filovirus

2. Family
• Filoviridae
Genus1
• Marburg Virus
Species
• Lake Victoria Marburg Virus
Genus2
• Ebola Virus
Species
• Ivory Coast Ebola Virus
• Reston Ebola Virus
• Sudan Ebola Virus
• Zaire Virus
• First Ebola outbreak:
1976 (Zaire, Sudan)
– Hundreds infected
– 70%-90% fatal
• Sporadic outbreaks
still occur in Africa

3. • Genome
• Linear
• Single stranded RNA
• Non-segmented
• Negative sense
• Capsid
• Enveloped
• Helical symmetry
• Long, filamentous shape(hence “filo”)
• Replication takes place in cytoplasm.

4. PATHOGENESIS
Africa, Philippines
Cause hemorrhagic fevers with high fatality rates (up to 90%)
Infection appears to be by close contact with infected person
• Highly contagious
First outbreak: 1967 (Marburg, Germany; Yugoslavia)
• Vaccine company was processing primary kidney cells from
African green monkeys (Cercopithecus aethiops)
• Several workers developed a hemorrhagic fever
• Several dozen infected by person-to-person transmission
• Fewer than half died

6. • Recovery mechanisms from filovirus
infections are unknown.
• Fatal infections usually end with high viremia
• No evidence of an immune response.
• Vaccine
• Experimental
• Developed in 2005
• Protects guinea pigs from infection

7. Bats are reservoirs?
– Suspected Ebola virus hosts
• Epomops franqueti (Franquet's epauleted bat)
• Hypsignathus monstrosus (hammer-headed bat)
• Myonycteris torquata (little collared fruit bat)
– Suspectecte Marburg virus host
• Rousettus aegyptiacus (Egyptian fruit bat)

8. COMPONENTS
•NP - nucleoprotein
•VP35 - nonstructural
•VP40 - matrix protein
•GP - glycoprotein spike
•VP30 - transcription factor
•VP24 - virus assembly,
STAT1 inhibitor