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The Blood Supply of the Brain and Spinal 
Cord 
MS: MILAD BASIM
Blood Supply of the Brain 
The brain is supplied by 
two internal carotid. 
two vertebral arteries. 
The four arteries lie within the 
subarachnoid space, and their 
branches anastomose on the 
inferior surface of the brain to 
form the circle of Willis.
Internal Carotid Artery 
 The internal carotid artery begins at the bifurcation of the 
common carotid artery. 
 It ascends the neck and perforates the base of the skull by passing 
through the carotid canal of the temporal bone. 
 The artery then runs horizontally forward through the cavernous 
sinus and emerges on the medial side of the anterior clinoid 
process by perforating the dura mater. 
 It now enters the subarachnoid space by piercing the arachnoid 
mater and turns posteriorly to the region of the medial end of the 
lateral cerebral sulcus. 
 Here, it divides into the anterior and middle cerebral arteries.
Branches of the Cerebral Portion 
 The ophthalmic artery 
It enters the orbit through the optic canal below and lateral to the 
optic nerve. 
 The posterior communicating 
artery 
It runs posteriorly above the 
oculomotor nerve to join the 
posterior cerebral artery, thus 
forming part of the circle of Willis. 
 The choroidal artery 
It passes posteriorly close to the optic tract, enters the inferior horn 
of the lateral ventricle, and ends in the choroid plexus.
 The anterior cerebral artery 
It runs forward and medially 
superior to the optic nerve and 
enters the longitudinal fissure 
of the cerebrum.Here, it is joined 
to the anterior cerebral artery of 
the opposite side by the anterior 
communicating artery. 
The cortical branches. 
The central branches. 
 The middle cerebral artery 
the largest branch of the internal carotid, 
runs laterally in the lateral cerebral sulcus. 
The cortical branches. 
The central branches.
Vertebral Artery 
 The vertebral artery, a branch of the first part of the subclavian 
artery, ascends the neck by passing through the foramina in the 
transverse processes of the upper six cervical vertebrae. 
 It enters the skull through the foramen magnum and pierces the 
dura mater and arachnoid to enter the subarachnoid space. 
 It then passes upward, forward, and medially on the medulla 
oblongata. 
 At the lower border of the pons, it joins the vessel of the 
opposite side to form the basilar artery.
Branches of the Cranial Portion 
 The posterior spinal artery 
may arise from the vertebral artery or the posterior inferior 
cerebellar artery. It descends on the posterior surface of the spinal 
cord close to the posterior roots of the spinal nerves. 
 The anterior spinal artery 
is formed from a contributory branch from each vertebral artery 
near its termination. The single artery descends on the anterior 
surface of the medulla oblongata and spinal cord and is embedded 
in the pia mater along the anterior median fissure.
 The meningeal branches 
are small and supply the bone and dura in the posterior cranial 
fossa. 
 The medullary arteries 
are very small branches that are 
distributed to the medulla oblongata. 
 The posterior inferior cerebellar 
artery 
the largest branch of the vertebral artery, 
passes on an irregular course between the 
medulla and the cerebellum.
Basilar Artery 
 The pontine arteries 
 The labyrinthine artery 
 The anterior inferior cerebellar artery 
 The superior cerebellar artery 
 The posterior cerebral artery 
The posterior cerebral artery, curves laterally and backward around 
the midbrain and is joined by the posterior communicating branch 
of the internal carotid artery 
The Cortical branches 
The Central branches 
The choroidal branch
Arteries of the inferior surface of the brain
Arteries to Specific Brain Areas 
The corpus striatum and the internal capsule are supplied 
mainly by the medial and lateral striate central branches of the 
middle cerebral artery, the central branches of the anterior cerebral 
artery supply the remainder of these structures. 
The thalamus is supplied mainly by branches of the posterior 
communicating, basilar, and posterior cerebral arteries. 
The midbrain is supplied by the posterior cerebral, superior 
cerebellar, and basilar arteries. 
The pons is supplied by the basilar and the anterior, inferior, and 
superior cerebellar arteries. 
The medulla oblongata is supplied by the vertebral, anterior and 
posterior spinal, posterior inferior cerebellar, and basilar arteries. 
The cerebellum is supplied by the superior cerebellar, anterior 
inferior cerebellar, and posterior inferior cerebellar arteries.
Veins of the Brain 
 External Cerebral Veins 
The superior cerebral veins 
The superficial middle cerebral veins 
The deep middle cerebral vein 
 Internal Cerebral Veins 
Veins of Specific Brain Areas 
The midbrain. 
The pons . 
The medulla oblongata. 
The cerebellum.
Blood Supply of the Spinal Cord 
The spinal cord receives its arterial supply from three small 
arteries: 
Two posterior spinal arteries. 
Anterior spinal artery. 
Posterior Spinal Arteries 
The posterior spinal arteries arise either directly from the vertebral 
arteries inside the skull or indirectly from the posterior inferior 
cerebellar arteries. 
Anterior Spinal Artery 
The anterior spinal artery is formed by the union of two arteries, 
each of which arises from the vertebral artery inside the skull.
The anterior and posterior spinal arteries are reinforced by 
radicular arteries that enter the vertebral canal through the 
intervertebral foramina.
Cerebral Artery Syndromes 
Anterior Cerebral Artery Occlusion 
1. Contralateral hemiparesis and hemisensory loss involving mainly 
the leg and foot (paracentral lobule of cortex). 
2. Inability to identify objects correctly, apathy, and personality 
changes (frontal and parietal lobes). 
Middle Cerebral Artery Occlusion 
1. Contralateral hemiparesis and hemisensory loss involving mainly 
the face and arm (precentral and postcentral gyri). 
2. Aphasia if the left hemisphere is affected (rarely if the right 
hemisphere is affected). 
3. Contralateral homonymous hemianopia (damage to the optic 
radiation). 
4. Anosognosia if the right hemisphere is affected (rarely if the left 
hemisphere is affected).
Posterior Cerebral Artery Occlusion 
1. Contralateral homonymous hemianopia with some degree of 
macular sparing (damage to the calcarine cortex, macular 
sparing due to the occipital pole receiving collateral blood 
supply from the middle cerebral artery). 
2. Visual agnosia (ischemia of the left occipital lobe). 
3. Impairment of memory (possible damage to the medial aspect 
of the temporal lobe).
Brain and Spinal Cord Blood Supply Explained

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Brain and Spinal Cord Blood Supply Explained

  • 1. The Blood Supply of the Brain and Spinal Cord MS: MILAD BASIM
  • 2. Blood Supply of the Brain The brain is supplied by two internal carotid. two vertebral arteries. The four arteries lie within the subarachnoid space, and their branches anastomose on the inferior surface of the brain to form the circle of Willis.
  • 3. Internal Carotid Artery  The internal carotid artery begins at the bifurcation of the common carotid artery.  It ascends the neck and perforates the base of the skull by passing through the carotid canal of the temporal bone.  The artery then runs horizontally forward through the cavernous sinus and emerges on the medial side of the anterior clinoid process by perforating the dura mater.  It now enters the subarachnoid space by piercing the arachnoid mater and turns posteriorly to the region of the medial end of the lateral cerebral sulcus.  Here, it divides into the anterior and middle cerebral arteries.
  • 4. Branches of the Cerebral Portion  The ophthalmic artery It enters the orbit through the optic canal below and lateral to the optic nerve.  The posterior communicating artery It runs posteriorly above the oculomotor nerve to join the posterior cerebral artery, thus forming part of the circle of Willis.  The choroidal artery It passes posteriorly close to the optic tract, enters the inferior horn of the lateral ventricle, and ends in the choroid plexus.
  • 5.  The anterior cerebral artery It runs forward and medially superior to the optic nerve and enters the longitudinal fissure of the cerebrum.Here, it is joined to the anterior cerebral artery of the opposite side by the anterior communicating artery. The cortical branches. The central branches.  The middle cerebral artery the largest branch of the internal carotid, runs laterally in the lateral cerebral sulcus. The cortical branches. The central branches.
  • 6. Vertebral Artery  The vertebral artery, a branch of the first part of the subclavian artery, ascends the neck by passing through the foramina in the transverse processes of the upper six cervical vertebrae.  It enters the skull through the foramen magnum and pierces the dura mater and arachnoid to enter the subarachnoid space.  It then passes upward, forward, and medially on the medulla oblongata.  At the lower border of the pons, it joins the vessel of the opposite side to form the basilar artery.
  • 7. Branches of the Cranial Portion  The posterior spinal artery may arise from the vertebral artery or the posterior inferior cerebellar artery. It descends on the posterior surface of the spinal cord close to the posterior roots of the spinal nerves.  The anterior spinal artery is formed from a contributory branch from each vertebral artery near its termination. The single artery descends on the anterior surface of the medulla oblongata and spinal cord and is embedded in the pia mater along the anterior median fissure.
  • 8.  The meningeal branches are small and supply the bone and dura in the posterior cranial fossa.  The medullary arteries are very small branches that are distributed to the medulla oblongata.  The posterior inferior cerebellar artery the largest branch of the vertebral artery, passes on an irregular course between the medulla and the cerebellum.
  • 9. Basilar Artery  The pontine arteries  The labyrinthine artery  The anterior inferior cerebellar artery  The superior cerebellar artery  The posterior cerebral artery The posterior cerebral artery, curves laterally and backward around the midbrain and is joined by the posterior communicating branch of the internal carotid artery The Cortical branches The Central branches The choroidal branch
  • 10. Arteries of the inferior surface of the brain
  • 11. Arteries to Specific Brain Areas The corpus striatum and the internal capsule are supplied mainly by the medial and lateral striate central branches of the middle cerebral artery, the central branches of the anterior cerebral artery supply the remainder of these structures. The thalamus is supplied mainly by branches of the posterior communicating, basilar, and posterior cerebral arteries. The midbrain is supplied by the posterior cerebral, superior cerebellar, and basilar arteries. The pons is supplied by the basilar and the anterior, inferior, and superior cerebellar arteries. The medulla oblongata is supplied by the vertebral, anterior and posterior spinal, posterior inferior cerebellar, and basilar arteries. The cerebellum is supplied by the superior cerebellar, anterior inferior cerebellar, and posterior inferior cerebellar arteries.
  • 12. Veins of the Brain  External Cerebral Veins The superior cerebral veins The superficial middle cerebral veins The deep middle cerebral vein  Internal Cerebral Veins Veins of Specific Brain Areas The midbrain. The pons . The medulla oblongata. The cerebellum.
  • 13. Blood Supply of the Spinal Cord The spinal cord receives its arterial supply from three small arteries: Two posterior spinal arteries. Anterior spinal artery. Posterior Spinal Arteries The posterior spinal arteries arise either directly from the vertebral arteries inside the skull or indirectly from the posterior inferior cerebellar arteries. Anterior Spinal Artery The anterior spinal artery is formed by the union of two arteries, each of which arises from the vertebral artery inside the skull.
  • 14. The anterior and posterior spinal arteries are reinforced by radicular arteries that enter the vertebral canal through the intervertebral foramina.
  • 15. Cerebral Artery Syndromes Anterior Cerebral Artery Occlusion 1. Contralateral hemiparesis and hemisensory loss involving mainly the leg and foot (paracentral lobule of cortex). 2. Inability to identify objects correctly, apathy, and personality changes (frontal and parietal lobes). Middle Cerebral Artery Occlusion 1. Contralateral hemiparesis and hemisensory loss involving mainly the face and arm (precentral and postcentral gyri). 2. Aphasia if the left hemisphere is affected (rarely if the right hemisphere is affected). 3. Contralateral homonymous hemianopia (damage to the optic radiation). 4. Anosognosia if the right hemisphere is affected (rarely if the left hemisphere is affected).
  • 16. Posterior Cerebral Artery Occlusion 1. Contralateral homonymous hemianopia with some degree of macular sparing (damage to the calcarine cortex, macular sparing due to the occipital pole receiving collateral blood supply from the middle cerebral artery). 2. Visual agnosia (ischemia of the left occipital lobe). 3. Impairment of memory (possible damage to the medial aspect of the temporal lobe).