1. The Pistoia AllianceStrategy, Progress, Momentum Ramesh Durvasula, PhD Director, Molecular Sciences & Candidate Optimization Informatics, Bristol-Myers Squibb Board Member of Pistoia Alliance BioITWorld Expo, Boston, April 2011

2. Agenda Industry Drivers The Origins of Pistoia The Mission and Strategy of Pistoia The Initiatives of Pistoia

3. What is Core to your Business? What is Critical? Core? Yes No ExternalizeforBest Practices Focus Staff on Innovation 1990 Yes Critical? 2011 No Externalize for Cost Reduction Reduce Non-Value Added Work

4. Pistoia Membership February2011

5. The Mission of the Pistoia Alliance Lowering the barriers to innovation by improving the interoperability of R&D business processes via pre-competitive collaborations

6. Domains of Action

7. The Focus of Each Domain 2010-2013 2012-2014 Biology Chemistry 2012+ Scientific Collaboration

8. The Biology Domain Sequence Services SESL Biology Domain Roadmap

9. Sequence Services Biology Domain

10. Sequence Services – the Rationale “It takes all the running you can do, to keep in the same place!” -- Red Queen

11. Sequences & Cloud

12. SESL Semantic Enrichment of Scientific Literature Biology Domain

13. Try this at your desk…. Which diseases are correlated to TCF7L2? Gene/Protein Literature – Full Text Literature - Abstracts Gene expression Inherited diseases

15. Gene Function

16. Literature statistics

17. Disease co-occurrences

18. Gene/protein interactions…all in one report from one search HOW? A standard ontology, data model, query language, report structure, etc.

19. The Deliverables of SESL A Proof-of-Concept to demonstrate feasibility and clarify requirements A functional specification for query brokering, result filtering, report generation A potential for a new Business Model

20. The Roadmap of the Domain Biology Domain

22. Sequence Services Secure integrated multi-domain information services Hosting & integration of private data ELIXIR EATRIS Multi-tenant Security Complexity of Service-Enablement SAGE caBIG … Large Scale Analytics SESL Breadth of Information Integrated (content) Sequences Expression Scientific Literature Biology Domain Roadmap

23. A Reality Check: Setting Expectations vs. vs.

24. Our industry needs a Disruptive Innovation. That Disruption...is Pistoia IF YOU WANT TO GO FAST, GO ALONE IF YOU WANT TO GO FAR, GO TOGETHER

25. Thank you http://goo.gl/0eytH www.pistoiaalliance.org