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Early Goal-Directed Therapy in Septic Shock
1. Early goal directed therapy in the treatment of severe sepsis and septic shock Presented by: Dana Darwish PGY1 SICU CCF
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8. SIRS criteria and SBP<90 or Lactate>4 Assessment and consent Randomization N=263 Standard therapy N=133 Early goal-directed Therapy N=130 Vitals, lab data, cardiac monitoring, Pulse ox, urinary cath, arterial And central venous cath Standard care: CVP 8-12mmHg MAP>65mmHg UO>.5cc/kg/hr Early goal directed therapy>6hrs: CVP 8-12mmHg MAP>65mmHg UO>.5cc/kg/hr SCvO2>70%, SaO2>90%, HCT>30%, CI, VO2. Hospital admission Vitals and lab data Q 12hrs For 72 hrs Follow Up