The document discusses the Mesopotamian civilization between rivers Tigris and Euphrates rivers from 4000 BC to 400 BC. It summarizes the Sumerian, Akkadian, Babylonian, Hittite, Phoenician, Hebrew, Assyrian and Chaldean civilizations that occupied the region. The Sumerians established the first cities and introduced cuneiform writing and irrigation. Later, the Akkadian and Babylonian empires united the city-states and trade flourished. The Hittites were the first to use iron and horse-drawn carts.