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Pharmacokinetics In Special Populations

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PHARMACOKINETICS IN SPECIAL POPULATIONS Presented by: P.C.Campo
 
MATERNAL ADAPTATIONS IN PREGNANCY Expanded intravascular volume Increased renal blood flow and GFR Increased progesterone activated hepatic metabolism Decreased gastrointestinal motility Increased thinning of fetomaternal barrier with advancing gestation Increased minute ventilation Decreased albumin
 
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PEDIATRIC PHARMACOKINETICS Adult pattern Adult pattern Colonization phase MICROBIAL FLORA Developed Developed by 1 yr Decreased PANCREATIC ENZYME ACTIVITY Developed Developed Underdeveloped BILIARY FUNCTION Normal Normal Reduced ABSORBING GUT SURFACE Increased Increased Decreased, irregular INTESTINAL MOTILITY Decreased Decreased at 6-8 mth Increased Increased (delayed) GASTRIC EMPTYING Adult values Adult values at 3 mth Neutral at birth up to 1 hrs GASTRIC CHILDREN INFANTS NEWBORNS PHYSIOLOGIC VARIABLES FACTORS AFFECTING ABSORPTION IN CHILDREN
 
 
 
 
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Pharmacokinetics In Special Populations

  • 1. PHARMACOKINETICS IN SPECIAL POPULATIONS Presented by: P.C.Campo
  • 2.  
  • 3. MATERNAL ADAPTATIONS IN PREGNANCY Expanded intravascular volume Increased renal blood flow and GFR Increased progesterone activated hepatic metabolism Decreased gastrointestinal motility Increased thinning of fetomaternal barrier with advancing gestation Increased minute ventilation Decreased albumin
  • 4.  
  • 5.
  • 6.
  • 7.  
  • 8. PEDIATRIC PHARMACOKINETICS Adult pattern Adult pattern Colonization phase MICROBIAL FLORA Developed Developed by 1 yr Decreased PANCREATIC ENZYME ACTIVITY Developed Developed Underdeveloped BILIARY FUNCTION Normal Normal Reduced ABSORBING GUT SURFACE Increased Increased Decreased, irregular INTESTINAL MOTILITY Decreased Decreased at 6-8 mth Increased Increased (delayed) GASTRIC EMPTYING Adult values Adult values at 3 mth Neutral at birth up to 1 hrs GASTRIC CHILDREN INFANTS NEWBORNS PHYSIOLOGIC VARIABLES FACTORS AFFECTING ABSORPTION IN CHILDREN
  • 9.  
  • 10.  
  • 11.  
  • 12.