Identifying women with GDM is important because appropriate therapy can decrease maternal and fetal morbidity .
Can prevent two generations from developing diabetes in the future.
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Gestational Diabetes Mellitus.pptx
1. • Chairperson Elect ICOG –Indian College of OB/GY
• National Corresponding Editor-Journal of OB/GY of India JOGI
• National Corresponding Secretary Association of Medical Women, India
• Founder Patron & President –ISOPARB Vidarbha Chapter 2019-21
• Chairperson-IMS Education Committee 2021-23
• President-Association of Medical Women, Nagpur AMWN 2021-24
• Nagpur Ratan Award @ hands of Union Minister Shri Nitinji Gadkari
• Received Bharat excellence Award for women’s health
• Received Mehroo Dara Hansotia Best Committee Award for her work as
Chairperson HIV/AIDS Committee, FOGSI 2007-2009
• Received appreciation letter from Maharashtra Government for her work in the
field of SAVE THE GIRL CHILD
• Senior Vice President FOGSI 2012
• President Menopause Society, Nagpur 2016-18
• President Nagpur OB/GY Society 2005-06
• Delivered 11 orations and 450 guest lectures
• Publications-Thirty National & Eleven International
• Sensitized 2 lakh boys and girls on adolescent health issues
Dr. Laxmi Shrikhande
MBBS; MD(OB/GY);
FICOG; FICMU; FICMCH
Medical Director-
Shrikhande Fertility Clinic
Nagpur, Maharashtra
4. Gestational diabetes
mellitus
Pre Existing Diabetes
Hyperglycemia during
pregnancy that is not
diabetes
Diagnosed before the
start of pregnancy OR
Hyperglycemia diagnosed for the
first time in pregnancy. Meets
WHO criterion for diabetes
mellitus in the nonpregnant
state
Hyperglycemia diagnosed for
the first time during
pregnancy
May occur any time during
pregnancy including the first
trimester
May occur any time during
pregnancy but most likely
>24 weeks
5. Prevalence
22 million women between 20-39 years have diabetes -2010 data
Expected to rise by 20% in next 10 years
54 million women with IGT or pre diabetes have the potential to
develop GDM if they become pregnant.
The prevalence of GDM in India varies from 3.8 to 21% in different
parts of the country, depending on the geographical locations and
diagnostic methods used.
GDM has been found to be more prevalent in urban areas than in
rural areas
7. Pathophysiology of GDM
Gestational
diabetes
mellitus
Insulin resistance
due to placental
secretion of anti-
insulin hormones
Maternal hepatic
glucose production
increases by 15%-
30% to meet fetal
demand late in
pregnancy Pancreatic -cell
dysfunction due to
• Genetics
• Autoimmune disorders
• Chronic insulin resistance
Inturrisi M, et al. Endocrinol Metab Clin N Am. 2011;40:703-726. Metzger BE, et al. Diabetes Care. 2007;30(2):S251-S260.
8. Screening versus diagnostic testing
The purpose of screening is to identify asymptomatic
individuals with a high probability of having or developing a
specific disease.
9. Whom to screen ?
Universal screening appears to be the optimum approach as
the Indian women have 11 fold increased risk of developing
glucose intolerance during pregnancy compared to
Caucasian women .
10. Which screening method ?
Diabetes in Pregnancy Study Group of India (DIPSI) Criteria
One step approach - The one step approach has been
proposed by the DIPSI and endorsed by the GOI .
On 14th March 2007, Government of India issued the
instructions that universal screening of glucose intolerance
during pregnancy should be mandatory.
The order recommends that all women should be screened
between 24 and 28 weeks of gestation with 2 h 75 g oral
glucose.
11. How to do it ?
75 gms glucose with 300 ml water
Irrespective of last meal
Ingestion to be completed within 5-10 min
Measure blood sugar after 2 hour
If vomiting within 30 min of intake-repeat test next day
13. Advantages of DIPSI Criteria
Simple, feasible, convenient, economical and acceptable in
Indian scenario
In India, women have to travel long distances for check-up,
hence this non-fasting single test becomes more acceptable to
the pregnant women
Indian population is diverse and variable, hence international
criteria on Indian population may not be practical and feasible.
15. Why Diagnose and Treat GDM?
Identifying women with GDM is important because appropriate
therapy can decrease maternal and fetal morbidity .
Can prevent two generations from developing diabetes in the
future.
19. Outline for GDM management
Primary management strategy for GDM: dietary changes
and exercise
If uncontrolled hyperglycemia with lifestyle change:
Insulin should be first line therapy
Use Metformin, if insulin cannot be used
20. Management Issues-
Patient education
Medical Nutrition therapy
Pharmacological therapy
Glycemic monitoring: SMBG & Targets
Fetal monitoring: ultrasound
Planning on delivery
Postpartum care
21. GDM: Management During Pregnancy
Receive nutrition counseling by registered dietician to
achieve their nutrition, weight and blood glucose goals
Eat healthy diet and Replace high-Glycemic Index foods
with low-Glycemic Index foods to reduce need for insulin
initiation
Discuss appropriate weight gain and healthy lifestyle
interventions throughout pregnancy
22. Medical Nutrition Therapy (MNT)
Therapeutic goals:
Adequate nutrition
Adequate weight gain
Prevention of ketosis
Prevention of postprandial hyperglycemia.
24. GDM Diet
Diet- 30 kcal/kg – normal weight women, 24 Kcal/kg for
overweight women, and 12 Kcal/kg for morbidly obese women.
Diet should contain carbohydrate 50%, protein 20% and fat 25-
30%.
Usually three meal regimen, with breakfast 25% of the total
intake, lunch 30%, dinner 30%.
25. Physical Activity
Unless contraindicated, physical activity should be
included in a pregnant woman’s daily regimen
Regular moderate-intensity physical activity (eg, walking)
can help to reduce glucose levels in patients with GDM
Other appropriate forms of exercise during pregnancy
Cardiovascular training with weight-bearing, limited to
the upper body to avoid mechanical stress on the
abdominal region
26. Target weight gain in GDM
Prepregnancy BMI Category Total weight gain
<18.5 Underweight 12.5-18 Kg
18.5-24.9 Normal weight 11.5-16 Kg
25-29.9 Overweight 7-11.5 Kg
>30 Obese 5-9 Kg
27. Insulin initiation during pregnancy
About 50% of women initially treated with diet alone will require
additional therapy, and insulin therapy usually is recommended.
Insulin management must be individualized, but most pregnant
women require about 0.7 units/kg daily.
two thirds of the insulin is administered in the morning and one
third is administered in the evening, with a 1:2 ratio of short- to
intermediate- (or long-) acting insulin.
Kahn, CR, King GL., Moses AC., . Joslin's Diabetes Mellitus (14th Edition).Weir GC., Jacobson AM., Smith RJ JOSLIN
DIABETES CENTER. Boston, Lippincott Williams & Wilkins, 2005, chapter 61
33. Hypoglycaemia
Any Pregnant women on insulin can develop hypoglycemia at
any time.
Hypoglycemia is diagnosed when blood sugar level is < 70 mg/dL
It is important to recognize symptoms of hypoglycemia & treat
immediately
34. How to recognize hypoglycaemia?
Early symptoms - Tremors of hands, sweating, palpitations,
hunger, easy fatigability, headache, mood changes, irritability,
low attentiveness, tingling sensation around the mouth/lips or
any other abnormal feeling
Severe - Confusion, abnormal behavior or both, visual
disturbances, nervousness or anxiety.
Uncommon - Seizures and loss of consciousness
35. How to manage hypoglycaemia?
Ask pregnant women to take 3 TSF of glucose powder (15-20 grams)
dissolved in a glass of water.
If glucose is not available, take one of the following: Sugar - 6 TSF in a glass
of water/ fruit juice/honey/anything which is sweet/any food.
After taking oral glucose, she must take rest & avoid any physical activity.
15 minutes after taking glucose, she must eat one chapati with
vegetable/rice/one glass of milk/idli/fruits/anything eatable which is
available.
If hypoglycemia continues, repeat same amount of glucose and wait.
If pregnant women develops >1 episode of hypoglycemia in a day, she
should consult any doctor immediately.
36. Status of OHA in pregnancy
Metformin and the sulfonylurea glyburide are the 2 most commonly
prescribed oral antihyperglycemic agents during pregnancy
transfer category B, others
Due to efficacy and safety concerns, the ADA and DIPSI does not
recommend oral antihyperglycemic agents for gestational diabetes mellitus
(GDM) or preexisting T2DM
Medication Crosses Classification Notes
Placenta
Metformin Y
es Category B Metformin and glyburide may be
insufficient to maintain normoglycemia at
all times, particularly during postprandial
period
Glyburide Minimal Some formulations
category C
37. OHA in pregnancy
Metformin
Insulin sensitizer
Give with meal
Start at 500 mg once or twice daily with food
Increase slowly weekly to 2000 mg per day (2500 mg/day)
No teratogenic risks demonstrated
pregnancy risk factor: B (No evidence of risk in studies)
Not FDA approved for use in pregnancy
39. Monitoring Blood Glucose
At least 4 times-self monitoring
Fasting and 3 one and half hour postprandial
After achieving target level, lab monitoring till 28wks- once
in a month
28-32 weeks once in 2 weeks
>32 once a week
Other parameters to be monitored: fundus,micro
albuminuria
40. Glycemic targets
Mean plasma glucose -105 mg/dl
Maintain FPG at 90 & PP at 120
Mean plasma glucose should never go below 86
46. Special precaution during labour
Pregnant women with GDM on medical management
(metformin or insulin) require blood sugar monitoring during
labor by a glucometer.
The morning dose of insulin/metformin is withheld on the day of
induction/labour and the pregnant women should be started on
2 hourly monitoring of blood sugar.
IV infusion with normal saline (NS) to be started & regular
insulin to be added according to blood sugar levels as per the
table below:
47. During Labour
Diagnosis and management of Gestational Diabetes Mellitus Technical and Operational
Guidelines (Maternal Health Division, Ministry of Health and Family Welfare of India)
48. Care in labour & delivery
Institutional delivery
Presence of expert obstetrician
Close electronic monitoring
49. Care in labour & delivery
Close monitoring in second stage
W/F foetal distress
Vaginal delivery should be preferred and LSCS should be done for obstetric indications only.
50. Insulin Management during Labour &
Delivery
Usual dose of intermediate-acting insulin is given at bedtime
Morning dose of insulin is withheld
I.V infusion of normal saline is begun
Once active labor begins or glucose levels fall below 70 mg/dl, infusion is
changed from saline to 5% dextrose & delivered at a rate of 2.5 mg/kg/min
Glucose levels are checked hourly using a portable meter allowing for
adjustment in infusion rate
Regular (short-acting) insulin is administered by iv infusion if glucose levels
exceed 140 mg/dl
51. Immediate neonatal care for baby
of mother with GDM
All neonates should receive immediately essential new-born care
with emphasis on early breastfeeding to prevent hypoglycaemia.
52. Immediate postpartum care-GDM on MNT
Cease blood glucose monitoring immediately after delivery
Regular postnatal care
OGTT 6 weeks postpartum
American Diabetes Association. Standards for medical care in diabetes 2018. Diabetes Care 2018
53. Immediate postpartum care-GDM on OHAs
In most women, glucose tolerance will normalize immediately after delivery
Cease pharmacological therapy immediately after delivery
Continue pre prandial BGL monitoring QID for 24 hrs
If preprandial BGL 72 – 126mg/dl – discontinue monitoring
If BGL <72mg/dl or >126mg/dl – seek medical review and continue monitoring
1 – 8% may continue to be glucose intolerant and need OHAs
Metformin, glibenclamide / glyburide safe during lactation
Queensland clinical guideline 2015
54. Preprandial BGL monitoring QID for 24 hrs
If BGL >126mg/dl –medical review & start OHAs
Insulin therapy is generally not indicated unless marked
fasting hyperglycemia (200–250 mg/dL)
Queensland clinical guideline 2015
Immediate postpartum care-GDM on Insulin
55. Risk factors for persistent diabetes
Pregnancy fasting glucose levels greater than or equal to 126
mg/dL
Diagnosis of GDM during the first trimester
A prior history of GDM without documented normal glucose
tolerance outside of pregnancy
Metzger BE. Summary and recommendations of the 4th International Workshop-
Conference on Gestational Diabetes Mellitus. Diabetes Care 1998;21(Suppl 2):B1617.
56. Monitor for persistent diabetes
Recommend OGTT at 6 weeks postpartum to screen for
persistant diabetes
Recommend lifelong screening for diabetes every 3 yrs
Early glucose monitoring in future pregnancy
57. Breast feeding
Should be encouraged to breastfeed immediately after
delivery in order to avoid neonatal hypoglycemia [Grade D,
Consensus] and
To continue for at least 3-4 months postpartum in order to
prevent childhood obesity [Grade C, Level 3] and diabetes in
the offspring [Grade D, Level 4] and
To reduce risk of type 2 diabetes and hypertension in the
mother [Grade C, Level 3]
59. Can we Prevent GDM ?
In women at high risk for GDM based on pre-
existing risk factors,
nutrition counseling should be provided on
healthy eating and
prevention of excessive gestational weight gain in
early pregnancy, ideally before 15 weeks of
gestation,
to reduce the risk of GDM [Grade B, Level 2]
60. Preconception Recommendations
Women with preexisting diabetes who are planning a pregnancy should ideally be
managed beginning in preconception in a multidisciplinary clinic including an
endocrinologist, maternal- fetal medicine specialist. Registered dietitian nutritionist, and
diabetes care and education specialist when available.
In addition to focused attention on achieving glycemic targets, standard preconception
care should be augmented with extra focus on nutrition, diabetes education, and
screening for diabetes comorbidities and complication.
Women with preexisting type 1 or type 2 diabetes who are planning pregnancy or who
have become pregnant should be counselled on the risk of development and/ or
progression of diabetic retinopathy.
Dilated eye examinations should occur ideally before pregnancy or in the first trimester,
and then patients should be monitored every trimester and for 1 year postpartum as
indicated by the degree of retinopathy and as recommended by the eye care provider.
61. Key points
Universal testing of all pregnant women for GDM
Testing recommended twice in pregnancy; at 1st antenatal visit and then at 24-28 weeks of gestation. DIPSI
recommends additional screening at ~34 weeks.
Single step 75 gm 2 hr OGTT test performed.
Pregnant women testing positive(2hr OGTT≥140mg/dL) should be started on MNT for 2 weeks.
If 2 hr PPBS ≥120 mg/dL after MNT and physical exercise, medical management (metformin or insulin therapy) of
pregnant women to be started as per guidelines.
Early delivery with administration of prophylactic corticosteroid therapy for fetal lung maturity to be planned only if
uncontrolled blood sugar or any other obstetric indication
Vaginal delivery preferred, LSCS for only obstetric indications or fetal macrosomia.
Neonatal monitoring for hypoglycemia and other complications
Postpartum evaluation of glycemic status by a 75 g OGTT at 6 weeks after delivery.
62. Pregnant women with GDM
and their offspring’s are at
increased risk of developing
Type II Diabetes mellitus in
later life.
They should be counselled for
healthy lifestyle and
behaviour, particularly role of
diet & exercise