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www.xiTechnology.com
  xi Technology, LLC




                       Innovation Partners / Technology Scouting Program




                       Xi Technology, LLC
                       Robert Dunki-Jacobs
www.xiTechnology.com
  xi Technology, LLC




                       Innovation




                       •   Innovation is the life-blood of business

                       •   Life science and Medical Device
                           Innovation is fueled by the
                           intersection of science, engineering,
                           and clinical practice

                                                                      Copyright The New Yorker, “Annals of Innovations: In the Air”, May 12, 2008
www.xiTechnology.com
  xi Technology, LLC




                       Innovation In The Air


                                                            The phenomenon of simultaneous discovery

                                                            The law of the conservation of energy, so significant in
                       • Vey similar innovation, solving    science and philosophy, was formulated four times
                                                            independently in 1847, by Joule, Thomson, Colding
                         very similar problems, occurs      and Helmholz. They had been anticipated by Robert
                         nearly simultaneously and in       Mayer in 1842. There seem to have been at least six
                         more than one location             different inventors of the thermometer and no less
                                                            than nine claimants of the invention of the telescope.
                                                            Typewriting machines were invented simultaneously
                                                            in England and in America by several individuals in
                       • In a sense, Innovation is in the   these countries. The steamboat is claimed as the
                         air!                               “exclusive” discovery of Fulton, Jouffroy, Rumsey,
                                                            Stevens and Symmington.
                                                            - Ogburn and Thomas , 1922 “Inventions and Discoveries Made
                                                                Independently by Two or More Persons”
www.xiTechnology.com
  xi Technology, LLC




                       Innovation, Insight & Readiness




                                                                  •   Innovation is a product of readiness and
                                                                      insight

                                                                  •   Uncovering innovation is a product of
                                                                      readiness and opportunity




                        “Chance favors the prepared mind.”
                                             - Louis J. Pasteur
www.xiTechnology.com
  xi Technology, LLC




                       I N N O V AT I O N P A R T N E R S P R O G R A M
                       CONNECTING OPPORTUNITY AND INNOVATION
Innovation Partners Program
www.xiTechnology.com
  xi Technology, LLC




                       C o n n e c t i n g   o p p o r t u n i t y   a n d   i n n o v a t i o n



                       • Market need - sourcing
                            • Public / Large companies
                                 • Solve product development or pipeline challenges using “Open Innovation” model
                                 • Augment Licensing & Acquisition groups
                                 • Faster time to market
                                 • Maintain or enhance competitive position
                                 • Innovate outside of core competency
                                 • Expanded network of contacts to ID and acquire technology
                            • Small / Start-up companies
                                 • Source solutions to product challenges that are outside core competency
                                 • Enhance pipeline through strategic alliances
                                 • Expanded network of contacts to ID solutions
                       • Market need – intelligence
                            •Public / Large companies
                                 • Early identification of technologies, technology trends, technology shocks
                                 • Raising awareness of threats and opportunities of technology development
Innovation Partners Program
www.xiTechnology.com
  xi Technology, LLC




                       C o n n e c t i n g   o p p o r t u n i t y   a n d   i n n o v a t i o n




                       Identification, assessment and
                        coalescing of information on
                         technology developments


                                                        Intelligence         Management




                                                                     Scouting
Innovation Partners Program
www.xiTechnology.com
  xi Technology, LLC




                       C o n n e c t i n g   o p p o r t u n i t y   a n d   i n n o v a t i o n




                       Identification, assessment and                                            Acquisition, development,
                        coalescing of information on                                           compiling, using and selling of
                         technology developments                                                 technological knowledge


                                                        Intelligence         Management




                                                                     Scouting
Innovation Partners Program
www.xiTechnology.com
  xi Technology, LLC




                       C o n n e c t i n g   o p p o r t u n i t y   a n d   i n n o v a t i o n




                       Identification, assessment and                                               Acquisition, development,
                        coalescing of information on                                              compiling, using and selling of
                         technology developments                                                    technological knowledge


                                                        Intelligence         Management




                                                                     Scouting

                                                        Building and using a network of experts
                                                             and early-stage companies for
                                                                competitive advantage
Innovation Partners Program
www.xiTechnology.com
  xi Technology, LLC




                       C o n n e c t i n g   o p p o r t u n i t y   a n d   i n n o v a t i o n




                                                      Intelligence           Management

                               Selection and assessment of new                           Facilitate sourcing of new
                                         technologies                                           technologies


                                                                     Scouting



                              Technology Scouting
Innovation Partners Program
www.xiTechnology.com
  xi Technology, LLC




                       C o n n e c t i n g   o p p o r t u n i t y   a n d   i n n o v a t i o n




                              Partner Company




                                                      Intelligence           Management




                                                                     Scouting



                              Xi Technology
www.xiTechnology.com
  xi Technology, LLC




                       IPP Overview
                       • Goals
                          –   Early identification of technologies, technology trends and technology shocks
                          –   Raising awareness of threats and opportunities of technology developments
                          –   Stimulating innovation by combining technology reports with business reality
                          –   Facilitation of external sourcing of technology by leveraging the scouting
                              network of experts and early-stage companies


                       • Process
                          –   Identification / cataloging of technology opportunities
                          –   Selection of interesting opportunities
                          –   Assessment of opportunities
                          –   Dissemination of information
www.xiTechnology.com
  xi Technology, LLC




                       IPP Process: Identification
                       •   How                                    •   Process
                           – Networking to identify and access         – Undirected (Technology Scanning)
                             sources of information on                 – Directed (Technology Monitoring)
                             technological developments
                               • Academia
                                                                  •   Deliverables
                               • National labs
                                                                       – Keyword searchable database
                               • Private labs
                                                                       – Per technology
                               • Early-stage companies
                                                                           • Description
                               • Product companies
                                                                           • Research / Commercialization
                               • Tech transfer offices                        status
                               • Other incubators                          • Business potential
                           – Newsletters                               – Per opportunity
                           – Society Journals and News vehicles
                       •   When
                           – Continuous
www.xiTechnology.com
  xi Technology, LLC




                       IPP Process: Selection
                       •   How                                        •   Process
                           – Monitoring: Establish partner                 – Database search as defined by
                             requirements                                    partners for projects
                               • Core product                              – Database search as defined by IPP for
                               • Whitespace                                  general interest
                           – Scanning: Establish ‘general interest’
                             categories                               •   Deliverables
                               • VC activity                               – Commissioned Reports as requested
                               • Partner interest surveys                    by partners for projects
                               • Clinical thought leader surveys           – General Interest Reports quarterly
                       •   When                                            – Breaking News Reports as needed
                           – Monitoring: On request from
                             partners
                           – Scanning: Semi-annual
www.xiTechnology.com
  xi Technology, LLC




                       IPP Process: Assessment
                       •   How                                 •   Process
                           – As defined by partner initiated        – Use Technomic Analysis™ stages as
                             project                                  required by project definition


                       •   When                                •   Deliverable
                           – As commissioned by partner             – As defined by partner project
www.xiTechnology.com
  xi Technology, LLC




                       IPP Process: Delivery
                       • How                         • Process
                         – Newsletter                   – Defined by partner needs
                         – Partner Conferences
                         – Reports                   • Deliverables
                                                        – Newsletter
                       • When                           – Conferences
                         – Monthly newsletter           – Reports
                         – Quarterly conferences
                         – As commissioned reports
www.xiTechnology.com
  xi Technology, LLC




                       The Ideal Technology Scout


                           An employee of the company , a consultant to the company:

                               an innovation partner

                           Engaged part-time or full time:

                               an active partner

                           A lateral thinker, knowledgeable in science and technology, respected in
                           the community, cross-disciplinary orientation, imaginative

                               an active network builder with broad-based experience, insight
                                and demonstrated results
www.xiTechnology.com
  xi Technology, LLC




                       Technomic Analysis™ Case Study




                         Company desires to broaden its product offering to include new customers
                         and revenue streams by bringing in a product line that does not fit with its
                         technical and marketing core competency yet leverages its sales and
                         distribution network.
www.xiTechnology.com
  xi Technology, LLC




                       Technomic Analysis™ Case Study
                       •       Desired attributes
                                 a)    Immediate and recurring revenue
                                 b)    CAGR > 25%
                                 c)    Competitive advantage  (i)technology and (ii)clinical
                                 d)    Robust pipeline built on core technology
                                 e)    Professional products today, consumer products tomorrow
                                 f)    Not tied to medical reimbursement system


                       •       Process
                                 –    Identified market that satisfied attributes b) and f)
                                 –    Technology Assessment process identified several potential solutions for attributes a and c(i) with potential for d.
                                 –    Clinical / Market validation validated c(ii) and e)
                                 –    Healthcare market affordability was self evident due to self-pay market
                                 –    Created business rationale for top three operational scenarios and using strategic market and financial analysis tools
                                      to recommend an acquisition strategy
                                 –    Sold strategy to Corporate management and under confidentiality validated d)


                       •       End result
                                 –    Process and data gathered were recognized by corporate business and finance executives as the model by which
                                      future deals of this size would be measured




                           Technomic Analysis™ is the trademark of Xi Technology, LLC
xi Technology, LLC
                     www.xiTechnology.com




XI TECHNOLOGY, LLC
www.xiTechnology.com
  xi Technology, LLC




                       Overview
                       •   Medical Devices and Life Sciences Technology Assessment and Strategic Market entry
                           consulting company

                       •   Founded in 2007.

                       •   Principal – Robert Dunki-Jacobs
                            –   35 years in industry
                                  •   8 years medical devices business development / licensing & acquisition (J&J, xi)
                                  •   6 years advanced R&D management (GE, J&J)
                                  •   8 years product development engineering (GE, Westinghouse)
                                  •   5 years R&D project management (GE)
                                  •   8 years advanced R&D development engineering (GE)
                            –   Prolific inventor
                                  •   11 issued US patents with multiple PCT counterparts
                                  •   25 published US patent applications
                                  •   1 unpublished application
                            –   Experienced scout
                                  •   8 years as Technology Scout following more than 20 technology spaces
                                  •   Evaluated hundreds of opportunities: early-stage, early product, established private, public
www.xiTechnology.com
  xi Technology, LLC




                       Selected Technology Scouting Projects
                       •   Conscious Sedation Alternatives (Final FDA approval being sought by J&J)
                            –   Are there ways to improve ad hoc methods to control the delivery of fast-acting sedatives to improve control of
                                conscious sedation for out-patient procedures?


                       •   Drug / Device alternatives for colorectal cancer screening (Timing)
                            –   Are there ways to improve the sensitivity and specificity of colorectal cancer screening and simultaneously remove
                                the psychological barriers to compliance?


                       •   Drug / Device alternatives for delivery of opioids for acute pain relief (Product on market)
                            –   Alternative solutions to manufacturing issues uncovered during phase 3 clinical trials


                       •   Alternatives for radiation therapy delivery
                            –   Alternative means to provide more effective and controllable radiation doses for localized tumors


                       •   Alternatives for endoscopic and laparoscopic visualization
                            –   Are there viable methods for improvement of laparoscopic and endoscopic visualization that provide additional,
                                clinically beneficial, information and allow reduction in visualization footprint?


                       •   Alternatives for bundling of imaging and therapeutic devices
                            –   In response to competitive threats to a major product line, are there commercially viable opportunities to develop or
                                acquire imaging technology to bundle with current therapeutic offerings?
www.xiTechnology.com
  xi Technology, LLC




                       Services
                       •   Opportunity Assessment (Technology Scouting, Intelligence & Management)
                            –   Drive investment, acquisition, and development decisions by analyzing technology and markets
                            –   Identify critical factors that differentiate the opportunity from direct competitors and alternative solutions


                       •   Market Entry Strategy
                            –   Use unique concept and product market research techniques and environmental analysis to identify attractive market
                                segments
                            –   Prioritize product and IP portfolios
                            –   Create a Multi-Generation Product Plan and sustainable growth


                       •   Business Case Preparation (Technomic Analysis™)
                            –   Provide experienced acquirer perspective during the planning phases of business plan generation
                            –   Provide VC / funding source perspective during preparation of presentation materials in support of funding activities


                       •   Focused Innovation
                            –   Leverage the broad physical and life sciences knowledge base of xi Technology and its network of clinical and scientific
                                luminaries
                            –   Add value to the product pipeline by creating innovative solutions
www.xiTechnology.com
  xi Technology, LLC




                       Experience is the difference
                       •   Medical                                  •   Physics
                            –   Drug Delivery Devices                    –   Nuclear
                            –   Drug/Device Combinations Devices         –   Optics, Spectroscopy, Holography
                            –   Surgical Devices                         –   Lasers
                            –   High Intensity Focused Ultrasound        –   Acoustics & Ultrasonics
                            –   Laser Therapy                            –   Nano structures
                            –   Photo Dynamic Therapy
                                                                    •   Biology & Life Sciences
                       •   Imaging                                       –   Cell cycle interventions
                            –   Ultrasound                               –   Energy – tissue interactions
                            –   Computed Tomography (X-ray, MRI,         –   Molecular Markers
                                Ultrasound, Optical)
                            –   Nuclear Imaging
                                                                    •   Other
                            –   Laser Confocal Microscopy
                                                                         –   1D, 2D, 3D signal processing & analysis
                            –   Spectral Imaging
                                                                         –   3D display systems
                            –   Molecular Markers
                                                                         –   Special Purpose Computer Systems




                                Contact us at 513.204.5822 or by email to rdj@xitechnology.com
www.xiTechnology.com
  xi Technology, LLC




                       “A C C E L E R AT E W I T H C O N F I D E N C E ”

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Technology Scouting

  • 1. www.xiTechnology.com xi Technology, LLC Innovation Partners / Technology Scouting Program Xi Technology, LLC Robert Dunki-Jacobs
  • 2. www.xiTechnology.com xi Technology, LLC Innovation • Innovation is the life-blood of business • Life science and Medical Device Innovation is fueled by the intersection of science, engineering, and clinical practice Copyright The New Yorker, “Annals of Innovations: In the Air”, May 12, 2008
  • 3. www.xiTechnology.com xi Technology, LLC Innovation In The Air The phenomenon of simultaneous discovery The law of the conservation of energy, so significant in • Vey similar innovation, solving science and philosophy, was formulated four times independently in 1847, by Joule, Thomson, Colding very similar problems, occurs and Helmholz. They had been anticipated by Robert nearly simultaneously and in Mayer in 1842. There seem to have been at least six more than one location different inventors of the thermometer and no less than nine claimants of the invention of the telescope. Typewriting machines were invented simultaneously in England and in America by several individuals in • In a sense, Innovation is in the these countries. The steamboat is claimed as the air! “exclusive” discovery of Fulton, Jouffroy, Rumsey, Stevens and Symmington. - Ogburn and Thomas , 1922 “Inventions and Discoveries Made Independently by Two or More Persons”
  • 4. www.xiTechnology.com xi Technology, LLC Innovation, Insight & Readiness • Innovation is a product of readiness and insight • Uncovering innovation is a product of readiness and opportunity “Chance favors the prepared mind.” - Louis J. Pasteur
  • 5. www.xiTechnology.com xi Technology, LLC I N N O V AT I O N P A R T N E R S P R O G R A M CONNECTING OPPORTUNITY AND INNOVATION
  • 6. Innovation Partners Program www.xiTechnology.com xi Technology, LLC C o n n e c t i n g o p p o r t u n i t y a n d i n n o v a t i o n • Market need - sourcing • Public / Large companies • Solve product development or pipeline challenges using “Open Innovation” model • Augment Licensing & Acquisition groups • Faster time to market • Maintain or enhance competitive position • Innovate outside of core competency • Expanded network of contacts to ID and acquire technology • Small / Start-up companies • Source solutions to product challenges that are outside core competency • Enhance pipeline through strategic alliances • Expanded network of contacts to ID solutions • Market need – intelligence •Public / Large companies • Early identification of technologies, technology trends, technology shocks • Raising awareness of threats and opportunities of technology development
  • 7. Innovation Partners Program www.xiTechnology.com xi Technology, LLC C o n n e c t i n g o p p o r t u n i t y a n d i n n o v a t i o n Identification, assessment and coalescing of information on technology developments Intelligence Management Scouting
  • 8. Innovation Partners Program www.xiTechnology.com xi Technology, LLC C o n n e c t i n g o p p o r t u n i t y a n d i n n o v a t i o n Identification, assessment and Acquisition, development, coalescing of information on compiling, using and selling of technology developments technological knowledge Intelligence Management Scouting
  • 9. Innovation Partners Program www.xiTechnology.com xi Technology, LLC C o n n e c t i n g o p p o r t u n i t y a n d i n n o v a t i o n Identification, assessment and Acquisition, development, coalescing of information on compiling, using and selling of technology developments technological knowledge Intelligence Management Scouting Building and using a network of experts and early-stage companies for competitive advantage
  • 10. Innovation Partners Program www.xiTechnology.com xi Technology, LLC C o n n e c t i n g o p p o r t u n i t y a n d i n n o v a t i o n Intelligence Management Selection and assessment of new Facilitate sourcing of new technologies technologies Scouting Technology Scouting
  • 11. Innovation Partners Program www.xiTechnology.com xi Technology, LLC C o n n e c t i n g o p p o r t u n i t y a n d i n n o v a t i o n Partner Company Intelligence Management Scouting Xi Technology
  • 12. www.xiTechnology.com xi Technology, LLC IPP Overview • Goals – Early identification of technologies, technology trends and technology shocks – Raising awareness of threats and opportunities of technology developments – Stimulating innovation by combining technology reports with business reality – Facilitation of external sourcing of technology by leveraging the scouting network of experts and early-stage companies • Process – Identification / cataloging of technology opportunities – Selection of interesting opportunities – Assessment of opportunities – Dissemination of information
  • 13. www.xiTechnology.com xi Technology, LLC IPP Process: Identification • How • Process – Networking to identify and access – Undirected (Technology Scanning) sources of information on – Directed (Technology Monitoring) technological developments • Academia • Deliverables • National labs – Keyword searchable database • Private labs – Per technology • Early-stage companies • Description • Product companies • Research / Commercialization • Tech transfer offices status • Other incubators • Business potential – Newsletters – Per opportunity – Society Journals and News vehicles • When – Continuous
  • 14. www.xiTechnology.com xi Technology, LLC IPP Process: Selection • How • Process – Monitoring: Establish partner – Database search as defined by requirements partners for projects • Core product – Database search as defined by IPP for • Whitespace general interest – Scanning: Establish ‘general interest’ categories • Deliverables • VC activity – Commissioned Reports as requested • Partner interest surveys by partners for projects • Clinical thought leader surveys – General Interest Reports quarterly • When – Breaking News Reports as needed – Monitoring: On request from partners – Scanning: Semi-annual
  • 15. www.xiTechnology.com xi Technology, LLC IPP Process: Assessment • How • Process – As defined by partner initiated – Use Technomic Analysis™ stages as project required by project definition • When • Deliverable – As commissioned by partner – As defined by partner project
  • 16. www.xiTechnology.com xi Technology, LLC IPP Process: Delivery • How • Process – Newsletter – Defined by partner needs – Partner Conferences – Reports • Deliverables – Newsletter • When – Conferences – Monthly newsletter – Reports – Quarterly conferences – As commissioned reports
  • 17. www.xiTechnology.com xi Technology, LLC The Ideal Technology Scout An employee of the company , a consultant to the company:  an innovation partner Engaged part-time or full time:  an active partner A lateral thinker, knowledgeable in science and technology, respected in the community, cross-disciplinary orientation, imaginative  an active network builder with broad-based experience, insight and demonstrated results
  • 18. www.xiTechnology.com xi Technology, LLC Technomic Analysis™ Case Study Company desires to broaden its product offering to include new customers and revenue streams by bringing in a product line that does not fit with its technical and marketing core competency yet leverages its sales and distribution network.
  • 19. www.xiTechnology.com xi Technology, LLC Technomic Analysis™ Case Study • Desired attributes a) Immediate and recurring revenue b) CAGR > 25% c) Competitive advantage  (i)technology and (ii)clinical d) Robust pipeline built on core technology e) Professional products today, consumer products tomorrow f) Not tied to medical reimbursement system • Process – Identified market that satisfied attributes b) and f) – Technology Assessment process identified several potential solutions for attributes a and c(i) with potential for d. – Clinical / Market validation validated c(ii) and e) – Healthcare market affordability was self evident due to self-pay market – Created business rationale for top three operational scenarios and using strategic market and financial analysis tools to recommend an acquisition strategy – Sold strategy to Corporate management and under confidentiality validated d) • End result – Process and data gathered were recognized by corporate business and finance executives as the model by which future deals of this size would be measured Technomic Analysis™ is the trademark of Xi Technology, LLC
  • 20. xi Technology, LLC www.xiTechnology.com XI TECHNOLOGY, LLC
  • 21. www.xiTechnology.com xi Technology, LLC Overview • Medical Devices and Life Sciences Technology Assessment and Strategic Market entry consulting company • Founded in 2007. • Principal – Robert Dunki-Jacobs – 35 years in industry • 8 years medical devices business development / licensing & acquisition (J&J, xi) • 6 years advanced R&D management (GE, J&J) • 8 years product development engineering (GE, Westinghouse) • 5 years R&D project management (GE) • 8 years advanced R&D development engineering (GE) – Prolific inventor • 11 issued US patents with multiple PCT counterparts • 25 published US patent applications • 1 unpublished application – Experienced scout • 8 years as Technology Scout following more than 20 technology spaces • Evaluated hundreds of opportunities: early-stage, early product, established private, public
  • 22. www.xiTechnology.com xi Technology, LLC Selected Technology Scouting Projects • Conscious Sedation Alternatives (Final FDA approval being sought by J&J) – Are there ways to improve ad hoc methods to control the delivery of fast-acting sedatives to improve control of conscious sedation for out-patient procedures? • Drug / Device alternatives for colorectal cancer screening (Timing) – Are there ways to improve the sensitivity and specificity of colorectal cancer screening and simultaneously remove the psychological barriers to compliance? • Drug / Device alternatives for delivery of opioids for acute pain relief (Product on market) – Alternative solutions to manufacturing issues uncovered during phase 3 clinical trials • Alternatives for radiation therapy delivery – Alternative means to provide more effective and controllable radiation doses for localized tumors • Alternatives for endoscopic and laparoscopic visualization – Are there viable methods for improvement of laparoscopic and endoscopic visualization that provide additional, clinically beneficial, information and allow reduction in visualization footprint? • Alternatives for bundling of imaging and therapeutic devices – In response to competitive threats to a major product line, are there commercially viable opportunities to develop or acquire imaging technology to bundle with current therapeutic offerings?
  • 23. www.xiTechnology.com xi Technology, LLC Services • Opportunity Assessment (Technology Scouting, Intelligence & Management) – Drive investment, acquisition, and development decisions by analyzing technology and markets – Identify critical factors that differentiate the opportunity from direct competitors and alternative solutions • Market Entry Strategy – Use unique concept and product market research techniques and environmental analysis to identify attractive market segments – Prioritize product and IP portfolios – Create a Multi-Generation Product Plan and sustainable growth • Business Case Preparation (Technomic Analysis™) – Provide experienced acquirer perspective during the planning phases of business plan generation – Provide VC / funding source perspective during preparation of presentation materials in support of funding activities • Focused Innovation – Leverage the broad physical and life sciences knowledge base of xi Technology and its network of clinical and scientific luminaries – Add value to the product pipeline by creating innovative solutions
  • 24. www.xiTechnology.com xi Technology, LLC Experience is the difference • Medical • Physics – Drug Delivery Devices – Nuclear – Drug/Device Combinations Devices – Optics, Spectroscopy, Holography – Surgical Devices – Lasers – High Intensity Focused Ultrasound – Acoustics & Ultrasonics – Laser Therapy – Nano structures – Photo Dynamic Therapy • Biology & Life Sciences • Imaging – Cell cycle interventions – Ultrasound – Energy – tissue interactions – Computed Tomography (X-ray, MRI, – Molecular Markers Ultrasound, Optical) – Nuclear Imaging • Other – Laser Confocal Microscopy – 1D, 2D, 3D signal processing & analysis – Spectral Imaging – 3D display systems – Molecular Markers – Special Purpose Computer Systems Contact us at 513.204.5822 or by email to rdj@xitechnology.com
  • 25. www.xiTechnology.com xi Technology, LLC “A C C E L E R AT E W I T H C O N F I D E N C E ”