S CdiferenciacióNpormatriz

Stem Cells ,[object Object],[object Object],April 22, 2009

Stem Cells: What are they? ,[object Object],[object Object],[object Object],[object Object],[object Object],http://www.brown.edu/Courses/BI0032/adltstem/adult-stem-cell.gif

Stem Cells: Types ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Pluripotent Stem Cells ,[object Object],[object Object],[object Object],[object Object],[object Object],http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675(06)70552-6

Pluripotent Stem Cells ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Pluripotent Stem Cells ,[object Object],[object Object],[object Object],[object Object]

Adult Stem Cells ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Adult Stem Cells ,[object Object],[object Object],[object Object],Adult stem cell from bone marrow (http://www.rochester.edu/pr/Review/V69N1/feature1.html)

Progress ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Progress ,[object Object],[object Object],[object Object],Product Description Disease Treatment Stage GRNOPC1 hESC-derived Oligodendrocytes Spinal Cord Injury Clinical (Phase I) GRNCM1 hESC-derived cardiomyocytes Heart Disease Preclinical GRNIC1 hESC-derived Islets Osteoblasts Chondrocytes hESC-Derived cells for drug screening Immature dendritic cells Type I Diabetes Osteoporosis Osteoarthritis Liver disease Immune Rejection Research GRNVAC2 Mature Dendritic Cells Cancer Immunotherapy Product Research

Therapeutic Challenges ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Controlling Differentiation ,[object Object],[object Object]

Introduction ,[object Object],[object Object],[object Object],[object Object],[object Object],http://www.umdnj.edu/gsbsnweb/stemcell/scofthemonth/2007/msc/1.jpg

Effect of microenvironment ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Effect of matrix elasticity ,[object Object],[object Object],[object Object],[object Object],Mechanotransduction of endothelial shear stress ( http://content.onlinejacc.org/cgi/content-nw/full/j.jacc.2007.02.059v1/FIG4 )

How? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Matrix Elasticity ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Results ,[object Object],[object Object],[object Object],[object Object],[object Object]

Matrix can specify lineage ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Soluble factors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Soluble Factors ,[object Object],[object Object],[object Object],[object Object]

Focal Adhesions ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Conclusions ,[object Object],[object Object],[object Object]

References/Citations ,[object Object],[object Object],[object Object],[object Object]

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