NCBI; Introduction, Homepage and about Tools and database of NCBI BLAST; Introduction, Homepage and types of BLAST Some databases of NCBI References Acknowledgements

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TOOLS AND DATA BASES OF NCBI
Presentation report by
IPSITA SAHOO
Registration No – 200705180160
DEPARTMENT OF ZOOLOGY
Under the supervision of
Dr. Bibhudutta Mishra
Assistant Professor, School of Applied Sciences
Centurion University of Technology and Management, Bhubaneswar, Odisha
SCHOOL OF APPLIED SCIENCES (SOAS)
Centurion University of Technology and Management, Bhubaneswar, Odisha

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CONTENTS
NCBI; Introduction, Homepage and about
Tools and database of NCBI
BLAST; Introduction, Homepage and types of BLAST
Some databases of NCBI
References
Acknowledgements

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NCBI; Introduction
 NCBI stands for “National Center for
Biotechnology Information”
 It is part of the United States National Library of
Medicine (NLM), a branch of the National
Institutes of Health (NIH).
 It is approved and funded by the government of
the United States.
 The NCBI is located in Bethesda, Maryland and
was founded in 1988 through legislation sponsored
by US Congressman Claude Pepper.
 The NCBI houses a series of databases relevant
to biotechnology and biomedicine and is an
important resource for bioinformatics tools and services.
 Major databases include GenBank for DNA sequences and PubMed, a
bibliographic database for biomedical literature. Other databases include
the NCBI Epigenomics database. All these databases are available online through
the Entrez search engine.
Tools and Databases of NCBI

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Home page of NCBI

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About NCBI

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BIAST
 BIAST stands for Basic local Alignment Search Tool.
 BLAST was developed by Stephen Atschu, Warren Gish, Webb Miller, Eugene
Myers, and David J. Lipman at NCBI in 1990.
 It is a local alignment tool.
 It helps to find regions of local similarity between sequences.
 It is a program compares nucleotide or protein sequences to sequence databases
and calculates the statistical significance of matches.
 BLAST can be used to infer functional and evolutionary relationships between
sequences as well as help identify members of gene families.
Types of BLAST

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Homepage of BLAST

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Some databases of NCBI
Nucleotide database
The Nucleotide sequence database is a collection of sequences from GenBank, RefSeq,
and Third Party Annotation (TPA). Genome, gene and transcript sequence data provide
the foundation for biomedical research and discovery.
Protein sequence database
The Protein sequence database is a collection of data from several sources, including
translations from annotated coding regions in GenBank, RefSeq and TPA, as well as
records from SwissProt, PIR, PRF, and PDB.
Structural databases
Structural databases are essential tools for all crystallographic work and often need to
be consulted at several stages of the process of producing, solving, refining and
publishing the structure of a new material.
OMIM - Online Mendelian Inheritance in Man
OMIM is a comprehensive, authoritative compendium of human genes and genetic
phenotypes that is freely available and updated daily. OMIM is authored and edited at
the McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School
of Medicine, under the direction of Dr. Ada Hamosh. Its official home is omim.org.

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References
 National Center for Biotechnology Information (US). (2013). The NCBI
handbook. National Center for Biotechnology Information (US).
 https://blast.ncbi.nlm.nih.gov/Blast.cgi
 https://www.ncbi.nlm.nih.gov/
 https://en.wikipedia.org/wiki/National_Center_for_Biotechnology_Information
Acknowledgements
• My subject teacher: Dr. Bibhudutta Mishra
• Dr. Yashaswi Nayak, HOD and Dean SOAS
• All the Faculty members of Department of Zoology, School of Applied sciences,
CUTM
• Family and friends