2. Learning objectives
• Describe general considerations and goals related to orthopedic
surgery
• Describe specific consideration associated with orthopedic
surgery ,their anesthetic implications and management
• Describe briefly about special orthopedic condition and their
anesthetic concerns
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3. • General consideration
1. Perioperative Goals
a) Pre op considerations
b) Intraoperative Goals
c) Post operative considerations
2. Age specific orthopedic conditions
3. Medical comorbidities
4. Co existing medications
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4. • Specific considerations
1. Positioning
2. Bone cement Implantation syndrome
3. Pneumatic Tourniquets
4. Fat embolism
5. Deep vein thrombosis and thromboembolism
6. Regional anesthesia and anticoagulation
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5. • Pre op considerations
1. Age
2. Co morbidities
3. Medications
4. Diagnostic studies
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6. Pre op considerations
• 1.Age of the patients
• Elderly
• Medical Conditions(MI,COPD,HTN CVD,DM)
• Anticoagulation therapy
• Renal dysfunctions
• Airway difficulties
• Osteoporesis
• Pediatrics
• Congenital deformities
• Undiagnosed muscular dystrophies
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7. Pre-op considerations
2. Comorbidities
• Trauma- stabilization
• Geriatric populations- HTN,CAD,CVD,COPD, osteoarthritis, RA
• Obesity-HTN,CAD,DM
3. Medications
• Steroids
• Opiods
• Antihypertensives
• NSAIDS
• Immunotherapy-Methotrexate
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9. Choice of Anesthetic Technique
• Regional anesthesia vs General anesthesia
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10. Choice Of Anesthesia Technique contd..
Many orthopedic surgery because of localized peripheral sites led
themselves to RA techniques
Advantages of RA
• No or minimal airway manipulation
• Improved postoperative analgesia
• Decreased incidence of PONV
• Less respiratory and cardiac depression
• Reduced blood loss
• Decrease risk of DVT/Thromboembolism
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11. Upper Extremity Surgery
RA (+/- GA)
1. IRVA(Intravenous Regional Anesthesia)
• Advantage: simplicity of technique, rapid onset of action, controllable
duration of action and rapid return of function.
• Disadvantage: continuous use of tourniquet, the potential toxic effect
of the drug and lack of postoperative analgesia.
2. Brachial Plexus Block
3. Blockade of peripheral nerves
• Radial Nerve block.
• Median Nerve block.
• Ulnar Nerve block.
• Digital Nerves.
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12. Lower Extremity Surgery
• Can be completely performed under regional anesthesia
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13. Regional anesthesia technique for surgery of the
lower extremity
1. Hip
2. Knee
3. Lower leg
4. Ankle
5. Foot
• Spinal, epidural, lumbar plexus block.
• Spinal,epidural,3 in 1 block, femoral
sciatic block.
• Spinal, epidural, sciatic block, femoral-
sciatic block, sciatic and saphenous
block.
• Spinal, sciatic block
• Spinal, sciatic, ankle block, trans
metatarsal block.
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14. Intraoperative Goals
• Surgical anesthesia
To provide optimal surgical operating conditions
Appropriate depth of anesthesia
Adequate pain control
• Optimize surgical exposure
Neuromuscular blockade in GA
Neuraxial anesthesia
Peripheral nerve block
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15. Intraoperative Goals
• Proper positioning to Prevent stretch/compression nerve
injuries
• Prevent significant blood loss
may be reduced through
• proper positioning
• intraoperative blood salvage,
• induced hypotension,
• intraoperative hemodilution, and
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16. Post operative considerations
• Postoperative pain management
• Peripheral nerve blockade with or without catheter
• Opioids for breakthrough pain/multimodal analgesia
• NSAIDs and adjuvant analgesic medications
• Others
• ICU/Post op care
• Mechanical ventilation: if needed
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18. Positioning
• Why positioning important??
1. Patient safety
2. Prevent nerve injuries
3. Enable iv access, ET Tube , catheter to remain patent
4. Enable proper monitor
5. Facilitates surgical approach
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19. Positioning
• Supine
• Lateral
• Prone
• Beach chair
• Fracture table
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20. Positioning contd..
• Supine
• Patient on back
• Arms on arm boards
• Arm < 90 degrees
• Arm is supinated ( palm up)
• Place padding under elbow if
able
• Arm tucked
• Check fingers
• Check IV lines and SpO2
probe
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21. Positioning contd..
Lateral
Body alignment
Keep neck in neutral position
Always place axillary roll
Place padding between knees
Place padding below lateral aspect
of dependent leg
Position arms to parallel to one
another
Place padding between arms or
place non-dependent arm on
padded surface
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22. Positioning contd…
• Prone
• Face down
• Head placement
• Head straight forward
• ET tube placement and
patency
• Check bilateral eyes/ears
for pressure points
• Head turned
• Check dependent eye/ear,
ETT placement
• Be aware of potential
vascular occlusion
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23. Positioning contd..
• Prone
Arm placement
Tucked – similar to supine
Abducted
▪ Check neck rotation and arm
extension to avoid brachial
plexus injury
▪ Elbow are padded
Chest rolls
Iliac support
Padding in placed under iliac crests
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24. Positioning contd..
Beach Chair
• Arms- supported to prevent
stretching of the brachial
plexus.
• Elastic stockings and active leg
compression devices - help
maintain venous return.
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25. Positioning contd..
• Fracture chair
• Maintenance of traction on the
fractured extremity, allowing
• manipulation for closed reduction
and fixation, and
• access to the fracture site for
radiography in several planes
• The ipsilateral arm is positioned on
an arm board or sling without
stretching the brachial plexus
• Gentiles protection
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26. Bone Cement Implantation Syndrome
• Bone cement Syndrome
Characterised by hypoxia , hypotension or both and or unexpected
loss of consciousness occurring at the time of cementation,
prosthesis insertion ,reduction of joint or occasionally, limb
tourniquet deflation in a patient undergoing cemented bone
surgery
• Bone cement-
Methyl methacrylate(MMA) an acrylic bone cement used during
arthroplastic procedures.
Donaldson et al 2009
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28. •Clinical presentations
• Fever
• Hypoxia
• Hypotension
• Tachycardia
• Dysrhythmia
• Mental status change
• Dyspnea
• Decreased End tidal CO2
• Right ventricular failure and
cardiac arrest
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29. •Treatment strategies
1. Increasing FiO2 prior to cementing
2. Monitoring & maintaining hydration
3. Creating vent hole in the distal femur
4. High pressure lavage of femoral shaft to remove debris
5. Using cementless prosthesis
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31. Pneumatic tourniquet
• To create bloodless field
• Not > 2 hours
• Prolonged inflation (>2hrs) leads
to
-transient muscle dysfunction
- rhabdomyolysis,
-nerve injuries
• 100 mmHg above systolic blood
pressure
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Department of Anesthesiology and Critical
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32. Pneumatic tourniquet
• Advantage
• Eliminate intraoperative
bleeding
• Disadvantages
• Neurologic effect
• Muscle change
• Systemic effects of the
tourniquet inflation
• Systemic effects of the
tourniquet release
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33. Pneumatic tourniquet
•Problems with inflation
• Pain
• Sympathetic stimulation:
Marked HTN, tachycardia, and diaphoresis
• Arterial thromboembolism, pulmonary embolism
• If prolonged >2 hour
Transient muscle dysfunction rhabdomyolysis, permanent
nerve damage
• Folds or lines under tourniquet may cause bruising or pressure
necrosis of skin
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34. • Problems with deflation
• The good: decreases the tourniquet pain experienced
• Disadvantages
• Increase in blood level of: PaCo2, lactate, potassium: d/t washout of
accumulated waste
• Increase. in MV of spontaneously breathing patients
• Transient metabolic acidosis
• Core temperature decreases
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35. Prevention
• Select patients
• Wide, low-pressure cuff
• Apply the lowest pressure to prevent bleeding
• Limit time to 2 hours
• Set maximum pressure
-Arm 50-75 mmHg above systolic
-Leg 75-100 mmHg above systolic
• Doppler guided tourniquet pressure inflation
• Adequate padding underneath
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36. Fat Embolism Syndrome
• A well known complication of skeletal trauma and surgery
involving femoral medullary canal
• A physiologic response to fat within systemic circulation
• FES <2 - 22% , all long bone fracture
• Mortality rate - 10-20 %
• Presents within 72 hrs. following fracture of long bone,pelvis
with triad of – Dyspnea, confusion, petechiae
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38. Clinical manifestations
• Neurologic: agitation, confusion,
stupor, coma
• Hematologic: thrombocytopenia,
prolonged CT
• Cutaneous: petechiae
(pathognomonic)
• Pulmonary: mild hypoxia, resp.
failure, ARDS (10%)
• CVS: persistent tachycardia,
hypotension
Dyspnea
Confusion Petechiae
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39. Gurd's Diagnosis of FES
• Major Features (at least one)
• Respiratory insufficiency: PaO2 <60
mm Hg, FiO2: 0.4
• Cerebral involvement: altered
mentation
• Petechial rash
• Minor Features (at least four)
• Pyrexia
• Tachycardia
• Retinal changes
• Jaundice
• Renal changes
• Laboratory Features
• Fat microglobulinemia
• Anemia
• Thrombocytopenia
• High ESR
Gurd AR, Wilson RI: The fat embolism syndrome. J Bone Joint Surg Br 56:408-416, 1974
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40. Schonfield index
• A score of >5 required for
the diagnosis of FES
Schonfeld SA, Ploysongsang Y, DiLisio R, et al: Fat embolism prophylaxis with corticosteroids: A prospective
study in high risk patients. Ann Int Med 99:438-443, 1983.
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41. How to diagnose FES under GA
• Decline in end tidal CO2
• Decline in arterial oxygen saturation
• Rise in pulmonary artery pressures
ECG
• Ischemic-appearing ST segment changes
• Right sided heart strain
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42. Treatment
Prophylactic
Early stabilization of the fracture
Supportive
Respiratory care
▪ O2 therapy (with CPAP ventilation - ARDS)
Invasive monitoring
▪ Volume status, Inotrops
▪ Vasodilators for Pulmonary HTN
High dose corticosteroid
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43. One of the leading causes of morbidity and mortality after
major orthopedic surgeries like THA, TKA, hip and pelvic
fracture surgeries.
• Incidence of DVT : 40-80% without prophylaxis
• Incidence pulmonary embolism is 20%(Fatality-1-3%)
• Major pathophysiological mechanism(Virchow’s Triad)
• Venous stasis
• Hypercoagulable state
• Endothelial damage
DVT And Thromboembolism
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44. DVT/Thromboembolism contd..
Risk Factors
• Obesity
• Age > 60 years
• Previous PE and DVT
• Cancer
• Procedure > 30 mins
• Use of tourniquet
• Lower extremities fracture
• Immobilization > 4 days
• Thrombophilia: mainly
hereditary eg. Factor V Leiden
(most common)
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45. Prevention
• Non-pharmacological
• Intermittent pneumatic compression
• TED stockings
• IVC filters: in patients C/I for anticoagulation
• Pharmacological
• Low dose heparin (UF)
• Warfarin
• LMWH
• Recent alternatives to:
• Fondaparinux
• Dabigatran
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46. •Treatment
• Anticoagulants OR Thrombolytics?
• Venous thrombi Fibrin thrombi anticoagulation for Prevention and treatment
• Severe, possibly fatal PE Thrombolytics
WARFARIN
Blocking of Vit K dependent
coagulation factors
II, VII, IX, and X)
LMWH
inactivating thrombin and activated factor X
(factor Xa) through an antithrombin (AT)-
dependent mechanism
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47. Regional Anesthesia and anticoagulation
• Regional anesthesia and anticoagulation are important
considerations in orthopedic surgeries.
• A plan management for anticoagulant and anesthetic technique
must be taken for the specific patient under anticoagulation
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52. Osteoarthritis
• Anesthetic concrens
• Reduced joint movement
• Airway management
• IV access
• Spinal or epidural - difficult
• Positioning
• Concurrent analgesic therapy
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53. Ankylosing spondylitis
• Ankylosing spondylitis involves ossification of the axial ligaments
progressing from the sacral lumbar region cranially,
• Significant loss of spinal mobility
• Regional anesthesia may be difficult
• Reduced movement of C-spine and TMJ
• Thoracic spine movement restriction
• Difficulty in positioning
• Others:
• Aortic insufficiency, cardiac conduction defects, and pleural effusions.
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54. Anesthesia for spinal surgery
•Pathological condition requiring spine surgery are
– Spinal cord compression
– Herniation of an intervertebral disk
– Spinal deformities (scoliosis)
– Tumor or infection
– Vascular malformation
– Post traumatic stabilization
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56. Monitoring
•Standard monitoring:
•NIBP, SPO2, HR, ECG, Capnograph, temperature
•Special monitoring:
•Invasive blood pressure, central venous pressure and urine output
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57. Problems associated with prone position in
Spine Surgery
1. Chest pressure - decreased chest compliance and impaired
respiration.
2. Abdominal pressure -inferior vena cava compression -
retrograde venous flow into the vertebral venous plexus -
resulting in epidural venous engorgement.
3. Peripheral nerve damage - as a result of excessive pressure or
traction.
4. Eyes, ears, nose, breast, and genitalia must be protected from
excessive pressure
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59. Take home message
• Older age is a significant risk factor for poor outcome after
orthopedic surgery. They often have multiple comorbid
conditions that must be considered in the perioperative plan
• Proper positioning for orthopaedic procedures is paramount to
providing optimal surgical conditions, as well as avoiding
potential stretch and compression injuries.
• Fat embolism syndrome and bone cement implantation
syndrome - result in life threatening emergency thus
anticipation and management should be prompt
• Patients undergoing major orthopaedic are at high risk for
thromboembolic complications. Use of current pharmacologic
and mechanical methods of thromboprophylaxis is required
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60. Take home message
• Pneumatic tourniquets are often used to create a bloodless field but
also are associated with potential problems; hemodynamic changes,
pain, metabolic alterations, arterial thromboembolus, and even
pulmonary embolism
• Regional anaesthesia reduces perioperative complications compared
with GA, and may provide superior analgesia
• Regional anaesthesia and anticoagulation are important
considerations in orthopaedic surgeries. A plan management for
anticoagulant and anesthetic technique must be taken for the
specific patient under anticoagulation
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61. References
• Mikhail & Morgan’s Clinical Anesthesiology, 5th edition
• Barash, Paul G Cullen Clinical Anesthesia, 8th edition
• Ronald D. Miller Miller's Anesthesia , 7th edition
• American Society of Regional Anesthesia and Pain Medicine, Evidence-
Based Guidelines on regional anesthesia and anticoagulation,
3rd Edition
• Internet: www.asra.com/advisory-guidelines/article/4/interventional-
spine-and-pain-procedures-in-patients-on-antiplatelet-and-anticoa
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A plan management for anticoagulant including heparin ,warfarin factor X a inhibitors and antiplatelets agents must be agreed upon my medical surgical team anesthetic technique must take account the specific of each patients anticoagulation status and plan
Pediatric muscular dystrophies-rhabdomylysis hyperkalemia cardiac arrest secondary to sux ,inhalation agents – MH Usual pediatric patient considerations: airway, fluid, temperature, etc.
Concerns for latex allergy, MH
spinar cord injury – spinal shock and autonomic dysreflexia may be particular concern Orthpedic pt may have coexisting disease or trauma requiring special attention to distorted airway anatomy or limited neck mobility All medications reviewd during preop visits
RA pt on chronic steroids may require perioperative steroid replacement . Patinet taking opiods > 4 weeks often develop tolerance and opoids induced hyperalgesia Patients with RA or osteoarthritis commonly receive NSAIDS for pain mtn .have serious effects like GI bleed ,renal toxicity and platelet dysfunction
cxrayXray- c-spine atlantoccipital subluxation instability (protrusion of odontoid process into the foramen magnum during intubation comprising vertebral blood flow and compressing the spinal cord
General anesthesia : not amenable to RA , and contraindications to RA
Decrease risk of DVT/Thromboembolism: RA causes sympethectomy leads to increased lower extremities blood flow and decrease venous stasis
inhibition of platelet and leucocyte adhesion and stimulation of endothelial fibrinolysis. RA leads to hypotension causes decreased blood loss and increased vaso constriction . Full anticoagulation is a contraindication Interval of 12hrs bw LMW and neuraxial block Epidural catheter removal 8-12hrs of LMW Admn and 1-2hrs before next admn
Hyperkinetic lower extremity blood flow and associated decrease in venous stasis and thrombus formation
Beeficial circulatory effects from epinephrine added to local anesthetic solution
Altered coagulation and fibrinolytic responses to surgery under neural blockade, resulting in decreased tendency for blood to clot
Absence of positive pressure ventilation and its effects on circulation
Direct local anesthetic effects (decreased platelet aggregation)
Esmarch bandage … 2 cuff..distal and proximal..proximal inflated and 0.5 percent lidocaine or 2% lidocaine 50 ml for upper and 100 ml for thigh….45-60 min..after that distal inflated and proximal deflated 20 min
3 in 1 block- fascia iliaca FNB and adductor canal 9saphenous) nerve block
Appropriate pt positioning produces optimal surgical conditions while avoiding complications related to stretch,pressure and hemodynamic changes.Direct compression neural and soft tissue result in ischemia and tissue damage
Complications: brachial plexus root injury long thoracic nerve injury(winging of scapula) axillary trauma from humeral head (> 90 degree abduction) Radial nerve compression (c6-8 t1) median nerve dysfunction,ulnar neuropathy
Complication : injury to eye and ear (dependent [art) if lids not closed ,weight of head can press downside ear …..Neck injury ..if cervicakk arthritis ..avoid lateral or ventral flexion or rotation
Complcations- eyes and ear injury..conjunctival edema (If head is below level of heart..posterior ischemic neuropathy ..blindness-venous congestion in optic canal and potentially reduce optic nerve perfusion pressure ..causes head lower than heart, obesity leading to potential elevation of IAP and long surgical duration, neck problems brachial plexus injury breast injuryabdominal compression and genitals injury
Shoulder surgery - patients in the sitting, or “beach chair,” position with the head and upper torso elevated 30 to 90 degrees from the supine position. Anesthesia in this position is associated with rare but significant and devastatingneurologic complications including stroke, ischemic brain injury The cause is a decrease in cerebral perfusion pressure resulting in insufficient blood supply to the brain. This is due to the arterial blood pressure gradient that develops between the heart and brain in this position. For each centimeter of head elevation above the level of the heart, there is a decrease in arterial blood pressure of 0.77 mm Hg. Therefore, arterial blood pressure measured at the level of the heart is not the blood and perfusion pressure at the brain.
Is frequently required for joint arthroplasty .the cement interdigitates within the intestices of cancellous bone and strongly bind prosthesis device to pt bone.
Mixing polymerized MMA powder with liquid methylmethacrylated causes polymerization and cross linking of polymerchains.the exothermic rxn leads to hardening of cement and expansion of prosthetic component .the resultant intramedullary HTN (>500mmhg) cause embolization of fat marrow cement air into venous channel
Emboli-most commonly occur during insertion of a femoral prosthesis for hip arthroplasty
Emboli can trigger cascade of histamine relese ,endothelial damage and complement activation that contributes to severity of BCIS
Hypoxia-increased intrapul shunt
250 mmHg for arm
350 mmHg for leg
By 8 min mitochondrial PO2 approaches 0
Anaerobic metabolism
Decreased ATP, NAD+, decreased pH
Release of myoglobin, K+, intracellular enzymes, thromboxane
Tissue edema develops after 60 min
Exsanguination of extremity causes shift of blood volume into central compartment , rise in CVP and arterial BP that may not be well tolerated in pat. with LV dysfunction
Break through bleeding- during inflation due to intramedullary blood flow in long bones
Cuff should be large enough to comfortably encircle limb,width shd be more than half the limb diameter
Fat embolism is defined by the presence of fat globules in the pulmonary circulation.
The term fat embolism syndrome (FES) refers to the clinical syndrome that follows an identifiable insult which releases fat into the circulation, resulting in pulmonary and systemic symptoms.
Other causes- CPR
-Parental feeding and lipid infusion
-Liposuction
These signs exacerbated by hypoxiadirectly toxic to pneumocytes and capillary endothelium in the lung, → interstitial hemorrhage, edema and chemical pneumonitis
Diagnosis- petechiae on chest upper extremities axilla and conjunctiva. Fat globules observed in retina,urine sputum
Features of Schonfeld Index
Petechial rash gets the highest point.
Respiratory signs also get priority.
Typical right ventricular strain pattern: ST depression and T-wave inversion in V1-4 (plus lead III), in this case due to right ventricular hypertrophy.
T-wave inversions are seen in the right precordial (V1-4) and inferior leads (III, aVF) in this patient with acute right ventricular dilatation due to massive pulmonary embolism.
PE >>> DVT (almost 18X)
Malignancy-4 -6 fold
American college of chest physicans recommend -14 days thromboprophylaxis and use of mech compressed device for significant risk of thrombo.The dose is 5000 U given subcutaneously. This should be started within two hours of operation (evidence level II) and then every 8 or 12 hours. There is decreased dosing schedule and decreased risk of heparin induced thrombocytopenia with LMWH compared to UH .calf length pneumatic compression devices seem to offer the same protection for VTE as LMWH or low dose heparin .Comprssion stockings do not create enough pressure to prevent stasis in the deep leg veins or alter lower extremity blood flow and fibrinolysis.Fondaparinux: is a synthetic pentasaccharides, a selective inhibitor of factor Xa and plasma half life of 18 hours Dabigatran: is a thrombin inhibitor with plasma half life of approx. 8 hours Will also prolong APTT but this effect is not linear and should not be relied upon to assess the degree of anticoagulation Only reversal agent for dabigatran is recombinant factor VIIa
When warfarin is used to treat an acute deep vein thrombosis (DVT) or pulmonary embolism (PE), a bridge with a parenteral anticoagulant is absolutely necessary for 2 reasons:Warfarin takes about 5 days to achieve full anticoagulation (INR above 2).
During the first few days of warfarin therapy, patients are prothrombotic due to a decrease in protein C and S (natural anticoagulants) before thrombin levels diminish significantly.DayAnticoagulation PlanPre-op Day 5 Stop warfarin (last dose on Pre-op Day 6).Pre-op Day 3Start therapeutic enoxaparin bridging (1 mg/kg SC q12h) or heparin infusion when INR < goal range.Pre-op Day 1Check INR, give vitamin K mg orally if INR > 1.5. Last dose of therapeutic enoxaparin (if using) must be > 24 hours prior to surgery.Day of SurgeryCheck INR, consider additional vitamin K if INR > Stop heparin infusion (if using) 4-6 hours prior to surgery. Assess hemostasis postoperatively. May resume warfarin evening of surgery if patient taking fluids.Post-op Day 1Standard bleeding risk: Resume therapeutic enoxaparin or heparin infusion 24 hours after surgery if hemostasis achieved.High bleeding risk: Consider no bridging or low-dose enoxaparin (40 mg SC daily) 24 hours after surgery if hemostasis achieved.Post-op Day 2High bleeding risk: Resume therapeutic enoxaparin or heparin infusion hours after surgery if hemostasis achieved.Post-op Day 4+Discontinue bridging when INR in goal range.Exit
Heparin is a complex polysaccharide that exerts its anti- coagulant effect by binding to antithrombin III. The conformational change in antithrombin accelerates its ability to inactivate thrombin, factor Xa, and factor IXa. The anticoagulant effect of subcutaneous heparin takes 1 to 2 hours, but the effect of intravenous heparin is immediate. Heparin has a half-life of 1.5 to 2 hours. The activated partial thromboplastin time (aPTT) is used to monitor the effect of heparin; therapeutic anticoagulation is achieved with a prolongation of the aPTT to >1.5 times the baseline value.
Aspirin stopped 2-3 days for thoracic and cervical Clopidogrel-discontinue for 7 days ticlopidine-14 days…dnt perform block in >1 antplatelet If neuroaxial tobe performed in cliopidogrel , 7days –P2Y12 assay perform
Warfarin check INR discontinue-4-5 days INR<1.4 before neuraxial or epidural removal
SC heparin-not a contraindication ,neuraxial block preferably performed before SC heparin .risk of thrombocytopenia with sc therapy > 5days
Intavenous hep- neuraxial block 2-4 hr after last iv heparin , wait > 1 hr after neuraxial block before giving iv
LMWH- no concomitant antiplatelet,dextran or heparin
Time interval between placement and removal afer last dose- enoxaparin 0.5 mg/kg bd dose(prophylaxis): 12 hr
24 hr- 1mg/kg BD dose (therapeutic) 1.5mg/kg (OD) dalteparin 120 u/kg BD, 200mg/kg od
LMWH postop- shouldn’t be started before 24 hr, should be given > 2 hr after epidural catheter removal
Fibrinolytics/thrombolytics-10 days ( no definitive in ASRA) no data on safety interval for neuraxial performance
Aspirin stopped 2-3 days for thoracic and cervical Clopidogrel-discontinue for 7 days ticlopidine-14 days…dnt perform block in >1 antplatelet If neuroaxial tobe performed in cliopidogrel , 7days –P2Y12 assay perform
WARFARIN AND EPIDURAL ANALGESIA
INR should be monitored daily.
Neurologic testing of sensory and motor function should be performed routinely
CATHETER REMOVAL: When INR < 1.5
BUT, WHAT IF..
INR 1.5 – 3 ? Apply caution, review that other anticoagulants are not administered, assess neurologic status continually until INR stabilizes at desired prophylaxis level
INR >3 ? Warfarin dose be held or reduced in patients with indwelling neuraxial catheter.
NO RECOMMENDATION: for removal of catheter in patients with THERAPEUTIC LEVEL of anticoagulation.
Warfarin check INR discontinue-4-5 days INR<1.4 before neuraxial or epidural removal ,
Heparin and LMW-heparins prevent clot formation by binding antithrombin. The heparin-antithrombin complex can then bind to and inactivate either thrombin (Factor II) or activated-Factor Xa. Low-molecular weight heparin will only bind and inactivate activated Factor Xa.SC heparin-not a contraindication ,neuraxial block preferably performed before SC heparin .risk of thrombocytopenia with sc therapy > 5days
Intavenous hep- neuraxial block 2-4 hr after last iv heparin , wait > 1 hr after neuraxial block before giving iv
LMWH- no concomitant antiplatelet,dextran or heparin
Time interval between placement and removal afer last dose- enoxaparin 0.5 mg/kg bd dose(prophylaxis): 12 hr
24 hr- 1mg/kg BD dose (therapeutic) 1.5mg/kg (OD) dalteparin 120 u/kg BD, 200mg/kg od
LMWH postop- shouldn’t be started before 24 hr, should be given > 2 hr after epidural cathe
Fibrinolytics/thrombolytics-10 days ( no definitive in ASRA) no data on safety interval for neuraxial performance
RA is characterized by immune mediated joint destruction with chr and progressive inflammation of synovial membrane.it is a systemic disease affecting multiple organ system. Atlantoccipital unstabilitytracheal intubation should be performed with inline stabilization using video laryngo or fibreoptic If the distance from the anterior arch of the atlas to the odontoid process exceeds 3 mm, the patient should undergo an awake fiberoptic tracheal
intubation and the cervical spine should be protected with a cervical collar during the procedure.
Respiratory considerations include an inability to cough and clear secretions, which may result in atelectasis and infection.
Cardiovascular considerations are based on loss of sympathetic nervous system innervation (“spinal shock”) below the level of spinal cord transection. (Cardioaccelerator fiber [T1–T4] loss results in bradycardia and possible absence of compensatory tachycardia if blood loss occurs.)
Occurs in 85% of patients with spinal cord transection above T5
Paroxysmal hypertension with bradycardia (baroreceptor reflex)
Cardiac dysrhythmias
Cutaneous vasoconstriction below and vasodilation above the level of transection
Precipitated by any noxious stimulus (distention of a hollow viscus)
Treatment is removal of stimulus, deepening of anesthesia, and administration of a vasodilator
A plan management for anticoagulant including heparin ,warfarin factor X a inhibitors and antiplatelets agents must be agreed upon my medical surgical team anesthetic technique must take account the specific of each patients anticoagulation status and plan