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Mouth
Oral (buccal) cavity
– Bounded by lips, cheeks, palate, and tongue
– Lined with stratified squamous epithelium
Functions
– Ingestion
– Mechanical digestion
– Chemical digestion
– Propulsion
4. © 2013 Pearson Education, Inc.
Figure 23.7a Anatomy of the oral cavity (mouth).
Palatoglossal
arch
Soft
palate
Hard
palate
Oral cavity
Palatine
tonsil
Tongue
Oropharynx
Lingual tonsil
Epiglottis
Hyoid bone
Laryngopharynx
Esophagus
Trachea
Uvula
Sagittal section of the oral cavity and pharynx
5. © 2013 Pearson Education, Inc.
Figure 23.7b Anatomy of the oral cavity (mouth).
Gingivae
(gums)
Palatine
raphe
Hard
palate
Soft
palate
Palatine
tonsil
Sublingual
fold with
openings of
sublingual
ducts
Oral vestibule
Lower lip
Uvula
Upper lip
Superior
labial
frenulum
Palatoglossal
arch
Palatopharyngeal
arch
Posterior wall
of oropharynx
Tongue
Lingual frenulum
Opening of
Submandibular
duct
Gingivae (gums)
Inferior labial
frenulum
Anterior view
6. © 2013 Pearson Education, Inc.
Tongue
Skeletal muscle
Functions include
– Repositioning and mixing food during chewing
– Formation of bolus
– Initiation of swallowing, speech, and taste
Intrinsic muscles change shape of tongue
Extrinsic muscles alter tongue's position
Lingual frenulum: attachment to floor of mouth
7. © 2013 Pearson Education, Inc.
Tongue
Surface bears papillae
– Some contain taste buds
– All help give traction on food
8. © 2013 Pearson Education, Inc.
Figure 23.8 Dorsal surface of the tongue, and the tonsils.
Epiglottis
Palatopharyngeal
arch
Palatine tonsil
Lingual tonsil
Palatoglossal
arch
Terminal sulcus
Foliate papillae
Vallate papilla
Medial sulcus
of the tongue
Dorsum of tongue
Fungiform papilla
Filiform papilla
9. © 2013 Pearson Education, Inc.
Salivary Glands
• Lie outside oral cavity
• Parotid
• Submandibular
• Sublingual
Functions of saliva
• Cleanses mouth
• Dissolves food chemicals for taste
• Moistens food; compacts into bolus
• Begins breakdown of starch with enzymes
10. © 2013 Pearson Education, Inc.
Figure 23.9 The salivary glands.
Tongue
Teeth
Frenulum
of tongue
Mylohyoid
muscle (cut)
Anterior belly of
digastric muscle
Masseter muscle
Body of mandible
(cut)
Posterior belly of
digastric muscle
Serous cells
forming demilunes
Mucous cells
Parotid
gland
Submandibular
duct
Submandibular
gland
Ducts of
sublingual
gland
Sublingual
gland
Parotid duct
11. © 2013 Pearson Education, Inc.
Salivary Glands
• Two types of secretory cells
– Serous cells
• Watery, enzymes, ions, bit of mucin
– Mucous cells
• Mucus
• Parotid, submandibular glands mostly
serous; sublingual mostly mucous
12. © 2013 Pearson Education, Inc.
• 97–99.5% water, slightly acidic
– Electrolytes—Na+, K+, Cl–, PO4
2–, HCO3–
– Salivary amylase and lingual lipase
– Mucin
– Metabolic wastes—urea and uric acid
– Lysozyme, IgA, defensins, and a cyanide
compound protect against microorganisms
PLAY Animation: Rotating head
Composition of Saliva
13. © 2013 Pearson Education, Inc.
Control of Salivation
• 1500 ml/day
• Intrinsic glands continuously keep mouth moist
• Major salivary glands activated by
parasympathetic nervous system when
– Ingested food stimulates chemoreceptors and
mechanoreceptors in mouth
– Salivatory nuclei in brain stem send impulses along
parasympathetic fibers in cranial nerves VII and IX
• Strong sympathetic stimulation inhibits salivation
and results in dry mouth (xerostomia)
14. © 2013 Pearson Education, Inc.
Teeth
Mechanical digestion
• Incisors cut
• Canines tear or pierce
• Premolars (bicuspids) grind & crush
• Molars grind & crush
15. © 2013 Pearson Education, Inc.
Figure 23.10 Human dentition.
Incisors
Central (6–8 mo)
Lateral (8–10 mo)
Canine (eyetooth)
(16–20 mo)
Molars
First molar
(10–15 mo)
Second molar
(about 2 yr)
Incisors
Central (7 yr)
Lateral (8 yr)
Canine (eyetooth)
(11 yr)
Premolars
(bicuspids)
First premolar
(11 yr)
Second premolar
(12–13 yr)
Molars
First molar (6–7 yr)
Second molar
(12–13 yr)
Third molar
(wisdom tooth)
(17–25 yr)
Permanent
teeth
Deciduous
(milk) teeth
16. © 2013 Pearson Education, Inc.
Number and types of Teeth
Primary:
Permanent:
17. © 2013 Pearson Education, Inc.
Figure 23.11 Longitudinal section of a canine tooth within its bony socket (alveolus).
Enamel
Dentin
Dentinal
tubules
Pulp cavity
(contains
blood vessels
and nerves)
Gingival
sulcus
Gingiva
(gum)
Cement
Root canal
Periodontal
ligament
Apical
foramen
Bone
Crown
Neck
Root
18. College or Department name here
Tooth & gum disease
Cavities (dental caries) due to destruction of
enamel & dentin by lactic acid made by
bacteria digesting sugar in a film on tooth
surface.
Periodontal (gum) disease: affects up to 95%
over age 35, accounts for 80-90% of adult
tooth loss. Due to bacterial infection btn tooth
& gum, preventable by flossing & brushing.
19. College or Department name here
Pharynx = throat, passes air and food via
sequential contraction of muscles
20. College or Department name here
Esophagus
• Carries food from throat to stomach,
collapsed when empty
• Diaphragm and esophageal sphincter (and
gravity) keep food in stomach
• Heartburn: often due to "gastroesophageal
(GE) reflux" (stomach contents spurting up
into esophagus), which can be caused by
hiatal hernia (top of stomach protrudes
above diaphragm)
21. © 2013 Pearson Education, Inc.
Deglutition=swallowing
• Involves coordinated contraction of
muscles in tongue, soft palate, pharynx,
esophagus
• Buccal phase
– Voluntary contraction of tongue
• Pharyngeal-esophageal phase
– Involuntary – primarily vagus nerve
– Control center in the medulla and lower pons
22. Figure 23.13 Deglutition (swallowing)
Bolus of food
Tongue
Pharynx
Epiglottis
Glottis
Trachea
During the buccal phase, the upper
esophageal sphincter is contracted.
The tongue presses against the hard
palate, forcing the food bolus into the
oropharynx.
1
Uvula
Bolus
Epiglottis
Esophagus
The pharyngeal-esophageal phase
begins as the uvula and larynx rise to prevent
food from entering respiratory passageways.
The tongue blocks off the mouth. The upper
esophageal sphincter relaxes, allowing food
to enter the esophagus.
The constrictor muscles of the
pharynx contract, forcing food into
the esophagus inferiorly. The upper
esophageal sphincter contracts
(closes) after food enters.
Peristalsis moves
food through the
esophagus to the
stomach.
The gastroesophageal
sphincter surrounding the
cardial oriface opens, and
food enters the stomach.
Relaxed muscles
Circular muscles
contract
Bolus of food
Longitudinal muscles
contract
Gastroesophageal
sphincter closed
Relaxed
muscles
Circular muscles contract
Gastroesophageal
sphincter opens
Upper
esophageal
sphincter
Bolus
2
4
3
5
Stomach
23. © 2013 Pearson Education, Inc.
Stomach: Gross Anatomy
Cardia
Fundus
Body
Pyloric region
Pyloric sphincter (valve)
24. © 2013 Pearson Education, Inc.
Figure 23.14a Anatomy of the stomach.
Cardia
Esophagus
Muscularis
externa
Lesser
curvature
Duodenum
Pyloric sphincter
(valve) at pylorus
Pyloric
canal
Pyloric
antrum
Greater
curvature
Rugae of
mucosa
Lumen
Body
Serosa
Fundus
• Oblique layer
• Circular layer
• Longitudinal layer
25. © 2013 Pearson Education, Inc.
Figure 23.30b Mesenteries of the abdominal digestive organs.
Liver
Lesser omentum
Small intestine
Cecum
Urinary bladder
Gallbladder
Stomach
Duodenum
Transverse colon
26. © 2013 Pearson Education, Inc.
Greater omentum
Transverse colon
Transverse
mesocolon
Descending colon
Mesentery
Sigmoid
mesocolon
Jejunum
Sigmoid colon
Ileum
Figure 23.30c Mesenteries of the abdominal digestive organs.
27. © 2013 Pearson Education, Inc.
Surface
epithelium
Mucosa Lamina
propria
Muscularis
mucosae
Oblique
layer
Circular
layer
Longitudinal
layer
Submucosa
(contains
submucosal
plexus)
Muscularis
externa
(contains
myenteric
plexus)
Serosa
Layers of the stomach wall
Stomach wall
Figure 23.15a Microscopic anatomy of the stomach.
28. © 2013 Pearson Education, Inc.
Enteroendocrine cell
Enlarged view of gastric pits and
gastric glands
Chief cell
Parietal cell
Mucous neck cells
Surface epithelium
(mucous cells)
Gastric pits
Gastric
pit
Gastric
gland
Figure 23.15b Microscopic anatomy of the stomach.
29. © 2013 Pearson Education, Inc.
Figure 23.15c Microscopic anatomy of the stomach.
Mitochondria
Parietal cell
Chief cell
Enteroendocrine
cell
Location of the HCl-producing parietal cells
and pepsin-secreting chief cells in a gastric
gland
HCI
Pepsin
Pepsinogen
30. © 2013 Pearson Education, Inc.
Gastric Gland Secretions
• Parietal cells
• Hydrochloric acid (HCl): pH 1.5–3.5 denatures
protein, activates pepsin, breaks down plant cell
walls, kills bacteria
• Intrinsic factor
• Glycoprotein required for vitamin B12 absorption
• Chief cells
• Pepsinogen: Inactive protease; activated to pepsin by
HCl and by pepsin itself (positive feedback)
• Lipases
• Enteroendocrine cells
• Serotonin1, histamine1, somatostatin1,2, gastrin2
1. Paracrine (acts locally); 2. Hormone
31. © 2013 Pearson Education, Inc.
Mucosal Barrier
• Harsh digestive conditions in stomach
• Has mucosal barrier to protect
– Thick layer of bicarbonate-rich mucus
– Tight junctions between epithelial cells
• Prevent juice seeping underneath tissue
– Damaged epithelial cells quickly replaced by
division of stem cells
• Surface cells replaced every 3–6 days
32. © 2013 Pearson Education, Inc.
Homeostatic Imbalance
• Gastritis
– Inflammation caused by anything that
breaches mucosal barrier
• Peptic or gastric ulcers
– Erosions of stomach wall
• Can perforate peritonitis; hemorrhage
– Most caused by Helicobacter pylori bacteria
– Some by NSAIDs
33. © 2013 Pearson Education, Inc.
Figure 23.16 Photographs of a gastric ulcer and the H. pylori bacteria that most commonly cause it.
A gastric ulcer lesion H. pylori bacteria
Bacteria
Mucosa
layer of
stomach
34. © 2013 Pearson Education, Inc.
Digestive Processes in the Stomach
• Mechanical breakdown
• Chemical digestion
– Denaturation of proteins by HCl
– Enzymatic digestion of proteins by pepsin
• Propulsion: delivers chyme to small
intestine
• Absorption: alcohol, aspirin, secretion of
intrinsic factor for B12 absorption in S.I.
35. © 2013 Pearson Education, Inc.
Neural & Hormonal Regulation
of Gastric Secretion
• Neural
– Vagus nerve activity secretion
– Sympathetic activity secretion
• Hormonal
– Gastrin
• Gastrin ⇒ enzyme and HCl secretion
• Most small intestine secretions are gastrin
antagonists
36. © 2013 Pearson Education, Inc.
Phases of Gastric Secretion
• Cephalic (reflex) phase: conditioned reflex
triggered by aroma, taste, sight, thought
• Gastric phase: 3–4 hours
– Stimulated by gastrin (from G cells),
distension, peptides, low acidity
• Intestinal phase
– Chyme entering S.I. is initially and briefly
stimulatory to stomach
– Later, chyme in SI inhibits stomach
secretion: enterogastric reflex
– Too much chyme entering SI ⇒ dumping
syndrome (nausea, vomiting), common
after gastric reduction surgery
37. Figure 23.17 Neural and hormonal regulation of gastric secretion
Lack of
stimulatory
impulses to
parasym-
pathetic
center
Gastrin
secretion
declines
Overrides
parasym-
pathetic
controls
Sympathetic
nervous
system
activation
Cerebral
cortex
G cells
Emotional
stress
Excessive
acidity
(pH < 2)
in stomach
Loss of
appetite,
depression
Entero-
gastric
reflex
Local
reflexes
Pyloric
sphincter
Vagal
nuclei
in medulla
Distension
of duodenum;
presence of
fatty, acidic, or
hypertonic
chyme; and/or
irritants in
the duodenum
Release of
enterogastrones
(secretin, cholecystokinin,
vasoactive intestinal
peptide)
Distension;
presence of
fatty, acidic,
partially
digested food
in the
duodenum
Intestinal
(enteric)
gastrin
release
to blood
Brief
effect
Gastrin
release
to blood
Vagus
nerve
Vagus
nerve
Conditioned reflex
Local
reflexes
Vagovagal
reflexes
G cells
Presence of
partially digested
foods in duodenum
or distension of the
duodenum when
stomach begins to
empty
Stimulate
Inhibit
Hypothalamus
and medulla
oblongata
Cerebral cortex
Medulla
Stomach
distension
activates
stretch
receptors
Food chemicals
(especially peptides and
caffeine) and rising pH
activate chemoreceptors
Stimulation of
taste and smell
receptors
Sight and thought
of food
1
1
2
1
2
1
2
1
2
1
Stimulatory events Inhibitory events
Cephalic
phase
Gastric
phase
Intestinal
phase
Stomach
secretory
activity
38. © 2013 Pearson Education, Inc.
Response of the Stomach to Filling
• Stretches to accommodate incoming food
– Pressure constant until 1.5 L food ingested
• Reflex-mediated receptive relaxation
– Coordinated by swallowing center of brain stem
– Gastric accommodation
• Plasticity (stress-relaxation response) of smooth
muscle (see Chapter 9)
39. © 2013 Pearson Education, Inc.
Gastric Contractile Activity
• Peristaltic waves move toward pylorus at
rate of 3 per minute
• Distension and gastrin increase force of
contraction
• Most vigorous near pylorus
40. © 2013 Pearson Education, Inc.
Figure 23.19 Deglutition (swallowing). Slide 1
Pyloric
valve
closed
Pyloric
valve
slightly
opened
Pyloric
valve
closed
Grinding: The most
vigorous peristalsis and
mixing action occur close to
the pylorus.
Retropulsion: The pyloric
end of the stomach acts as a
pump that delivers small amounts
of chyme into the duodenum,
simultaneously forcing most of its
contained material backward into
the stomach.
2
Propulsion: Peristaltic
waves move from the fundus
toward the pylorus.
1 3
41. © 2013 Pearson Education, Inc.
Small Intestine: Gross Anatomy
• Major organ of digestion and absorption
• 2-4 m long; from pyloric sphincter to
ileocecal valve
• Subdivisions
– Duodenum (retroperitoneal)
– Jejunum (attached posteriorly by mesentery)
– Ileum (attached posteriorly by mesentery)
42. © 2013 Pearson Education, Inc.
Figure 23.1 Alimentary canal and related accessory digestive organs.
Mouth (oral cavity)
Tongue*
Esophagus
Liver*
Gallbladder*
Small
intestine
Salivary
glands*
Pharynx
Stomach
Pancreas*
Large
intestine
(Spleen)
Parotid gland
Sublingual gland
Submandibular gland
Duodenum
Jejunum
Ileum
Anus
Transverse colon
Descending colon
Ascending colon
Cecum
Sigmoid colon
Rectum
Appendix
Anal canal
43. © 2013 Pearson Education, Inc.
Figure 23.21 The duodenum of the small intestine, and related organs.
Right and left
hepatic ducts
of liver
Common hepatic duct
Bile duct and sphincter
Accessory pancreatic duct
Tail of pancreas
Pancreas
Jejunum
Main pancreatic duct and sphincter
Head of pancreas
Hepatopancreatic
ampulla and sphincter Duodenum
Mucosa
with folds
Gallbladder
Major duodenal
papilla
Cystic duct
44. © 2013 Pearson Education, Inc.
Small Intestine
• Duodenum
0.25 m long; receives bile & pancreatic
enzymes; common bile duct, main pancreatic
duct join at hepatopancreatic ampulla, enter
duodenum at major duodenal papilla, controlled
by hepatopancreatic sphincter
• Jejunum
2.5 m long
• Ileum
3.6 m long; joins large intestine at ileocecal
valve
45. © 2013 Pearson Education, Inc.
Small Intestine
• Innervated by vagus nerve
(parasympathetic) and sympathetics from
thoracic splanchnic nerves
• Blood supply: Superior mesenteric artery
• Portal circulation
– Capillaries to portal vein to more capillaries:
– Nutrient-rich blood from small intestine caps
goes by hepatic portal vein to liver & liver
capillaries
46. © 2013 Pearson Education, Inc.
Structural Features to
Increase Surface Area
• Circular folds
Permanent folds (~1 cm deep) force chyme to
slowly spiral through lumen, increases nutrient
absorption
• Villi
Extensions (~1 mm high) of mucosa with
capillary bed and lacteal for absorption
• Microvilli (brush border)
Contain enzymes for carbohydrate and protein
digestion
47. © 2013 Pearson Education, Inc.
Figure 23.22a Structural modifications of the small intestine that increase its surface area for digestion and
absorption.
Vein carrying
blood to
hepatic portal
vessel
Muscle
layers
Circular
folds
Villi
Lumen
48. © 2013 Pearson Education, Inc.
Microvilli
(brush border)
Absorptive
cells
Villus
Lacteal
Goblet
cell
Blood
capillaries
Mucosa-
associated
lymphoid
tissue
Intestinal
crypt
Muscularis
mucosae
Duodenal
gland
Enteroendocrine
cells
Venule
Lymphatic vessel
Submucosa
Figure 23.22b Structural modifications of the small intestine that increase its surface area for digestion and
absorption.
49. © 2013 Pearson Education, Inc.
Figure 23.22c Structural modifications of the small intestine that increase its surface area for digestion and
absorption.
Goblet
cells
Absorptive cells
Villi
Intestinal crypt
50. © 2013 Pearson Education, Inc.
Homeostatic Imbalance
• Chemotherapy targets rapidly dividing
cells
– Kills cancer cells
– Kills rapidly dividing GI tract epithelium
nausea, vomiting, diarrhea
51. © 2013 Pearson Education, Inc.
Mucosa
• Peyer's patches protect especially distal
part against bacteria
– May protrude into submucosa
• B lymphocytes leave intestine, enter
blood, protect intestinal lamina propria with
their IgA
• Duodenal (Brunner's) glands of the
duodenum secrete alkaline mucus to
neutralize acidic chyme
52. © 2013 Pearson Education, Inc.
Intestinal Juice
• 1-2 L secreted daily in response to
distension or irritation of mucosa
• Slightly alkaline; isotonic with blood
plasma
• Largely water; enzyme-poor (enzymes of
small intestine only in brush border);
contains mucus
• Facilitates transport and absorption of
nutrients
53. © 2013 Pearson Education, Inc.
Accessory Organs:
Liver and Gallbladder
• Liver
– Many functions
– Digestive function: produce bile (emulsify fats)
– Largest gland
• Gallbladder
– Chief function: store bile
55. Right and left
hepatic ducts
of liver
Common hepatic duct
Bile duct and sphincter
Accessory pancreatic duct
Tail of pancreas
Pancreas
Jejunum
Main pancreatic duct and sphincter
Head of pancreas
Hepatopancreatic
ampulla and sphincter Duodenum
Mucosa
with folds
Gallbladder
Major duodenal
papilla
Cystic duct
Figure 23.21 Liver, Pancreas, Duodenum
56. © 2013 Pearson Education, Inc.
Figure 23.25a–b Microscopic anatomy of the liver.
Lobule Central
vein
Connective
tissue septum
57. © 2013 Pearson Education, Inc.
Liver: Microscopic Anatomy
• Portal triad at each corner of lobule
– Branch of hepatic artery supplies oxygen
– Branch of hepatic portal vein brings nutrient-rich
blood
– Bile duct receives bile from bile canaliculi
• Liver sinusoids - leaky capillaries between
hepatic plates
58. © 2013 Pearson Education, Inc.
Interlobular veins
(to hepatic vein)
Central vein
Sinusoids
Plates of
hepatocytes
Portal vein
Stellate macrophages
in sinusoid walls
Bile canaliculi
Bile duct (receives
bile from bile
canaliculi)
Fenestrated
lining (endothelial
cells) of sinusoids
Bile duct
Portal venule
Hepatic arteriole
Portal triad
Microscopic anatomy of the liver
59. Jean Louis Cesar Lair, 1819
Hepatocytes
• Abundant rough &
smooth ER, Golgi,
mitochondria
• Process bloodborne
nutrients
• Store fat-soluble
vitamins
• Detoxification
• Produce ~900 ml bile
per day
• Regenerative capacity
60. © 2013 Pearson Education, Inc.
Homeostatic Imbalance
• Hepatitis
– Usually viral infection, drug toxicity, wild
mushroom poisoning
• Cirrhosis
– Progressive, chronic inflammation from
chronic hepatitis or alcoholism
– Liver fatty, fibrous portal hypertension
• Liver transplants successful, but livers
scarce
61. © 2013 Pearson Education, Inc.
Bile
• Yellow-green, alkaline solution containing
– Bile salts = compounds derived from
cholesterol. Help emulsify & absorb lipids.
– Bilirubin = pigment formed from heme
• Brown color of feces due to bilirubin, after bacteria
convert it to stercobilin
– Cholesterol
– Triglycerides, phospholipids, electrolytes
– Water
62. © 2013 Pearson Education, Inc.
The Gallbladder
• Thin-walled muscular sac on ventral
surface of liver
• Stores and concentrates bile by absorbing
water and ions
• Muscular contractions release bile via
cystic duct, which flows into bile duct
• “Biliary tree” = gall bladder plus the ducts
63. Gallstones
• Cholelithiasis = gallstone formation
• “Stones” are crystals of compounds found in bile
• Most gallstones are cholesterol stones
– Bile salts help keep cholesterol in solution
– Cholesterol stones more likely to form if bile is low in bile salts
• Obstruct flow of bile from gallbladder
• May cause pain, obstructive jaundice, fat
malabsorption, diarrhea, …
• Tx: drugs, lithotripsy, minimally invasive removal
• If recurrent: cholecystectomy = gall bladder removal
– Many patients do OK without a gall bladder (must modify diet)
– Some have pain, diarrhea, bloating, etc
64. © 2013 Pearson Education, Inc.
Pancreas
• Mostly retroperitoneal, deep to greater
curvature of stomach; head by duodenum,
tail by spleen
• Endocrine: pancreatic islets secrete insulin
and glucagon
• Exocrine: secretes pancreatic juice
– To duodenum via main pancreatic duct
– Zymogen granules contain proenzymes
– Secreted in inactive form, activated in gut
66. © 2013 Pearson Education, Inc.
Pancreatic Juice
• 1200-1500 ml/day, alkaline (pH 8, HCO3
-)
neutralizes chyme
• Enzymes
– Amylase, lipases, nucleases secreted in
active form but require ions or bile for optimal
activity
– Proteases secreted in inactive form, activated
in duodenum
– Trypsinogen activated to trypsin by brush
border enzyme enteropeptidase
– Procarboxypeptidase, chymotrypsinogen
activated by trypsin
67. © 2013 Pearson Education, Inc.
Figure 23.27 Activation of Pancreatic Proteases in Small Intestine
Stomach
Pancreas
Epithelial
cells
Membrane-bound
enteropeptidase
Trypsinogen
(inactive)
Chymotrypsinogen
(inactive)
Procarboxypeptidase
(inactive)
Trypsin
Chymotrypsin
Carboxypeptidase
68. © 2013 Pearson Education, Inc.
Regulation of Bile Secretion
• Bile secretion stimulated by secretin from
intestinal cells
• Gallbladder contraction stimulated by
– Cholecystokinin (CCK) from intestinal cells
exposed to acidic, fatty chyme
– Vagal activity
• CCK also causes
– Secretion of pancreatic juice
– Hepatopancreatic sphincter to relax
69. © 2013 Pearson Education, Inc.
Regulation of Pancreatic Secretion
• CCK induces secretion of enzyme-rich
pancreatic juice by acini
• Secretin causes secretion of bicarbonate-
rich pancreatic juice by duct cells
• Vagal stimulation also causes release of
pancreatic juice (minor stimulus)
70. Promotion of Bile and Pancreatic Juice
Secretion and Release
1. Chyme entering
duodenum
causes duodenal
enteroendocrine
cells to release
cholecystokinin
(CCK) and
secretin.
2. CCK (red dots)
and secretin
(yellow dots)
enter blood.
3. CCK, secretin
induce pancreatic
juice secretion.
4. Bile salts &
secretin stimulate
liver to produce
more bile.
5. CCK causes
gallbladder to
contract and
hepatopancreatic
sphincter to
relax; bile enters
duodenum.
6. During cephalic
and gastric phases,
vagus nerve
activity causes
weak gallbladder
contractions.
CCK secretion
Secretin secretion
Figure 23.28
71. © 2013 Pearson Education, Inc.
Digestion in the Small Intestine
• Chyme from stomach contains
– Partially digested carbohydrates and proteins
– Undigested fats
• 3–6 hours in small intestine
– Most water absorbed
– ~ All nutrients absorbed
• Small intestine, like stomach, no role in
ingestion or defecation
72. © 2013 Pearson Education, Inc.
Requirements for Digestion and Absorption
in the Small Intestine
• Slow delivery of acidic, hypertonic chyme
• Delivery of bile, enzymes, and bicarbonate
ions from liver and pancreas
• Mixing
73. © 2013 Pearson Education, Inc.
Motility of the Small Intestine
• Segmentation
– Most common motion of small intestine
– Initiated by intrinsic pacemaker cells
– Mixes/moves contents toward ileocecal valve
– Intensity altered by long & short reflexes;
hormones
• Parasympathetic ; sympathetic
– Wanes in late intestinal (fasting) phase
74. © 2013 Pearson Education, Inc.
Motility of the Small Intestine
• Peristalsis
– Initiated by rise in hormone motilin in late
intestinal phase; every 90–120 minutes
– Each wave starts distal to previous
• Migrating motor complex
– Meal remnants, bacteria, and debris moved to
large intestine
– From duodenum ileum ~ 2 hours
75. © 2013 Pearson Education, Inc.
Figure 23.3a Peristalsis and segmentation.
From
mouth
Peristalsis: Adjacent segments of alimentary
tract organs alternately contract and relax,
moving food along the tract distally.
76. © 2013 Pearson Education, Inc.
Motility of the Small Intestine
• Local enteric neurons coordinate intestinal
motility
• Cholinergic sensory neurons may activate
myenteric plexus
– Causes contraction of circular muscle
proximally and of longitudinal muscle distally
– Forces chyme along tract
77. © 2013 Pearson Education, Inc.
Motility of the Small Intestine
• Ileocecal sphincter relaxes, admits
chyme into large intestine when
– Gastroileal reflex enhances force of
segmentation in ileum
– Gastrin increases motility of ileum
• Ileocecal valve flaps close when chyme
exerts backward pressure
– Prevents regurgitation into ileum
78. © 2013 Pearson Education, Inc.
Large Intestine
Cecum: connects to ileum at ileocecal valve
Appendix: part of MALT of immune system
Colon: more below
Rectum
Anal canal
• Opens to body exterior at anus
• Internal anal sphincter—smooth muscle
• External anal sphincter—skeletal muscle
79. © 2013 Pearson Education, Inc.
Unique features of Large Intestine
• Teniae coli
Three bands of longitudinal smooth muscle in
muscularis
• Haustra
Pocketlike sacs created by tone of teniae coli
• Epiploic appendages
Fat-filled pouches of visceral peritoneum
80. © 2013 Pearson Education, Inc.
Figure 23.29a Large Intestine
Right colic
(hepatic) flexure
Transverse colon
Superior
mesenteric artery
Ascending colon
IIeum
IIeocecal valve
Cecum
Appendix
Left colic
(splenic) flexure
Transverse
mesocolon
Epiploic
appendages
Descending colon
Cut edge of
mesentery
Tenia coli
Sigmoid colon
Rectum
Anal canal External anal sphincter
Haustrum
81. © 2013 Pearson Education, Inc.
Colon
• Retroperitoneal except for transverse and
sigmoid regions
• Ascending colon (right side – to level of
right kidney)
• Transverse colon
• Descending colon
• Sigmoid colon in pelvis rectum
83. Figure 23.30d Mesenteries of the Abdomen
Liver
Lesser omentum
Pancreas
Stomach
Duodenum
Transverse mesocolon
Transverse colon
Mesentery
Greater omentum
Jejunum
Ileum
Visceral peritoneum
Parietal peritoneum
Urinary bladder
Rectum
84. Figure 23.29b Rectum and Anus
Rectum
Hemorrhoidal
veins
Anal canal
External anal
sphincter
Internal anal
sphincter
Anus
85. © 2013 Pearson Education, Inc.
Bacterial Flora
• Enter from small intestine or anus
– Colonize colon
– Synthesize B complex vitamins and vitamin K
– Metabolize some host-derived molecules
(mucin, heparin, hyaluronic acid)
– Ferment indigestible carbohydrates
– Release irritating acids and gases (~500
ml/day)
86. © 2013 Pearson Education, Inc.
Digestive Processes in the Large Intestine
• Residue remains in large intestine 12–24
hours
• No food breakdown except by enteric
bacteria
• Vitamins (made by bacterial flora), water,
and electrolytes (especially Na+ and Cl–)
reclaimed
• Major functions - propulsion of feces to
anus; defecation
• Colon not essential for life
87. © 2013 Pearson Education, Inc.
Large Intestinal Motility
• Most colonic activity is haustral
contractions
– Slow segmenting movements
• Gastrocolic reflex
– Initiated by presence of food in stomach
– Activates three to four slow powerful
peristaltic waves per day in colon (mass
movements)
88. © 2013 Pearson Education, Inc.
Homeostatic Imbalance
• Irritable bowel syndrome
– Functional GI disorder
– Recurring abdominal pain, stool changes,
bloating, flatulence, nausea, depression
– Stress common precipitating factor
• Stress management important in treatment
89. Figure 23.31 Defecation Reflex
Impulses from
cerebral cortex
(conscious
control)
Voluntary motor
nerve to external
anal sphincter
External anal
sphincter
(skeletal muscle)
Sensory
nerve fibers
Sigmoid
colon
Rectum
Stretch receptors in wall
Involuntary motor nerve
(parasympathetic division)
Internal anal sphincter (smooth muscle)
Feces move into and
distend the rectum,
stimulating stretch receptors
there. The receptors transmit
signals along afferent fibers
to spinal cord neurons.
A spinal reflex is initiated in which
parasympathetic motor (efferent) fibers
stimulate contraction of the rectum and
sigmoid colon, and relaxation of the
internal anal sphincter.
If it is convenient to defecate,
voluntary motor neurons are inhibited,
allowing the external anal sphincter to
relax so feces may pass.
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