mHealth Israel_A New era for Life Sciences: Reimagining medicine with data and digital

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Jeremy Sohn, VP, Digital BD&L, Novartis, presenting on Nov 5, 2020. Title: "A New era for Life Sciences: Reimagining medicine with data and digital". Presentation begins with using data and digital to diagnose cancer. Overview of the "Map of Life", an initiative to explore, and analyze Novartis' historical clinical trial data, with applications like Qubit, Chord, Chronograph. There is an example of taking the first step toward in-silico development.

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A New era for Life Sciences: Reimagining
medicine with data and digital
Jeremy Sohn, VP, Digital BD&L, Novartis
Novartis Digital

Novartis Digital
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Novartis Digital
Business Use Only3

Novartis Digital
Business Use Only4

Novartis Digital
Business Use Only5

Novartis Digital

Novartis Digital
Business Use Only7

Novartis Digital

Novartis Digital
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1st step toward in-silico development

Novartis Digital
Business Use Only10

Novartis Digital
Business Use Only11

Novartis Digital
Business Use Only12

Novartis Digital
Business Use Only13

Novartis Digital
Business Use Only14

Novartis Digital
Business Use Only15

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Overview of activities in Life Science of Hadasit, the technology transfer arm of Hadassah Hospital in Jerusalem. Includes details about Jerusalem Biodesign program; spinouts like Brainwatch; details about tech transfer (the Secret Engine Behind Israel’s Success); relationship and examples of TTOs enabling Israel's greatest success stories; contrasting of Adademia (Scientific driven research, Creation of new knowledge, Publication, Sharing of Material, Social responsibilities) and Industry (Applied research & specific objectives, Develop new products, Product development, Secrecy and patent protection, Organization responsibilities); Development gap between initial inventions and product development; the Art of translation (from academic research to medical companies); Tech transfer transforms cutting-edge research into marketable healthcare technologies; LICENSING TO EXISTING COMPANIES; SPINNING OFF STARTUPS; CO-DEVELOPMENT OF JOINT IP; Technology Transfer Offices from Academia/Research Hospitals – to Industry; Overview of Hadassah and Hadasit (TECHNOLOGY TRANSFER COMPANY AND INNOVATION ENGINE OF HADASSAH UNIVERSITY HOSPITALS); Examples of “HADASSAH MADE” PRODUCTS IN THE GLOBAL MARKET; RECENT TECH TRANSFER SUCCESS; Example- Lineage Exclusive Worldwide Collaboration with Genentech Opregen® RPE Cell Therapy for the Treatment of Ocular Disorders; HADASIT PILLARS- NURTURING INTERNAL INNOVATION, Tech Transfer, EXTERNAL INNOVATION. External- SERVICES & COLLABORATIONS WITH COMPANIES, BIOHOUSE FOR STARTUPS, DIGITAL HEALTH ACCELERATOR); Internal Innovation- NURTURING INTERNAL INNOVATION, HADASSAH SEED FUND, JERUSALEM BIODESIGN PROGRAM; TYPES OF RELATIONS WITH EXTERNAL COMPANIES- CONSULTING, SAB, CLINICAL TRIALS, R&D SERVICES, DATA LICENCE, ALPHA/BETA SITE, PILOTS, DESIGN PARTNERSHIPS.

HADASIT: Tech Transfer and More in Life Science

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HADASIT: Tech Transfer and More in Life Science

Presenting to Investors and the Media, lecture by Drew Levinson, LifeSci Communications to mHealth Israel. Three sections: Making a good presentation, Handling interviews with reporters and Answers that resonate. PRESENTING TO INVESTORS AND THE MEDIA- Compelling delivery, Commanding a room, • Lasting Impact. A good presentation includes Information, Motivation and Excitement. Never put them to sleep. Audience impact includes content, credibility and delivery. Decisions are made leading to potential partnerships, winning business, so much more than a deck, your business, your brand, you. How to captivate begins with storytelling and conversation. More than features- benefits, humanize, positive impact. Don't complicate your message with jargon. Feel the passion- contagious, vision, determination. Know your audience- who are they, what do they know about you, how much do they know, interests, concerns. Articulate your vision- see it, feel it, believe in it. Take them on your journey- compelling narrative, make it personal, why are you doing this, inspiration. Your team- experienced, knowledgeable, aligned, execute. Risks and challenges- recognize, address, plan to mitigate. Test drive your room. What does it look like? Where is the podium? Where will I be standing? Where will you be sitting? Feel comfortable. Three parts to attention. The beginning- attention, interest, what's in it for them, entusiasm, preview. The middle- core, insights, challenges, solutions, relatable. The ending- summary, reinforce, messages, benefits, call to action, keep the momentum going. How to answer questions. The Four R's: repeat, reinforce, refer, remember. Talking to reporters- necessity; Good interview can enhance reputation; Bad interview can tarnish reputation; Preparation is vital. Shapes public opinion: Elevates your brand; Establishes authority; Showcases your business; A bridge; Reputation; Trust; Visibility. Know the reporter. Audience; What have they written; Previous stories; Questions asked. Concise- clear, succinct, engaging. Make it relatable: Stories; Anecdotes; Experiences; Examples; Metaphors; Connect. Honesty and transparency. It is okay not to know every answer. You don’t have to answer every question. Control the narrative. What not to do when talking to reporters. Come up with another way to say no comment. What to wear- solid colors, blues and grays, nothing distracting. Expertise, passion, vision, lasting impression, connections. High stakes, high rewards. Preparation; Know your audience; Deliver with confidence; Enthusiasm; Authenticity. Begin the journey. Engage in dialogue; Build relationships; Inspire trust and confidence; Valued; Enlightened; Motivated and excited.

Presenting to Investors & the Media.pdf

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Overview by Beyeonics CEO, Ron Schneider, about the company. Beyeonics One is the first ophthalmic exoscope with an augmented reality surgical headset. It is a high-definition, fully digital imaging platform enabling surgeons to see a magnified, three-dimensional (3D) image of the surgical field. The small footprint, the fast setup, automation, and zero turnover time between procedures all contribute to the efficiency operating rooms strive for. Over 3000 cases to date. Unconstrained Movement. Unconstrained workflow. Data connectivity. Designed for continuous innovation.

Beyeonics CEO, Ron Schneider, Advances in Medical XR

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XRHealth is revolutionizing healthcare, bringing patient care into the Metaverse. Includes a description of the TeleHealth Platform. Lessons Learned – Building the clinical Metaverse. Last mile delivery Building a product in the Metaverse is easy – getting people to use it is hard. Virtual Care can’t be based only on XR. HMDs bring friction – Charging, Guardian, Safety, Passwords etc. Expanding virtually in a brick & mortar payer environment. Once you cross the chasm – adherence/ satisfaction/retention goes ballistic. Patient Outcomes- Patients report significant improvement in symptoms following treatment. Adherence - patients follow Home Exercise Plans as prescribed. 92.2% with XRHealth vs 50% with regular treatment. Patient satisfaction - 85 NPS vs 38 NPS in healthcare 93.3% patient retention -complete treatment cycle as prescribed. XRHealth Luna AI Reduces Hot Flashes and Improves Psychological Well-Being in Women with Breast and Ovarian Cancer: A Pilot Study. Virtual reality immersion compared to monitored anesthesia care for hand surgery: A randomized controlled trial. Lessons Learned – Autism Spectrum Disorder. The future of the Mediverse.

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April, 2023 presentation by Gil Bashe, Global Chair, Health Practice, FINN Partners. Insights and analytics, in collaboration with Galen Growth, tracking Digital Health collaboration, adoption, integration, and best practices across the leading US Health Systems. There is a section about focus areas for digital health in health systems and hospitals. The most active health systems are partnering more in diagnosis and have a higher share of digital tools for research. Comprehensive breakout of digital health activities at the Top 10 players: Mayo, Mount Sinai, Cleveland Clinic, Sloan Kettering, Massachusetts General, Northwell, Cedars Sinai, Brigham & Women's, InterMountain. Global breakout of health systems with digital health partnerships at scale. Geographical breakout of digital health partner headquarters (by region). Strong preference for B2B business model. 1/3 of digital health partnerships with Early Stage venture companies. Emphasis is on strong clinical evidence. Portfolio size allows greater diversity. Cluster distribution depends on therapeutic area. Digital health analytics breakout including alpha score, venture similarity score, venture valuation, team signal, partnership signal, evidence signal.

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Course Syllabus (Digital Rosh): The Future of Digital Medicine- Biology, Gene...

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Overview of Israel's leading BioFoundry, Alagene by Roni Cohen, CEO. Overview of Synthetic Biology- Taking biology into engineering mode. Using synthetic genes, to program cells to become factories to make devices, sensors, pharmaceuticals, renewable chemicals, fuels and food. Alagene has four partners with complementary expertise. Hylabs is an established and experienced, highly regulated service company. Reichman University is an academic partner with a commercialization mindset. The Israel Innovation Authority is the government and Aleph VC is an investment firm. Alagene is a home for innovation and R&D center in SynBio, serving as a one-stop—shop for knowledge, methods, and instrumentation to enable our customers in Israel and worldwide to get to their proof of concept. Alagene is anend to end Infrastructure supporting gene & host optimization in microbial systems. The infrastructure enables two Major Implementations- Biomanufacturing and Direct Microbial Application. One example is the development of a Dairy Milk Producing System, using Genetic Optimization and Process Optimization and Validation. Finally, Alagene shared the following recent project examples: Computational prediction for introducing new genes into microbes; Precision fermentation for yeast producing dairy proteins; Bio production of psychoactive / cannabinoid molecule in yeast; Bio production of growth factors for the cultured meat industry; Developing new inhouse tools to support strain optimization; Bio production of egg protein; Computational modeling of full metabolic network in Algae; Bio production of rare sugars with a low glycemic index.

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EU Medical Device Regulatory Framework_Dec, 2022

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FINN Partners Global State of Digital Health Q3 2022

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Digitally powered participant-directed studies. A Strategy for Decentralized Care. The Evolution of the Digital Patient Experience in Oncology & opportunities for Human Augmented Intelligence and Touch. Outlne: Precedent and example; Opportunities for Artificial Intelligence and/or Machine Learning? The human touch to augment technology; Challenges from a behavioral economics standpoint; Future directions. Digitally powered participant-directed studies are the right direction and may be the new reality. Patient Symptoms During Their Cancer Journey. We must shift our focus to the ‘other’ 99% of time. Patient centricity unrestricted by provider encounters. Patient Generated Health Data. Evolving the Digital Patient Experience in Oncology. AI in Health & Medicine. TREATING THE WHOLE PERSON; Health coaching to address social determinants to: Solve the 4000-hour problem; Keep patients healthy at home; Close care gaps between clinic visits; Motivate healthy behavior changeto drive better outcomes. Digital Health Possibilities for Community-Based Support. Insights from a Pilot of Digital Health Coaching. Pilot Study Data. Outcomes of a Pilot Study Exploring the Role of Digital Health Coaching for Men with Prostate Cancer. Data, Healthcare and Technology...REMEMBER THAT THERE ARE SILOS INSIDE OF EACH OF THESE SILOS – THEY ARE THEMSELVES NOT MONOLITHS. EMPHASIS SHOULD BE THAT WE ARE NOT ONLY CREATING A BRIDGE TO OPEN COMMUNICATION. WE ARE ALSO CREATING A NEW PERSON WHO HAS EXPERTISE IN ALL AREAS BROADLY – NOT ONLY JUST THESE 3.

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mHealth Israel_Unmet Needs and Opportunities – Farm animals

mHealth Israel_Unmet Needs and Opportunities – Farm animals

mHealth Israel_Unmet Needs and Opportunities – Farm animals

September 19, 2022 presentation about Animal Health Landscape- by Andras Bolcskei, Executive Vice President & Global Commercial Lead, CEVA Sante Animal Health. Three part agenda covers Global macroeconomic outlook, Animal Health industry trends, Implication on the Animal Health industry. Inflation Growth and Unemployment Costs. China’s consumer Inflation. CASH- Cost and availability of cash is changing which means that there is again a cost associated to taking risk = investors start being more selective. ATTRACTIVITY- In this context, attractivity of the AH sector is increased, especially in Pets, given the track record of resilience of the sector vs. other investment opportunities. We will continue to see M&A activity and R&D investment in the sector. CORPORATIZATION- Despite the increased cost of money, the predictability and history of AH and veterinary business in the last financial crises and the early stage of vet clinics consolidations in many markets are strong drivers for continued, fast-paced corporatization to continue. PET PARENT AND CONSUMER POWER- It will continue to increase in the AH, with megatrends like online 24/7 availability omnichannel, pet as family member, steady increase of pet plans / pet insurance / data driven personalization. This creates value in the market for agile companies. Transactional Customers- Know what they want, Treat you as commodity, Digital interaction, Cost focus, Buy on price, Short term. Consultative Customers- Share problems, Value your value add, Digital & analogue interaction, Advice focus, Buy on expertise and trust, Long term. Vet Landscape Evolution 2022-2025. Market consolidation. Independent Vet clinics. Companion Animals. Corporates. GPOs. Corporate landscape in Europe (data Q2 2022)- A number of large, well capitalized veterinary strategic accounts are expanding. Global trends in pet population. There are currently billions of pets worldwide. Pet ownership is rising globally, particularly in millennial households. Expanding middle class is driving pet population growth in emerging markets. Pet ownership leads to improved human health outcomes for people including better heart health, lower levels of depression and anxiety, etc. Brands & blockbusters. Increasing brand value. Zoetis, Elanco (and BI indirectly through their sales reporting) qualify blocbkusters as products > $100m – 25 brands. One Heath Concept. Sustainability. Technology innovation. Veterinary / Nurse shortage. Farms, trades, on-line shop, independent. More customers are moving to the extremes. More want deeper consultative relationships. More buy transactionally

mHealth Israel- Animal Health Landscape

mHealth Israel- Animal Health Landscape

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Human and Animal Healthcare- Where do they meet? Sept 29, 2022 animal health presentation by Cindy Cole, Partner, Digitalis Ventures. Overview of Digitalis Ventures and their $100 million Companion Fund, Mars-backed VC Fund dedicated to the companion animal space. Context about solving a problem vs creating a want. For example, dogs are not small humans. Specific Opportunities include supplements. This is a huge market, very fragmented, Very little science to support the activies. How do you differentiate your products? Example of Telemedicine- a cautionary tale for startups and investors. Summary- if your coming from human healthcare…Understand dogs and cats, Don’t over index on the “humanization” of pets, Solving a problem or creating a want. YouTube video recording available, along with other presenters, Ila Shukla Roof, Executive Commercial Director, Covetrus; Andras Bolcksei, Executive Vice President and Global Commercial Lead, CENA Sante; Avner Finger, VP Global R&D- Vaccines, Phibro; Moderated by Gil Bashe, Head of Global Health and PURPOSE, Finn Partners.

mHealth Israel: Human and Animal Healthcare- Where do they meet? Presentation...

mHealth Israel: Human and Animal Healthcare- Where do they meet? Presentation...

mHealth Israel: Human and Animal Healthcare- Where do they meet? Presentation...

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Science 37 Overview

Science 37 Overview

Science 37 Overview

springboard for digital healthcare in the heart of Europe 15th June 2022 Presentation by Luxembourg Health officials (Christian Oberlé, President CNS; Carole Brückler PhD, Head of Digital Health Technologies, MECO) for mHealth Israel, June 16, 2022 in Tel Aviv. Incudes Building digital readiness,; Evolution of income and expenditure encourages a move towards preventative medicine leveraged by digital health; 855 mio EUR p.a. social care insurance – opportunity to leverage digital health for longer care at home; A strong basis of research excellence; The European Digital Health Market; potential of the digital health market in Europe; Luxembourg plays an active role in shaping the digital health regulatory framework in Europe; Europe’s 2-pronged way towards Digital Medical regulation; Building regulations around trans-EU use cases; Principle Digital Medicine Design features; Luxembourg integrates digital medicine and translational capacities across borders; Increasing interoperable data sourcing across borders; Luxembourg is driving clinical research in personalized medicine; Putting the patient in the center through Digital Health Applications; DiHA – the German DiGA; the international DTx (digital therapeutics): Patient-centric application with a direct benefit for patients; Pan-European harmonization of DiGA/DTx/DiHA regulation initiated; European DiHA; To obtain the best initiative and build the most effective and concrete pan-European consensus; Digital HealthCare Services Translational Research- Strategy for Europe; Luxembourg as a gate to Europe’s digital health market; A phygital (physical and virtual) campus in Esch

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Luxembourg Health Tech Overview

Luxembourg Health Tech Overview

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HADASIT: Tech Transfer and More in Life Science

HADASIT: Tech Transfer and More in Life Science

Presenting to Investors & the Media.pdf

Presenting to Investors & the Media.pdf

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Nissan Elimelech, Founder, Augmedics: How I Built the World's First XR Surgic...

Nissan Elimelech, Founder, Augmedics: How I Built the World's First XR Surgic...

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Beyeonics CEO, Ron Schneider, Advances in Medical XR

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XRHealth Founder, Miki Levy

XRHealth Founder, Miki Levy

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Digital Health in US Health Systems.pptx

Digital Health in US Health Systems.pptx

Course Syllabus (Digital Rosh): The Future of Digital Medicine- Biology, Gene...

Course Syllabus (Digital Rosh): The Future of Digital Medicine- Biology, Gene...

Course Syllabus (Digital Rosh): The Future of Digital Medicine- Biology, Gene...

Alagene BioFoundry: Releasing the Genie Out of the Bottle

Alagene BioFoundry: Releasing the Genie Out of the Bottle

Alagene BioFoundry: Releasing the Genie Out of the Bottle

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Digital Health Ecosystem- 2022 3rd Quarter Report

Digital Health Ecosystem- 2022 3rd Quarter Report

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FINN Partners Global State of Digital Health Q3 2022

FINN Partners Global State of Digital Health Q3 2022

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A Peek into the Future of Health Systems, Mark Coticchia, Baptist Health

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mHealth Israel: The Speed of Change is Faster Than Our Response_Howard Yana S...

mHealth Israel: The Speed of Change is Faster Than Our Response_Howard Yana S...

mHealth Israel: The Speed of Change is Faster Than Our Response_Howard Yana S...

mHealth Israel_Unmet Needs and Opportunities – Farm animals

mHealth Israel_Unmet Needs and Opportunities – Farm animals

mHealth Israel_Unmet Needs and Opportunities – Farm animals

mHealth Israel- Animal Health Landscape

mHealth Israel- Animal Health Landscape

mHealth Israel- Animal Health Landscape

mHealth Israel: Human and Animal Healthcare- Where do they meet? Presentation...

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mHealth Israel: Human and Animal Healthcare- Where do they meet? Presentation...

Science 37 Overview

Science 37 Overview

Science 37 Overview

Luxembourg Health Tech Overview

Luxembourg Health Tech Overview

Luxembourg Health Tech Overview

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UC goals: Learn from the past: leverage experience from stability data generated from 1000s past formulations Connect heterogeneous data: integrate data in the same context coming from diverse source systems “Bring your data and models”: make your data and models available to a wider user community User journey: problem statement #1 I am testing two variants of my drug product, which is currently formulated as a liquid in vial. I am exploring two possible strengths of this drug: 5mg and 10mg. I have one batch of each strength available for testing and I am putting these on stability testing. My goal is to validate if this drug product is stable chemically and physically both at 5mg potency and in 10 mg potency. Performing the experiment, my drug product resulted not stable at certain conditions (e.g. 6 months at 40°C/75% RH) Opportunities for Data Science and AI:: Is the failure at 6 months a true failure, or a data outlier? Should I try to continue or should I stop here and change formulation? The failure is at 40°C/75%RH, but how critical it is for 25°C/60% RH? Could we have predicted the failure basing on historical data? If yes, what is the common element to the failing experiments? Could we have started mitigation work earlier? Can we help finding a root cause? Were there similar failures in the past? Were there anomalies in the production?