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Karen sought help from Dr. Margot Kruskall, a doctor at the Beth Israel Deaconess Medical
Center in Boston, Massachusetts. Karen asserted that these were her children, conceived
naturally, without the help of any reproductive technologies. Dr. Kruskall decided to rerun all of
the HLA tests on Karen and her sons' blood. The tests yielded similar results. This time Karen's
husband was also tested. The tests indicated that he had an HLA haplotype of 5 and 6. Dr.
Kruskall also verified that Karen had a normal chromosome number of 46 XX . Questions for
Part II 1. Make a chart or table or family tree/pedigree chart of Karen's family, displaying their
HLA haplotype combinations. (You will add a little more to this in Part 3 so allow space for that,
you can hand draw these and the Punnett square and insert a photo but make a note here that I
will find your answer in the photo.) 2. Draw a Punnett square using Karen and her husband's
haplotypes showing the possible haplotype combinations of their offspring.

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Karen sought help from Dr- Margot Kruskall- a doctor at the Beth Israe.docx

  • 1. Karen sought help from Dr. Margot Kruskall, a doctor at the Beth Israel Deaconess Medical Center in Boston, Massachusetts. Karen asserted that these were her children, conceived naturally, without the help of any reproductive technologies. Dr. Kruskall decided to rerun all of the HLA tests on Karen and her sons' blood. The tests yielded similar results. This time Karen's husband was also tested. The tests indicated that he had an HLA haplotype of 5 and 6. Dr. Kruskall also verified that Karen had a normal chromosome number of 46 XX . Questions for Part II 1. Make a chart or table or family tree/pedigree chart of Karen's family, displaying their HLA haplotype combinations. (You will add a little more to this in Part 3 so allow space for that, you can hand draw these and the Punnett square and insert a photo but make a note here that I will find your answer in the photo.) 2. Draw a Punnett square using Karen and her husband's haplotypes showing the possible haplotype combinations of their offspring.