Library Research: Tips, Tricks & Time Savers for graduate Students

1. Library Research: Tips,
Tricks & Time Savers for
graduate Students
Nazi Torabi
Allyn & Betty Taylor Library
Fall 2012
http://www.slideshare.net/ntorabi
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2. Content
 Navigating library website
 Information in Multiple Places –Databases
 Structured Search Strategies - PubMed
 Web of Knowledge
 Citation tracking
o Backward tracking
o Forward tracking
 RefWorks
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3. 3

4. From Program Guide pages or databases page
Bookmark PubMed from here
Bookmark Google Scholar from here

5. Title search in the library
catalogue
 Springer Protocols
 Current Protocols
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6. 6

7. Subject search in library
catalogue
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8. Browse Library Tutorials
 Library tutorial page is available at
http://www.lib.uwo.ca/tutorials/browse
 How To Find Dissertations
 Introduction to RefWorks
 How to Find An Impact Factor
 How to Import Citations from PubMed into
RefWorks
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9. Which Resources (Databases)?
 Points to consider:
 1) Does it cover the desired subject area?
 2) Does it contain the key resources?
 3) What is the time span for coverage?
 4) What types of resources does it cover?
 5) Overlap with other resources, unique content?
 Program Guide Pages
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10. Search Strategies
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11. Structured Search Methodology
1. Have a research topic in the form of question
2. Isolate the concepts
3. Search concepts separately (Using OR)
4. Combine concept sets (Using AND)
5. Evaluate results and refine
6. Apply limits if necessary
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12. Sample article
Zheng F, Zhan C-G. (2012). Modeling of
Pharmacokinetics of Cocaine in Human Reveals the
Feasibility for Development of Enzyme Therapies
for Drugs of Abuse. PLoS Comput Biol,
DOI: 10.1371/journal.pcbi.1002610
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13. Abstract
 " A promising strategy for drug abuse treatment is to accelerate the drug
metabolism by administration of a drug-metabolizing enzyme. The
question is how effectively an enzyme can actually prevent the drug from
entering brain and producing physiological effects. In the present study,
we have developed a pharmacokinetic model through a combined use of in
vitro kinetic parameters and positron emission tomography data in human
to examine the effects of a cocaine-metabolizing enzyme in plasma on the
time course of cocaine in plasma and brain of human. …It has been
demonstrated that administration of a cocaine hydrolase/esterase
(CocH/CocE) can considerably decrease the cocaine half-lives in both brain
and plasma, ….The estimated maximum cocaine plasma concentration
which a given concentration of drug-metabolizing enzyme can effectively
prevent from entering brain and producing physiological effects can be
used to guide future preclinical/clinical studies on cocaine-metabolizing
enzymes. ….”
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14. What is the Question?
What is the role of drug metabolising enzymes in the
treatment of cocaine abuse?
Identify the main keywords
drug-metabolizing enzyme
cocaine abuse
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15. Simple Search in Google Scholar
 drug-metabolizing enzyme
AND cocaine abuse
 How many hits?
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16. Simple Search in PubMed
 drug-metabolizing enzyme AND
cocaine abuse
 drug metabolism AND enzyme AND
cocaine abuse
Not about enzyme therapy thought!
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17. Search Strategies
 Pearl methodology framework
(Sandieson, 2006)
 Subject headings
 Citation tracking
 Backward tracking
 Forward tracking

18. Pearl methodology framework
 Step 1: Choosing a Representative Sample
of Articles
 Step 2: Extracting the Relevant Search
Keywords and expanding on them
 Step 3: Refining the List of Search Keywords
 Step 4: Validating the Search Keywords
(Sandienson, 2011)
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19. Synonyms, related terms, variant
spellings, truncation and wildcards
 When designing a search strategy, in order to be as
comprehensive as possible, it is necessary to
include a wide range of keyword terms for each of
the concepts selected. For example:
 synonyms:
 related terms:
 variant spellings:
 truncation and wildcards:
 truncation: random* (for random or randomised
or randomized or randomly, etc); and
 wildcard: behavio?r (for behaviour or behavior).

20. Searching Using Subject Headings
http://youtu.be/wlrZPaIDDwg
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21. Databases
• Search syntax varies across interfaces.
• Subject heading varies across databases.
– Subject heading = MeSH= Descriptors = Control
vocabulary = ...
• Search strategy has to be tailored for each database.
– *Tip: For further details refer to the “Help” files
for the database in question.
Developing a search strategy is an iterative process!

22. Structured Search Methodology
1. Have a research topic in the form of question
2. Isolate the concepts
3. Search concepts separately (Using OR)
4. Combine concept sets (Using AND)
5. Evaluate results and refine
6. Apply limits if necessary
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23. What is the Question?
What is the role of drug metabolising enzymes in the
treatment of cocaine abuse?
Identify the main concepts
Enzyme therapy
Drug addiction
Metabolism
Cocaine 23

24. 24

25. Search Each Concept Separately
Drug Addiction enzyme therapy
Substance-Related Disorders drug abuse
cocaine esterase Substance Abuse
drug overdose pharmacogenetics
Enzymotherapy cocaine hydrolase
Pharmacokinetics pharmacology
Drug Dependence
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26. Concept Map
Concept 1 Concept 2 Concept 3 Concept 4
Drug cocaine Enzymotherapy Pharmacokinetics
Addiction hydrolase
drug abuse cocaine enzyme therapy metabolism
esterase
drug overdose Cocaine Drug therapy pharmacogenetics
Drug pharmacology
Dependence
Substance
Abuse
Substance-
Related
Disorders
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28. 28

29. Searching using subheadings
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30. MeSH
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31. Using broader term
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32.  Designing a good search
strategy is like playing
chess well.
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33. My NCBI
 Customize PubMed display
 Save collections (sharing)
 Save search strategies
 Set up alerts
 Need to register for My NCBI

34. Web of Knowledge
 Online environment which allows searching of
 BIOSIS Previews
 Web of Science
 Medline
 Zoological Record
 Journal Citation Reports
 Cross searching
 Cross database navigation
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35. Web of Science
 Consists of 5 databases:
 Science Citation Index Expanded (1945-present)
 Social Sciences Citation Index (1898-present)
 Arts & Humanities Citation Index (1975-present)
 Conference Proceedings Citation Index- Science (1990-present)
 Multidisciplinary subject coverage
 Citation searching capability
 Coverage back to 1955 online
 In print back to 1945
 Create citation report
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36. Journal Citation Reports
 Determine the relative importance of
journals within subject categories
 Look up Impact Factor as well as other
indices for journals
 Various editions – science & social science
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37. WOS
 Run the same search in WOS
 What is the most cited articles in your
result list?
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38. Concept Map
Concept 1 Concept 2 Concept 3 Concept 4
Drug cocaine Enzymotherapy Pharmacokinetics
Addiction hydrolase
drug abuse cocaine enzyme therapy metabolism
esterase
drug overdose Cocaine Drug therapy pharmacology
Drug
Dependence
Substance
Abuse
Substance-
Related
Disorders
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39. WOS Search
#3 Topic=("Drug therapy" OR Enzymotherapy OR "enzyme therapy")
# 2 Topic=("cocaine hydrolase" OR "cocaine esterase" OR cocaine)
# 1 Topic=("Drug Addiction" OR "drug abuse" OR "drug overdose" OR
"Drug Dependence" OR "Substance Abuse" OR "Substance Related
Disorders")
Limit by: Research Areas=( BIOCHEMISTRY MOLECULAR BIOLOGY ) AND Document Types=(
ARTICLE OR REVIEW ) AND Languages=( ENGLISH )
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41. Cited Reference
Using Google Scholar and Web of Science, please identify
how many times this article has been cited.
Hardman A. E. The influence of exercise on postprandial
triacylglycerol metabolism. ATHEROSCLEROSIS 141: S93-
S100 Suppl. 1 DEC 1998
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42. Using Scopus
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43. Locating Articles
Group 1
Lenhard K, Bommer GT, Asutay S, Schauer R, Brabletz T,
Goke B, Lamerz R, Kolligs FT. Analysis of promoter
methylation in stool: a novel method for the detection
of colorectal cancer. Clin Gastroenterol Hepatol. 2005
Feb;3(2):142-9. PMID: 15704048 [PubMed - indexed for
MEDLINE]
Group 2
Herlyn M, Sears HF, Verrill H, Koprowski H. Increased
sensitivity in detecting tumor-associated antigens in
sera of patients with colorectal carcinoma. J Immunol
Methods. 1984 Dec 14;75(1):15-21. PMID: 6512262
[PubMed - indexed for MEDLINE]

44. Introduction to
RefWorks

45. What is RefWorks?
 Personal bibliographic citation managers
 Save citations as you search
 Organize your research, Include citations while
you write your paper
 Import references from many data sources
including databases, the UWO catalogue, even
from web pages
 Create bibliographies
 Share citations with friends, colleagues,
students, etc.

46. Why Use RefWorks?
 free to all UWO faculty, staff, and students
 web-based so available anywhere and anytime
 data is stored on a server in Toronto
 data is backed up every night so you will not lose
your data

47. Create a Folder
References organization by default:
o Last imported folder
o References not in a folder
o Deleted references (deleted references will
store here for 30 days)
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48. Create a Folder

49. Editing References
 Duplicates
 Upload attachments

50. Direct import
 This will automatically launch RefWorks and
store the citations in your "Last Imported"
folder. Direct export functionality is available
from most database providers. e.g. SCOPUS
 Tutorial available at:
http://www.lib.uwo.ca/taylor/grad/intro_refworks_import.shtml

51. Indirect Import
 References have to be imported into RefWorks
from a text file (txt.) created by saving references
from a wide variety of online services and other
bibliographic management programs. Text file will
be imported into RefWorks via specific filters. e.g.
PubMed
 Video Tutorial available at:
http://www.lib.uwo.ca/tutorials/refworksimportingcitationsfrompubme
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52. Create a bibliography
 Output Style
 Format a Bibliography from a List of
References

53. Using Write-N-Cite
Enables you to incorporate citations into your
paper while you write. Automatically
generates a bibliography when you're
done. Please watch the following video
Write- N- cite
From north California State University Libraries

54. RefWorks off campus access
1) Visit www.lib.uwo.ca
2) Login to off-Campus Access (connect to proxy)
3) Then, sign into RefWorks
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55. Online Help for RefWorks
 Taylor Support for RefWorks
 Scholars Portal help guide

56. Thank You for Your Attention!
Need library help. Please feel free to contact:
Nazi Torabi
519-661-2111 ext 88992 Taylor Service Desk
ntorabi@uwo.ca 519-661-3168
tayref@uwo.ca
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