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Basic pharm
1. L E A R N I N G S O M E B A S I C S O V E R T H E S U M M E R W I L L
G I V E Y O U A H E A D S T A R T I N T H E F A L L
INTRODUCTION TO
ANESTHESIA PHARMACOLOGY
2. GENERIC NAME: PROPOFOL
TRADE NAME: DIPRIVAN
• Classification:
Sedative, hypnotic
• Pharmacologic category:
• 2,6 di-isopropylphenol
• Uses:
• Induction of general anesthesia
• Sedation
• Mechanism of Action
• Probably potentiation of GABAA
receptors
• Onset IV: Within 40 seconds
• Peak: 1 minute
• Duration: 5-10 minutes
• Metabolized by:
• Liver
• Lungs
• Eliminated by:
• Kidneys
• Dosage:
• Induction of General Anesthesia 1-
2.5 mg/kg
• Continuous infusion for sedation 25-
100 mcg/kg/min
• Contraindicated in:
• Egg allergy
• Soybean oil allergy
• Side effects:
• Respiratory depression & Apnea
• Hypotension
• Pain on injection
• Precautions:
• Do not use after 6 hours of opening