2. Out line
• Classification and etiology
• Pathophysiology , Sign and Symptom
• Normal pressure hydrocephalus
• Neuroradiologic features of hydrocephalus
• Physiologic testing of cerebrospinal fluid dynamics
• Management
• Shunt
3. Classification and etiology
• Greek : Hydro(water) + Kefale(skull)
• The state of excessive intracranial accumulation
of CSF that results from excessive production,
circulation, or absorption of CSF
4. Classification and etiology
• Communicating Hydrocephalus
• Panventricular dilation and occurs as a result of
obstruction to the flow of CSF in the subarachnoid space,
distal to the foramina of Luschka and Magendie
• Noncommunicating or Obstructive Hydrocephalus
• Pattern of ventricular dilation that reflects the site of
obstruction
5.
6. Classification and etiology
• Long-Standing Overt Ventriculomegaly in Adults
• This form of hydrocephalus develops during
childhood, with symptoms being manifested during
adulthood
• Normal-Pressure Hydrocephalus
• Gait disturbance, dementia, incontinence with normal CSF
pressure and dilate ventricles
7. Classification and etiology
• Isolated Fourth Ventricle Syndrome
• fourth ventricle no longer communicates with the third
ventricle
• prolonged infection or multiple shunt operations
• Arrested Hydrocephalus
• Hydrocephalus reach a state in which ventricular size
remains unchanged in the absence of a shunt or in the
presence of a nonfunctioning one
14. Neuroradiologic features
• Evans’ index : maximal
width of the anterior
ventricular horn /
maximal width of the
calvaria at the level of
Foramen of Monroe
• >0.3 ventricular
enlargement
15. Neuroradiology features
• Bicaudate ratio :
minimal intercaudate
distance / by the
brain width along the
same line
• > 0.25 ventriculomegaly
16. Neuroradiology features
• One of the following support
• enlargement of the temporal horns of the lateral ventricles
not entirely attributable to hippocampus atrophy
• callosal angle of 40 degrees or greater
• evidence of altered brain water content, including
periventricular signal changes not attributable to
microvascular ischemic changes or demyelination
• aqueductal or fourth ventricular flow void on MRI
23. Cerebrospinal Fluid Drainage
and Dynamics
• Communicating hydrocephalus
• Intrathecal injection of radioisotropes
• Ventricular > 48 hr ventricular stasis or reflux
24. Mathematical Modeling of the
Cerebrospinal Fluid Circulation—
a Platform for
Interpretation of Pressure-Volume
25. Monitoring of Intracranial pressure
• Overnight monitoring : Lundberg “B waves.”
• B waves are slow waves of ICP lasting 20 seconds to
2 minutes
• Intraparenchymal probe
• Normal : < 15 mmHg
• Vasogenic wave : greater
• than 25 mmHg, for a period
• around 10 min
26. Monitoring of Intracranial pressure
• The average overnight RAP index should be less
than 0.6 in patients with good compensatory
reserve.
• The overnight magnitude of slow waves is
considered increased when their average value is
greater than 1.5 mm Hg.
27. Clinical tests of
cerebrospinal fluid dynamics
• The computerized infusion test
• Resistance to CSF outflow
= Plateau P – Resting P
infusion rate
28. NPH and Brain atrophy
NPH Brain atrophy
1.Baseline ICP
2.Resistance to
CSF outflow
3.AMP
4.RAP
5.Elastance
coefiicient
normal (<18 mmHg)
Increase (>13 mmHg/ml
/minute)
Correlated with Mean ICP
Good (< 0.6 )
Increase (E > 0.2 1/ml)
Low (<12 mmHg)
Low (<12 mmHg/ml
/minute)
Low (<2mmHg)
Good (<0.5)
Low (E < 0.2 1/ml)
36. Shunt insertion
• VP shunt : most common
• Lumboperitoneal shunt
• Lumbopleural shunt
• Ventriculoatrial shunt
37. Endoscopic third ventriculostomy
• Obstructive hydrocephalus
• Passage an endoscopre through lateral ventricle to
third ventricle create stoma at floor of 3rd
ventricle
• Advantage : prevent shunt infection, lifelong risk for
revision
41. Shunt
• Magnetric programming : prevent magnetric field
near
• Overdrainage : dependence on diameter and length
of the distal drain
• Membrane device : impede CSF flow by skin tense
• A flow –regulating : may permanent increase
hydrodynamic resistance
Symptomatic acute or chronic hydrocephalus, idiopathic NPH
VP shunt : frontal or occipital approach
LP ในใช้กรณี ICP c small ventricular size
VA shunt : truncal obesity, extensive abdominal abnormality, multiple abdominal procedure
NPH have a late onset of relative aqueduct stenosis
3 part : inlet tubing(0.9-1.2 mm), valve, distal drain
1.Pressure valve ที่คงที่
2.สามารถปรับได้โดยใช้ magnetric program
3.Flow คงที่ โดยที่ไม่ขึ้นกับ pressure
4.ควบคุม Flow และป้องกันการ overdrainage in upright position
1.flow is controlled by an elastic membrane that changes the area of the outlet orifice
2.flow depends on compression of a spring (flat or helical) supporting a ball moving along the cone that constitutes the outlet orifice.
3.flow depends on deflection of the silicon mite
4.flow depends on the area of a slit in soft silicone rubber
5.flow is stabilized within a certain fixed range of pressure.