This document discusses glucose monitoring and the AlphaTRAK blood glucose monitoring system. It notes that there are over 1 million diabetic dogs and cats in the US, many of which are undiagnosed or untreated. Untreated diabetes can lead to serious diseases. Early detection through monitoring symptoms and risk factors is important. The AlphaTRAK system provides accurate glucose readings for pets in just seconds using a small blood sample size. It is validated for veterinary patients and has benefits for managing diabetes.

1. Key Concepts of Glucose Monitoring and the AlphaTRAK® Blood Glucose Monitoring System ALPHA-347 January 2010 ©2010 Abbott Laboratories

2. Canine/Feline Diabetic Cases There are an estimated 1.43 million diabetic dogs and cats in the U.S. 600,000 (43%) diabetic patients are undiagnosed 270,000 (19%) are diagnosed, but untreated Data Sources: Populations – Pet Food institute, 2005. Incidence and Treatment – IMS, 2003 and 2005 and from Humane Society website: WWW.hsus.org ALPHA-347 January 2010 ©2010 Abbott Laboratories

3. Untreated Diabetes Untreated diabetes can lead to other serious diseases: Ketoacidosis Neuropathy (nerve damage) Increased incidence of infections (i.e. Urinary Tract Infections) Cataracts (dogs) Gastrointestinal dysfunction Early treatment of diabetes could help a pet live a healthier life ALPHA-347 January 2010 ©2010 Abbott Laboratories

4. Early detection can be accomplished by: Understanding the symptoms e.g., Excessive urination, drinking, hunger Weight loss Understanding and actively looking for the risk factors e.g., Age Obesity Inactivity Genetics ALPHA-347 January 2010 ©2010 Abbott Laboratories

5. Early detection can be accomplished by: Understand and look for risk factors that lead to medical claims… According to Veterinary Pet Insurance (VPI), the top ten medical claims are: Dogs #1 Ear infections #2 Skin Allergies #3 Psyoderma/Hot Spots #4 Gastritis / vomiting #5 Enteritis/Diarrhea #6 Urinary Tract Infection #7 Benign Skin Tumors #8 Eye Inflammation #9 Osteoarthritis #10 Hypothyroidism Cats #1 Urinary Tract Infection #2 Gastritis / vomiting #3 Chronic Renal Failure #4 Enteritis/Diarrhea #5 Diabetes #6 Skin Allergies #7 Colitis/Constipation #8 Ear Infections #9 Respiratory Infections #10 Hyperthyroidism ALPHA-347 January 2010 ©2010 Abbott Laboratories

6. Managing Diabetes ALPHA-347 January 2010 ©2010 Abbott Laboratories

7. Key Factors in Managing Diabetes Managing and treating diabetes occurs with: Diet Exercise Insulin Regulation Monitoring “Our goal is that when we’re treating pets with insulin, we want to keep their glucose levels down to a point where their clinical signs are going into remission.” Dr. David Bruyette, DVM, DACVIM ALPHA-347 January 2010 ©2010 Abbott Laboratories

8. Importance of Blood Glucose Monitoring Monitoring is the process of tracking the patient’s glucose level over time: Helps access the effectiveness of prescribed treatment Helps enable changes to optimize treatment Helps balance the appropriate level of insulin necessary Blood Glucose Curve ALPHA-347 January 2010 ©2010 Abbott Laboratories

10. Achieving readings more frequently than possible in-clinic“Achieving good control of blood glucose levels quickly is key to preventing negative side effects associated with diabetes. This rapidity of control can only be achieved through the use of injectable insulin and home blood glucose monitoring.” Dr. Sara Ford, DVM, DACVIM ALPHA-347 January 2010 ©2010 Abbott Laboratories

11. AlphaTRAK® Blood Glucose Monitoring System The AlphaTRAK® System provides unique benefits to you and your patients ALPHA-347 January 2010 ©2010 Abbott Laboratories

12. Accuracy Proven results equivalent to those from a reference method, the “gold standard” “Our studies found that the AlphaTRAK® Meter was more accurate in determining blood glucose levels in dogs and cats than portable human meters.1” Dr. Elizabeth Cozzi, Ph.D. 1 – Data on specific meters on file. ALPHA-347 January 2010 ©2010 Abbott Laboratories

13. Validated for Veterinary Patients Human blood is different than dog or cat blood The AlphaTRAK® Meter is calibrated and validated specifically for cats and dogs 1 Mackay EM. The Distribution of Glucose in Human Blood (From the Scripps Metabolic Clinic). J Biological Chem. May 1932:685-8. 2 Coldman MF and Good W. The distribution of sodium, potassium and glucose in the blood of some mammals. Comp Biochem Physiol. April 1967;21(1) 201-6. ALPHA-347 January 2010 ©2010 Abbott Laboratories

14. Now Validated for Glucose Monitoring in Horses and Ferrets A hand-held meter is easy for use in the field or in-clinic The AlphaTRAK® Meter provides accurate results in just seconds ALPHA-347 January 2010 ©2010 Abbott Laboratories

15. Expanded Testing Range Now provides validated numeric readings up to 750 mg/dL in cats and dogs “This is a significant improvement because many newly-diagnosed and unregulated cats have glucose values above 500 mg/dL. Being able to better quantify the glucose level in the upper range will help to significantly improve our resulting treatment plan.” Dr. Gary D. Norsworthy, DVM, DABVP ALPHA-347 January 2010 ©2010 Abbott Laboratories

16. Easy to Use Obtain an accurate blood glucose result in four simple steps … ALPHA-347 January 2010 ©2010 Abbott Laboratories

17. Small Sample Size Small Sample Size Requires only 0.3µL of blood without the need for a needle and syringe Speed Gives you accurate numeric readings in seconds ALPHA-347 January 2010 ©2010 Abbott Laboratories

18. AlphaTRAK®Blood Glucose Monitoring System Look to the AlphaTRAK Meter for: Accurate results Specific species blood glucose readings An expanded testing range Readings within seconds ALPHA-347 January 2010 ©2010 Abbott Laboratories

19. To learn more about Abbott Animal Health, our dedication to animal health excellence and our quality products, contact your local Abbott sales representative or Customer Service at 888-299-7416 or visit www.AbbottAnimalHealth.com ALPHA-347 January 2010 ©2010 Abbott Laboratories