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209 trans blood vision™
1.
© 2002 Slide
1 Trans-Blood Vision™ Possibilities for Vulnerable Plaque A Presentation for the 3rd Annual Vulnerable Plaque Symposium March 16, 2002
2.
© 2002 Slide
2 Seeing Through Blood The technique is adapted from military methods to see through smoke, mist, fog, etc. SWIR WavelengthVisible Wavelengths For example, the following satellite photos of a section of the Oahu coastline illustrate how mist and haze seen at visible wavelengths disappear when viewed in the Short Wave IR band. Trans-Blood Vision™ is a patented infrared technique to see directly through blood.
3.
© 2002 Slide
3 System Illustration Monitor – already in place CardioOptics IR Instrument: - IR illumination source - IR video camera IR interconnect cable Sterile, disposable IR fiberoptic catheter:
4.
© 2002 Slide
4 • Looking directly through flowing blood in a live animal • Clip begins with exploration of bifurcation in the portal vein system & ends with canulation of selected branch • Raw, unprocessed video. Black & white presentation. Video Clip: Endocardial Imaging of IVC-Portal Vein System 1 2 To Heart (Inferior Vena Cava) Portal Vein System Caudal Vein
5.
© 2002 Slide
5 Video Clip of Vein Bifurcation Unprocessed proof of concept video taken through flowing blood.
6.
© 2002 Slide
6 Comments • Structures appear as if viewed through water • High degree of reflectivity from tissue surfaces • No video enhancement techniques have yet been applied, which will dramatically improve images.
7.
© 2002 Slide
7 Augmentative Technologies o Dimensional measurement: The ability to quantitatively measure the size of structures visualized. This includes granularity and surface feature detail assessment. o Tissue/material characterization: The ability to provide the clinician with information about the nature of the structure in the TBV™ view (e.g., detection of calcification, presence of lipids). o Real-time motion analysis: The ability to perform real-time dynamic elastic properties assessment. o Membrane penetration: The ability to determine tissue/material characterization below the surface of membranes associated with Vulnerable Plaque lesions. Note: The following are extensions of Trans-Blood Vision ™. They have been theorized, tested to some degree in vitro, but not yet tested in vivo or on Vulnerable Plaque lesions.
8.
© 2002 Slide
8 Vulnerable Plaque Potential Find lesions without first entering them (forward view) Determine size & surface characteristics in high resolution Look at material constituents, both on and below the surface (within limited IR wavelengths) Perform dynamic elastic velocity profiles in real time But not: Provide direct visual guidance for therapy Penetrate deeply like ultrasound Combining Trans-Blood Vision™ with these promising augmentative technologies provides the potential to simultaneously in real-time: Measure lesion temperature (though a temperature probe could be visually guided)
9.
© 2002 Slide
9 Conclusion: Trans-Blood Vision™ has sufficient potential to provide a platform for real-time, simultaneous, multi-mode Vulnerable Plaque lesion detection, analysis, and therapy guidance that it warrants significant investigation, possibly in combination with other technologies currently under development.
10.
© 2002 Slide
9 Conclusion: Trans-Blood Vision™ has sufficient potential to provide a platform for real-time, simultaneous, multi-mode Vulnerable Plaque lesion detection, analysis, and therapy guidance that it warrants significant investigation, possibly in combination with other technologies currently under development.
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