Ramesh Durvasula, Pistoia Alliance board member, discusses the Pistoia Alliance mission and recaps activities in 2011-12, with particular emphasis on the successful completion of the Sequence Squeeze Competition and Sequence Services Phase 2. The presentation was delivered at BioITWorld in Boston in April 2012.

1. The Pistoia Alliance
Update on Strategy & Progress
Ramesh Durvasula, PhD
Director, Informatics, Bristol-Myers Squibb
Board Member of the Pistoia Alliance
Presentation to #BioIT12
http://pistoiaalliance.org @PistoiaAlliance

2. Agenda
• Industry Drivers
• The Origins of Pistoia
• The Mission and Strategy of Pistoia
• The Initiatives of Pistoia

3. Rapidly Evolving Info Ecosystem
Yesterday Today Tomorrow
Big Life
Science
Company
Yesterday Today Tomorrow
Innovation Heterogeneity of collaborations. Part
Innovation inside Searching for Innovation
Model of the wider ecosystem
Struggling with change
IT Internal apps & data
Security and Trust
Cloud/Services
Data Mostly inside Inside  Outside Distributed
Portfolio Internally driven and owned Partially shared Shared portfolio

4. What is Needed: Glue between Nodes
Proprietary
content
Public provider
content
provider
CRO
Regulatory
authorities
Academic
group
Service provider
Software vendor

5. The Mission of the Pistoia Alliance
Lowering the barriers to innovation
by improving the interoperability of
R&D business processes
via pre-competitive collaborations

6. Dec 2011
Pistoia Alliance Membership

7. Chemistry Externalization Processes

8. Potential Projects

9. Pistoia-Led Successes
• Sequence Services
– Phase 1 (2011): 4 proofs of concept
– Phase 2 (2012): 3 demos at Pistoia Conference
• Semantic Enrichment of Scientific
Literature
– Transfer to IMI’s OpenPHACTS
• Sequence Squeeze
– $15K prize for best new NGS compression
algorithm

10. www.sequencesqueeze.org
All source code from entries available on
SourceForge under BSD-2 license

11. Sequence Squeeze Results & Winner
James Bonfield
Wellcome Trust Sanger Institute

12. A recent innovation attributed to
Pistoia
• ODDT (Open Drug Discovery Teams) – an iPad app for
rare and neglected disease collaboration that is
chemistry-aware and uses social media
• Launched April 12, 2012
• Presented @ ACS
• Idea-innovation, 2 months

13. Pistoia Conference (24 April 2012)
• Twitter: #PistoiaCon12 @PistoiaAlliance
• Dragon’s Den, pitching new projects
• Review output of Sequence Services
– Cycle Computing & Eagle Genomics
– HP
– Constellation Technologies & Genestack

14. Pistoia Alliance Publications
1. “The Pistoia Alliance - The Sequence Services Project” - Simon
Thornber et al. - G.I.T. Laboratory Journal 1-2/2011
2. “Need for Collaborative Technologies in Drug Discovery” - Chris
L. Waller et al. Book Chapter in “Collaborative Computational
Technologies for Biomedical Research” – Edited by Sean Ekins et
al. Wiley May 2011
3. “What are the obstacles to innovation in the Pharmaceutical
Industry? The Pistoia Alliance responds” – The Pistoia Alliance –
Drug Discovery World
4. “Empowering Industrial Research With Shared Biomedical
Vocabularies” – Lee Harland et al - Drug Discovery Today in press
5. “ELNs - An Essential Productivity Tool – But Which One to Use”
– John Wise - European Pharmaceutical Review - Issue 4, 2011

15. Pistoia Projects in the Pipeline
• Vocabulary standards
• Biomarker exchange standards
• Screening Data Standards
• Canonical models for large molecules
• Disease explorer
• Data exchange with CROs
For more info, visit http://www.pistoiaalliance.org

16. A Reality Check: Setting Expectations

17. www.pistoiaalliance.org
Twitter: @PistoiaAlliance
Our industry needs a Disruptive Innovation.
That Disruption...is Pistoia
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