How can cells precisely measure time-varying external signals? - Giulia Malaguti
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How can cells precisely measure time-varying external signals? - Giulia Malaguti
- 1. Giulia Malaguti Pieter Rein ten Wolde's group AMOLF, Amsterdam Quantitative Laws II, Como June 13th, 2016 How can cells precisely measure time-varying external signals?
- 2. Cell sensing system is surprisingly accurate ligand molecules receptors cell surface readout molecules ATP
- 3. ligand molecules receptors cell surface readout molecules Cell sensing system is surprisingly accurate NOISE NOISE ATP
- 4. Cell sensing system is surprisingly accurate ligand molecules receptors cell surface readout moleculesNOISE NOISE What is the fundamental limit on the precision of concentration measurements? ATP
- 5. Cell sensing system is surprisingly accurate ligand molecules receptors cell surface readout moleculesNOISE NOISE Berg and Purcell (1977). Bialek and Setayeshgar (2005). Ueda and Shibata (2007). Wang et al. (2007). Govern and ten Wolde (2012). Lang et al. (2014). Kaizu et al. (2014). Govern and ten Wolde (2014). Rappel et al. (2008). Endres and Wingreen (2009) Mora and Wingreen (2010). Skoge et al (20112013). What is the fundamental limit on the precision of concentration measurements? ATP
- 6. Cell sensing system is surprisingly accurate ligand molecules receptors cell surface readout moleculesNOISE NOISE What is the fundamental limit on the precision of concentration measurements? When measuring time-varying ligand concentrations! Timevarying! ATP
- 7. Cell resources fundamentally limit the sensing precision t
- 8. t unbound bound N samples Cell resources fundamentally limit the sensing precision unbound bound N samples unbound bound N samples
- 9. t unbound bound N samples # receptors Cell resources fundamentally limit the sensing precision
- 10. t unbound bound N samples ATP # receptors Cell resources fundamentally limit the sensing precision
- 11. t unbound bound N samples ATP # receptors # readout molecules Cell resources fundamentally limit the sensing precision
- 12. t unbound bound N samples ATP # receptors # readout molecules power Cell resources fundamentally limit the sensing precision
- 13. t unbound bound N samples ATP # receptors # readout molecules power Cell resources fundamentally limit the sensing precision Optimal resource allocation
- 14. Thank you for your attention! AMOLF Biochemical Networks group Yao Li Adithya Vijaykumar Pieter Rein ten Wolde Joris Paijmans Michele Monti Harmen Wierenga Sosuke Ito