Do you know your ergolines, tryptamines and phenethylamines? Learn the essential chemistry of psychedelics. Expanded consciousness is something that people have pursued since before recorded history. In the modern western world, psychedelic drugs are a common tool used to explore the universe both inside and outside ourselves. This workshop is an introduction to what psychedelics are, their structure, benefits, and dangers. Come learn about the chemistry, natural sources, physical makeup, and effects of different psychedelic drugs. (Note: this presentation does NOT cover synthesis or extraction of psychedelic drugs.) Saturday 12:30-1:30pm By: Doctor Triptamine
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Introduction to Psychedelic Chemistry: The Science Behind the Trip
1. Introduction to The Science Behind The Trip
Dr. Tryptamine
Psychedelic Chemistry
2. Disclaimer
This presentation is for
informational purposes only.
All information contained in this
presentation was taken from freely
available sources on the internet.
Nothing in this presentation should
be construed as to encourage or
condone illegal activity.
The author suggests that all
applicable laws be followed at all
times.
Be Safe.
3. Psychedelic
From Ancient Greek
ψυχή (psychê, “mind, soul”) +
δῆλος (dêlos, “manifest, visible”)
Psychedelic states are an array of
experiences including changes of
perception such as
hallucinations, synesthesia,
altered states of awareness or
focused consciousness, variation
in thought patterns, trance or
hypnotic states, mystical states,
and other mind alterations.
4. Organic Chemistry
• The chemistry of carbon-based
compounds
• Naming:
1 carbon = methyl
2 carbons = ethyl
3 carbons = propyl
4 carbons = butyl
5 carbons = pentyl
6 carbons = benzyl or phenyl
• Amines contain nitrogen
• The symbol for benzene is a
hexagon
5. Why We Trip
• Serotonin
Monoamine neurotransmitter
Closely associated with mood and happiness,
also regulates intestinal activity.
• Dopamine
Monoamine neurotransmitter,
regulates mood, reward, attention, learning,
sexual gratification.
• Norepinephrine
Monoamine neurotransmitter, hormone
regulates cardiovascular activity, attention, flight or
fight response
7. Classification
• Descriptive classification -
Based on the effects of the
compound and user
experiences.
Examples: Entheogens,
Empathogens/Entatctogens,
Dissociatives
• Chemical classification -
Based on the chemical makeup
and structure.
Examples: Ergolines,
Tryptamines, Phenethylamines
9. Etheogens
An entheogen ("generating the
divine within") is a psychoactive
substance used in a religious,
shamanic, or spiritual context.
Entheogens can supplement
many diverse practices for
healing, transcendence, and
revelation, including: meditation,
psychonautics, art projects, and
psychedelic therapy.
Examples: LSD, Peyote,
Psilocybin, DMT, Salvia,
Ibogaine
10. Empathogens
The terms empathogen and
entactogen are used to describe
a class of psychoactive drugs
that produce distinctive
emotional and social effects
such as feelings of empathy,
love, and emotional closeness to
others.
The terms are used
interchangeably.
Examples: MDA, MDMA, 2C-B,
2C-I, 2C-T-7
11. Dissociatives
Dissociatives are a class of
hallucinogen which reduce or
block signals to the conscious
mind from other parts of the
brain.
The characteristic features of
dissociative anesthesia are
described as catalepsy,
amnesia and analgesia.
Examples: Nitrous Oxide,
Ketamine, Methoxetamine,
Ibogaine
17. LSD
• Chemical name: d-lysergic acid diethylamide
• Semi-Synthetic, synthesized by Albert Hoffmann in 1938 from ergotamine
• Common names: Acid; L; Tabs; Blotter; Dose(s); Trips, Liquid
• LSD is the best known and most researched psychedelic. It is the
standard against which all other psychedelics are compared. It is active at
extremely low doses and is most commonly available on blotter or in
liquid form.
• Dosage: Threshold 20 ug, Common 50 - 150 ug, Heavy 400 + ug
• Concerns: Existential/Psychological crisis, dosage control, illegal
18. MDMA
• Chemical name: 3,4-methylenedioxymethamphetamine
• Class: Euphoric Empathogen; Stimulant; Phenethylamine
• Common names: Ecstasy; E; X; XTC; Rolls; Beans; Adam; Molly
• Comments: MDMA, or 'ecstasy' is a psychedelic amphetamine that has
gained popularity over the past 20 years because of its ability to
produce strong feelings of comfort, empathy, and connection to others.
• Dosage: Threshold: 30 mg, Common: 75 - 125 mg, Heavy: 200 + mg
• Concerns: Hydration, cardiovascular complications, possible
neurotoxicity, delayed crash, illegal
19. MDA
• Chemical name: 3,4-methylenedioxyamphetamine
• Class: Euphoric Empathogen; Stimulant; Phenethylamine
• Common names: Sass or Sassafras
• Comments: MDA is a synthetic empathogen sometimes found in ecstasy
tablets. It is closely related to MDMA though its effects are said to be slightly
more psychedelic.
• Dosage: Threshold: 30 - 50 mg, Common: 100 - 150 mg, Heavy: 100 - 150
mg
• Concerns: Hydration, cardiovascular complications, possible neurotoxicity,
delayed crash, illegal
20. Psilocybin
• Chemical name:[3-(2-Dimethylaminoethyl)-1H-indol-4-yl] dihydrogen phosphate
• Class: Psychedelic Tryptamine
• Common names: Shrooms; Magic Mushrooms; Sacred Mushrooms; teonanácatl;
Boomers; Fungi
• Comments: There are more than 180 species of mushrooms which contain the
psychedelics psilocybin or psilocin. They have a long history of use in Mexico and
are currently one of the most popular and commonly available natural
psychedelics.
• Dosage: Threshold: .2g, Common 1-2.5g, Heavy: 5+g (Dried Psilocybe Cubensis)
• Concerns: Existential/psychological crisis, dosage, illegal
21. Mescaline
• Chemical name: 3,4,5-trimethoxyphenethylamine
• Class: Psychedelic Phenethylamine
• Common names: Peyote, Cactus, San Pedro, Buttons, Mescalito
• Comments: Mescaline is a naturally occurring psychedelic with a long
history of human use. It is best known as the primary active chemical in
the peyote cactus.
• Dosage: Threshold: 100mg, Common: 200-300mg, Heavy: 500-700mg
• Concerns: Existential/psychological crisis, purity, illegal*
22. DMT
• Chemical name: N,N-dimethyltryptamine
• Class: Psychedelic Tryptamine
• Common names: DMT, Beard, Business Man’s Trip, Deemsters
• Comments: DMT is a powerful, visual psychedelic which produces short-
acting effects when smoked. It is used orally in combination with an MAOI, as
in ayahuasca brews. It is naturally produced in the human body and by many
plants.
• Dosage: Threshold: 2-5mg, Common: 20-40mg, Strong: 40-60mg
• Concerns: Existential/psychological crisis, Dosage control, illegal*, alien
abduction
23. Ketamine
• Chemical name: (RS)-2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone
• Class: Dissociative Anaesthetic; Psychedelic
• Common names: K; Special K; Cat Tranquilizer
• Comments: Ketamine is a dissociative psychedelic used medically as a
veterinary and human anaesthetic. It is one of the few addictive
psychedelics and is associated with researcher John Lilly.
• Dosage: Threshold: 10-15mg, Common: 30-70mg, Strong: 60-125mg
• Concerns: K-Hole, compulsive behavior, loss of consciousness, death,
illegal
25. 2C Series (2C-B, 2C-E, 2C-I, 2C-T-7)
• Chemical name: 4-bromo-2,5-dimethoxyphenethylamine (2C-B), 2,5-
dimethoxy-4-ethylphenethylamine (2C-E), 2,5-dimethoxy-4-
iodophenethylamine (2C-I), 2,5-Dimethoxy-4-n-propylthiophenethylamine
(2C-T-7)
• Class: Psychedelic Phenethylamines
• Common names: Nexus; Bees; Venus; Bromo Mescaline; BDMPEA,
• Comments: 2C is a general name for the family of psychedelic
phenethylamines containing methoxy groups on the 2 and 5 positions of the
benzene ring. Most of these compounds also carry lipophilic substituents at
the 4 position, usually resulting in more potent and more metabolically stable
and longer acting compounds.
• Dosage: Varies, 10-25mg commonly
• Concerns: Cardiovascular issues, death, illegal
26. Cathinones
• Chemical name: Mephedrone (4-methylmethcathinone),
Methylone (bk-MDMA, 3,4-methylenedioxy-N-methylcathinone,
• Class: Euphoric Empathogen; Phenethylamine
• Common names: Meow, M-Cat, Megatron, Molly Roger,
Explosion, Ease,
• Comments: Cathinones are relatives of the amphetamine family
of phenethylamines, found in khat, cathinone has a ketone
group in the beta position.
• Dosage: Varies greatly and depends on route of administration
• Concerns: compulsive behavior, death, illegal
27. Bathsalts
• Chemical name: 3,4-methylenedioxypyrovalerone (MDPV)
• Class: Stimulant
• Common names: MDPV; NRG-1; Bath Salts
• Comments: MDPV is an uncommon stimulant with a short history of human use.
It is known for its tendency to cause compulsive redosing and some users report
sexual arousal as an effect. MDPV has been found in products labeled as "bath
salts" and "plant food/fertilizer".
• Dosage: No comment
• Concerns: Compulsive behavior, death, illegal
28. Methoxetamine
• Chemical name: 2-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone; 3-MeO-2-Oxo-PCE
• Class: Dissociative; Sedative
• Common names: Methoxetamine; MXE; Mexxy; Roflcopter
• Comments: Methoxetamine is a near chemical analog of ketamine and PCP. Its use was
first publicly reported in 2010. Methoxetamine's effects are described by some as similar
to ketamine or high-dose DXM, while others report not finding it similar to those
substances. A number of accounts describe compulsive redosing and unintentional
consumption of more than was initially planned.
• Dosage: Varies greatly and depends on route of administration
• Concerns: Compulsive behavior, death, illegal
29. NBOMe
• Chemical name: 2C-C-NBOMe = (25C-NBOMe; NBOMe-2C-C); 2C-I-NBOMEe = (25I-
NBOMe; NBOMe-2C-I); mescaline-NBOMe = (345-NBOMe; NBOMEe-mescaline);
• Class: Psychedelic; Stimulant; Euphoriant
• Common names: Molly Acid, “Not” Acid Acid, Mescaline Molly, Bome
• Comments: The NBOMe series of chemicals are primarily N-o-methoxybenzyl analogs of the
2C-X family of phenethylamines, and are 5-HT2A (serotonin 2A) receptor agonists. A few are
amphetamine analogs. With few exceptions (e.g. mescaline-NBOMe), compounds in this
group are active at verly low sub-milligram doses. These chemicals have nearly no history of
human use prior to 2010 when they first became available online.
• Dosage: Very active at sub-milligram levels. Extreme caution!
• Concerns: Death, illegal
32. Acknowledgments
• Erowid
www.erowid.org
• Wikipedia
www.wikipedia.org
• DMTNexus
https://www.dmt-nexus.me/
• Anne & Sasha Shulgin
• Alex Grey
• The International Association of
Psychedelic Guides
