regulation of cardiac out put

Addis Ababa University Collage of Health Science Department of Physiology By : Robel Abay September 19 09/30/11 Regulation of cardiac out put

Objectives ,[object Object],[object Object],[object Object],09/30/11

Cardiac output ,[object Object],[object Object],[object Object],09/30/11

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],09/30/11

Normal values cont… ,[object Object],[object Object],09/30/11

Regulation of cardiac out put ,[object Object],[object Object],09/30/11

Regulation cont…. ,[object Object],[object Object],[object Object],09/30/11

Venous Return ,[object Object],[object Object],09/30/11

Factors aiding venous return ,[object Object],[object Object],[object Object],[object Object],09/30/11

Factors resisting venous return ,[object Object],[object Object]

[object Object],[object Object],09/30/11

Regulation cont…. ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],09/30/11

Determinants of cardiac output ,[object Object],[object Object],[object Object],[object Object],09/30/11

Cardiac output is controlled by venous return ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],09/30/11

Factors effecting cardiac performance 09/30/11 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Factors affecting preload ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],09/30/11

Factors Affecting End-diastolic Volume Ventricular EVD Ventricular performance Total blood volume Body position Intrathoracic pressure Atrial contrib. to vent. filling Pumping action to skeletal muscle Venous tone Intrapericardial pressure ventricular compliance STRETCHING OF MYOCARDIUM 09/30/11

Preload vs Afterload Venules / veins Arterioles Capacitance vessels Resistance vessels Affect preload Affect afterload 09/30/11

Regulation of heart rate ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],09/30/11 +25 0 -25 -50 -75 mV

Regulation of heart rate ,[object Object],[object Object],[object Object],[object Object],[object Object],09/30/11 +25 0 -25 -50 -75 mV

Effect of Bainbridge and Baroreceptor Reflex on HR Intravenous infusion Increased right atrial pressure Stimulate atrial receptors Bainbridge reflex Increased cardiac output Increased arterial pressure Baroreceptor reflex Heart rate 09/30/11

C. Humoral regulation HR/CO INSULIN THYROID GLUCAGON CATECHOLAMINES STEROIDS POTENTIATION

CARDIAC OUTPUT HEART RATE MYOCARDIAL CONTRACTILITY PRELOAD AFTERLOAD CARDIAC FACTORS COUPLING FACTORS 09/30/11

Reference ,[object Object],[object Object],[object Object],09/30/11

regulation of cardiac out put

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