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1. TRAINING MANUAL
HEPATITIS B VIRUS
THIS MANUAL IS MEANT FOR INTENAL
CIRCULATION ONLY.

2. INTRODUCTION
Chronic hepatitis B is a major global healthcare problem. Affecting an
estimated 350 to 400 million people worldwide, chronic hepatitis B
results in approximately one million deaths each year, making it the
world's tenth leading cause of death. The progression of chronic
hepatitis B is variable, ranging from mild asymptomatic infection to
severe chronic liver disease. In about 15% to 25% of patients,
ongoing viral replication leads to serious complications including
hepatic decompensation, cirrhosis, and hepato-cellular carcinoma
(HCC).