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Class newer routes of drug delivery
1. Dr.RAGHU PRASADA M S
MBBS,MD
ASSISTANT PROFESSOR
DEPT. OF PHARMACOLOGY
SSIMS & RC.
2. 1. Delayed release system
2. Extended release system
3. Site specific and receptor targeting
4. Rate controlled delivery system-Diffusion
systems –reservoir device, matrix device,
transdermal patches
5. Controlled release by stimulation
6. Target drug delivery system-nano particles
7. Colloidal drug carriers
8. Block copolymers
9. Liposomes as drug carriers
10. Ligand mediated targeting
3. 11. Resealed erythrocytes
12. Bioadhesives
13. Tissue engineered delivery systems
14. Stent implantation in angioplasty
15. Encapsulated cells
16. Refillable biohybrid artificial pancreas
17. Microchip delivery system
18. Micro fabricated micro needles
19. Powdered drug delivery
4. Repeated intermitent dosing of a drug
Ex. Enteric coated tablets
Extended release system- maintainance of
therapeutic blood and tissue levels of drug
5. Ocuserts –thin epithelial microunits
Ex. Pilocarpine occusert-gloucoma
Progestaserts- intrauterine
contraceptive device
Drug encapsulated in liposomes for
intravenous infusion –Amphotericin B
7. Targeting a drug directly to a
certain biological location
Rate controlled delivery system
Diffusion systems –reservoir device,
matrix device, transdermal patches
Dissolution system-encapsulated,
matrix
8. Active ingredient is delivered across the skin for systemic distribution.
Example: transdermal scopolamine, transdermal nitroglycerine,
20. Uses a tiny electrical current to promote flow of
drug (usually charged) through the skin.
Example: Dexamethasone.
21. It is a computerized syringe which delivers
insulin into the subcutaneous tissue every few
minutes in tiny amount 24 hours a day
through a canula placed in the subcutaneous
tissue.
Intermitenty-GnRH
Contineously-Insulin
22. Delivers insulin subcutaneously without using needle.
Achieved by pressurizing the liquid through a small
orifice which creates high speed jet that can
penetrate the skin and underlying tissue.
23. It is a stent placed into narrowed, diseased
peripheral or coronary arteries that slowly
release a drug to block cell proliferation hence
preventing fibrosis and re- stenosis.
Notas del editor
Gold absorbs more than iodine (3 x at 100 keV), enabling higher contrast at lower X-ray dose and higher resolution.
Gold nanoparticles stay in the blood longer. Repeated administration gives a higher concentration at a lower total dose than iodine.
Gold can be concentrated to 1.5 g Au/mL, 5 x higher than iodine agents. With 3 x higher absorption, this enables 15x higher opacity.
Gold nanoparticles are non-toxic. Iodine agents can produce adverse reactions including anaphylactic shock and kidney failure.
Very low osmolality helps avoid side-effects.
Low viscosity, even at very high concentration, unlike viscous iodine agents.
Golds K-edge at 80.7 keV enables imaging away from bone and soft tissue absorption. Bone interferes with iodine (K-edge 33 keV).
Gold nanoparticles enable targeted molecular imaging of tumor, atherosclerotic, inflammatory, stroke, and other markers.