1. Evaluation of Ceramic-based Microelectrode Arrays for In Vivo Recordings PM Talauliker F Pomerleau E Rutherford P Huettl JT Hastings GA Gerhardt AAAS (adapted)

2. Ceramic MEAs: From bench to bedside Flexible microelectrodes for human and nonhuman primate recordings (with Ad-Tech Medical Instrument Corp.) Mouse Rat NHP Cell culture Tissue slices Anesthetized Rat/mouse Acute experiments Awake behaving studies Microelectrode tip Subdural strip electrodes and Spencer-Gerhardt microelectrodes 20 x 150 µ m 100  m W2 20x150 μ m 600  m W1 15x333, 50x50  m 900  m S2 15x333  m 100  m

4. EM Imaging: Ceramic Surface Polished front & back Sides Polyimide over Al 2 O 3 Pt

5. EM Imaging: Post-removal 4 weeks 4 months Cellular / Proteinacous Matrix

6. Surface Analysis: AFM Unimplanted Recording Site At 4 weeks Surface Topography at 4 Weeks Surface Analysis: GFAP Immunolabel Optical Microscopy GFAP fluorescence scanning EM (astrocytes) 4 months post-implant