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Mutations
By: Jaelene Burkett, Heather Giavedoni, and
Dalton White.   HTTP://UPLOAD.WIKIMEDIA.ORG/WIKIPEDIA/COMMONS/E/E5/PORTULACA_GRANDIFLORA_MUTANT1.JPG
Point mutations
Point mutations
occur in a a single point in the DNA sequence
Point mutations
occur in a a single point in the DNA sequence
Point mutations
occur in a a single point in the DNA sequence



These include substitutions insertions and
deletions
Point mutations
occur in a a single point in the DNA sequence



These include substitutions insertions and
deletions
Point mutations
occur in a a single point in the DNA sequence



These include substitutions insertions and
deletions
Point mutations
occur in a a single point in the DNA sequence



These include substitutions insertions and
deletions




http://en.wikipedia.org/wiki/File:Point_mutations-en.png
Point mutations
occur in a a single point in the DNA sequence



These include substitutions insertions and
deletions




http://en.wikipedia.org/wiki/File:Point_mutations-en.png
Substitution
Substitution
one base is changed into a completely different
base

usually only affects one amino acid

this also can have no affect at all
                                  TUC- PYRIMIDINES




                                 AG- PURINES
Substitution
one base is changed into a completely different
base

usually only affects one amino acid

this also can have no affect at all
                                  TUC- PYRIMIDINES
       T         A         C


       A         T         G
                                 AG- PURINES
Substitution
one base is changed into a completely different
base

usually only affects one amino acid

this also can have no affect at all
                                  TUC- PYRIMIDINES
       T         A         T
                           C


       A         T         G
                                 AG- PURINES
Frameshift Mutations

Consist of insertions and deletions in the DNA
sequence.



They shift the “reading frame” and can change
every amino acid that follows that.
Insertion and Deletions




 EX. OF INSERTION    EX. OF DELETIONS
THE GATE IS CLOSE   THE GATE IS CLOSED
Insertion and Deletions
   Insertions have to many nucleotides in a DNA
   sequence

   Deletions can occur after an insertion or without
   one.




 EX. OF INSERTION               EX. OF DELETIONS
THE GATE IS CLOSE              THE GATE IS CLOSED
Insertion and Deletions
   Insertions have to many nucleotides in a DNA
   sequence

   Deletions can occur after an insertion or without
   one.




 EX. OF INSERTION               EX. OF DELETIONS
THE GATE IS CLOSED             THE GATE IS CLOSED
Insertion and Deletions
   Insertions have to many nucleotides in a DNA
   sequence

   Deletions can occur after an insertion or without
   one.




 EX. OF INSERTION               EX. OF DELETIONS
THE GATE IS CLOSED             THE GATE IS CLOSE
Insertion and Deletions
   Insertions have to many nucleotides in a DNA
   sequence

   Deletions can occur after an insertion or without
   one.




 EX. OF INSERTION               EX. OF DELETIONS
THE GATE IS CLOSED             THE GATE IS CLOSE
Insertion and Deletions
   Insertions have to many nucleotides in a DNA
   sequence

   Deletions can occur after an insertion or without
   one.




 EX. OF INSERTION               EX. OF DELETIONS
THE GATE IS CLOSED             THE GATE IS CLOSE
Insertion and Deletions
      Insertions have to many nucleotides in a DNA
      sequence

      Deletions can occur after an insertion or without
      one.




 EX. OF INSERTION                                                           EX. OF DELETIONS
THE GATE IS CLOSED                                                         THE GATE IS CLOSE
  PICTURE FROM: HTTP://EN.WIKIPEDIA.ORG/WIKI/FILE:INSERTION-GENETICS.PNG
Mutagens
Mutagens
   Chemical
                             Physical
   Mutagens
       Pesticide                 X-rays

  Few plant alkaloids       ultra-violet light

    tobacco smoke          ionizing radiations

environmental pollutants
Mutagens
These are chemical or physical agents in the environment

      Chemical
                                          Physical
      Mutagens
           Pesticide                           X-rays

    Few plant alkaloids                  ultra-violet light

       tobacco smoke                    ionizing radiations

 environmental pollutants



DNA Replication causes the mutation to grow at a faster rate.

Mutagens also cause the DNA strand to break, which is known as
Chromosomal Mutations
Picture from http://www.loc.gov/rr/scitech/mysteries/colors.html
Chromosomal Mutations
Chromosomal Mutations
This involves the number or structure change in
chromosomes.
Chromosomal Mutations
This involves the number or structure change in
chromosomes.

It can even change the number of copies of
some genes.
Chromosomal Mutations
This involves the number or structure change in
chromosomes.

It can even change the number of copies of
some genes.

Chromosomal mutations usually occur during
the formation of a zygote.
Chromosomal Mutations
This involves the number or structure change in
chromosomes.

It can even change the number of copies of
some genes.

Chromosomal mutations usually occur during
the formation of a zygote.

They may change by inversion, deletion,
duplication, or translocation.
Effects of Mutation
Genetic material can be altered by natural
artificial means.

Mutations do not always effect the organism.

The Cellular machinery that replicates DNA
inserts the incorrect base every 10 million bases.
Harmful Mutations
These dramatically change protein structure.

Defective proteins can disrupt normal, biological activities and results
in genetic disorder.

Some cancers are the result of mutations.

Sickle cells are a mutation of red blood cells. The shape is no longer
circular.

If a mutation is in sex cells, the mutation   Symptoms of sickle cells
can be in all the cells of the offspring
                                                 anemia       frequent infections

                                               severe pain     stunted growth
Beneficial Effects
Mutations can often produce proteins that can
be helpful and new functions that can be helpful
to the environment.

A polyploidy is an organism that has an extra set
of chromosomes.This occurs naturally in citrus
plants.

This can be very bad for humans because of
mutated organisms.

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Mutations Powerpoint

  • 2. Mutations By: Jaelene Burkett, Heather Giavedoni, and Dalton White. HTTP://UPLOAD.WIKIMEDIA.ORG/WIKIPEDIA/COMMONS/E/E5/PORTULACA_GRANDIFLORA_MUTANT1.JPG
  • 4. Point mutations occur in a a single point in the DNA sequence
  • 5. Point mutations occur in a a single point in the DNA sequence
  • 6. Point mutations occur in a a single point in the DNA sequence These include substitutions insertions and deletions
  • 7. Point mutations occur in a a single point in the DNA sequence These include substitutions insertions and deletions
  • 8. Point mutations occur in a a single point in the DNA sequence These include substitutions insertions and deletions
  • 9. Point mutations occur in a a single point in the DNA sequence These include substitutions insertions and deletions http://en.wikipedia.org/wiki/File:Point_mutations-en.png
  • 10. Point mutations occur in a a single point in the DNA sequence These include substitutions insertions and deletions http://en.wikipedia.org/wiki/File:Point_mutations-en.png
  • 11.
  • 13. Substitution one base is changed into a completely different base usually only affects one amino acid this also can have no affect at all TUC- PYRIMIDINES AG- PURINES
  • 14. Substitution one base is changed into a completely different base usually only affects one amino acid this also can have no affect at all TUC- PYRIMIDINES T A C A T G AG- PURINES
  • 15. Substitution one base is changed into a completely different base usually only affects one amino acid this also can have no affect at all TUC- PYRIMIDINES T A T C A T G AG- PURINES
  • 16. Frameshift Mutations Consist of insertions and deletions in the DNA sequence. They shift the “reading frame” and can change every amino acid that follows that.
  • 17. Insertion and Deletions EX. OF INSERTION EX. OF DELETIONS THE GATE IS CLOSE THE GATE IS CLOSED
  • 18. Insertion and Deletions Insertions have to many nucleotides in a DNA sequence Deletions can occur after an insertion or without one. EX. OF INSERTION EX. OF DELETIONS THE GATE IS CLOSE THE GATE IS CLOSED
  • 19. Insertion and Deletions Insertions have to many nucleotides in a DNA sequence Deletions can occur after an insertion or without one. EX. OF INSERTION EX. OF DELETIONS THE GATE IS CLOSED THE GATE IS CLOSED
  • 20. Insertion and Deletions Insertions have to many nucleotides in a DNA sequence Deletions can occur after an insertion or without one. EX. OF INSERTION EX. OF DELETIONS THE GATE IS CLOSED THE GATE IS CLOSE
  • 21. Insertion and Deletions Insertions have to many nucleotides in a DNA sequence Deletions can occur after an insertion or without one. EX. OF INSERTION EX. OF DELETIONS THE GATE IS CLOSED THE GATE IS CLOSE
  • 22. Insertion and Deletions Insertions have to many nucleotides in a DNA sequence Deletions can occur after an insertion or without one. EX. OF INSERTION EX. OF DELETIONS THE GATE IS CLOSED THE GATE IS CLOSE
  • 23. Insertion and Deletions Insertions have to many nucleotides in a DNA sequence Deletions can occur after an insertion or without one. EX. OF INSERTION EX. OF DELETIONS THE GATE IS CLOSED THE GATE IS CLOSE PICTURE FROM: HTTP://EN.WIKIPEDIA.ORG/WIKI/FILE:INSERTION-GENETICS.PNG
  • 25. Mutagens Chemical Physical Mutagens Pesticide X-rays Few plant alkaloids ultra-violet light tobacco smoke ionizing radiations environmental pollutants
  • 26. Mutagens These are chemical or physical agents in the environment Chemical Physical Mutagens Pesticide X-rays Few plant alkaloids ultra-violet light tobacco smoke ionizing radiations environmental pollutants DNA Replication causes the mutation to grow at a faster rate. Mutagens also cause the DNA strand to break, which is known as Chromosomal Mutations Picture from http://www.loc.gov/rr/scitech/mysteries/colors.html
  • 28. Chromosomal Mutations This involves the number or structure change in chromosomes.
  • 29. Chromosomal Mutations This involves the number or structure change in chromosomes. It can even change the number of copies of some genes.
  • 30. Chromosomal Mutations This involves the number or structure change in chromosomes. It can even change the number of copies of some genes. Chromosomal mutations usually occur during the formation of a zygote.
  • 31. Chromosomal Mutations This involves the number or structure change in chromosomes. It can even change the number of copies of some genes. Chromosomal mutations usually occur during the formation of a zygote. They may change by inversion, deletion, duplication, or translocation.
  • 32. Effects of Mutation Genetic material can be altered by natural artificial means. Mutations do not always effect the organism. The Cellular machinery that replicates DNA inserts the incorrect base every 10 million bases.
  • 33. Harmful Mutations These dramatically change protein structure. Defective proteins can disrupt normal, biological activities and results in genetic disorder. Some cancers are the result of mutations. Sickle cells are a mutation of red blood cells. The shape is no longer circular. If a mutation is in sex cells, the mutation Symptoms of sickle cells can be in all the cells of the offspring anemia frequent infections severe pain stunted growth
  • 34. Beneficial Effects Mutations can often produce proteins that can be helpful and new functions that can be helpful to the environment. A polyploidy is an organism that has an extra set of chromosomes.This occurs naturally in citrus plants. This can be very bad for humans because of mutated organisms.

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