Protein Function

Protein Function (non-Catalytic)

4 Examples ,[object Object],[object Object],[object Object],[object Object]

Enzymes vs other proteins ,[object Object],[object Object]

Hemoglobin ,[object Object],[object Object],[object Object],[object Object]

Hemoglobin Function ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Heme group

Hemoglobin vs Myoglobin ,[object Object],[object Object]

Association Constant (Ka) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Myoglobin

K d , the Dissociation Constant ,[object Object],[object Object]

T to R Transition ,[object Object],[object Object],[object Object],[object Object]

Hemoglobin Binds O2 Cooperatively ,[object Object],[object Object],[object Object]

Equilibrium equations for allosteric proteins ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],nH = the (changing) slope of the Hill Plot line

Sickle Cell Anemia ,[object Object],[object Object],[object Object]

Immunoglobins and the Immune System ,[object Object],[object Object],[object Object],[object Object]

The Adaptive Immune Response ,[object Object],[object Object],[object Object],[object Object]

Immunoglobulins ,[object Object],[object Object],[object Object],[object Object],[object Object]

Functionality of the different Immunoglobulins ,[object Object],[object Object],[object Object],[object Object],[object Object]

Actin and Myosin ,[object Object],[object Object],[object Object],I band: region of muscle fiber containing only thin filaments A band: region containing the thick filament and overlapping thin filaments. Z-disk: structure to which the thin filaments are attached.

Actin and Myosin (cont.) ,[object Object],[object Object],[object Object],[object Object]

Myofibrils are surrounded by calcium-containing sarcoplasmic reticulum.

Overview of the process The muscle fiber is stimulated.

Overview of the process The muscle fiber is stimulated. Ca 2+ ions are released.

“ End-on” view of thick & thin filaments, showing the effect of calcium ions after release from the S.R.

Overview of the process The muscle fiber is stimulated. Ca 2+ ions are released. Thin filaments move to middle of sarcomere.

Calcium attaches to troponin/ tropomyosin; they roll away, exposing the active site on actin.

Myosin cross-bridges attach to active site on actin. After attachment, the cross-bridges pivot, pulling the thin filaments.

A fresh ATP replaces the ADP+P i , allowing myosin and actin to detach. Energy from the splitting of the fresh ATP allows repositioning of the myosin head.

This leads back to Step 1, which continues the cycle as long as calcium ions are attached to troponin/tropomyosin.

Overview of the process The muscle fiber is stimulated. Ca 2+ ions are released. Thin filaments move to middle of sarcomere. Muscle fiber contracts.

Overview of the process The muscle fiber is stimulated. Ca 2+ ions are released. Thin filaments move to middle of sarcomere. Muscle fiber contracts. Muscle tension increases.

Transport proteins ,[object Object],[object Object]

Active Transport ,[object Object]

Multidrug Resistance Transporter (MDR-1), ABCB-1 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

ATP ATP ADP ADP DRUG GlcCer Other Lipids DRUG MDR1 GlcCer DRUG

Practice Problems ,[object Object],[object Object]

Protein Function

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Protein Function