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Résistance aux AVK
- 1. RESISTANCE AUX ANTIVITAMINES K Jean-François SCHVED Laboratoire d'Hématologie CHU Montpellier
- 15. BIOLOGIE
- 16. Facteur Tissulaire (FT) VII X II - ----------> IIa Xa V -> Va XII -> XII a XI -> XI a IX VIIIa IXa VIII -> Fibrinogène Fibrine XIIIa FT- VIIa
- 17. Résidu glutamique VITAMINE K ( KH 2) VITAMINE K Epoxyde ( KO) CARBOXYLATION VITAMINE K EPOXYDE REDUCTASE (VKOR) PIVKA FACTEUR VIT. K DEPENDANT Résidu gamma carboxylé AVK
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- Hypothetical model of the vitamin K-dependent -carboxylation system. VKOR and -carboxylase are parts of a supramolecular assembly of proteins (the vitamin K-dependent -carboxylation system) in the endoplasmic reticulum (ER) membrane, and are responsible for the post-translational modification of vitamin K-dependent proteins. Reduced vitamin K 1 H 2 is produced by VKOR and is transferred to -carboxylase as an essential cofactor for -carboxylation. Calumenin binds to the supramolecular protein assembly as a chaperone and regulates the activity and warfarin sensitivity of the vitamin K-dependent -carboxylation system. Abbreviations: Gla, -carboxyglutamic acid; Glu, glutamic acid; K>O, vitamin K 1 2,3-epoxide. K-dependent -carboxylation system. Abbreviations: Gla, -carboxyglutamic acid; Glu, glutamic acid; K>O, vitamin K 1 2,3-epoxide.