Development & anomalies respiratory system embryology

1. Maj Rishi Pokhrel, MD
Anatomy
NAIHS
www.slideshare.net

2. What triggers labor of childbirth?

3. Respiratory diverticulum
25 Day embryo

4. Partition of tubes

5. Larynx
6 week 12 week
4th arch: superior laryngeal N 6th arch: superior laryngeal N

6. Trachea, bronchi & lungs
Prenatal: 17 generations
Postnatal: 6 generations

7. • Epithelium: endoderm
• Cartilage, muscles, connective tissue:
mesoderm

8. Pleural cavity

9. Maturation of lungs

10. DEVELOPMENT OF DIAPHRAGM

11. Defects in partition of foregut
esophageal atresia / Tracheo-esophagal fistula
Total Incidence: 1/3000
90%
4%4%
1% 1%

12. VACTERAL association
• V: Vertebral anomalies
• A: Anal atresia
• C: cardiac defects
• E: esophageal atresia
• R: renal anomalies
• L: limb defects

13. • Respiratory distress syndrome / hyaline
membrane disease
• Ectopic lung lobes
• Congenital cysts of lungs

14. Assignment
• Poly-hydraminos?
• Oligo-hydraminos?