11. Parkinson Agents
• MAO B Inhibitors
• Dopamine Agonist
• COMT Inhibitors
• Anticholinergic Agents
12. Parkinson’s Agents
• MAO B Inhibitors:
• rasagiline Azliect Monotherapy,
0.5, 1 mg adjunct therapy
• Selegiline Eldepryl At breakfast & lunch
5 mg orally disintegrating
1.25 mg dissolved on tongue
16 max
2.5 max oral disintegrating!
13. Parkinson’s Agents
• Dopamine Agonists:
• Apomorhine Apokyn SQ 10 mg/mL in 2
mL amp and 3 mL
cartridges
• Carbidopa Sinemet
• Levodopa Larodopa
• Pramipexole Mirapex
• Ropinirole Requip
14. Parkinson’s Agents
• COMT:
• Entacapone Comtan
– Inhibits metabolism of dopamine
– Reduce motor fluctuations
– Increases on time
– Reduces off time
– Always give with Carbidopa-Levodopa to reduce total daily
dosage needed
• Stalevo is a drug with all three agents
• Diarrhea, sedation, urine discolored, chorea, confusion,
hallucinations, orthostatic hypotension