This is the presentation generally given by our director or by one of the staff to orient people to what INBT is all about.

1. Founded May 15, 2006

2. Institute for
NanoBioTechnology
RESEARCH: at the interface
of engineering, the sciences,
medicine and public health
EDUCATION
: train the next
generation of OUTREACH:
scientists & create an
INBT entrepreneurial
engineers skilled
in many areas environment; tech
transfer
To learn more visit:
http://inbt.jhu.edu

3. Where is the Institute for
NanoBioTechnology?
Johns Hopkins 158 affiliated
School of Medicine
faculty from 5
divisions
Whiting School of
Bloomberg School of
Engineering
Public Health
INBT
Applied Krieger School of
Physics Lab Arts and Sciences
Offices located at 214 Maryland Hall on the
Homewood Campus

4. INBT: Research Foci
Nanoscience / Nanotechnology Cellular & Molecular Dynamics
“Basic Engineering Science” “Basic Biological Science”
Health &
Therapeutics Diagnostics
Environment
“Clinical Science” “Clinical Science”
“Public Health”

5. Seed Grants for Diagnostics
Research- $20,000
• “Tumor imaging by silica nanoparticles: binding to prostate
specific membrane antigen” Howard Katz (MatSc) & Ronnie
Mease (Radiology)
• “Diagnosing colon cancer risk through direct experimentation
on biopsied cells” Andre Levchenko (BioMed) & Andrew
Feinberg (Medicine/Oncology)
• “Nanomechanical techniques for cancer diagnosis” Sean Sun
(MechE), Greg Bowman (Biophysics) & Peter Searson (MatSc)
• “Innovative technologies to study mechanisms of inflammation-
induced CNS axonal degeneration” Nitish Thakor (BioMed),
Arun Venkatesan (Neurology) & Avindra Nath (Neurology)
• “An integrated microfluidic nanosensor platform for point
mutation detection of cancers” Jeff Wang (MechE) & Le-Ming
Shih (Pathology)

6. Seed Grants for Therapeutics
Research- $15,000-$25,000
• “Corrolazine nanoparticles for photodynamic therapy and magnetic
resonance imaging” David Goldberg (Chemistry), Jeff Bulte
(Radiology), & Anirban Maitra (Pathology/Oncology)
• “Bone-targeted biodegradable nano-spheres for localized treatment of
skeletal disease” Scott Kominsky (Orthopaedic Surgery/Oncology),
Justin Hanes (Chemical & Biomolecular Eng), & Kristy Weber
(Orthopaedic Surgery/Oncology)
• “Selective prodrug activation in cancer cells using protein switches” Marc
Ostermeier (Chemical & Biomolecular Engr), James Eshleman
(Pathology/Oncology), & Craig Townsend (Chemistry)
• “Quantum dots as artificial antigen-presenting cells (aAPC) for tumor
immunotherapy” Jonathan Schneck (Pathology), & Michael Edidin
(Biology)
• “In vivo evaluation of sugar-SCFA nanoparticles” Kevin Yarema
(Biomedical Engr) & Henry Brem (Neurosurgery)

7. Grants for Research in Cellular
and Molecular Dynamics-
$75,000
• “Nano- and micro-scale analysis of PKA regulation of cell
locomotion” Andre Levchenko (Biomedical Eng) & Jin Zhang
(Pharmacology and Neuroscience)
• “Glyco-nanoparticles targeting dendritic cells for enhanced
immune tolerance” Y. C. Lee (Biology), Hai-Quan Mao
(Materials Science & Eng) & Shau-Ku Huang (Medicine)
• “Polymeric nanoparticle drug delivery systems for the
development of an immunogenic ovarian tumor cell-based
vaccine” Chien-Fu Hung (Pathology) & Justin Hanes (Chemical
Eng)

8. INBT-Funded Pilot Projects
for Health & Environment
• Influence of surface chemistry on the fate and environmental impact of
carbon nanotubes in aquatic environments, Bill Ball (WSE), Howard
Fairbrother (KSAS)
• Exposure assessment: Probing size-dependent effects on the
concentration and speciation of transition metals in particulate
matter,
Alison Geyh (BSPH) & Howard Fairbrother (KSAS)
• Generation of dissolved toxic species through reaction of manganese
oxide nanoparticles with biofluids, Joe Bressler (BSPH & KKI), Alan
Stone (WSE) & David Veblem (KSAS)
• Nanomaterials as transporters of toxic agents into cell systems, Ellen
Silbergeld (BSPH) & Howard Katz (WSE)
• Toxicological evaluation of nanoparticles in a mouse model of chronic
lung disease, Shyam Biswal (BSPH) & Justin Hanes (WSE)

9. EDUCATION:
Training the Next
Generation
• NanoBioMed Training Program sponsored by
the Howard Hughes Medical Institute
• Physical & Biomolecular Foundations for
Designing Nanoprobes for Biology and Medicine
IGERT sponsored by the National Science
Foundation
• Highly selective summer REU funded by NSF
To learn more visit:
http://inbt.jhu.edu

10. Highlights:
Annual NanoBio Symposium
• May 1-2, 2008 at the Johns Hopkins School of
Medicine
• 500 people over two days
• “Nanotechnology for Cancer” workshop co-
hosted by Sidney Kimmel Comprehensive
Cancer Center with 10 Hopkins faculty
presenters
• Speakers from Harvard, Rice, NIH, Woodrow
Wilson Center, University at Buffalo
• 100+ posters
• 30+ businesses