ICx has a proprietary protein-polymer composite technology called BioImmobilization that can be applied to medical devices. This technology immobilizes proteins, enzymes, and other biomolecules within polymers to create materials with various applications, including analytical coatings for medical devices, self-decontaminating coatings, and responsive coatings that can deliver drugs or growth factors. ICx is looking to partner with companies to commercialize this technology for uses such as wound care dressings and medical device coatings.

1. Applications of ICx Protein-Polymer
Composites:
Medical Devices
paul.rohricht@icxt.com ICx BioImmobilization™
Vice President, Commercial Business Development
www.icxt.com

2. About ICx Technologies (NASDAQ: ICXT)
Advanced sensor and technology development company
Core business focus: military, homeland defense, security markets
Founded 2003
25 entrepreneurial teams (companies) located in U.S., UK, Germany
800+ multi-disciplinary workforce. 200+ engineers, 50+ scientists
Broad & diversified technology base: 35+ patents , 50+ filed
Substantial government development funding
2008 Revenues: $175M
Technologies developed within ICx have application outside of
security:
Wound care, in vitro diagnostics, medical devices
We are actively engaged in seeking partnerships to commercialize
products utilizing ICx technology and know-how
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3. ICx-Agentase
Agentase operates as a wholly-owned subsidiary of ICx (Pittsburgh, PA)
Developing low-cost tools for the detection/decontamination of hazardous chemicals
Technical expertise / IP
Applied enzymology
Formulation development
Enzyme-polymer synthesis
Urethanes
– Fabrics – Gels
– Films – Foams
Acrylates
Water-soluble protein-polymer conjugates
– PEG-ylation
– PEG-alternatives
Scaled synthesis
– Bench-top
– Pilot
– Production
Rapid prototyping
Launched commercial products based on our technology platform
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4. ICx BioImmobilization™
ICx BioImmobilization™ Technology
Proprietary immobilization of small molecules, enzymes and other
proteins into a variety of polymers, covalently bonded within a
growing polymer chain
Biomolecules act as co-monomers in polymerization synthesis
Applications
In Vitro Diagnostics
Wound healing: ‘smart’ bandages indicate healing progression, or
can respond and deliver drugs in situ
Medical device coatings: protein-polymer combinations can be pro-
healing or can inhibit (anti-microbial, anti-thrombosis, anti-adhesion)
Proteins can be immobilized within polymer foams and gels directly
(eg., spinal implants)
Versatility
Polymers can be made into sprays, gels, or foams
Pre-polymer material approved by FDA
FDA approved and in use as hydrophilic dressings
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5. ICx BioImmobilization™
Performance
Loading of proteins, enzymes or other molecules into polymer
allows target analytes to be detected at high sensitivity;
Activity and specificity of biomolecules are well maintained for long
periods through tertiary structure stabilization;
Protein environmental and thermal sensitivity are dramatically
reduced;
Dyes can be simultaneously loaded into polymers to provide
colorimetric indication of analyte presence (eg., wound progress
indication);
Covalent incorporation ensures molecules will not leach from
polymers during use.
Experience
More than 100 proteins successfully immobilized;
Multiple commercial products launched.
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6. Enzyme Immobilization
• Non-covalent immobilization (entrapment, adsorption)
• Covalent attachment (typically single site attachment)
+
Enzyme covalently
Enzyme Activated support
immobilized
• ICx BioImmobilization : Multiple and irreversible enzyme to matrix linkage
TM
ICx
+ Monomers
TM
BioImmobilization
Enzyme
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7. Applying BioImmobilization™ in healthcare
Applications
In Vitro Diagnostics
Development of an analyte-specific sensor for point-of-care IVD
Partners interested in working with us because of technology
attributes
Siemens
RapidPoint TM
– Stabilization of reagents and proteins
» Shelflife: enzymes and reagents formulated to be stable for years
without any special storage requirements
» Operational: sensors perform reproducibly for long periods of time
» Robust: work well under adverse and variable conditions
Medical Devices and Wound Care Dressings
Sensors
– Identification
– Qualification
– Quantification
Responsive, functional “smart” sponges, gels, materials, coatings,
dressings
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8. Biopolymers for
Medical Device Coatings
Convergence of drugs, devices, and polymers are creating new and
innovative biomaterials
TM
ICx BioImmobilization can be used as a device coating for
Accelerated healing and biocompatibility
Decreased immunogenicity
Protein eluting devices
Antiseptic production in situ infection control
Useful across a range of medical device products:
Neurological (infusion catheters, hydrocephalic shunts, stroke treatment,
embolic protection)
Cardiovascular (coronary stents, guidewires, occlusion devices, catheters,
heart valves, access systems)
Oncology (microcatheters)
Peripheral vascular (grafts, stents, imaging, closure devices)
Ophthamology (access instruments)
Cardiac Rhythm (CRT leads, implantable defibrillators, pacemaker leads,
catheters and guidewires)
Surgical (endoscopy accessories, obesity management, chest wound drainage)
Urogenital (incontinance devices, penile implants, stents and catheters,
contraceptive systems)
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9. BioImmobilization™ for the development of
‘Smart’ Medical Device Coatings
Potential to synthesize materials that respond to the physiological status
in situ
Analytical coatings
Biosensors integrated within material coatings currently used in medical devices
Markers for physiological condition at the site of device implantation
Self-decontaminating coatings
Utilize “decontaminating” enzymes to respond to detected high colony counts by
producing disinfectants at the site of implantation
Smart erodible materials
Microenvironment responsive
Potential delivery vehicle for actives
– Anti-microbials, anti-adhesion, anti-thrombosis
– Large MW drugs
– Protein fragments
– Prohealing factors (cytokines, growth factors)
Actively seeking partnerships to exploit these concepts
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10. Summary
ICx has proprietary technologies that can be directly
applied to the medical device coatings space
BioImmobilization™ technology is able to incorporate active
biomolecules and small molecules within biocompatible
polymer foams, plugs, gels, and sprays
We can use this technology to make advanced biomaterial
coatings that can be used with medical devices
Analytical devices
Smart decontaminating materials
Responsive materials
ICx is actively seeking partnerships in wound care to exploit
this know-how
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