GIT CRC 2010 lec.

1. Colorectal cancer (CRC): Dr.Mohammad Shaikhani. MBChB/CABM/FRCP.

13. Stratification of Colorectal Cancer Risk 5%–6% >50 years of age Average ( negative family history ) 10%–20% Familial : First - degree relative with colorectal cancer 20% Presence of chronic colitis due to ulcerative colitis or Crohn's colitis Moderate 80% Presence of hereditary nonpolyposis colorectal cancer 100% Presence of familial adenomatous polyposis High Lifetime Risk Risk Level

15. Factors Associated with the Development of CRC Cholecystectomy Excessive alcohol intake Smoking Obesity Lack of dietary calcium and folate Calcium and folate supplementation Physical inactivity Regular aerobic exercise Diet high in red meat, sucrose, fat Diet high in fruits and vegetables * Birth in North America or Northern Europe Birth in Asia or Africa Personal history of inflammatory bowel disease No family history of colorectal cancer or an inherited colorectal cancer syndrome Family history of colorectal cancer or an inherited colorectal cancer syndrome Protective Factors Risk Factors

17. Algorithm for screening symptomatic persons for CRC