SlideShare una empresa de Scribd logo
1 de 50
A linear motif atlas for phosphorylation-dependent signaling
location
 
 
 
signaling networks
phosphoproteomics
Linding, Jensen, Ostheimer et al.,  Cell , 2007
in vivo  phosphosites
kinases are unknown
sequence motifs
Miller, Jensen et al.,  Science Signaling , 2008
sequence specificity
kinase-specific
in vitro
context
association networks
Linding, Jensen, Ostheimer et al.,  Cell , 2007
NetworKIN
Linding, Jensen, Ostheimer et al.,  Cell , 2007
sequence motifs
NetPhorest
Miller, Jensen et al.,  Science Signaling , 2008
data organization
Miller, Jensen et al.,  Science Signaling , 2008
automated pipeline
compilation of datasets
redundancy reduction
training and evaluation
classifier selection
motif atlas
 
179 kinases
93 SH2 domains
8 PTB domains
BRCT domains
WW domains
14-3-3 proteins
phosphatases
model organisms
biological applications
disease-related kinases
Miller, Jensen et al.,  Science Signaling , 2008
cell-cycle kinases
variation and signaling
augmented browsing
Reflect
 
Acknowledgments ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 

Más contenido relacionado

La actualidad más candente

Abdulla compucell3d workshop
Abdulla compucell3d workshopAbdulla compucell3d workshop
Abdulla compucell3d workshop
Tariq Abdulla
 
Plegable Luisa Fda Naranjo P
Plegable Luisa Fda Naranjo PPlegable Luisa Fda Naranjo P
Plegable Luisa Fda Naranjo P
LuisaNaranjoP
 
Human genome project 2007
Human genome project 2007Human genome project 2007
Human genome project 2007
Hesham Gaber
 
Presentacion del plegable biologia molecular
Presentacion del plegable biologia molecular Presentacion del plegable biologia molecular
Presentacion del plegable biologia molecular
Laura0115
 
Alzhiemers
AlzhiemersAlzhiemers
Alzhiemers
cphcosu
 

La actualidad más candente (19)

The clinical value of telomere testing – dr. Mark Tager A4M May 2016
The clinical value of telomere testing – dr. Mark Tager A4M May 2016The clinical value of telomere testing – dr. Mark Tager A4M May 2016
The clinical value of telomere testing – dr. Mark Tager A4M May 2016
 
What is your true age?
What is your true age?What is your true age?
What is your true age?
 
Clinical use of telomere measurement in preventive and personalized medicine ...
Clinical use of telomere measurement in preventive and personalized medicine ...Clinical use of telomere measurement in preventive and personalized medicine ...
Clinical use of telomere measurement in preventive and personalized medicine ...
 
Facts on aging and health
Facts on aging and healthFacts on aging and health
Facts on aging and health
 
Ammg las vegas 2012 110312 final dr bill andrews
Ammg las vegas 2012 110312 final dr bill andrewsAmmg las vegas 2012 110312 final dr bill andrews
Ammg las vegas 2012 110312 final dr bill andrews
 
Telomeros, envejecimiento y prevencion Dr.A.Fernandez-Cruz - Barcelona - apr...
Telomeros, envejecimiento y prevencion  Dr.A.Fernandez-Cruz - Barcelona - apr...Telomeros, envejecimiento y prevencion  Dr.A.Fernandez-Cruz - Barcelona - apr...
Telomeros, envejecimiento y prevencion Dr.A.Fernandez-Cruz - Barcelona - apr...
 
The Models of Alzheimer's Disease Part II
The Models of Alzheimer's Disease Part IIThe Models of Alzheimer's Disease Part II
The Models of Alzheimer's Disease Part II
 
The Models of Alzheimer's Disease Part I
The Models of Alzheimer's Disease Part IThe Models of Alzheimer's Disease Part I
The Models of Alzheimer's Disease Part I
 
Breast cancer  edited
Breast cancer  editedBreast cancer  edited
Breast cancer  edited
 
Plegable biologia molecular
Plegable biologia molecularPlegable biologia molecular
Plegable biologia molecular
 
Abdulla compucell3d workshop
Abdulla compucell3d workshopAbdulla compucell3d workshop
Abdulla compucell3d workshop
 
Plegable Luisa Fda Naranjo P
Plegable Luisa Fda Naranjo PPlegable Luisa Fda Naranjo P
Plegable Luisa Fda Naranjo P
 
Lung cancer
Lung cancerLung cancer
Lung cancer
 
Lung cancer
Lung cancerLung cancer
Lung cancer
 
Tulane Workshop on Multi-omics integration
Tulane Workshop on Multi-omics integrationTulane Workshop on Multi-omics integration
Tulane Workshop on Multi-omics integration
 
Human genome project 2007
Human genome project 2007Human genome project 2007
Human genome project 2007
 
Presentacion del plegable biologia molecular
Presentacion del plegable biologia molecular Presentacion del plegable biologia molecular
Presentacion del plegable biologia molecular
 
Alzhiemers
AlzhiemersAlzhiemers
Alzhiemers
 
Lec-3 mutation and it types
Lec-3 mutation and it types Lec-3 mutation and it types
Lec-3 mutation and it types
 

Destacado

Using side effects for drug target identification
Using side effects for drug target identificationUsing side effects for drug target identification
Using side effects for drug target identification
Lars Juhl Jensen
 

Destacado (7)

Using side effects for drug target identification
Using side effects for drug target identificationUsing side effects for drug target identification
Using side effects for drug target identification
 
Substance searching in Reaxys - Webinar - 24 March 2015
Substance searching in Reaxys - Webinar - 24 March 2015Substance searching in Reaxys - Webinar - 24 March 2015
Substance searching in Reaxys - Webinar - 24 March 2015
 
Data integration and functional association networks
Data integration and functional association networksData integration and functional association networks
Data integration and functional association networks
 
Protein networks: A basis for large-scale data mining
Protein networks: A basis for large-scale data miningProtein networks: A basis for large-scale data mining
Protein networks: A basis for large-scale data mining
 
Disease Systems Biology
Disease Systems BiologyDisease Systems Biology
Disease Systems Biology
 
Solving Tough Chemistry Problems Using Reaxys
Solving Tough Chemistry Problems Using ReaxysSolving Tough Chemistry Problems Using Reaxys
Solving Tough Chemistry Problems Using Reaxys
 
Retrieve Relevant Results with Reaxys
Retrieve Relevant Results with ReaxysRetrieve Relevant Results with Reaxys
Retrieve Relevant Results with Reaxys
 

Similar a A linear motif atlas for phosphorylation-dependent signaling

Network biology: A basis for large-scale biomedical data mining
Network biology: A basis for large-scale biomedical data miningNetwork biology: A basis for large-scale biomedical data mining
Network biology: A basis for large-scale biomedical data mining
Lars Juhl Jensen
 
Network biology: A basis for large-scale biomedical data mining
Network biology: A basis for large-scale biomedical data miningNetwork biology: A basis for large-scale biomedical data mining
Network biology: A basis for large-scale biomedical data mining
Lars Juhl Jensen
 
Network biology: A basis for large-scale biomedical data mining
Network biology: A basis for large-scale biomedical data miningNetwork biology: A basis for large-scale biomedical data mining
Network biology: A basis for large-scale biomedical data mining
Lars Juhl Jensen
 
Making gene networks through data integration
Making gene networks through data integrationMaking gene networks through data integration
Making gene networks through data integration
Lars Juhl Jensen
 
Advanced bioinformatics methods for proteomics
Advanced bioinformatics methods for proteomicsAdvanced bioinformatics methods for proteomics
Advanced bioinformatics methods for proteomics
Lars Juhl Jensen
 
Systems biology: Large-scale biomedical data mining
Systems biology: Large-scale biomedical data miningSystems biology: Large-scale biomedical data mining
Systems biology: Large-scale biomedical data mining
Lars Juhl Jensen
 

Similar a A linear motif atlas for phosphorylation-dependent signaling (20)

Unraveling signaling networks by large-scale data integration
Unraveling signaling networks by large-scale data integrationUnraveling signaling networks by large-scale data integration
Unraveling signaling networks by large-scale data integration
 
Data Integration and Systems Biology
Data Integration and Systems BiologyData Integration and Systems Biology
Data Integration and Systems Biology
 
Unraveling cellular phosphorylation networks using computational biology
Unraveling cellular phosphorylation networks using computational biologyUnraveling cellular phosphorylation networks using computational biology
Unraveling cellular phosphorylation networks using computational biology
 
Combining sequence motifs and protein interactions to unravel complex phospho...
Combining sequence motifs and protein interactions to unravel complex phospho...Combining sequence motifs and protein interactions to unravel complex phospho...
Combining sequence motifs and protein interactions to unravel complex phospho...
 
From phosphoproteomics to signaling networks
From phosphoproteomics to signaling networksFrom phosphoproteomics to signaling networks
From phosphoproteomics to signaling networks
 
Integration of heterogeneous data
Integration of heterogeneous dataIntegration of heterogeneous data
Integration of heterogeneous data
 
Unraveling signal transduction networks through data integration
Unraveling signal transduction networks through data integrationUnraveling signal transduction networks through data integration
Unraveling signal transduction networks through data integration
 
Scientific Highlights: The Reflect and NetPhorest web resources
Scientific Highlights: The Reflect and NetPhorest web resourcesScientific Highlights: The Reflect and NetPhorest web resources
Scientific Highlights: The Reflect and NetPhorest web resources
 
Computational Biology - Signaling networks and drug repositioning
Computational Biology - Signaling networks and drug repositioningComputational Biology - Signaling networks and drug repositioning
Computational Biology - Signaling networks and drug repositioning
 
Cellular network biology: Proteome-wide analysis of heterogeneous data
Cellular network biology: Proteome-wide analysis of heterogeneous dataCellular network biology: Proteome-wide analysis of heterogeneous data
Cellular network biology: Proteome-wide analysis of heterogeneous data
 
Unraveling signaling networks by data integration
Unraveling signaling networks by data integrationUnraveling signaling networks by data integration
Unraveling signaling networks by data integration
 
Network biology
Network biologyNetwork biology
Network biology
 
Unraveling signaling networks by large-scale data integration
Unraveling signaling networks by large-scale data integrationUnraveling signaling networks by large-scale data integration
Unraveling signaling networks by large-scale data integration
 
Network biology: A basis for large-scale biomedical data mining
Network biology: A basis for large-scale biomedical data miningNetwork biology: A basis for large-scale biomedical data mining
Network biology: A basis for large-scale biomedical data mining
 
Network biology: A basis for large-scale biomedical data mining
Network biology: A basis for large-scale biomedical data miningNetwork biology: A basis for large-scale biomedical data mining
Network biology: A basis for large-scale biomedical data mining
 
Network biology: A basis for large-scale biomedical data mining
Network biology: A basis for large-scale biomedical data miningNetwork biology: A basis for large-scale biomedical data mining
Network biology: A basis for large-scale biomedical data mining
 
Advanced bioinformatics of proteomics datasets
Advanced bioinformaticsof proteomics datasetsAdvanced bioinformaticsof proteomics datasets
Advanced bioinformatics of proteomics datasets
 
Making gene networks through data integration
Making gene networks through data integrationMaking gene networks through data integration
Making gene networks through data integration
 
Advanced bioinformatics methods for proteomics
Advanced bioinformatics methods for proteomicsAdvanced bioinformatics methods for proteomics
Advanced bioinformatics methods for proteomics
 
Systems biology: Large-scale biomedical data mining
Systems biology: Large-scale biomedical data miningSystems biology: Large-scale biomedical data mining
Systems biology: Large-scale biomedical data mining
 

Más de Lars Juhl Jensen

Más de Lars Juhl Jensen (20)

One tagger, many uses: Illustrating the power of dictionary-based named entit...
One tagger, many uses: Illustrating the power of dictionary-based named entit...One tagger, many uses: Illustrating the power of dictionary-based named entit...
One tagger, many uses: Illustrating the power of dictionary-based named entit...
 
One tagger, many uses: Simple text-mining strategies for biomedicine
One tagger, many uses: Simple text-mining strategies for biomedicineOne tagger, many uses: Simple text-mining strategies for biomedicine
One tagger, many uses: Simple text-mining strategies for biomedicine
 
Extract 2.0: Text-mining-assisted interactive annotation
Extract 2.0: Text-mining-assisted interactive annotationExtract 2.0: Text-mining-assisted interactive annotation
Extract 2.0: Text-mining-assisted interactive annotation
 
Network visualization: A crash course on using Cytoscape
Network visualization: A crash course on using CytoscapeNetwork visualization: A crash course on using Cytoscape
Network visualization: A crash course on using Cytoscape
 
STRING & STITCH : Network integration of heterogeneous data
STRING & STITCH: Network integration of heterogeneous dataSTRING & STITCH: Network integration of heterogeneous data
STRING & STITCH : Network integration of heterogeneous data
 
Biomedical text mining: Automatic processing of unstructured text
Biomedical text mining: Automatic processing of unstructured textBiomedical text mining: Automatic processing of unstructured text
Biomedical text mining: Automatic processing of unstructured text
 
Medical network analysis: Linking diseases and genes through data and text mi...
Medical network analysis: Linking diseases and genes through data and text mi...Medical network analysis: Linking diseases and genes through data and text mi...
Medical network analysis: Linking diseases and genes through data and text mi...
 
Network Biology: A crash course on STRING and Cytoscape
Network Biology: A crash course on STRING and CytoscapeNetwork Biology: A crash course on STRING and Cytoscape
Network Biology: A crash course on STRING and Cytoscape
 
Cellular networks
Cellular networksCellular networks
Cellular networks
 
Cellular Network Biology: Large-scale integration of data and text
Cellular Network Biology: Large-scale integration of data and textCellular Network Biology: Large-scale integration of data and text
Cellular Network Biology: Large-scale integration of data and text
 
Statistics on big biomedical data: Methods and pitfalls when analyzing high-t...
Statistics on big biomedical data: Methods and pitfalls when analyzing high-t...Statistics on big biomedical data: Methods and pitfalls when analyzing high-t...
Statistics on big biomedical data: Methods and pitfalls when analyzing high-t...
 
STRING & related databases: Large-scale integration of heterogeneous data
STRING & related databases: Large-scale integration of heterogeneous dataSTRING & related databases: Large-scale integration of heterogeneous data
STRING & related databases: Large-scale integration of heterogeneous data
 
Tagger: Rapid dictionary-based named entity recognition
Tagger: Rapid dictionary-based named entity recognitionTagger: Rapid dictionary-based named entity recognition
Tagger: Rapid dictionary-based named entity recognition
 
Network Biology: Large-scale integration of data and text
Network Biology: Large-scale integration of data and textNetwork Biology: Large-scale integration of data and text
Network Biology: Large-scale integration of data and text
 
Medical text mining: Linking diseases, drugs, and adverse reactions
Medical text mining: Linking diseases, drugs, and adverse reactionsMedical text mining: Linking diseases, drugs, and adverse reactions
Medical text mining: Linking diseases, drugs, and adverse reactions
 
Network biology: Large-scale integration of data and text
Network biology: Large-scale integration of data and textNetwork biology: Large-scale integration of data and text
Network biology: Large-scale integration of data and text
 
Medical data and text mining: Linking diseases, drugs, and adverse reactions
Medical data and text mining: Linking diseases, drugs, and adverse reactionsMedical data and text mining: Linking diseases, drugs, and adverse reactions
Medical data and text mining: Linking diseases, drugs, and adverse reactions
 
Cellular Network Biology
Cellular Network BiologyCellular Network Biology
Cellular Network Biology
 
Network biology: Large-scale integration of data and text
Network biology: Large-scale integration of data and textNetwork biology: Large-scale integration of data and text
Network biology: Large-scale integration of data and text
 
Biomarker bioinformatics: Network-based candidate prioritization
Biomarker bioinformatics: Network-based candidate prioritizationBiomarker bioinformatics: Network-based candidate prioritization
Biomarker bioinformatics: Network-based candidate prioritization
 

Último

Modular Monolith - a Practical Alternative to Microservices @ Devoxx UK 2024
Modular Monolith - a Practical Alternative to Microservices @ Devoxx UK 2024Modular Monolith - a Practical Alternative to Microservices @ Devoxx UK 2024
Modular Monolith - a Practical Alternative to Microservices @ Devoxx UK 2024
Victor Rentea
 
Finding Java's Hidden Performance Traps @ DevoxxUK 2024
Finding Java's Hidden Performance Traps @ DevoxxUK 2024Finding Java's Hidden Performance Traps @ DevoxxUK 2024
Finding Java's Hidden Performance Traps @ DevoxxUK 2024
Victor Rentea
 
Harnessing Passkeys in the Battle Against AI-Powered Cyber Threats.pptx
Harnessing Passkeys in the Battle Against AI-Powered Cyber Threats.pptxHarnessing Passkeys in the Battle Against AI-Powered Cyber Threats.pptx
Harnessing Passkeys in the Battle Against AI-Powered Cyber Threats.pptx
FIDO Alliance
 

Último (20)

Modernizing Legacy Systems Using Ballerina
Modernizing Legacy Systems Using BallerinaModernizing Legacy Systems Using Ballerina
Modernizing Legacy Systems Using Ballerina
 
AI+A11Y 11MAY2024 HYDERBAD GAAD 2024 - HelloA11Y (11 May 2024)
AI+A11Y 11MAY2024 HYDERBAD GAAD 2024 - HelloA11Y (11 May 2024)AI+A11Y 11MAY2024 HYDERBAD GAAD 2024 - HelloA11Y (11 May 2024)
AI+A11Y 11MAY2024 HYDERBAD GAAD 2024 - HelloA11Y (11 May 2024)
 
WSO2's API Vision: Unifying Control, Empowering Developers
WSO2's API Vision: Unifying Control, Empowering DevelopersWSO2's API Vision: Unifying Control, Empowering Developers
WSO2's API Vision: Unifying Control, Empowering Developers
 
UiPath manufacturing technology benefits and AI overview
UiPath manufacturing technology benefits and AI overviewUiPath manufacturing technology benefits and AI overview
UiPath manufacturing technology benefits and AI overview
 
Modular Monolith - a Practical Alternative to Microservices @ Devoxx UK 2024
Modular Monolith - a Practical Alternative to Microservices @ Devoxx UK 2024Modular Monolith - a Practical Alternative to Microservices @ Devoxx UK 2024
Modular Monolith - a Practical Alternative to Microservices @ Devoxx UK 2024
 
Finding Java's Hidden Performance Traps @ DevoxxUK 2024
Finding Java's Hidden Performance Traps @ DevoxxUK 2024Finding Java's Hidden Performance Traps @ DevoxxUK 2024
Finding Java's Hidden Performance Traps @ DevoxxUK 2024
 
Web Form Automation for Bonterra Impact Management (fka Social Solutions Apri...
Web Form Automation for Bonterra Impact Management (fka Social Solutions Apri...Web Form Automation for Bonterra Impact Management (fka Social Solutions Apri...
Web Form Automation for Bonterra Impact Management (fka Social Solutions Apri...
 
WSO2 Micro Integrator for Enterprise Integration in a Decentralized, Microser...
WSO2 Micro Integrator for Enterprise Integration in a Decentralized, Microser...WSO2 Micro Integrator for Enterprise Integration in a Decentralized, Microser...
WSO2 Micro Integrator for Enterprise Integration in a Decentralized, Microser...
 
WebRTC and SIP not just audio and video @ OpenSIPS 2024
WebRTC and SIP not just audio and video @ OpenSIPS 2024WebRTC and SIP not just audio and video @ OpenSIPS 2024
WebRTC and SIP not just audio and video @ OpenSIPS 2024
 
Harnessing Passkeys in the Battle Against AI-Powered Cyber Threats.pptx
Harnessing Passkeys in the Battle Against AI-Powered Cyber Threats.pptxHarnessing Passkeys in the Battle Against AI-Powered Cyber Threats.pptx
Harnessing Passkeys in the Battle Against AI-Powered Cyber Threats.pptx
 
Overview of Hyperledger Foundation
Overview of Hyperledger FoundationOverview of Hyperledger Foundation
Overview of Hyperledger Foundation
 
Choreo: Empowering the Future of Enterprise Software Engineering
Choreo: Empowering the Future of Enterprise Software EngineeringChoreo: Empowering the Future of Enterprise Software Engineering
Choreo: Empowering the Future of Enterprise Software Engineering
 
Observability Concepts EVERY Developer Should Know (DevOpsDays Seattle)
Observability Concepts EVERY Developer Should Know (DevOpsDays Seattle)Observability Concepts EVERY Developer Should Know (DevOpsDays Seattle)
Observability Concepts EVERY Developer Should Know (DevOpsDays Seattle)
 
API Governance and Monetization - The evolution of API governance
API Governance and Monetization -  The evolution of API governanceAPI Governance and Monetization -  The evolution of API governance
API Governance and Monetization - The evolution of API governance
 
JohnPollard-hybrid-app-RailsConf2024.pptx
JohnPollard-hybrid-app-RailsConf2024.pptxJohnPollard-hybrid-app-RailsConf2024.pptx
JohnPollard-hybrid-app-RailsConf2024.pptx
 
Design and Development of a Provenance Capture Platform for Data Science
Design and Development of a Provenance Capture Platform for Data ScienceDesign and Development of a Provenance Capture Platform for Data Science
Design and Development of a Provenance Capture Platform for Data Science
 
Less Is More: Utilizing Ballerina to Architect a Cloud Data Platform
Less Is More: Utilizing Ballerina to Architect a Cloud Data PlatformLess Is More: Utilizing Ballerina to Architect a Cloud Data Platform
Less Is More: Utilizing Ballerina to Architect a Cloud Data Platform
 
AI in Action: Real World Use Cases by Anitaraj
AI in Action: Real World Use Cases by AnitarajAI in Action: Real World Use Cases by Anitaraj
AI in Action: Real World Use Cases by Anitaraj
 
DBX First Quarter 2024 Investor Presentation
DBX First Quarter 2024 Investor PresentationDBX First Quarter 2024 Investor Presentation
DBX First Quarter 2024 Investor Presentation
 
The Ultimate Prompt Engineering Guide for Generative AI: Get the Most Out of ...
The Ultimate Prompt Engineering Guide for Generative AI: Get the Most Out of ...The Ultimate Prompt Engineering Guide for Generative AI: Get the Most Out of ...
The Ultimate Prompt Engineering Guide for Generative AI: Get the Most Out of ...