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Gastro-esophageal Reflux Disease (GERD)
overview
GERD Commonly known as heartburn  Backflow of gastric and/or duodenal contents into the esophagus and past the lower esophageal sphincter (LES), without associated belching or vomiting Reflux may cause symptoms or pathologic changes
Persistent reflux can cause reflux esophagitis ,[object Object],Prognosis: varies with the underlying cause
Pathophysiology and Etiology
Normally, gastric contents don't back up into the esophagus because the LES creates enough pressure around the lower end of the esophagus to close it Reflux occurs when LES pressure is deficient or pressure in the stomach exceeds LES pressure When this happens, the LES relaxes, allowing gastric contents to regurgitate into the esophagus
The acidity of gastric content and amount of time in contact with esophageal mucosa are related to the degree of mucosal damage Inflammation and ulceration of the esophagus may result ,[object Object],[object Object]
Agents that lowers LES pressure:  ,[object Object]
Alcohol
Cigarettes
Anticholinergics
Atropine
Belladonna
propantheline
Other drugs
Morphine
Diazepam
calcium channel blockers
meperidine,[object Object]
Reflux esophagitis ,[object Object],Esophageal stricture Esophageal ulcer ,[object Object],Barrett’s esophagus ,[object Object],[object Object]
Clinical manifestations
Heartburn (pyrosis) ,[object Object]
typically occurring 30-60 min after meals and with reclining positions
complaints of spontaneous reflux (regurgitation) of sour or bitter gastric contents into the mouthOther typical symptoms: Globus (sensation of something in throat) Mild epigastric pain Dyspepsia Nausea and/or vomiting
Dysphagia ,[object Object],Atypical symptoms: ,[object Object]
Hoarseness
Recurrent sore throat
Frequent throat clearing
Chronic cough
Dental enamel loss
Bronchospasm (asthma/wheezing)
Odynophagia (sharp substernal pain on swallowing),[object Object]
Dysphagia                   rule out
Odynophagia               cancer
GI bleeding                  or
shortness of breath      esophageal
weight loss                  stricture,[object Object]
Uncomplicated GERD ,[object Object],Endoscopy ,[object Object],Biopsy  ,[object Object],Esophagealmanometry ,[object Object],[object Object]
done before a pH probe for determination of correct catheter placementAcid perfusion (Bernstein test) ,[object Object]
differentiates between cardiac and noncardiac chest pain,[object Object]
determines the amount of gastroesophageal acid reflux and has a 70% to 90% specificity rateBarium esophagography ,[object Object],[object Object]
Lifestyle Modifications
Head of bed raised 6-8 inches (15-20 cm) Do not lie down for 3 to 4 hours after eating - time frame for greatest reflux Bland diet ,[object Object],[object Object]
Pharmacologic treatment
Antacids ,[object Object]
Use on an as-needed basis
Provide symptomatic relief but do not heal esophageal lesionsHistamine-2 (H2) receptor antagonists ,[object Object]
Provide symptomatic relief
May require lifelong therapy

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Gastroesophageal Reflux Disease (GERD)