2. Catabolism of heme
Heme
Bile pigments ( Bilirubin and Biliverdin)
Sites
Reticulo-
endothelial cells of
liver, spleen and
bone marrow.
Sources
• Senescent RBC’s (80%)
• Other heme containing proteins
(Myoglobin, cytochromes) (10%)
• Ineffective erythropoiesis (10%)
Heme degraded
per day – 6gm
3. Steps of Heme degradation
Formation of bilirubin
Uptake of bilirubin by liver
Conjugation of bilirubin
Fate of bilirubin
• Secretion of bilirubin into bile
• Formation of urobilins in the intestine
• Excretion in urine and stool