2. THE AGING MYTH
Our lives are a giant forest, and the second we're born
a fire is set to it. During our lives we can do things to
FAN those flames (like by not eating right, abusing
drugs, etc) and burn the forest down faster.
We can also do things to SLOW it down, too.
But you can't douse that fire totally
It ALWAYS burns.
And eventually, ALL our forests burn down.
4. Aging is the Largest Killer
In India 1 in 25 will be a senior citizen in 2020
This ratio is several times higher in the Western
countries
With state of the art technologies we can now evaluate
the status of aging in the body and monitor it.
We also have technologies that can reduce the rate of
aging at the cellular and molecular level
This is evidenced by improvement in all the
Physiological, Biochemical and Molecular parameters
of Aging
5. So...what is 'aging', exactly?
Aging is:
The life-long accumulation of damage to the tissues,
cells, and molecules of the body that occurs as an
intrinsic side-effect of the body's normal operation.
The body can tolerate some damage, but too much of it
causes disease and disability.
6.
7.
8.
9.
10. Genetics of Aging:
Aging is not a passive activity,
But an actively regulated metabolic process
Specific genes identified that regulate aging,
Aging and Longevity are only partially under genetic influence
Rest of Gain is from Nutrition
It is possible to increase life span by environmental modification;
caloric restriction can increase life span
dysregulation of glucose homeostasis is a hallmark of aging in
humans
type 2 diabetes, a disease of glucose homeostasis, is a form of
accelerated aging
Aging and Diabetes are both common risk factors for a wide range of
diseases
Aging and Diabetes are related at a molecular level
15. The Future of Living Well to 100
Healthy aging presents an enormous challenge
Advances in biological sciences provide the knowledge and tools needed
to
understand nutrition at genetic and molecular levels and
elevate the scientific basis underlying nutritional recommendations
Understanding roles requires interdisciplinary cooperation of:
nutrition
genetics,
inflammation
Developing partnerships among specialties to promote the goal of
healthy aging
come together as a science community
generate the evidence base to influence recommendations
Value of nutrition and genetics in achieving healthy aging
Am. J. Clinical Nutrition, Feb 2006; 83: 488s - 490s. Gordon W Duff, Peter Libby, José M Ordovas, and Philip R Reilly
16. The Different Paths to 100
Most centenarians do not have significant disability
90% of centenarians functionally independent @ ave. age
of 92 years
A more enabling point of view emerges to achieve extreme
old age :
The older an individual gets, the healthier he or she has
been
Centenarians show
Relative resistance to age-related diseases
Slower aging
17. Where are we heading
1 centenarian per 10,000 persons in the United States
NOW
1 centenarian per 5,000 persons for industrialized
nations SOON
Ability to survive to extreme old age appears to be the
result of:
Complex combination of
Genetics,
Environment
Lifestyle (Diet, Exercise, Social Activities), and Luck
18. The Future Path lies in:
Better Perinatal Nutrition = Omega-3, Nutrients
Genetics of the Very Old
Identifying the molecular drivers of longevity or
mortality = omega 3/6 ratio
Discovering and targeting the pathways mediating aging
and disease susceptibility
Developing preventive and therapeutic agents that will
allow aging in good health
19.
20. How to Delay, Reverse The Aging?
i.e Anti Aging
Remove the damage or Inactive molecules and
cells
Restore function to several molecules by repair &
Replacement
Modify the Genetic Program to prevent the aging
process from continuing
How are we going to do Above changes...???
22. Who Can take Anti-Aging
Treatment
Absolutely healthy aging (King of Good Times)
Patients with age related diseases (Struggler King)
Aging patients with serious & Advanced diseases
(Bankrupt King)
23. Holistic approach to Anti-aging Therapy
Congnitive Behavioral Therapy(W C Bushwell 2006)
What How
Enhancing Self healing
capacities
Mobilization of dormant
or sleeping stem cells
Activate body immune
system
Decreasing Free radicals
Link between nutrition &
gene to be established
telomers
Diet – Veg & Fruits,
Green Tea
Workout, Meditation,
Breathing Exercises
Coping the stress
Calorie Restrictions
Antioxidants
Growth hormone
supplements
24. Congnitive Behavioural Therapy
Main action is on bone marrow and pineal gland
Increasing molecular mediators like DHEA, IL4, IL10
& Melatonin & Growth hormones
Enhancing health and anti aging effects using
dormant stem cells & immune system
25. “Not only to give more years to life
but especially to give more life to
years by stem cells therapy…”
26. Human
An Adult Human once a tiny cell, is a self assembling
machine made of trillions of microscopic components
Roughly a human being consist of
~7 x 1027 atoms and ~5 x 105 molecular genetic particles.
Here we see = Gene proteins- an organic nano
structure working with molecular precession to form
complete cell.
At age 30 around 30 million stem cells are in
circulation
29. Why Stem Cells...
Stem cells and biological science is poised to
become next revolution in medicine to provide
exciting and promising alternatives to most
traditional solutions (allopathic), surgery and
drugs within the reach of everyday people.
“Treating Today’s medical Problem with
tomorrow's solution.”
30. Gene Therapy
If aging may be Reversed by expressing of key genes
then gene therapy holds a great future promise
Delivers major information of aging in human body
Involves use of vector for specific purpose for inserting
DNAs in cells
RNAi
Limitation:- Small Bandwidth for information
31. Cell Therapy
Cell therapy has greater bandwidth
Cells can be genetically engineered In vitro prior to be
used for treatment.
32. THE ADVANTAGES Of Stem Cell Anti-Aging Treatment
Stem Cells from your own body are used
No chemicals or drugs are needed
Better breathing and sleeping pattern.
Energy levels restored
Age spots fade
Complexion brightens and skin softens
No more expensive supplements or creams required
Hormones are re-balanced
Sugar levels controlled
33. Heightened sexual drive
Increased metabolism and surprisingly an average 4-7
kg weight loss.
Hair color darkening and volume increasing.
There is also a better control of blood pressure and
improved vision
Emotional and cognitive improvement occurs,
memory improves, concentration ability increases and
your ability to handle complex tasks, as you did before,
is regained.