Research, the leading business intelligence provider, has released its latest research: Obesity Therapeutics to 2019 – Safety Concerns Hinder Drug Performance Despite Large Market Opportunity”. Obesity is often described as a global endemic, with incidence dramatically increasing over the past decades, particularly in developed countries. Being overweight or obese is a major risk factor in the development of many chronic diseases, including cardiovascular diseases, cancer, and diabetes, of which treatment incurs extensive economic and healthcare costs. Numerous anti-obesity drugs have been approved in the past decade, including Knoll Pharmaceutical’s Meridia (sibutramine) and Acomplia (rimonabant), only for them to be removed from the market due to evidence of suicidal thoughts, depression and cardiovascular problems with their long-term use. As such, healthcare professionals have a negative perception of such drugs and do not widely prescribe them, a major barrier to the growth of the anti-obesity therapeutics market. Only orlistat is currently deemed safe for the long-term treatment of obesity; being proven to produce a placebo-adjusted weight-loss average of a limited 3kg. Two anti-obesity drugs were approved in June and July 2012, and GBI Research believes that only one, Vivus’ Qsymia, has a strong enough safety and efficacy (average placebo-adjusted weight loss of 5kg at the medium dose) profile to make a significant impact on the market, providing it is proven safe in long-term-use studies. View Detail Report With TOC At : http://www.researchmoz.us/obesity-therapeutics-to-2019-safety-concerns-hinder-drug-performance-despite-large-market-opportunity-report.html

1. Obesity Therapeutics to 2019 - Safety Concerns Hinder Drug Performance Despite Large Market Opportunity
GBI Research, the leading business intelligence provider, has released its latest research: Obesity
Therapeutics to 2019 – Safety Concerns Hinder Drug Performance Despite Large Market
Opportunity”. Obesity is often described as a global endemic, with incidence dramatically increasing
over the past decades, particularly in developed countries. Being overweight or obese is a major risk factor in
the development of many chronic diseases, including cardiovascular diseases, cancer, and diabetes, of which
treatment incurs extensive economic and healthcare costs.
Numerous anti-obesity drugs have been approved in the past decade, including Knoll Pharmaceutical’s
Meridia (sibutramine) and Acomplia (rimonabant), only for them to be removed from the market due to
evidence of suicidal thoughts, depression and cardiovascular problems with their long-term use. As such,
healthcare professionals have a negative perception of such drugs and do not widely prescribe them, a major
barrier to the growth of the anti-obesity therapeutics market. Only orlistat is currently deemed safe for the
long-term treatment of obesity; being proven to produce a placebo-adjusted weight-loss average of a limited
3kg. Two anti-obesity drugs were approved in June and July 2012, and GBI Research believes that only one,
Vivus’ Qsymia, has a strong enough safety and efficacy (average placebo-adjusted weight loss of 5kg
at the medium dose) profile to make a significant impact on the market, providing it is proven safe in
long-term-use studies.
If proven safe, GBI Research expects the sales of Qsymia and other drugs expected to be approved over the
forecast period to increase the market size to $2.7 billion. Although moderate, this is significantly below the
market potential given the size of the prevalence population. Optimally safe and effective anti-obesity drugs
which overcome healthcare professionals’ negative opinions will have to be developed if the size of the
market is ever to reflect the prevalence of obesity.
Scope
The report analyzes the incidence of obesity, current treatment options, pipeline and market forecasts, and
deals surrounding anti-obesity drugs.
The report includes:
A brief introduction to obesity; detailed analysis of recent, current and projected incidence trends;
co-morbidities; economic implications of their treatment; and the current treatment options Analysis of the
currently marketed anti-obesity drugs, including recent sales figures, safety and efficacy data, and a discussion
of each drug’s expected performance within the forecast period Comprehensive reviews of the pipeline
for anti-obesity drugs, including analysis by molecule type and mechanism of action Statistical analysis of
clinical trial duration, size, and failure rate by Phase and molecule type An in-depth forecast model for the
anti-obesity drugs market in the US, UK, France, Germany, Italy, Spain and Japan. Each model is based on the
anticipated market performance of marketed drugs and those expected to be approved within the forecast
period, and takes into account drug cost, efficacy, safety, and likely prescription volumes. A detailed
discussion of the drivers and barriers for this immature market
Reasons to Buy
The report will enhance your decision-making capability by allowing you to:
Understand the large number of potential molecular targets for the development of an anti-obesity drug, as
Obesity Therapeutics to 2019 - Safety Concerns Hinder Drug Performance Despite Large Market Opportunity

2. well as the strengths, weaknesses, and risks of each drug type Gain an in-depth view of the current status of
the anti-obesity drug pipeline, including the most common molecular targets and molecule types in
development Observe the trends in clinical trial duration and size by Phase, molecule type and mechanism of
action, and use the clinical trial failure rate analysis to assess the risk profiles of current and future
developmental programs Assess the potential clinical and commercial impact of current late-stage pipeline
molecules on the anti-obesity drugs market Analyze current and past deals surrounding anti-obesity drugs,
including their value, year of deal and in depth details of the highest value deals
table Of Contents
1 Table Of Contents
1.1 List Of Tables
1.2 List Of Figures
2 Introduction
2.1 Etiology And Pathophysiology
2.2 Classification
2.3 Epidemiology
2.3.1 The Us
2.3.2 Obesity In The Top Five European Markets
2.3.3 Japan
2.4 Comorbidities
2.4.1 Type 2 Diabetes
2.4.2 Hypertension
2.4.3 Dyslipidemia
2.4.4 Respiratory Problems
2.4.5 Osteoarthritis
2.4.6 Cancer Risk
2.5 Economic Burden
2.6 Current Therapy Options
2.6.1 Lifestyle And Behavioral Modifications
2.6.2 Bariatric Surgery
2.6.3 Pharmacotherapy
2.6.4 Treatment Algorithms And Prescription Habits
2.6.5 Method Of Determining Treatment Effectiveness
2.7 Why Develop Therapeutic Anti-obesity Drugs?
2.8 Gbi Research Report Guidance
3 Marketed Products
3.1 Amphetamine-like Drugs
Obesity Therapeutics to 2019 - Safety Concerns Hinder Drug Performance Despite Large Market Opportunity

3. 3.1.1 Overview
3.1.2 Efficacy Profile
3.1.3 Safety Profile
3.2 Qsymia, Vivus, Inc.
3.2.1 Overview
3.2.2 Efficacy Profile
3.2.3 Safety Profile
3.2.4 Discussion
3.3 Orlistat
3.3.1 Overview
3.3.2 Efficacy Profile
3.3.3 Safety Profile
3.3.4 Discussion
3.4 Belviq, Arena Pharmaceuticals
3.4.1 Introduction
3.4.2 Efficacy Profile
3.4.3 Safety Profile
3.4.4 Discussion
3.5 Low Long-term Success Rate Of Marketed Anti-obesity Drugs
3.6 Discussion
4 Pipeline
4.1 Overview Of Pipeline By Phase, Molecule Type And Molecular Target
4.2 Clinical Trial Duration And Size
4.2.1 Clinical Trial Duration
4.2.2 Clinical Trial Size
4.3 Clinical Trial Failure, Attrition Rate And Reasons For Clinical Trial Failure
4.4 Primary And Secondary Endpoints
4.5 Late-stage Drugs Of The Developmental Pipeline
4.5.1 Contrave, Orexigen Therapeutics
4.5.2 Cametor, Norgine Bv
4.5.3 Victoza, Novo Nordisk
4.5.4 Tesofensine (neurosearch)
4.6 Discussion
5 Market Forecasts
5.1 Global Market
5.2 The Us
5.2.1 Epidemiology And Treatment Usage Patterns
5.2.2 Annual Cost Of Therapy
5.2.3 Market Size
Obesity Therapeutics to 2019 - Safety Concerns Hinder Drug Performance Despite Large Market Opportunity

4. 5.3 Europe
5.3.1 Treatment Usage Patterns
5.3.2 Annual Cost Of Therapy
5.3.3 Market Size
5.4 Japan
5.4.1 Treatment Usage Patterns
5.4.2 Annual Cost Of Therapy
5.4.3 Market Forecast
5.5 Discussion
5.6 Drivers And Barriers Of The Anti-obesity Market
5.7 Obesity Market Drivers
5.7.1 Obesity Is A Very Prevalent Disease With Large Potential Target Populations Globally
5.7.2 Recent Approval Of Qsymia To Drive Market Growth Providing Its Long-term Safety Is Proved
5.7.3 Diversification Of Molecular Targets
5.8 Obesity Market Barriers
5.8.1 Low Treatment Rate
5.8.2 Reimbursement Issues
6 Licensing And Co-development Deals
6.1 Licensing Deals
6.1.1 Emd Serono Enters Into Collaboration And Licensing Agreement With Theratechnologies
6.1.2 Amylin Pharma Enters Into Licensing Agreement With Takeda Pharma
6.1.3 Palatin Technologies Extends License Agreement With Astrazeneca
6.1.4 Zealand Pharma Enters Into Licensing And Collaboration Agreement With Boehringer
ingelheim
6.2 Co-development Deals
6.2.1 Isis Enters Into Collaboration Agreement With Ortho-mcneil
6.2.2 Orexigen Therapeutics Enters Into Co-development Agreement With Takeda Pharma For
contrave
7 Appendix
7.1 References
7.2 Abbreviations
7.3 All Pipeline Drugs By Phase
7.3.1 Discovery
7.3.2 Preclinical
7.3.3 Phase I
7.3.4 Phase Ii
7.3.5 Phase Iii
7.3.6 Pre-registration
7.4 Market Forecasts To 2019
Obesity Therapeutics to 2019 - Safety Concerns Hinder Drug Performance Despite Large Market Opportunity

5. 7.4.1 Global
7.4.2 The Us
7.4.3 Uk
7.4.4 France
7.4.5 Germany
7.4.6 Italy
7.4.7 Spain
7.4.8 Japan
7.5 Methodology
7.6 Secondary Research
7.7 Therapeutic Landscape
7.8 Epidemiology-based Forecasting
7.9 Market Size By Geography
7.10 Pipeline Analysis
7.11 Contact Us
7.12 Disclaimer
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Obesity Therapeutics to 2019 - Safety Concerns Hinder Drug Performance Despite Large Market Opportunity