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Diclofenac
1.
DICLOFENAC GENERIC NAME :
DICLOFENAC ROUTE : oral, intramuscular, rectalroute, topical gel, ophthalmic preparation( eye drops) DOSE : 50 mg BD or 100 mg sustained release preparation OD PHARMACOLOGICAL CLASS : NSAIDS; non-selective COX inhibitor (aryl aceticacid derivatives) MECHANISM OF ACTION : An analgesic- antipyretic- anti inflammatory drug It has potent anti inflammatory effect It inhibit prostaglandin (PG) synthesis It gets concentrated in synovial fluid, hence preferred in arthritis Its anti-platelet action is short lasting Neutrophil chemotaxis & superoxide production at inflammatory site are reduced THERAPEUTIC USES : Rheumatoid & osteoarthritis Bursitis Ankylosing spondylitis Toothache Dysmenorrhoea Post traumatic & post operative inflammatory conditions Affords quick relief of pain & wound edema. ADVERSE EFFECTS : Mild epigastric pain (combined use of diclofenac with misoprostal reduces GI irritation & peptic ulcer) Nausea,vomiting, headache,dizziness, rashes Gastric ulceration & bleeding Reversible elevation of serum amino transferases Rarely kidney damage
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