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Anti depressant and its classifications

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Anti depressant and its classifications

  1. 1. Anti-Depressant and itsClassificationByNatasha PuriM.Sc Forensic Science(3rdSem.)
  2. 2. What is Depression ??? Serious disorder of mood, ranges from mild tovery serious condition Most serious mental problem which people facingtoday Most common Psychological Disorder Some people referred depression as “CommonCold” of mental illness Can affect people of all ages,religion and race Twice common in female as compared to male Risk of suicide is high
  3. 3. Type of Depression Depression are of Following types :a. Uni-polar - Mind of subject swing in somedirectionb. Bi-polar - Depression associated withmania some times called asmanic depressionc. Endogenous – Depression due to shock orstressful life events
  4. 4. CausesFollowing are the main causes : Family History Positive and negative events Certain medication Use of alcohol Imbalance of certain chemicals in the brain
  5. 5. Symptoms Vary from subject to subject but having to keysigns are: a. loss of interest in thingslike to dob. sadness or irritability Divided into followingBiological EmotionalPhysical
  6. 6. Biochemical TheoryIn 1950, Reserpine induce Depressionand study shows that it depletes thestorage of NE and 5-HT Then Biochemical or monoaminetheory was Proposed in 1965 bySchildkrant Theory state that there is decreased orfunctional deficiency inmonoamine i.e NE , 5-HT, DAtransmission in the CNS
  7. 7. TreatmentPsychotherapy Electroconvulsive Therapy Natural alternatives MedicationThe drug which is used for therelieve or prevention of depression and itssymptoms known as Anti-depressant Drugs
  8. 8. Anti Depressant DrugsDrugs which are used to relieve or preventdepression known as Anti depressant Anti depressant was first developed in1950’s Work by stabilize and normalize the level ofneurotransmitter in brain.Neurotransmitterlike NE,5-HT,DA play an important role inregulating the mood Practically all antidepressants affectmonoaminergic transmission in the brain
  9. 9. Classification Tricyclic Antidepressants (TCAs)i. NA+5-HT reuptake inhibitor- Imipramine- Trimipramine- Amitriptyline- Doxepinii. Predominantly NA reuptake inhibitors- Desipramine- Nortriptyline- Reboxetine
  10. 10.  Selective Serotonin reuptake inhibitors(SSRIs)- Citalopram- Escitalopram- Fluoxetine- Paroxetine- Sertraline5-HT / NE Reuptake Inhibitors (SNRIs)- Duloxetine- Venlafaxine
  11. 11. Atypical Antidepressants- Buproprion- Mirtazapine- Nefazodone- Trazodone Monoamine Oxidase Inhibitors- Phenelzine- Selegiline- Tranylcypromine
  12. 12. Mechanism of TCAs Drugs
  13. 13. Mechanism of SSRIs Drugs
  14. 14. Mechanism of monoamineoxidase Inhibitors
  15. 15. Side EffectClassification Side effects PharmacokineticsTCAs Blurred Vision ,xerostomia , constipation,Increased appetite, Nausea,cardiac arrhythmiaWell absorbed OrallyPass BBBMetabolised in liverSSRIs Nausea, anxiety, insomnia,sexual dysfunction, gastricupsetWell absorbed OrallyFood effect absorptionMetabolised in LiverSNRIs Nausea,anxiety,insomnia,sexualdysfunction, gastric upsetWell absorbed OrallyMetabolised in LiverAtypical Antidepressant Dry mouth , nervousness,seizures at high doseWell absorbed orallyMAOIs Nausea, Headache, Stiffneck, dry mouth, DruginteractionWell absorbed orally
  16. 16. References Tripathi K.D “Essential of Medical Pharmacology” 6thEdition , JaypeeBrothers Medical Publishers(P)ltd. Goodman and Gilman’s “Manual of Pharmacology and Therapeutics”10thEdition, McGraw Hill Companies Finkel Richard, “Pharmacolgy”,4thEdition, Lippincott Williamsand Wilkin Hollinger A. Mannfred, “ Introduction to Pharmacology” ,2ndEdition ,Taylor & Francis Group Dipiro T. Joseph, “ Pharmacotherapy” ,7thEdition , McGraw HillCompanies Stahl SM. Essential Psychopharmacology,2ndEdition, CambridgeUniversity Press, New York Foye O.William, Principles of Medicinal Chemistry,3rdEdition,Varghese Publishing House