SlideShare una empresa de Scribd logo

Modeling the dynamic assembly of cell cycle complexes from high-throughput data

•Descargar como PPT, PDF•
•
Lars Juhl Jensen
Lars Juhl Jensen

EMBO Young Investigators Programme, 3rd Symposium, European Molecular Biology Laboratory, Heidelberg, Germany, June 24-26, 2005

Tecnología
1 de 16
Lars Juhl Jensen EMBL Heidelberg Modeling the dynamic assembly of cell cycle complexes from high-throughput data
A qualitative model of the yeast cell cycle ,[object Object],[object Object],[object Object],© Chen et al., Mol. Biol. Cell, 2004
Getting the parts list Yeast culture Microarrays Gene expression Expression profile Cho & Spellman et al. 600 periodically expressed genes (with associated peak times) that encode “dynamic proteins” The parts list New analysis
Constructing a reliable protein network ,[object Object],[object Object],[object Object],[object Object]
Extracting a cell cycle interaction network Cell cycle microarray data Physical PPI interactions with confidence scores Expand the set of proteins to include non-periodic proteins that are strongly connected to periodic proteins Raw Data Node selection List of periodically expressed proteins with peak time Interactions Require compatible compartments and high confidence Extract cell cycle network
The temporal interaction network ,[object Object],[object Object]
[object Object],[object Object],Static proteins play a major role
Cdc28p and its interaction partners
Just-in-time synthesis vs. just-in-time assembly ,[object Object],[object Object],[object Object],[object Object]
Assembly of the pre-replication complex
Network as a discovery tools ,[object Object],[object Object],[object Object]
Transcription is linked to phosphorylation ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Is it possible to predict binding affinities? ,[object Object],[object Object],[object Object],[object Object],[object Object]
Conclusions and outlook ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Acknowledgments ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Thank you!

Recomendados

Dynamic complex formation during the yeast cell cycle
Dynamic complex formation during the yeast cell cycleDynamic complex formation during the yeast cell cycle
Dynamic complex formation during the yeast cell cycleLars Juhl Jensen
 
STRING - Cross-species integration of known and predicted protein-protein int...
STRING - Cross-species integration of known and predicted protein-protein int...STRING - Cross-species integration of known and predicted protein-protein int...
STRING - Cross-species integration of known and predicted protein-protein int...Lars Juhl Jensen
 
Dynamic complex formation during the yeast cell cycle
Dynamic complex formation during the yeast cell cycleDynamic complex formation during the yeast cell cycle
Dynamic complex formation during the yeast cell cycleLars Juhl Jensen
 
STRING - Modeling of pathways through cross-species integration of large-scal...
STRING - Modeling of pathways through cross-species integration of large-scal...STRING - Modeling of pathways through cross-species integration of large-scal...
STRING - Modeling of pathways through cross-species integration of large-scal...Lars Juhl Jensen
 
STRING - Prediction of functionally associated proteins from heterogeneous ge...
STRING - Prediction of functionally associated proteins from heterogeneous ge...STRING - Prediction of functionally associated proteins from heterogeneous ge...
STRING - Prediction of functionally associated proteins from heterogeneous ge...Lars Juhl Jensen
 
STRING - Prediction of functional relations, modules, and networks from heter...
STRING - Prediction of functional relations, modules, and networks from heter...STRING - Prediction of functional relations, modules, and networks from heter...
STRING - Prediction of functional relations, modules, and networks from heter...Lars Juhl Jensen
 
STRING - Prediction of protein networks through integration of diverse large-...
STRING - Prediction of protein networks through integration of diverse large-...STRING - Prediction of protein networks through integration of diverse large-...
STRING - Prediction of protein networks through integration of diverse large-...Lars Juhl Jensen
 
my 6th paper
my 6th papermy 6th paper
my 6th paperchristopher russell
 

Recomendados

Dynamic complex formation during the yeast cell cycle
Dynamic complex formation during the yeast cell cycleDynamic complex formation during the yeast cell cycle
Dynamic complex formation during the yeast cell cycleLars Juhl Jensen
 
STRING - Cross-species integration of known and predicted protein-protein int...
STRING - Cross-species integration of known and predicted protein-protein int...STRING - Cross-species integration of known and predicted protein-protein int...
STRING - Cross-species integration of known and predicted protein-protein int...Lars Juhl Jensen
 
Dynamic complex formation during the yeast cell cycle
Dynamic complex formation during the yeast cell cycleDynamic complex formation during the yeast cell cycle
Dynamic complex formation during the yeast cell cycleLars Juhl Jensen
 
STRING - Modeling of pathways through cross-species integration of large-scal...
STRING - Modeling of pathways through cross-species integration of large-scal...STRING - Modeling of pathways through cross-species integration of large-scal...
STRING - Modeling of pathways through cross-species integration of large-scal...Lars Juhl Jensen
 
STRING - Prediction of functionally associated proteins from heterogeneous ge...
STRING - Prediction of functionally associated proteins from heterogeneous ge...STRING - Prediction of functionally associated proteins from heterogeneous ge...
STRING - Prediction of functionally associated proteins from heterogeneous ge...Lars Juhl Jensen
 
STRING - Prediction of functional relations, modules, and networks from heter...
STRING - Prediction of functional relations, modules, and networks from heter...STRING - Prediction of functional relations, modules, and networks from heter...
STRING - Prediction of functional relations, modules, and networks from heter...Lars Juhl Jensen
 
STRING - Prediction of protein networks through integration of diverse large-...
STRING - Prediction of protein networks through integration of diverse large-...STRING - Prediction of protein networks through integration of diverse large-...
STRING - Prediction of protein networks through integration of diverse large-...Lars Juhl Jensen
 
my 6th paper
my 6th papermy 6th paper
my 6th paperchristopher russell
 
STRING - Cross-species integration of known and predicted protein-protein int...
STRING - Cross-species integration of known and predicted protein-protein int...STRING - Cross-species integration of known and predicted protein-protein int...
STRING - Cross-species integration of known and predicted protein-protein int...Lars Juhl Jensen
 
Proteomics - Analysis and integration of large-scale data sets
Proteomics - Analysis and integration of large-scale data setsProteomics - Analysis and integration of large-scale data sets
Proteomics - Analysis and integration of large-scale data setsLars Juhl Jensen
 
Protein interaction, types by kk sahu
Protein interaction, types by kk sahuProtein interaction, types by kk sahu
Protein interaction, types by kk sahuKAUSHAL SAHU
 
From systems biology
From systems biologyFrom systems biology
From systems biologybrnbarcelona
 
20042016_pizzaclub_part2
20042016_pizzaclub_part220042016_pizzaclub_part2
20042016_pizzaclub_part2RSG Luxembourg
 
20080516 Spontaneous separation of bi-stable biochemical systems
20080516 Spontaneous separation of bi-stable biochemical systems20080516 Spontaneous separation of bi-stable biochemical systems
20080516 Spontaneous separation of bi-stable biochemical systemsJonathan Blakes
 
evolutionary game theory presentation
evolutionary game theory presentationevolutionary game theory presentation
evolutionary game theory presentationYiming Yu, Msc, ARe, CEEM,CFA Level I passed
 
Bioinformatics of cellular processes
Bioinformatics of cellular processesBioinformatics of cellular processes
Bioinformatics of cellular processesLars Juhl Jensen
 
Presentation july 31_2015
Presentation july 31_2015Presentation july 31_2015
Presentation july 31_2015gkoytiger
 
Introduction to Network Medicine
Introduction to Network MedicineIntroduction to Network Medicine
Introduction to Network MedicineMarc Santolini
 
Systems biology: Bioinformatics on complete biological system
Systems biology: Bioinformatics on complete biological systemSystems biology: Bioinformatics on complete biological system
Systems biology: Bioinformatics on complete biological systemLars Juhl Jensen
 
A6.3 Longchamps
A6.3 LongchampsA6.3 Longchamps
A6.3 Longchampsjohn-longchamps
 
Network motifs in integrated cellular networks of transcription–regulation an...
Network motifs in integrated cellular networks of transcription–regulation an...Network motifs in integrated cellular networks of transcription–regulation an...
Network motifs in integrated cellular networks of transcription–regulation an...Samuel Sattath
 
Systems Biology Approaches to Cancer
Systems Biology Approaches to CancerSystems Biology Approaches to Cancer
Systems Biology Approaches to CancerRaunak Shrestha
 
Introduction to systems biology
Introduction to systems biologyIntroduction to systems biology
Introduction to systems biologylemberger
 
STRING - Prediction of protein networks through integration of diverse large-...
STRING - Prediction of protein networks through integration of diverse large-...STRING - Prediction of protein networks through integration of diverse large-...
STRING - Prediction of protein networks through integration of diverse large-...Lars Juhl Jensen
 
System biology and its tools
System biology and its toolsSystem biology and its tools
System biology and its toolsGaurav Diwakar
 
NetBioSIG2013-KEYNOTE Stefan Schuster
NetBioSIG2013-KEYNOTE Stefan SchusterNetBioSIG2013-KEYNOTE Stefan Schuster
NetBioSIG2013-KEYNOTE Stefan SchusterAlexander Pico
 
NetBioSIG2014-Talk by Hyunghoon Cho
NetBioSIG2014-Talk by Hyunghoon ChoNetBioSIG2014-Talk by Hyunghoon Cho
NetBioSIG2014-Talk by Hyunghoon ChoAlexander Pico
 
Bioinformatics
BioinformaticsBioinformatics
Bioinformaticsdagunisa
 
Open Innovation
Open InnovationOpen Innovation
Open InnovationStalin Carrión
 
Agosto 1o. 2008
Agosto 1o. 2008Agosto 1o. 2008
Agosto 1o. 2008Observador Tapachula
 

Más contenido relacionado

La actualidad más candente

STRING - Cross-species integration of known and predicted protein-protein int...
STRING - Cross-species integration of known and predicted protein-protein int...STRING - Cross-species integration of known and predicted protein-protein int...
STRING - Cross-species integration of known and predicted protein-protein int...Lars Juhl Jensen
 
Proteomics - Analysis and integration of large-scale data sets
Proteomics - Analysis and integration of large-scale data setsProteomics - Analysis and integration of large-scale data sets
Proteomics - Analysis and integration of large-scale data setsLars Juhl Jensen
 
Protein interaction, types by kk sahu
Protein interaction, types by kk sahuProtein interaction, types by kk sahu
Protein interaction, types by kk sahuKAUSHAL SAHU
 
From systems biology
From systems biologyFrom systems biology
From systems biologybrnbarcelona
 
20042016_pizzaclub_part2
20042016_pizzaclub_part220042016_pizzaclub_part2
20042016_pizzaclub_part2RSG Luxembourg
 
20080516 Spontaneous separation of bi-stable biochemical systems
20080516 Spontaneous separation of bi-stable biochemical systems20080516 Spontaneous separation of bi-stable biochemical systems
20080516 Spontaneous separation of bi-stable biochemical systemsJonathan Blakes
 
Bioinformatics of cellular processes
Bioinformatics of cellular processesBioinformatics of cellular processes
Bioinformatics of cellular processesLars Juhl Jensen
 
Presentation july 31_2015
Presentation july 31_2015Presentation july 31_2015
Presentation july 31_2015gkoytiger
 
Introduction to Network Medicine
Introduction to Network MedicineIntroduction to Network Medicine
Introduction to Network MedicineMarc Santolini
 
Systems biology: Bioinformatics on complete biological system
Systems biology: Bioinformatics on complete biological systemSystems biology: Bioinformatics on complete biological system
Systems biology: Bioinformatics on complete biological systemLars Juhl Jensen
 
Network motifs in integrated cellular networks of transcription–regulation an...
Network motifs in integrated cellular networks of transcription–regulation an...Network motifs in integrated cellular networks of transcription–regulation an...
Network motifs in integrated cellular networks of transcription–regulation an...Samuel Sattath
 
Systems Biology Approaches to Cancer
Systems Biology Approaches to CancerSystems Biology Approaches to Cancer
Systems Biology Approaches to CancerRaunak Shrestha
 
Introduction to systems biology
Introduction to systems biologyIntroduction to systems biology
Introduction to systems biologylemberger
 
STRING - Prediction of protein networks through integration of diverse large-...
STRING - Prediction of protein networks through integration of diverse large-...STRING - Prediction of protein networks through integration of diverse large-...
STRING - Prediction of protein networks through integration of diverse large-...Lars Juhl Jensen
 
System biology and its tools
System biology and its toolsSystem biology and its tools
System biology and its toolsGaurav Diwakar
 
NetBioSIG2013-KEYNOTE Stefan Schuster
NetBioSIG2013-KEYNOTE Stefan SchusterNetBioSIG2013-KEYNOTE Stefan Schuster
NetBioSIG2013-KEYNOTE Stefan SchusterAlexander Pico
 
NetBioSIG2014-Talk by Hyunghoon Cho
NetBioSIG2014-Talk by Hyunghoon ChoNetBioSIG2014-Talk by Hyunghoon Cho
NetBioSIG2014-Talk by Hyunghoon ChoAlexander Pico
 
Bioinformatics
BioinformaticsBioinformatics
Bioinformaticsdagunisa
 

La actualidad más candente (20)

STRING - Cross-species integration of known and predicted protein-protein int...
STRING - Cross-species integration of known and predicted protein-protein int...STRING - Cross-species integration of known and predicted protein-protein int...
STRING - Cross-species integration of known and predicted protein-protein int...
 
Proteomics - Analysis and integration of large-scale data sets
Proteomics - Analysis and integration of large-scale data setsProteomics - Analysis and integration of large-scale data sets
Proteomics - Analysis and integration of large-scale data sets
 
Protein interaction, types by kk sahu
Protein interaction, types by kk sahuProtein interaction, types by kk sahu
Protein interaction, types by kk sahu
 
From systems biology
From systems biologyFrom systems biology
From systems biology
 
20042016_pizzaclub_part2
20042016_pizzaclub_part220042016_pizzaclub_part2
20042016_pizzaclub_part2
 
20080516 Spontaneous separation of bi-stable biochemical systems
20080516 Spontaneous separation of bi-stable biochemical systems20080516 Spontaneous separation of bi-stable biochemical systems
20080516 Spontaneous separation of bi-stable biochemical systems
 
evolutionary game theory presentation
evolutionary game theory presentationevolutionary game theory presentation
evolutionary game theory presentation
 
Bioinformatics of cellular processes
Bioinformatics of cellular processesBioinformatics of cellular processes
Bioinformatics of cellular processes
 
Presentation july 31_2015
Presentation july 31_2015Presentation july 31_2015
Presentation july 31_2015
 
Introduction to Network Medicine
Introduction to Network MedicineIntroduction to Network Medicine
Introduction to Network Medicine
 
Systems biology: Bioinformatics on complete biological system
Systems biology: Bioinformatics on complete biological systemSystems biology: Bioinformatics on complete biological system
Systems biology: Bioinformatics on complete biological system
 
A6.3 Longchamps
A6.3 LongchampsA6.3 Longchamps
A6.3 Longchamps
 
Network motifs in integrated cellular networks of transcription–regulation an...
Network motifs in integrated cellular networks of transcription–regulation an...Network motifs in integrated cellular networks of transcription–regulation an...
Network motifs in integrated cellular networks of transcription–regulation an...
 
Systems Biology Approaches to Cancer
Systems Biology Approaches to CancerSystems Biology Approaches to Cancer
Systems Biology Approaches to Cancer
 
Introduction to systems biology
Introduction to systems biologyIntroduction to systems biology
Introduction to systems biology
 
STRING - Prediction of protein networks through integration of diverse large-...
STRING - Prediction of protein networks through integration of diverse large-...STRING - Prediction of protein networks through integration of diverse large-...
STRING - Prediction of protein networks through integration of diverse large-...
 
System biology and its tools
System biology and its toolsSystem biology and its tools
System biology and its tools
 
NetBioSIG2013-KEYNOTE Stefan Schuster
NetBioSIG2013-KEYNOTE Stefan SchusterNetBioSIG2013-KEYNOTE Stefan Schuster
NetBioSIG2013-KEYNOTE Stefan Schuster
 
NetBioSIG2014-Talk by Hyunghoon Cho
NetBioSIG2014-Talk by Hyunghoon ChoNetBioSIG2014-Talk by Hyunghoon Cho
NetBioSIG2014-Talk by Hyunghoon Cho
 
Bioinformatics
BioinformaticsBioinformatics
Bioinformatics
 

Destacado

Elvalordeunapersona
ElvalordeunapersonaElvalordeunapersona
Elvalordeunapersonaangelicatd
 
STRING: Prediction of protein networks through integration of diverse large-s...
STRING: Prediction of protein networks through integration of diverse large-s...STRING: Prediction of protein networks through integration of diverse large-s...
STRING: Prediction of protein networks through integration of diverse large-s...Lars Juhl Jensen
 
Varsovia
VarsoviaVarsovia
VarsoviaJaguit
 
Black Ink Cashflow Secrets Your Accountant Never Shared
Black Ink Cashflow Secrets Your Accountant Never SharedBlack Ink Cashflow Secrets Your Accountant Never Shared
Black Ink Cashflow Secrets Your Accountant Never SharedTom Shay
 

Destacado (7)

Open Innovation
Open InnovationOpen Innovation
Open Innovation
 
Agosto 1o. 2008
Agosto 1o. 2008Agosto 1o. 2008
Agosto 1o. 2008
 
Elvalordeunapersona
ElvalordeunapersonaElvalordeunapersona
Elvalordeunapersona
 
Delicious2 Fall2008
Delicious2 Fall2008Delicious2 Fall2008
Delicious2 Fall2008
 
STRING: Prediction of protein networks through integration of diverse large-s...
STRING: Prediction of protein networks through integration of diverse large-s...STRING: Prediction of protein networks through integration of diverse large-s...
STRING: Prediction of protein networks through integration of diverse large-s...
 
Varsovia
VarsoviaVarsovia
Varsovia
 
Black Ink Cashflow Secrets Your Accountant Never Shared
Black Ink Cashflow Secrets Your Accountant Never SharedBlack Ink Cashflow Secrets Your Accountant Never Shared
Black Ink Cashflow Secrets Your Accountant Never Shared
 

Similar a Modeling the dynamic assembly of cell cycle complexes from high-throughput data

STRING - Prediction of a functional association network for the yeast mitocho...
STRING - Prediction of a functional association network for the yeast mitocho...STRING - Prediction of a functional association network for the yeast mitocho...
STRING - Prediction of a functional association network for the yeast mitocho...Lars Juhl Jensen
 
Interactomics, Integromics to Systems Biology: Next Animal Biotechnology Fron...
Interactomics, Integromics to Systems Biology: Next Animal Biotechnology Fron...Interactomics, Integromics to Systems Biology: Next Animal Biotechnology Fron...
Interactomics, Integromics to Systems Biology: Next Animal Biotechnology Fron...Varij Nayan
 
protein-protein interaction
protein-protein interactionprotein-protein interaction
protein-protein interactionZeshan Haider
 
Specificity and Evolvability in Eukaryotic Protein Interaction Networks
Specificity and Evolvability in Eukaryotic Protein Interaction NetworksSpecificity and Evolvability in Eukaryotic Protein Interaction Networks
Specificity and Evolvability in Eukaryotic Protein Interaction Networkspedrobeltrao
 
Yeast two hybrid system
Yeast two hybrid systemYeast two hybrid system
Yeast two hybrid systemiqraakbar8
 
Huwang-2-7.ppt
Huwang-2-7.pptHuwang-2-7.ppt
Huwang-2-7.pptkobra22
 
Computer simulation
Computer simulationComputer simulation
Computer simulationshashi kiran
 
00002 Jc Silva 2006 Mcp V5n1p144
00002 Jc Silva 2006 Mcp V5n1p14400002 Jc Silva 2006 Mcp V5n1p144
00002 Jc Silva 2006 Mcp V5n1p144jcruzsilva
 
Protein protein interaction, functional proteomics
Protein protein interaction, functional proteomicsProtein protein interaction, functional proteomics
Protein protein interaction, functional proteomicsKAUSHAL SAHU
 
High throughput approaches to understanding gene function and mapping archite...
High throughput approaches to understanding gene function and mapping archite...High throughput approaches to understanding gene function and mapping archite...
High throughput approaches to understanding gene function and mapping archite...Tintumann
 
Yeast two hybrid
Yeast two hybridYeast two hybrid
Yeast two hybridhina ojha
 
Protein protein interaction
Protein protein interactionProtein protein interaction
Protein protein interactionAashish Patel
 
Prediction of protein function
Prediction of protein functionPrediction of protein function
Prediction of protein functionLars Juhl Jensen
 
Project report: Investigating the effect of cellular objectives on genome-sca...
Project report: Investigating the effect of cellular objectives on genome-sca...Project report: Investigating the effect of cellular objectives on genome-sca...
Project report: Investigating the effect of cellular objectives on genome-sca...Jarle Pahr
 
Knowing Your NGS Downstream: Functional Predictions
Knowing Your NGS Downstream: Functional PredictionsKnowing Your NGS Downstream: Functional Predictions
Knowing Your NGS Downstream: Functional PredictionsGolden Helix Inc
 
Functional proteomics, and tools
Functional proteomics, and toolsFunctional proteomics, and tools
Functional proteomics, and toolsKAUSHAL SAHU
 
STRUCTURAL GENOMICS, FUNCTIONAL GENOMICS, COMPARATIVE GENOMICS
STRUCTURAL GENOMICS, FUNCTIONAL GENOMICS, COMPARATIVE GENOMICSSTRUCTURAL GENOMICS, FUNCTIONAL GENOMICS, COMPARATIVE GENOMICS
STRUCTURAL GENOMICS, FUNCTIONAL GENOMICS, COMPARATIVE GENOMICSSHEETHUMOLKS
 

Similar a Modeling the dynamic assembly of cell cycle complexes from high-throughput data (20)

STRING - Prediction of a functional association network for the yeast mitocho...
STRING - Prediction of a functional association network for the yeast mitocho...STRING - Prediction of a functional association network for the yeast mitocho...
STRING - Prediction of a functional association network for the yeast mitocho...
 
Interactomics, Integromics to Systems Biology: Next Animal Biotechnology Fron...
Interactomics, Integromics to Systems Biology: Next Animal Biotechnology Fron...Interactomics, Integromics to Systems Biology: Next Animal Biotechnology Fron...
Interactomics, Integromics to Systems Biology: Next Animal Biotechnology Fron...
 
protein-protein interaction
protein-protein interactionprotein-protein interaction
protein-protein interaction
 
Specificity and Evolvability in Eukaryotic Protein Interaction Networks
Specificity and Evolvability in Eukaryotic Protein Interaction NetworksSpecificity and Evolvability in Eukaryotic Protein Interaction Networks
Specificity and Evolvability in Eukaryotic Protein Interaction Networks
 
Yeast two hybrid system
Yeast two hybrid systemYeast two hybrid system
Yeast two hybrid system
 
whole body.pptx
whole body.pptxwhole body.pptx
whole body.pptx
 
Huwang-2-7.ppt
Huwang-2-7.pptHuwang-2-7.ppt
Huwang-2-7.ppt
 
Computer simulation
Computer simulationComputer simulation
Computer simulation
 
00002 Jc Silva 2006 Mcp V5n1p144
00002 Jc Silva 2006 Mcp V5n1p14400002 Jc Silva 2006 Mcp V5n1p144
00002 Jc Silva 2006 Mcp V5n1p144
 
Yeast two hybrid method
Yeast two hybrid methodYeast two hybrid method
Yeast two hybrid method
 
Protein protein interaction, functional proteomics
Protein protein interaction, functional proteomicsProtein protein interaction, functional proteomics
Protein protein interaction, functional proteomics
 
Applied Bioinformatics Assignment 5docx
Applied Bioinformatics Assignment 5docxApplied Bioinformatics Assignment 5docx
Applied Bioinformatics Assignment 5docx
 
High throughput approaches to understanding gene function and mapping archite...
High throughput approaches to understanding gene function and mapping archite...High throughput approaches to understanding gene function and mapping archite...
High throughput approaches to understanding gene function and mapping archite...
 
Yeast two hybrid
Yeast two hybridYeast two hybrid
Yeast two hybrid
 
Protein protein interaction
Protein protein interactionProtein protein interaction
Protein protein interaction
 
Prediction of protein function
Prediction of protein functionPrediction of protein function
Prediction of protein function
 
Project report: Investigating the effect of cellular objectives on genome-sca...
Project report: Investigating the effect of cellular objectives on genome-sca...Project report: Investigating the effect of cellular objectives on genome-sca...
Project report: Investigating the effect of cellular objectives on genome-sca...
 
Knowing Your NGS Downstream: Functional Predictions
Knowing Your NGS Downstream: Functional PredictionsKnowing Your NGS Downstream: Functional Predictions
Knowing Your NGS Downstream: Functional Predictions
 
Functional proteomics, and tools
Functional proteomics, and toolsFunctional proteomics, and tools
Functional proteomics, and tools
 
STRUCTURAL GENOMICS, FUNCTIONAL GENOMICS, COMPARATIVE GENOMICS
STRUCTURAL GENOMICS, FUNCTIONAL GENOMICS, COMPARATIVE GENOMICSSTRUCTURAL GENOMICS, FUNCTIONAL GENOMICS, COMPARATIVE GENOMICS
STRUCTURAL GENOMICS, FUNCTIONAL GENOMICS, COMPARATIVE GENOMICS
 

Más de Lars Juhl Jensen

One tagger, many uses: Illustrating the power of dictionary-based named entit...
One tagger, many uses: Illustrating the power of dictionary-based named entit...One tagger, many uses: Illustrating the power of dictionary-based named entit...
One tagger, many uses: Illustrating the power of dictionary-based named entit...Lars Juhl Jensen
 
One tagger, many uses: Simple text-mining strategies for biomedicine
One tagger, many uses: Simple text-mining strategies for biomedicineOne tagger, many uses: Simple text-mining strategies for biomedicine
One tagger, many uses: Simple text-mining strategies for biomedicineLars Juhl Jensen
 
Extract 2.0: Text-mining-assisted interactive annotation
Extract 2.0: Text-mining-assisted interactive annotationExtract 2.0: Text-mining-assisted interactive annotation
Extract 2.0: Text-mining-assisted interactive annotationLars Juhl Jensen
 
Network visualization: A crash course on using Cytoscape
Network visualization: A crash course on using CytoscapeNetwork visualization: A crash course on using Cytoscape
Network visualization: A crash course on using CytoscapeLars Juhl Jensen
 
STRING & STITCH : Network integration of heterogeneous data
STRING & STITCH : Network integration of heterogeneous dataSTRING & STITCH : Network integration of heterogeneous data
STRING & STITCH : Network integration of heterogeneous dataLars Juhl Jensen
 
Biomedical text mining: Automatic processing of unstructured text
Biomedical text mining: Automatic processing of unstructured textBiomedical text mining: Automatic processing of unstructured text
Biomedical text mining: Automatic processing of unstructured textLars Juhl Jensen
 
Medical network analysis: Linking diseases and genes through data and text mi...
Medical network analysis: Linking diseases and genes through data and text mi...Medical network analysis: Linking diseases and genes through data and text mi...
Medical network analysis: Linking diseases and genes through data and text mi...Lars Juhl Jensen
 
Network Biology: A crash course on STRING and Cytoscape
Network Biology: A crash course on STRING and CytoscapeNetwork Biology: A crash course on STRING and Cytoscape
Network Biology: A crash course on STRING and CytoscapeLars Juhl Jensen
 
Cellular Network Biology: Large-scale integration of data and text
Cellular Network Biology: Large-scale integration of data and textCellular Network Biology: Large-scale integration of data and text
Cellular Network Biology: Large-scale integration of data and textLars Juhl Jensen
 
Statistics on big biomedical data: Methods and pitfalls when analyzing high-t...
Statistics on big biomedical data: Methods and pitfalls when analyzing high-t...Statistics on big biomedical data: Methods and pitfalls when analyzing high-t...
Statistics on big biomedical data: Methods and pitfalls when analyzing high-t...Lars Juhl Jensen
 
STRING & related databases: Large-scale integration of heterogeneous data
STRING & related databases: Large-scale integration of heterogeneous dataSTRING & related databases: Large-scale integration of heterogeneous data
STRING & related databases: Large-scale integration of heterogeneous dataLars Juhl Jensen
 
Tagger: Rapid dictionary-based named entity recognition
Tagger: Rapid dictionary-based named entity recognitionTagger: Rapid dictionary-based named entity recognition
Tagger: Rapid dictionary-based named entity recognitionLars Juhl Jensen
 
Network Biology: Large-scale integration of data and text
Network Biology: Large-scale integration of data and textNetwork Biology: Large-scale integration of data and text
Network Biology: Large-scale integration of data and textLars Juhl Jensen
 
Medical text mining: Linking diseases, drugs, and adverse reactions
Medical text mining: Linking diseases, drugs, and adverse reactionsMedical text mining: Linking diseases, drugs, and adverse reactions
Medical text mining: Linking diseases, drugs, and adverse reactionsLars Juhl Jensen
 
Network biology: Large-scale integration of data and text
Network biology: Large-scale integration of data and textNetwork biology: Large-scale integration of data and text
Network biology: Large-scale integration of data and textLars Juhl Jensen
 
Medical data and text mining: Linking diseases, drugs, and adverse reactions
Medical data and text mining: Linking diseases, drugs, and adverse reactionsMedical data and text mining: Linking diseases, drugs, and adverse reactions
Medical data and text mining: Linking diseases, drugs, and adverse reactionsLars Juhl Jensen
 
Network biology: Large-scale integration of data and text
Network biology: Large-scale integration of data and textNetwork biology: Large-scale integration of data and text
Network biology: Large-scale integration of data and textLars Juhl Jensen
 
Biomarker bioinformatics: Network-based candidate prioritization
Biomarker bioinformatics: Network-based candidate prioritizationBiomarker bioinformatics: Network-based candidate prioritization
Biomarker bioinformatics: Network-based candidate prioritizationLars Juhl Jensen
 

Más de Lars Juhl Jensen (20)

One tagger, many uses: Illustrating the power of dictionary-based named entit...
One tagger, many uses: Illustrating the power of dictionary-based named entit...One tagger, many uses: Illustrating the power of dictionary-based named entit...
One tagger, many uses: Illustrating the power of dictionary-based named entit...
 
One tagger, many uses: Simple text-mining strategies for biomedicine
One tagger, many uses: Simple text-mining strategies for biomedicineOne tagger, many uses: Simple text-mining strategies for biomedicine
One tagger, many uses: Simple text-mining strategies for biomedicine
 
Extract 2.0: Text-mining-assisted interactive annotation
Extract 2.0: Text-mining-assisted interactive annotationExtract 2.0: Text-mining-assisted interactive annotation
Extract 2.0: Text-mining-assisted interactive annotation
 
Network visualization: A crash course on using Cytoscape
Network visualization: A crash course on using CytoscapeNetwork visualization: A crash course on using Cytoscape
Network visualization: A crash course on using Cytoscape
 
STRING & STITCH : Network integration of heterogeneous data
STRING & STITCH : Network integration of heterogeneous dataSTRING & STITCH : Network integration of heterogeneous data
STRING & STITCH : Network integration of heterogeneous data
 
Biomedical text mining: Automatic processing of unstructured text
Biomedical text mining: Automatic processing of unstructured textBiomedical text mining: Automatic processing of unstructured text
Biomedical text mining: Automatic processing of unstructured text
 
Medical network analysis: Linking diseases and genes through data and text mi...
Medical network analysis: Linking diseases and genes through data and text mi...Medical network analysis: Linking diseases and genes through data and text mi...
Medical network analysis: Linking diseases and genes through data and text mi...
 
Network Biology: A crash course on STRING and Cytoscape
Network Biology: A crash course on STRING and CytoscapeNetwork Biology: A crash course on STRING and Cytoscape
Network Biology: A crash course on STRING and Cytoscape
 
Cellular networks
Cellular networksCellular networks
Cellular networks
 
Cellular Network Biology: Large-scale integration of data and text
Cellular Network Biology: Large-scale integration of data and textCellular Network Biology: Large-scale integration of data and text
Cellular Network Biology: Large-scale integration of data and text
 
Statistics on big biomedical data: Methods and pitfalls when analyzing high-t...
Statistics on big biomedical data: Methods and pitfalls when analyzing high-t...Statistics on big biomedical data: Methods and pitfalls when analyzing high-t...
Statistics on big biomedical data: Methods and pitfalls when analyzing high-t...
 
STRING & related databases: Large-scale integration of heterogeneous data
STRING & related databases: Large-scale integration of heterogeneous dataSTRING & related databases: Large-scale integration of heterogeneous data
STRING & related databases: Large-scale integration of heterogeneous data
 
Tagger: Rapid dictionary-based named entity recognition
Tagger: Rapid dictionary-based named entity recognitionTagger: Rapid dictionary-based named entity recognition
Tagger: Rapid dictionary-based named entity recognition
 
Network Biology: Large-scale integration of data and text
Network Biology: Large-scale integration of data and textNetwork Biology: Large-scale integration of data and text
Network Biology: Large-scale integration of data and text
 
Medical text mining: Linking diseases, drugs, and adverse reactions
Medical text mining: Linking diseases, drugs, and adverse reactionsMedical text mining: Linking diseases, drugs, and adverse reactions
Medical text mining: Linking diseases, drugs, and adverse reactions
 
Network biology: Large-scale integration of data and text
Network biology: Large-scale integration of data and textNetwork biology: Large-scale integration of data and text
Network biology: Large-scale integration of data and text
 
Medical data and text mining: Linking diseases, drugs, and adverse reactions
Medical data and text mining: Linking diseases, drugs, and adverse reactionsMedical data and text mining: Linking diseases, drugs, and adverse reactions
Medical data and text mining: Linking diseases, drugs, and adverse reactions
 
Cellular Network Biology
Cellular Network BiologyCellular Network Biology
Cellular Network Biology
 
Network biology: Large-scale integration of data and text
Network biology: Large-scale integration of data and textNetwork biology: Large-scale integration of data and text
Network biology: Large-scale integration of data and text
 
Biomarker bioinformatics: Network-based candidate prioritization
Biomarker bioinformatics: Network-based candidate prioritizationBiomarker bioinformatics: Network-based candidate prioritization
Biomarker bioinformatics: Network-based candidate prioritization
 

Último

Apidays New York 2024 - Scaling API-first by Ian Reasor and Radu Cotescu, Adobe
Apidays New York 2024 - Scaling API-first by Ian Reasor and Radu Cotescu, AdobeApidays New York 2024 - Scaling API-first by Ian Reasor and Radu Cotescu, Adobe
Apidays New York 2024 - Scaling API-first by Ian Reasor and Radu Cotescu, Adobeapidays
 
WSO2's API Vision: Unifying Control, Empowering Developers
WSO2's API Vision: Unifying Control, Empowering DevelopersWSO2's API Vision: Unifying Control, Empowering Developers
WSO2's API Vision: Unifying Control, Empowering DevelopersWSO2
 
Why Teams call analytics are critical to your entire business
Why Teams call analytics are critical to your entire businessWhy Teams call analytics are critical to your entire business
Why Teams call analytics are critical to your entire businesspanagenda
 
Repurposing LNG terminals for Hydrogen Ammonia: Feasibility and Cost Saving
Repurposing LNG terminals for Hydrogen Ammonia: Feasibility and Cost SavingRepurposing LNG terminals for Hydrogen Ammonia: Feasibility and Cost Saving
Repurposing LNG terminals for Hydrogen Ammonia: Feasibility and Cost SavingEdi Saputra
 
MS Copilot expands with MS Graph connectors
MS Copilot expands with MS Graph connectorsMS Copilot expands with MS Graph connectors
MS Copilot expands with MS Graph connectorsNanddeep Nachan
 
Apidays New York 2024 - The value of a flexible API Management solution for O...
Apidays New York 2024 - The value of a flexible API Management solution for O...Apidays New York 2024 - The value of a flexible API Management solution for O...
Apidays New York 2024 - The value of a flexible API Management solution for O...apidays
 
Rising Above_ Dubai Floods and the Fortitude of Dubai International Airport.pdf
Rising Above_ Dubai Floods and the Fortitude of Dubai International Airport.pdfRising Above_ Dubai Floods and the Fortitude of Dubai International Airport.pdf
Rising Above_ Dubai Floods and the Fortitude of Dubai International Airport.pdfOrbitshub
 
Finding Java's Hidden Performance Traps @ DevoxxUK 2024
Finding Java's Hidden Performance Traps @ DevoxxUK 2024Finding Java's Hidden Performance Traps @ DevoxxUK 2024
Finding Java's Hidden Performance Traps @ DevoxxUK 2024Victor Rentea
 
Introduction to Multilingual Retrieval Augmented Generation (RAG)
Introduction to Multilingual Retrieval Augmented Generation (RAG)Introduction to Multilingual Retrieval Augmented Generation (RAG)
Introduction to Multilingual Retrieval Augmented Generation (RAG)Zilliz
 
Strategize a Smooth Tenant-to-tenant Migration and Copilot Takeoff
Strategize a Smooth Tenant-to-tenant Migration and Copilot TakeoffStrategize a Smooth Tenant-to-tenant Migration and Copilot Takeoff
Strategize a Smooth Tenant-to-tenant Migration and Copilot Takeoffsammart93
 
Architecting Cloud Native Applications
Architecting Cloud Native ApplicationsArchitecting Cloud Native Applications
Architecting Cloud Native ApplicationsWSO2
 
Strategies for Landing an Oracle DBA Job as a Fresher
Strategies for Landing an Oracle DBA Job as a FresherStrategies for Landing an Oracle DBA Job as a Fresher
Strategies for Landing an Oracle DBA Job as a FresherRemote DBA Services
 
Platformless Horizons for Digital Adaptability
Platformless Horizons for Digital AdaptabilityPlatformless Horizons for Digital Adaptability
Platformless Horizons for Digital AdaptabilityWSO2
 
presentation ICT roal in 21st century education
presentation ICT roal in 21st century educationpresentation ICT roal in 21st century education
presentation ICT roal in 21st century educationjfdjdjcjdnsjd
 
Vector Search -An Introduction in Oracle Database 23ai.pptx
Vector Search -An Introduction in Oracle Database 23ai.pptxVector Search -An Introduction in Oracle Database 23ai.pptx
Vector Search -An Introduction in Oracle Database 23ai.pptxRemote DBA Services
 
Boost Fertility New Invention Ups Success Rates.pdf
Boost Fertility New Invention Ups Success Rates.pdfBoost Fertility New Invention Ups Success Rates.pdf
Boost Fertility New Invention Ups Success Rates.pdfsudhanshuwaghmare1
 
ProductAnonymous-April2024-WinProductDiscovery-MelissaKlemke
ProductAnonymous-April2024-WinProductDiscovery-MelissaKlemkeProductAnonymous-April2024-WinProductDiscovery-MelissaKlemke
ProductAnonymous-April2024-WinProductDiscovery-MelissaKlemkeProduct Anonymous
 
Navigating the Deluge_ Dubai Floods and the Resilience of Dubai International...
Navigating the Deluge_ Dubai Floods and the Resilience of Dubai International...Navigating the Deluge_ Dubai Floods and the Resilience of Dubai International...
Navigating the Deluge_ Dubai Floods and the Resilience of Dubai International...Orbitshub
 
Cloud Frontiers: A Deep Dive into Serverless Spatial Data and FME
Cloud Frontiers: A Deep Dive into Serverless Spatial Data and FMECloud Frontiers: A Deep Dive into Serverless Spatial Data and FME
Cloud Frontiers: A Deep Dive into Serverless Spatial Data and FMESafe Software
 

Último (20)

Apidays New York 2024 - Scaling API-first by Ian Reasor and Radu Cotescu, Adobe
Apidays New York 2024 - Scaling API-first by Ian Reasor and Radu Cotescu, AdobeApidays New York 2024 - Scaling API-first by Ian Reasor and Radu Cotescu, Adobe
Apidays New York 2024 - Scaling API-first by Ian Reasor and Radu Cotescu, Adobe
 
WSO2's API Vision: Unifying Control, Empowering Developers
WSO2's API Vision: Unifying Control, Empowering DevelopersWSO2's API Vision: Unifying Control, Empowering Developers
WSO2's API Vision: Unifying Control, Empowering Developers
 
Why Teams call analytics are critical to your entire business
Why Teams call analytics are critical to your entire businessWhy Teams call analytics are critical to your entire business
Why Teams call analytics are critical to your entire business
 
Repurposing LNG terminals for Hydrogen Ammonia: Feasibility and Cost Saving
Repurposing LNG terminals for Hydrogen Ammonia: Feasibility and Cost SavingRepurposing LNG terminals for Hydrogen Ammonia: Feasibility and Cost Saving
Repurposing LNG terminals for Hydrogen Ammonia: Feasibility and Cost Saving
 
MS Copilot expands with MS Graph connectors
MS Copilot expands with MS Graph connectorsMS Copilot expands with MS Graph connectors
MS Copilot expands with MS Graph connectors
 
Apidays New York 2024 - The value of a flexible API Management solution for O...
Apidays New York 2024 - The value of a flexible API Management solution for O...Apidays New York 2024 - The value of a flexible API Management solution for O...
Apidays New York 2024 - The value of a flexible API Management solution for O...
 
Rising Above_ Dubai Floods and the Fortitude of Dubai International Airport.pdf
Rising Above_ Dubai Floods and the Fortitude of Dubai International Airport.pdfRising Above_ Dubai Floods and the Fortitude of Dubai International Airport.pdf
Rising Above_ Dubai Floods and the Fortitude of Dubai International Airport.pdf
 
Finding Java's Hidden Performance Traps @ DevoxxUK 2024
Finding Java's Hidden Performance Traps @ DevoxxUK 2024Finding Java's Hidden Performance Traps @ DevoxxUK 2024
Finding Java's Hidden Performance Traps @ DevoxxUK 2024
 
Introduction to Multilingual Retrieval Augmented Generation (RAG)
Introduction to Multilingual Retrieval Augmented Generation (RAG)Introduction to Multilingual Retrieval Augmented Generation (RAG)
Introduction to Multilingual Retrieval Augmented Generation (RAG)
 
Strategize a Smooth Tenant-to-tenant Migration and Copilot Takeoff
Strategize a Smooth Tenant-to-tenant Migration and Copilot TakeoffStrategize a Smooth Tenant-to-tenant Migration and Copilot Takeoff
Strategize a Smooth Tenant-to-tenant Migration and Copilot Takeoff
 
Architecting Cloud Native Applications
Architecting Cloud Native ApplicationsArchitecting Cloud Native Applications
Architecting Cloud Native Applications
 
Strategies for Landing an Oracle DBA Job as a Fresher
Strategies for Landing an Oracle DBA Job as a FresherStrategies for Landing an Oracle DBA Job as a Fresher
Strategies for Landing an Oracle DBA Job as a Fresher
 
Platformless Horizons for Digital Adaptability
Platformless Horizons for Digital AdaptabilityPlatformless Horizons for Digital Adaptability
Platformless Horizons for Digital Adaptability
 
presentation ICT roal in 21st century education
presentation ICT roal in 21st century educationpresentation ICT roal in 21st century education
presentation ICT roal in 21st century education
 
Vector Search -An Introduction in Oracle Database 23ai.pptx
Vector Search -An Introduction in Oracle Database 23ai.pptxVector Search -An Introduction in Oracle Database 23ai.pptx
Vector Search -An Introduction in Oracle Database 23ai.pptx
 
Boost Fertility New Invention Ups Success Rates.pdf
Boost Fertility New Invention Ups Success Rates.pdfBoost Fertility New Invention Ups Success Rates.pdf
Boost Fertility New Invention Ups Success Rates.pdf
 
ProductAnonymous-April2024-WinProductDiscovery-MelissaKlemke
ProductAnonymous-April2024-WinProductDiscovery-MelissaKlemkeProductAnonymous-April2024-WinProductDiscovery-MelissaKlemke
ProductAnonymous-April2024-WinProductDiscovery-MelissaKlemke
 
Navigating the Deluge_ Dubai Floods and the Resilience of Dubai International...
Navigating the Deluge_ Dubai Floods and the Resilience of Dubai International...Navigating the Deluge_ Dubai Floods and the Resilience of Dubai International...
Navigating the Deluge_ Dubai Floods and the Resilience of Dubai International...
 
+971581248768>> SAFE AND ORIGINAL ABORTION PILLS FOR SALE IN DUBAI AND ABUDHA...
+971581248768>> SAFE AND ORIGINAL ABORTION PILLS FOR SALE IN DUBAI AND ABUDHA...+971581248768>> SAFE AND ORIGINAL ABORTION PILLS FOR SALE IN DUBAI AND ABUDHA...
+971581248768>> SAFE AND ORIGINAL ABORTION PILLS FOR SALE IN DUBAI AND ABUDHA...
 
Cloud Frontiers: A Deep Dive into Serverless Spatial Data and FME
Cloud Frontiers: A Deep Dive into Serverless Spatial Data and FMECloud Frontiers: A Deep Dive into Serverless Spatial Data and FME
Cloud Frontiers: A Deep Dive into Serverless Spatial Data and FME
 

Modeling the dynamic assembly of cell cycle complexes from high-throughput data

  • 1. Lars Juhl Jensen EMBL Heidelberg Modeling the dynamic assembly of cell cycle complexes from high-throughput data
  • 2.
  • 3. Getting the parts list Yeast culture Microarrays Gene expression Expression profile Cho & Spellman et al. 600 periodically expressed genes (with associated peak times) that encode “dynamic proteins” The parts list New analysis
  • 4.
  • 5. Extracting a cell cycle interaction network Cell cycle microarray data Physical PPI interactions with confidence scores Expand the set of proteins to include non-periodic proteins that are strongly connected to periodic proteins Raw Data Node selection List of periodically expressed proteins with peak time Interactions Require compatible compartments and high confidence Extract cell cycle network
  • 6.
  • 7.
  • 8. Cdc28p and its interaction partners
  • 9.
  • 10. Assembly of the pre-replication complex
  • 11.
  • 12.
  • 13.
  • 14.
  • 15.