial plexus. • Elastic stockings and active leg compression devices - help maintain venous return. 2/7/2019 24 Department of Anesthesiology and Critical Care ,NAMS
  • 25. Positioning contd.. • Fracture chair • Maintenance of traction on the fractured extremity, allowing • manipulation for closed reduction and fixation, and • access to the fracture site for radiography in several planes • The ipsilateral arm is positioned on an arm board or sling without stretching the brachial plexus • Gentiles protection 2/7/2019 25 Department of Anesthesiology and Critical Care ,NAMS
  • 26. Bone Cement Implantation Syndrome • Bone cement Syndrome Characterised by hypoxia , hypotension or both and or unexpected loss of consciousness occurring at the time of cementation, prosthesis insertion ,reduction of joint or occasionally, limb tourniquet deflation in a patient undergoing cemented bone surgery • Bone cement- Methyl methacrylate(MMA) an acrylic bone cement used during arthroplastic procedures. Donaldson et al 2009 2/7/2019 26 Department of Anesthesiology and Critical Care ,NAMS
  • 27. 2/7/2019 Department of Anesthesiology and Critical Care ,NAMS 27
  • 28. •Clinical presentations • Fever • Hypoxia • Hypotension • Tachycardia • Dysrhythmia • Mental status change • Dyspnea • Decreased End tidal CO2 • Right ventricular failure and cardiac arrest 2/7/2019 28 Department of Anesthesiology and Critical Care ,NAMS
  • 29. •Treatment strategies 1. Increasing FiO2 prior to cementing 2. Monitoring & maintaining hydration 3. Creating vent hole in the distal femur 4. High pressure lavage of femoral shaft to remove debris 5. Using cementless prosthesis 2/7/2019 29 Department of Anesthesiology and Critical Care ,NAMS
  • 30. 2/7/2019 30 Department of Anesthesiology and Critical Care ,NAMS
  • 31. Pneumatic tourniquet • To create bloodless field • Not > 2 hours • Prolonged inflation (>2hrs) leads to -transient muscle dysfunction - rhabdomyolysis, -nerve injuries • 100 mmHg above systolic blood pressure 2/7/2019 31 Department of Anesthesiology and Critical Care ,NAMS
  • 32. Pneumatic tourniquet • Advantage • Eliminate intraoperative bleeding • Disadvantages • Neurologic effect • Muscle change • Systemic effects of the tourniquet inflation • Systemic effects of the tourniquet release 2/7/2019 32 Department of Anesthesiology and Critical Care ,NAMS
  • 33. Pneumatic tourniquet •Problems with inflation • Pain • Sympathetic stimulation: Marked HTN, tachycardia, and diaphoresis • Arterial thromboembolism, pulmonary embolism • If prolonged >2 hour Transient muscle dysfunction  rhabdomyolysis, permanent nerve damage • Folds or lines under tourniquet may cause bruising or pressure necrosis of skin 2/7/2019 33 Department of Anesthesiology and Critical Care ,NAMS
  • 34. • Problems with deflation • The good: decreases the tourniquet pain experienced • Disadvantages • Increase in blood level of: PaCo2, lactate, potassium: d/t washout of accumulated waste • Increase. in MV of spontaneously breathing patients • Transient metabolic acidosis • Core temperature decreases 2/7/2019 34 Department of Anesthesiology and Critical Care ,NAMS
  • 35. Prevention • Select patients • Wide, low-pressure cuff • Apply the lowest pressure to prevent bleeding • Limit time to 2 hours • Set maximum pressure -Arm 50-75 mmHg above systolic -Leg 75-100 mmHg above systolic • Doppler guided tourniquet pressure inflation • Adequate padding underneath 2/7/2019 35 Department of Anesthesiology and Critical Care ,NAMS
  • 36. Fat Embolism Syndrome • A well known complication of skeletal trauma and surgery involving femoral medullary canal • A physiologic response to fat within systemic circulation • FES <2 - 22% , all long bone fracture • Mortality rate - 10-20 % • Presents within 72 hrs. following fracture of long bone,pelvis with triad of – Dyspnea, confusion, petechiae 2/7/2019 36 Department of Anesthesiology and Critical Care ,NAMS
  • 37. 2/7/2019 Department of Anesthesiology and Critical Care ,NAMS 37
  • 38. Clinical manifestations • Neurologic: agitation, confusion, stupor, coma • Hematologic: thrombocytopenia, prolonged CT • Cutaneous: petechiae (pathognomonic) • Pulmonary: mild hypoxia, resp. failure, ARDS (10%) • CVS: persistent tachycardia, hypotension Dyspnea Confusion Petechiae 2/7/2019 38 Department of Anesthesiology and Critical Care ,NAMS
  • 39. Gurd's Diagnosis of FES • Major Features (at least one) • Respiratory insufficiency: PaO2 <60 mm Hg, FiO2: 0.4 • Cerebral involvement: altered mentation • Petechial rash • Minor Features (at least four) • Pyrexia • Tachycardia • Retinal changes • Jaundice • Renal changes • Laboratory Features • Fat microglobulinemia • Anemia • Thrombocytopenia • High ESR Gurd AR, Wilson RI: The fat embolism syndrome. J Bone Joint Surg Br 56:408-416, 1974 2/7/2019 39 Department of Anesthesiology and Critical Care ,NAMS
  • 40. Schonfield index • A score of >5 required for the diagnosis of FES Schonfeld SA, Ploysongsang Y, DiLisio R, et al: Fat embolism prophylaxis with corticosteroids: A prospective study in high risk patients. Ann Int Med 99:438-443, 1983. 2/7/2019 40
  • 41. How to diagnose FES under GA • Decline in end tidal CO2 • Decline in arterial oxygen saturation • Rise in pulmonary artery pressures ECG • Ischemic-appearing ST segment changes • Right sided heart strain 2/7/2019 41 Department of Anesthesiology and Critical Care ,NAMS
  • 42. Treatment Prophylactic  Early stabilization of the fracture Supportive  Respiratory care ▪ O2 therapy (with CPAP ventilation - ARDS)  Invasive monitoring ▪ Volume status, Inotrops ▪ Vasodilators for Pulmonary HTN  High dose corticosteroid 2/7/2019 42 Department of Anesthesiology and Critical Care ,NAMS
  • 43. One of the leading causes of morbidity and mortality after major orthopedic surgeries like THA, TKA, hip and pelvic fracture surgeries. • Incidence of DVT : 40-80% without prophylaxis • Incidence pulmonary embolism is 20%(Fatality-1-3%) • Major pathophysiological mechanism(Virchow’s Triad) • Venous stasis • Hypercoagulable state • Endothelial damage DVT And Thromboembolism 2/7/2019 43 Department of Anesthesiology and Critical Care ,NAMS
  • 44. DVT/Thromboembolism contd.. Risk Factors • Obesity • Age > 60 years • Previous PE and DVT • Cancer • Procedure > 30 mins • Use of tourniquet • Lower extremities fracture • Immobilization > 4 days • Thrombophilia: mainly hereditary eg. Factor V Leiden (most common) 2/7/2019 44 Department of Anesthesiology and Critical Care ,NAMS
  • 45. Prevention • Non-pharmacological • Intermittent pneumatic compression • TED stockings • IVC filters: in patients C/I for anticoagulation • Pharmacological • Low dose heparin (UF) • Warfarin • LMWH • Recent alternatives to: • Fondaparinux • Dabigatran 2/7/2019 45 Department of Anesthesiology and Critical Care ,NAMS
  • 46. •Treatment • Anticoagulants OR Thrombolytics? • Venous thrombi  Fibrin thrombi  anticoagulation for Prevention and treatment • Severe, possibly fatal PE  Thrombolytics WARFARIN Blocking of Vit K dependent coagulation factors II, VII, IX, and X) LMWH inactivating thrombin and activated factor X (factor Xa) through an antithrombin (AT)- dependent mechanism 2/7/2019 46 Department of Anesthesiology and Critical Care ,NAMS
  • 47. Regional Anesthesia and anticoagulation • Regional anesthesia and anticoagulation are important considerations in orthopedic surgeries. • A plan management for anticoagulant and anesthetic technique must be taken for the specific patient under anticoagulation 2/7/2019 47 Department of Anesthesiology and Critical Care ,NAMS
  • 48. 2/7/2019 48 Department of Anesthesiology and Critical Care ,NAMS
  • 49. 2/7/2019 49 Department of Anesthesiology and Critical Care ,NAMS
  • 50. 2/7/2019 50 Department of Anesthesiology and Critical Care ,NAMS
  • 51. Anesthetic considerations Rheumatoid arthritis 2/7/2019 51 Department of Anesthesiology and Critical Care ,NAMS
  • 52. Osteoarthritis • Anesthetic concrens • Reduced joint movement • Airway management • IV access • Spinal or epidural - difficult • Positioning • Concurrent analgesic therapy 2/7/2019 52 Department of Anesthesiology and Critical Care ,NAMS
  • 53. Ankylosing spondylitis • Ankylosing spondylitis involves ossification of the axial ligaments progressing from the sacral lumbar region cranially, • Significant loss of spinal mobility • Regional anesthesia may be difficult • Reduced movement of C-spine and TMJ • Thoracic spine movement restriction • Difficulty in positioning • Others: • Aortic insufficiency, cardiac conduction defects, and pleural effusions. 2/7/2019 53 Department of Anesthesiology and Critical Care ,NAMS
  • 54. Anesthesia for spinal surgery •Pathological condition requiring spine surgery are – Spinal cord compression – Herniation of an intervertebral disk – Spinal deformities (scoliosis) – Tumor or infection – Vascular malformation – Post traumatic stabilization 2/7/2019 54 Department of Anesthesiology and Critical Care ,NAMS
  • 55. Preoperative assessment •Airway evaluation •Respiratory evaluation •Cardiovascular evaluation •Neurological evaluation 2/7/2019 55 Department of Anesthesiology and Critical Care ,NAMS
  • 56. Monitoring •Standard monitoring: •NIBP, SPO2, HR, ECG, Capnograph, temperature •Special monitoring: •Invasive blood pressure, central venous pressure and urine output 2/7/2019 56 Department of Anesthesiology and Critical Care ,NAMS
  • 57. Problems associated with prone position in Spine Surgery 1. Chest pressure - decreased chest compliance and impaired respiration. 2. Abdominal pressure -inferior vena cava compression - retrograde venous flow into the vertebral venous plexus - resulting in epidural venous engorgement. 3. Peripheral nerve damage - as a result of excessive pressure or traction. 4. Eyes, ears, nose, breast, and genitalia must be protected from excessive pressure 2/7/2019 57 Department of Anesthesiology and Critical Care ,NAMS
  • 58. 2/7/2019 58 Department of Anesthesiology and Critical Care ,NAMS
  • 59. Take home message • Older age is a significant risk factor for poor outcome after orthopedic surgery. They often have multiple comorbid conditions that must be considered in the perioperative plan • Proper positioning for orthopaedic procedures is paramount to providing optimal surgical conditions, as well as avoiding potential stretch and compression injuries. • Fat embolism syndrome and bone cement implantation syndrome - result in life threatening emergency thus anticipation and management should be prompt • Patients undergoing major orthopaedic are at high risk for thromboembolic complications. Use of current pharmacologic and mechanical methods of thromboprophylaxis is required 2/7/2019 59 Department of Anesthesiology and Critical Care ,NAMS
  • 60. Take home message • Pneumatic tourniquets are often used to create a bloodless field but also are associated with potential problems; hemodynamic changes, pain, metabolic alterations, arterial thromboembolus, and even pulmonary embolism • Regional anaesthesia reduces perioperative complications compared with GA, and may provide superior analgesia • Regional anaesthesia and anticoagulation are important considerations in orthopaedic surgeries. A plan management for anticoagulant and anesthetic technique must be taken for the specific patient under anticoagulation 2/7/2019 60 Department of Anesthesiology and Critical Care ,NAMS
  • 61. References • Mikhail & Morgan’s Clinical Anesthesiology, 5th edition • Barash, Paul G Cullen Clinical Anesthesia, 8th edition • Ronald D. Miller Miller's Anesthesia , 7th edition • American Society of Regional Anesthesia and Pain Medicine, Evidence- Based Guidelines on regional anesthesia and anticoagulation, 3rd Edition • Internet: www.asra.com/advisory-guidelines/article/4/interventional- spine-and-pain-procedures-in-patients-on-antiplatelet-and-anticoa 2/7/2019 61 Department of Anesthesiology and Critical Care ,NAMS
  • 62. Thank You 2/7/2019 62 Department of Anesthesiology and Critical Care ,NAMS

Notas del editor

  1. A plan management for anticoagulant including heparin ,warfarin factor X a inhibitors and antiplatelets agents must be agreed upon my medical surgical team anesthetic technique must take account the specific of each patients anticoagulation status and plan Pediatric muscular dystrophies-rhabdomylysis hyperkalemia cardiac arrest secondary to sux ,inhalation agents – MH Usual pediatric patient considerations: airway, fluid, temperature, etc. Concerns for latex allergy, MH
  2. spinar cord injury – spinal shock and autonomic dysreflexia may be particular concern Orthpedic pt may have coexisting disease or trauma requiring special attention to distorted airway anatomy or limited neck mobility All medications reviewd during preop visits RA pt on chronic steroids may require perioperative steroid replacement . Patinet taking opiods > 4 weeks often develop tolerance and opoids induced hyperalgesia Patients with RA or osteoarthritis commonly receive NSAIDS for pain mtn .have serious effects like GI bleed ,renal toxicity and platelet dysfunction
  3. cxrayXray- c-spine atlantoccipital subluxation instability (protrusion of odontoid process into the foramen magnum during intubation comprising vertebral blood flow and compressing the spinal cord
  4. General anesthesia : not amenable to RA , and contraindications to RA
  5. Decrease risk of DVT/Thromboembolism: RA causes sympethectomy leads to increased lower extremities blood flow and decrease venous stasis inhibition of platelet and leucocyte adhesion and stimulation of endothelial fibrinolysis. RA leads to hypotension causes decreased blood loss and increased vaso constriction . Full anticoagulation is a contraindication Interval of 12hrs bw LMW and neuraxial block Epidural catheter removal 8-12hrs of LMW Admn and 1-2hrs before next admn Hyperkinetic lower extremity blood flow and associated decrease in venous stasis and thrombus formation Beeficial circulatory effects from epinephrine added to local anesthetic solution Altered coagulation and fibrinolytic responses to surgery under neural blockade, resulting in decreased tendency for blood to clot Absence of positive pressure ventilation and its effects on circulation Direct local anesthetic effects (decreased platelet aggregation)
  6. Esmarch bandage … 2 cuff..distal and proximal..proximal inflated and 0.5 percent lidocaine or 2% lidocaine 50 ml for upper and 100 ml for thigh….45-60 min..after that distal inflated and proximal deflated 20 min
  7. 3 in 1 block- fascia iliaca FNB and adductor canal 9saphenous) nerve block
  8. Appropriate pt positioning produces optimal surgical conditions while avoiding complications related to stretch,pressure and hemodynamic changes.Direct compression neural and soft tissue result in ischemia and tissue damage
  9. Complications: brachial plexus root injury long thoracic nerve injury(winging of scapula) axillary trauma from humeral head (> 90 degree abduction) Radial nerve compression (c6-8 t1) median nerve dysfunction,ulnar neuropathy
  10. Complication : injury to eye and ear (dependent [art) if lids not closed ,weight of head can press downside ear …..Neck injury ..if cervicakk arthritis ..avoid lateral or ventral flexion or rotation
  11. Complcations- eyes and ear injury..conjunctival edema (If head is below level of heart..posterior ischemic neuropathy ..blindness-venous congestion in optic canal and potentially reduce optic nerve perfusion pressure ..causes head lower than heart, obesity leading to potential elevation of IAP and long surgical duration, neck problems brachial plexus injury breast injuryabdominal compression and genitals injury
  12. Shoulder surgery - patients in the sitting, or “beach chair,” position with the head and upper torso elevated 30 to 90 degrees from the supine position. Anesthesia in this position is associated with rare but significant and devastatingneurologic complications including stroke, ischemic brain injury The cause is a decrease in cerebral perfusion pressure resulting in insufficient blood supply to the brain. This is due to the arterial blood pressure gradient that develops between the heart and brain in this position. For each centimeter of head elevation above the level of the heart, there is a decrease in arterial blood pressure of 0.77 mm Hg. Therefore, arterial blood pressure measured at the level of the heart is not the blood and perfusion pressure at the brain.
  13. Is frequently required for joint arthroplasty .the cement interdigitates within the intestices of cancellous bone and strongly bind prosthesis device to pt bone. Mixing polymerized MMA powder with liquid methylmethacrylated causes polymerization and cross linking of polymerchains.the exothermic rxn leads to hardening of cement and expansion of prosthetic component .the resultant intramedullary HTN (>500mmhg) cause embolization of fat marrow cement air into venous channel
  14. Emboli-most commonly occur during insertion of a femoral prosthesis for hip arthroplasty Emboli can trigger cascade of histamine relese ,endothelial damage and complement activation that contributes to severity of BCIS
  15. Hypoxia-increased intrapul shunt
  16. 250 mmHg for arm 350 mmHg for leg By 8 min mitochondrial PO2 approaches 0 Anaerobic metabolism Decreased ATP, NAD+, decreased pH Release of myoglobin, K+, intracellular enzymes, thromboxane Tissue edema develops after 60 min
  17. Exsanguination of extremity causes shift of blood volume into central compartment , rise in CVP and arterial BP that may not be well tolerated in pat. with LV dysfunction
  18. Break through bleeding- during inflation due to intramedullary blood flow in long bones
  19. Cuff should be large enough to comfortably encircle limb,width shd be more than half the limb diameter
  20. Fat embolism is defined by the presence of fat globules in the pulmonary circulation. The term fat embolism syndrome (FES) refers to the clinical syndrome that follows an identifiable insult which releases fat into the circulation, resulting in pulmonary and systemic symptoms. Other causes- CPR -Parental feeding and lipid infusion -Liposuction
  21. These signs exacerbated by hypoxiadirectly toxic to pneumocytes and capillary endothelium in the lung, → interstitial hemorrhage, edema and chemical pneumonitis
  22. Diagnosis- petechiae on chest upper extremities axilla and conjunctiva. Fat globules observed in retina,urine sputum
  23. Features of Schonfeld Index Petechial rash gets the highest point. Respiratory signs also get priority.
  24. Typical right ventricular strain pattern: ST depression and T-wave inversion in V1-4 (plus lead III), in this case due to right ventricular hypertrophy. T-wave inversions are seen in the right precordial (V1-4) and inferior leads (III, aVF) in this patient with acute right ventricular dilatation due to massive pulmonary embolism.
  25. PE >>> DVT (almost 18X)
  26. Malignancy-4 -6 fold
  27. American college of chest physicans recommend -14 days thromboprophylaxis and use of mech compressed device for significant risk of thrombo.The dose is 5000 U given subcutaneously. This should be started within two hours of operation (evidence level II) and then every 8 or 12 hours. There is decreased dosing schedule and decreased risk of heparin induced thrombocytopenia with LMWH compared to UH .calf length pneumatic compression devices seem to offer the same protection for VTE as LMWH or low dose heparin .Comprssion stockings do not create enough pressure to prevent stasis in the deep leg veins or alter lower extremity blood flow and fibrinolysis.Fondaparinux: is a synthetic pentasaccharides, a selective inhibitor of factor Xa and plasma half life of 18 hours Dabigatran: is a thrombin inhibitor with plasma half life of approx. 8 hours Will also prolong APTT but this effect is not linear and should not be relied upon to assess the degree of anticoagulation Only reversal agent for dabigatran is recombinant factor VIIa
  28. When warfarin is used to treat an acute deep vein thrombosis (DVT) or pulmonary embolism (PE), a bridge with a parenteral anticoagulant is absolutely necessary for 2 reasons: Warfarin takes about 5 days to achieve full anticoagulation (INR above 2). During the first few days of warfarin therapy, patients are prothrombotic due to a decrease in protein C and S (natural anticoagulants) before thrombin levels diminish significantly.DayAnticoagulation PlanPre-op Day 5 Stop warfarin (last dose on Pre-op Day 6).Pre-op Day 3Start therapeutic enoxaparin bridging (1 mg/kg SC q12h) or heparin infusion when INR < goal range.Pre-op Day 1Check INR, give vitamin K mg orally if INR > 1.5. Last dose of therapeutic enoxaparin (if using) must be > 24 hours prior to surgery.Day of SurgeryCheck INR, consider additional vitamin K if INR > Stop heparin infusion (if using) 4-6 hours prior to surgery. Assess hemostasis postoperatively. May resume warfarin evening of surgery if patient taking fluids.Post-op Day 1Standard bleeding risk: Resume therapeutic enoxaparin or heparin infusion 24 hours after surgery if hemostasis achieved.High bleeding risk: Consider no bridging or low-dose enoxaparin (40 mg SC daily) 24 hours after surgery if hemostasis achieved.Post-op Day 2High bleeding risk: Resume therapeutic enoxaparin or heparin infusion hours after surgery if hemostasis achieved.Post-op Day 4+Discontinue bridging when INR in goal range.Exit Heparin is a complex polysaccharide that exerts its anti- coagulant effect by binding to antithrombin III. The conformational change in antithrombin accelerates its ability to inactivate thrombin, factor Xa, and factor IXa. The anticoagulant effect of subcutaneous heparin takes 1 to 2 hours, but the effect of intravenous heparin is immediate. Heparin has a half-life of 1.5 to 2 hours. The activated partial thromboplastin time (aPTT) is used to monitor the effect of heparin; therapeutic anticoagulation is achieved with a prolongation of the aPTT to >1.5 times the baseline value.
  29. Aspirin stopped 2-3 days for thoracic and cervical Clopidogrel-discontinue for 7 days ticlopidine-14 days…dnt perform block in >1 antplatelet If neuroaxial tobe performed in cliopidogrel , 7days –P2Y12 assay perform Warfarin check INR discontinue-4-5 days INR<1.4 before neuraxial or epidural removal SC heparin-not a contraindication ,neuraxial block preferably performed before SC heparin .risk of thrombocytopenia with sc therapy > 5days Intavenous hep- neuraxial block 2-4 hr after last iv heparin , wait > 1 hr after neuraxial block before giving iv LMWH- no concomitant antiplatelet,dextran or heparin Time interval between placement and removal afer last dose- enoxaparin 0.5 mg/kg bd dose(prophylaxis): 12 hr 24 hr- 1mg/kg BD dose (therapeutic) 1.5mg/kg (OD) dalteparin 120 u/kg BD, 200mg/kg od LMWH postop- shouldn’t be started before 24 hr, should be given > 2 hr after epidural catheter removal Fibrinolytics/thrombolytics-10 days ( no definitive in ASRA) no data on safety interval for neuraxial performance
  30. Aspirin stopped 2-3 days for thoracic and cervical Clopidogrel-discontinue for 7 days ticlopidine-14 days…dnt perform block in >1 antplatelet If neuroaxial tobe performed in cliopidogrel , 7days –P2Y12 assay perform WARFARIN AND EPIDURAL ANALGESIA INR should be monitored daily. Neurologic testing of sensory and motor function should be performed routinely CATHETER REMOVAL: When INR < 1.5 BUT, WHAT IF.. INR 1.5 – 3 ? Apply caution, review that other anticoagulants are not administered, assess neurologic status continually until INR stabilizes at desired prophylaxis level INR >3 ? Warfarin dose be held or reduced in patients with indwelling neuraxial catheter. NO RECOMMENDATION: for removal of catheter in patients with THERAPEUTIC LEVEL of anticoagulation. Warfarin check INR discontinue-4-5 days INR<1.4 before neuraxial or epidural removal ,
  31. Heparin and LMW-heparins prevent clot formation by binding antithrombin. The heparin-antithrombin complex can then bind to and inactivate either thrombin (Factor II) or activated-Factor Xa. Low-molecular weight heparin will only bind and inactivate activated Factor Xa.SC heparin-not a contraindication ,neuraxial block preferably performed before SC heparin .risk of thrombocytopenia with sc therapy > 5days Intavenous hep- neuraxial block 2-4 hr after last iv heparin , wait > 1 hr after neuraxial block before giving iv LMWH- no concomitant antiplatelet,dextran or heparin Time interval between placement and removal afer last dose- enoxaparin 0.5 mg/kg bd dose(prophylaxis): 12 hr 24 hr- 1mg/kg BD dose (therapeutic) 1.5mg/kg (OD) dalteparin 120 u/kg BD, 200mg/kg od LMWH postop- shouldn’t be started before 24 hr, should be given > 2 hr after epidural cathe
  32. Fibrinolytics/thrombolytics-10 days ( no definitive in ASRA) no data on safety interval for neuraxial performance
  33. RA is characterized by immune mediated joint destruction with chr and progressive inflammation of synovial membrane.it is a systemic disease affecting multiple organ system. Atlantoccipital unstabilitytracheal intubation should be performed with inline stabilization using video laryngo or fibreoptic If the distance from the anterior arch of the atlas to the odontoid process exceeds 3 mm, the patient should undergo an awake fiberoptic tracheal intubation and the cervical spine should be protected with a cervical collar during the procedure.
  34. Respiratory considerations include an inability to cough and clear secretions, which may result in atelectasis and infection. Cardiovascular considerations are based on loss of sympathetic nervous system innervation (“spinal shock”) below the level of spinal cord transection. (Cardioaccelerator fiber [T1–T4] loss results in bradycardia and possible absence of compensatory tachycardia if blood loss occurs.) Occurs in 85% of patients with spinal cord transection above T5 Paroxysmal hypertension with bradycardia (baroreceptor reflex) Cardiac dysrhythmias Cutaneous vasoconstriction below and vasodilation above the level of transection Precipitated by any noxious stimulus (distention of a hollow viscus) Treatment is removal of stimulus, deepening of anesthesia, and administration of a vasodilator
  35. A plan management for anticoagulant including heparin ,warfarin factor X a inhibitors and antiplatelets agents must be agreed upon my medical surgical team anesthetic technique must take account the specific of each patients anticoagulation status and plan