Atherosclerosis, Pathophysiology of Atherosclerosis, Pathology of Atherosclerosis, causes of Atherosclerosis, Diagnosis of Atherosclerosis, Complications of Atherosclerosis, symptoms of atherosclerosis

1. B Y
MR. KRUSHNA K. ZAMBARE
H O D , P H A R M A C O L O G Y
S B S P M B . P H A R M A C Y C O L L E G E , A M B A J O G A I
Prof. K. K. Zambare
Atherosclerosis

2. Definition
Prof. K. K. Zambare
 Atherosclerosis is a disease in which fibro fatty
plaque builds up inside your arteries.
 The fibro fatty deposit is called as plaque
 Plaque may rupture and cause blockage of artery
by clotting

3. Causes
Prof. K. K. Zambare
 Hypertension
 Obesity
 Fatty diet
 Smoking
 Diabetes
 Family history of cardiac diseases

4. Causes
Prof. K. K. Zambare
 Lack of exercise
 Familial history of cardiac disease
 Inflammation due to arthritis and lupus

5. Symptoms
Prof. K. K. Zambare
Usually disease does not show any symptom but if
plaque rupture or of large size and reduces the
blood supply then shows following symptoms
 Shortness of breath
 Pain or pressure in upper body
 Chest pain

6. Symptoms
Prof. K. K. Zambare
 Pain in arms, neck, or jaw.
 Numbness in arms
 Headache
 Paralysis
 Difficulty in speaking
 Facial numbness

7. Diagnosis
Prof. K. K. Zambare
 Blood test
High cholesterol level can be checked in blood.
 X-ray
Useful for detecting hardening and narrowing of
arteries
 CT / MRI scan
It is useful for detecting hardening and
narrowing of large arteries, aneurysms and
calcium deposits in artery walls

8. Diagnosis
Prof. K. K. Zambare
 Angiogram
Dye injected in arteries, the arteries become
visible on X-ray, revealing areas of blockage
 Electriocardiogram (ECG):
Abnormal ECG may be indication of coronary
atheroma.

9. Complications
Prof. K. K. Zambare
 Stroke
It is life threatening condition due to blockage in blood
vessels of brain.
 Cardiac arrhythmia
Atherosclerosis may sometimes responsible for
arrhythmia.
 Renal failure
Blockage in renal artery may lead to renal failure.

10. Complications
Prof. K. K. Zambare
 Heart failure/ coronary artery disease
Atherosclerosis may lead to decreased cardiac output.
 Heart attack
Coronary atherosclerosis may lead to reduced blood
supply to heart which may cause heart attack.
 Aneurysm
In this condition walls of artery form balloon which may
burst and may be life threatening