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Andropause & Sarcopenia , Prabhakar Shetty

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Andropause & Sarcopenia , Prabhakar Shetty

  1. 1. Andropause & Sarcopenia Stay Young … Strong and Lively By Prabhakar Shetty, Body Satva Essentials www.bodysatva.com
  2. 2. Andraiz T Testosterone level begins to decline in the late thirties declines at 0.8 % to 1.6% per year (Massachusetts Male Ageing Study, MMAS; Feldman et al., 2002). In adults skeletal muscle mass is 60% of total body mass up to age 40 years and then declines to 40% by the age of 70 years. (Basualto-Alarcón et al., Frontiers in Endocrinology, Dec 2014 ;Vol5:Art 217) Additionally, loss of testicular mass, low androgen production, accelerated testosterone metabolism or malfunctioning androgen receptors are extrinsic factors for Sarcopenia. (Basualto-Alarcón et al., Frontiers in Endocrinology, Dec 2014 ;Vol5:Art 217) Aging is associated with lower levels of LH and therefore Testosterone. Simultaneously, there is an increase in SHBG, leading to lower levels of free Testosterone available to tissues like muscles and causing Sarcopenia. Andropause & Sarcopenia are progressive Andropause is characterized by insidious onset and slow progression
  3. 3. Andraiz T  Erectile Dysfunction, Low libido  Low sperm counts, Prostate problems  Weakness, Fatigue  Reduced muscle mass  Disturbed sleep, Depression,  Anxiety, Irritability  Impairment of Memory & Cognitive function  Osteoporosis, Frailty  Low immunity, Slow wound healing Andropause or Male Menopause Symptoms Andropause is characterized by insidious onset and slow progression Some of the common symptoms Intervene early with D.E.A.R. Diet, Exercise And Rest
  4. 4. Andraiz T Sarcopenia is the age-related decline in skeletal muscle mass and strength generation, the primary function of skeletal muscle mass Synthesis and degradation of muscle proteins is regulated by various systemic hormones. Levels of circulating testosterone, estrogens, IGF-1, vitamin D, and thyroid hormones decrease with age Men with low free testosterone levels were 57% more likely to develop mobility limitation and 68% to experience increase in mobility limitation. The synthesis of myosin heavy chain (MHC) protein is reduced. Myosin is 25-30% of skeletal muscles. The muscle tissue undergoes a fiber- type shift from fast to slow contracting muscle tissue, with increasing age Sarcopenia is age-related and progressive Sarcopenia has many intrinsic and extrinsic factors affecting the onset and steady progression of diseases Basualto-Alarcón et al., Frontiers in Endocrinology, Dec 2014 ;Vol 5: Art 217 Intervene early with D.E.A.R. Diet, Exercise And Rest
  5. 5. Andraiz T Intervene early and prevent Sarcopenia  Balanced Diet  Regular Exercise  Stress Reduction  Adequate Sleep &  Testosterone Therapy if needed TE treatment increases expression of Androgen Receptor protein and Insulin-like Growth Factor I (IGF-I) at 1 month and remained increased throughout TE administration. We conclude that physiological and near-physiological increases of testosterone in older men will increase muscle protein anabolism and muscle strength. (Ferrando A A et al, Am J Physiol Endocrinol Metab 282: E601–E607, 2002.) European Working Group on Sarcopenia in Older People 2 (EWGSOP2) recommends increased awareness of Sarcopenia, early detection and treatment ( Alphonso J et al, Age and Ageing 2019; 48: 16–31 )
  6. 6. Andraiz T Benefits & Safety of increasing Testosterone in the physiological range Testosterone Therapy (TTh) in the physiologic range for men with Testosterone Deficiency is a safe and effective therapeutic modality and imparts great benefits on health and QOL. Increases Lean Body Mass, Decreases Fat Mass, and Improves Body Composition Ameliorates Components of MetS, Increases Insulin Sensitivity, and Lowers Risk of T2DM Improves sexual function and ameliorates lower urinary tract symptoms Improves Mood and Depressive Symptoms, Energy, and Quality of Life Improves Bone Mineral Density and improves Anemia In a meta analysis of 22 RCTs involving 2,351 men, those who received TTh were at no greater risk of developing PCa (prostate cancer) than men who received placebo. Of 52,579 men with PCa, those with exposure to TTh were at no greater risk for having developed high-grade PCa than untreated men. (Traish AM, Sex Med Rev 2018;6:86e105.)
  7. 7. Andraiz T Total of 11 RCTs (1,392 participants) showed no significant increase in PSA levels following TRT. Subgroup analysis revealed that PSA levels did not increase following long-term TRT. Short term TRT increased PSA levels significantly. Transdermal administration increased PSA levels more than the injection or the oral administration TRT did not increase IPSS (International Prostate Symptom Score) significantly in an analysis of 7 RCTs, involving 893 participants (short term or long term treatment with injection, transdermal or oral). Prostate volume increased by an average of 1.58 following TRT, but no significant differences in prostate volume with long term TRT in a total of 8 RCTs, involving 663 participants. A total of 6 RCTs, involving 1,351 participants reveals that TRT did not increase the number of serious adverse events (Cancer, Mortality, PE, DVT, MI, HF) ( ChangCheng Guo et al, EXPERIMENTAL AND THERAPEUTIC MEDICINE 11: 853-863, 2016 ) Benefits & Safety of increasing Testosterone in the physiological range
  8. 8. Andraiz T Androgenic Aid for Muscle Building, Sarcopenia and Erectile Dysfunction Dietary Supplement Stay Young ……. Strong and Lively Raises Testosterone, activates androgen receptors and improves muscle synthesis Aromatase Inhibition reduces conversion of Testosterone to Estrogen and reduces body fat accumulation Reduces Cortisol, stress and muscle catabolism Manufactured in a WHO GMP approved plant with ISO & HACCP certifications Andraiz T Tablets Increases Testosterone & Inhibits Aromatase
  9. 9. Andraiz T Andraiz T is a blend of proven natural Testosterone enhancers, with Unique Tongkat Ali along with Shilajit, Tribulus, Horny Goat Weed & Zinc Natural Aromatase Inhibitors like Gingko Biloba and Grape Seed Extract, reduce conversion of Testosterone to Estrogen & reduce body fat accumulation. Andraiz T Tablets Increases Testosterone Inhibits Aromatase Stay Young Strong and Lively
  10. 10. Andraiz T Significant improvements in the TA group for Tension (−11%), Anger (−12%), and Confusion (−15%). Stress hormone profile significantly improved, with reduced cortisol exposure (−16%) and increased testosterone (+37%) In men with low testosterone levels, tongkat ali extract (200 mg/day) daily for 1 month resulted in a significant improvement in serum testosterone levels and quality-of-life parameters, suggesting a role for tongkat ali as an “adaptogen” against aging-related stress This “ancient” remedy may be an effective approach to shielding the body from the detrimental effects of “modern” chronic stress, which may include general day-to-day stress, as well as the stress of dieting, sleep deprivation, and exercise training. Stay Young ……. Strong and Lively Effect of Tongkat Ali on stress hormones and psychological mood state in moderately stressed subjects (63 patients, 32 men & 31 women) Talbott SM et al, J Intl Society of Sports Nutrition 2013, 10:28
  11. 11. Andraiz T Tongkat ali enhances muscle mass and strength gains, while accelerating fat loss, may be considered a natural ergogenic aid for athletes and dieters alike. Study of middle-aged women (aged 45–59 yrs) found that twice-weekly strength training plus 100 mg/day of E.longifolia for 12 wks enhanced fat free mass to a greater degree. In a trial of endurance cyclists, cortisol levels were 32% lower and testosterone levels were 16% higher in supplemented subjects, a more favorable biochemical profile for promoting an “anabolic” hormone state. Several weeks of dieting or overtraining raises Cortisol and drops Testosterone levels. Tongkat ali helps faster and more complete recovery. Effect of Tongkat Ali on stress hormones and psychological mood state in moderately stressed subjects (63 patients, 32 men & 31 women) Talbott SM et al, J Intl Society of Sports Nutrition 2013, 10:28 Stay Young ……. Strong and Lively
  12. 12. Andraiz T LOH Patients (76) were treated with 200 mg/day of Tongkat ali for 1 month. While the AMS score decreased from 38.05 (± 9.25) to 23.67 (± 5.11) after treatment, the testosterone concentration increased from 5.66(±1.52) to 8.31(± 2.47) nm, which represents an average increase of 46.8%. These changes are highly significant (P < 0.0001). Tongkat ali, a suitable herbal supplement in overcoming symptoms of LOH and managing hypogonadism. It may be used as an adjunct to testosterone replacement therapy to enhance DHEA. Standardized water-soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late-onset hypogonadism? Tambi MI et al, Andrologia. 2012, 44(Suppl 1):226–30. Stay Young ……. Strong and Lively Tongkat Ali has anti-inflammatory action, antioxidant effect by activating Nrf2, increases insulin sensitivity & glucose uptake. improves bone formation & reduces bone resorption Rehman S U et al, Molecules 2016, 21, 331
  13. 13. Andraiz T Review on a Traditional Herbal Medicine, Eurycoma longifolia Jack (Tongkat Ali): Rehman S U et al, Molecules 2016, 21, 331 E. longifolia extracts enhance male fertility (higher semen volumes, sperm count, and motility) in rodents and in human trials. The aphrodisiac effect of E.longifolia extract in men, was investigated in a 12wk study (109 men, age 30-55 yrs) using 300mg/d. The E.longifolia treated group showed improvement in sexual libido, sperm motility and semen-volume. Henkel et al. investigating the ergogenic effect of E. longifolia (400 mg/day for 5 weeks), found it a potential herbal supplement for physically active aged males and females (age 57–72 yrs). Significant increases in total and free testosterone & muscular force in men & women. Stay Young ……. Strong and Lively
  14. 14. Andraiz T Andraiz T Tablets Increases Testosterone Inhibits Aromatase Stay Young Strong and Lively Ingredients and Evidence Tribulus terrestris improved the sexual drive in 60% of ED cases, and was accompanied by significant improvement in DHEA levels. (Adimodelja A et al, Int. J. Impotence Res., v9, supp1,1997) Tribulus Terrestris (TTE) improves testosterone production in healthy male. TTE enhances production of luteinizing hormone (LH) and muscle growth. By increasing testosterone, reducing inflammation and oxidative damage in muscle, TT appears to be a potent performance enhancer. (Sellami et al. J.Int.Society of Sports Nutrition (2018) 15:14) Tribulus terrestris (Saponins and Phytosterols) has beneficial effects on physical fitness, libido, prostate function and urinary system. (Sellami et al. J.Int.Society of Sports Nutrition (2018) 15:14) Horny Goat Weed Extract (Icariin) increases NO synthesis in the penis, inhibit PDE5 (like Sildenafil), have positive neurotrophic effect, enhance smooth muscle proliferation and mimic endogenous androgens. Icariin has anti-inflammatory, anti-osteoporotic and neuroprotective properties.(Corazza et al, BioMed Res. Intl, Vol 2014, Art. ID 841798)
  15. 15. Andraiz T Andraiz T Tablets Increases Testosterone Inhibits Aromatase Stay Young Strong and Lively Ingredients and Evidence Shilajit (Fulvic acid) treatment for 90 days (250 mg twice daily), significantly increases total testosterone, free testosterone and DHEA. which plays a role in Testosterone biosynthesis. Gonadotropic hormones (LH and FSH) levels were well maintained in the RCT on healthy volunteers (Pandit S et al, Andrologia 2016, 48, 570–575) Shilajit 500 mg/d for 8 weeks promoted the retention of maximal muscular strength following fatiguing and decreased baseline hydroxyproline (HYP), thus eliciting favorable muscle and connective tissue adaptations. HYP is an indirect biomarker of collagen degradation and the integrity of connective tissue following high-intensity exercise. (Keller et al, J Intl Society of Sports Nutrition, 2019;16:3 ) Ginkgo biloba is a popular phytomedicine used for disorders of the CNS, CV and circulatory diseases. The three major flavonoids (kaempferol, quercetin, and isorhamnetin) synergistically inhibit estrogen biosynthesis through aromatase inhibition and induce transcriptional suppression. (Y.J.Park et al, Asian Pacific Journal of Cancer Prevention, Vol 16, 2015).
  16. 16. Andraiz T Andraiz T Tablets Increases Testosterone Inhibits Aromatase Stay Young Strong and Lively Ingredients and Evidence Ginkgo biloba extracts have been suggested to improve sexual function by improving the blood flow to the brain and to the genital organs. They increase NO bioavailability, which may have positive impact on sexual function. (Corazza et al, BioMed Res. Intl, Vol 2014, Art. ID 841798) Grape Seed Extract Is an Aromatase Inhibitor and a Suppressor of Aromatase Expression (I Kijima et al, Cancer Res 2006; 66: 5960-5967). Zinc deficiency is associated with hypogonadism in men. One study found that zinc supplementation for 6 months in marginally zinc-deficient elderly men resulted in an almost two-fold increase in serum testosterone levels. (Gunnels et al, J Plant Biochem Physiol 2014, 2:2) Piperine aids the absorption and increases the bio-availability of the other ingredients; in addition to numerous health benefits. Stay Young ……. Strong and Lively
  17. 17. Andraiz T Andraiz T Tablets Increases Testosterone Inhibits Aromatase Stay Young Strong and Lively Androgenic Aid for Muscle Building, Sarcopenia and Erectile Dysfunction Manufactured in a WHO GMP approved plant with ISO & HACCP certifications Disclaimer Body Satva Essentials’ Team has taken maximum care to ensure authenticity of the information provided, by sourcing from reputed Medical journals and books. Body Satva Essentials’ Team urges members to seek professional advice before commencing any regimen of diet, exercise and medication. The products sold on this site are not for treating any disease or medical condition, without medical supervision. We do not advice self-medication. Buy at www.bodysatva.com E-mail: bodysatva.om@gmail.com Thank You

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