1. The document discusses the host defense mechanisms in the gingiva and periodontium. It describes the roles of saliva, gingival epithelium, gingival crevicular fluid, complement system, and inflammatory cells like neutrophils, macrophages, and lymphocytes in the defense against bacteria.
2. The key inflammatory cells - neutrophils, macrophages, and lymphocytes - work together to detect bacteria via chemotaxis, phagocytose and kill them using various mechanisms, and induce adaptive immune responses through cytokine signaling.
3. The complement system aids in this process through opsonization, chemotaxis, and cytolysis of bacteria. Together these host defenses maintain homeostasis against the bacterial challenge in the
Dental plaque is a biofilm that forms on teeth and consists of hundreds of microbial species embedded in an extracellular matrix. It contains bacteria, epithelial cells, macrophages, and leukocytes as well as organic and inorganic compounds. Plaque exists as either supragingival or subgingival plaque. Subgingival plaque is associated with periodontal disease and contains pathogens like Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola that make up the "red complex". The development of plaque involves initial pellicle formation, bacterial adhesion and colonization, and the accumulation of early colonizers from the yellow, purple, and green complexes that are later joined by orange complex bacteria which
Leukocyte and lymphocyte: Cytotoxicity. Dmitri Popov
This document discusses leukocytes and lymphocytes and their response to acute radiation exposure. It provides background on these immune cells, noting that leukocytes include both myeloid cells and lymphocytes. It then discusses how radiation can functionally alter the immune system by breaking self-tolerance and damaging these cells, with implications for immune responses and treatment of radiation sickness. Specific cell types like polymorphonuclear leukocytes are also examined in terms of their roles and enzyme contents.
The document discusses the stages of gingivitis. It describes 4 stages: initial lesion, early lesion, established lesion, and advanced lesion. Each stage is characterized by specific clinical and microscopic features that progress as gingivitis advances. The initial lesion shows vasculitis and fluid exudation. The early lesion displays erythema and bleeding on probing. The established lesion has blood stasis and junctional epithelium proliferation. The advanced lesion results in bone loss, pocket formation, and collagen loss. The document also discusses classification of gingivitis, changes in gingival position, causes of recession, and clinical significance of recession.
This document summarizes information about gingival pigmentation. It discusses the etiology, classification, and indexes used for measuring pigmentation. Physiologic pigmentation results from normal melanocyte activity and presents as symmetric pigmentation over many sites. Pathologic pigmentation can be caused by factors like smoking or systemic conditions like Addison's disease. Melanin is the main pigment produced by melanocytes through a process called melanogenesis. The document outlines the types of melanin and their properties. It also discusses diagnostic criteria and treatment approaches for different types of pigmentation.
The dental pulp is soft connective tissue located within the tooth. It contains specialized cells called odontoblasts along the periphery that are in contact with dentin. The pulp-dentin complex is surrounded by rigid tooth structure so the pulp cannot expand during injury or inflammation. The pulp receives a minimal blood supply and innervation from both sensory and autonomic nerves. Throughout life, secondary dentin deposition gradually reduces the size of the pulp chamber and root canals.
Initially, interleukins were thought to be produced by leukocytes and act on other leukocytes, leading to their name. Interleukins stimulate immune cell growth and differentiation and activate effector mechanisms. They are cytokines secreted by activated immune cells like macrophages and lymphocytes. Interleukins modulate immune and inflammatory responses.
1. The document discusses the host defense mechanisms in the gingiva and periodontium. It describes the roles of saliva, gingival epithelium, gingival crevicular fluid, complement system, and inflammatory cells like neutrophils, macrophages, and lymphocytes in the defense against bacteria.
2. The key inflammatory cells - neutrophils, macrophages, and lymphocytes - work together to detect bacteria via chemotaxis, phagocytose and kill them using various mechanisms, and induce adaptive immune responses through cytokine signaling.
3. The complement system aids in this process through opsonization, chemotaxis, and cytolysis of bacteria. Together these host defenses maintain homeostasis against the bacterial challenge in the
Dental plaque is a biofilm that forms on teeth and consists of hundreds of microbial species embedded in an extracellular matrix. It contains bacteria, epithelial cells, macrophages, and leukocytes as well as organic and inorganic compounds. Plaque exists as either supragingival or subgingival plaque. Subgingival plaque is associated with periodontal disease and contains pathogens like Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola that make up the "red complex". The development of plaque involves initial pellicle formation, bacterial adhesion and colonization, and the accumulation of early colonizers from the yellow, purple, and green complexes that are later joined by orange complex bacteria which
Leukocyte and lymphocyte: Cytotoxicity. Dmitri Popov
This document discusses leukocytes and lymphocytes and their response to acute radiation exposure. It provides background on these immune cells, noting that leukocytes include both myeloid cells and lymphocytes. It then discusses how radiation can functionally alter the immune system by breaking self-tolerance and damaging these cells, with implications for immune responses and treatment of radiation sickness. Specific cell types like polymorphonuclear leukocytes are also examined in terms of their roles and enzyme contents.
The document discusses the stages of gingivitis. It describes 4 stages: initial lesion, early lesion, established lesion, and advanced lesion. Each stage is characterized by specific clinical and microscopic features that progress as gingivitis advances. The initial lesion shows vasculitis and fluid exudation. The early lesion displays erythema and bleeding on probing. The established lesion has blood stasis and junctional epithelium proliferation. The advanced lesion results in bone loss, pocket formation, and collagen loss. The document also discusses classification of gingivitis, changes in gingival position, causes of recession, and clinical significance of recession.
This document summarizes information about gingival pigmentation. It discusses the etiology, classification, and indexes used for measuring pigmentation. Physiologic pigmentation results from normal melanocyte activity and presents as symmetric pigmentation over many sites. Pathologic pigmentation can be caused by factors like smoking or systemic conditions like Addison's disease. Melanin is the main pigment produced by melanocytes through a process called melanogenesis. The document outlines the types of melanin and their properties. It also discusses diagnostic criteria and treatment approaches for different types of pigmentation.
The dental pulp is soft connective tissue located within the tooth. It contains specialized cells called odontoblasts along the periphery that are in contact with dentin. The pulp-dentin complex is surrounded by rigid tooth structure so the pulp cannot expand during injury or inflammation. The pulp receives a minimal blood supply and innervation from both sensory and autonomic nerves. Throughout life, secondary dentin deposition gradually reduces the size of the pulp chamber and root canals.
Initially, interleukins were thought to be produced by leukocytes and act on other leukocytes, leading to their name. Interleukins stimulate immune cell growth and differentiation and activate effector mechanisms. They are cytokines secreted by activated immune cells like macrophages and lymphocytes. Interleukins modulate immune and inflammatory responses.
The document provides information on trauma from occlusion and coronoplasty. It defines trauma from occlusion as damage to the periodontium caused by excessive occlusal forces. Coronoplasty involves selective reduction of occlusal surfaces to influence mechanical contact conditions and sensory input, with the aim of reducing excessive tooth mobility and providing functional stimulation for periodontal health. The document discusses the diagnosis, classification, and clinical features of trauma from occlusion, as well as the objectives, methods, and techniques used in performing coronoplasty.
Interleukins are a group of cytokines that were first seen to be expressed by white blood cells and act as signaling molecules between immune cells. They promote the development and differentiation of T and B lymphocytes. The majority of interleukins are synthesized by helper T cells, monocytes, macrophages, and endothelial cells. There are several common families of interleukins that play various roles, such as interleukin 1 which participates in immune responses and inflammation, interleukin 2 which induces T cell proliferation, and interleukin 6 which stimulates antibody production.
This document discusses the microbiology of periodontal diseases. It describes the typical microbiota found in healthy sites, gingivitis sites, and chronic or aggressive periodontitis sites. The microbiota shifts from mostly gram-positive facultative bacteria in health to include more gram-negative anaerobic bacteria in disease. Key pathogenic bacteria associated with periodontitis include Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, Aggregatibacter actinomycetemcomitans, and Prevotella intermedia. These bacteria produce virulence factors like proteases, lipopolysaccharides, and leukotoxins that promote tissue destruction.
Cytokines are small secreted proteins that mediate and regulate immunity, inflammation, and hematopoiesis. They are produced in response to an immune stimulus and act as signaling molecules between cells during immune responses. There are several main classes of cytokines, including interleukins, interferons, tumor necrosis factors, growth factors, colony stimulating factors, and chemokines. Cytokines bind to specific cell surface receptors and influence cellular processes like proliferation, differentiation, and activation.
The document discusses cytokines, which are low-molecular-weight regulatory proteins or glycoproteins secreted by immune cells and other cells. Cytokines play major roles in immune, inflammatory, and hematopoietic systems by binding to specific cell receptors and altering gene expression. They have pleiotropic, redundant, synergistic, antagonistic, and cascading properties. Cytokines are classified into families based on structure and receptors. They signal through receptor families like immunoglobulin, class I and II cytokine receptors, TNF receptor, and chemokine receptors to regulate the immune response.
Dental plaque is a sticky biofilm that forms on teeth daily. It is made up of bacteria and other microorganisms from saliva. If plaque is not removed regularly through brushing, it can build up and the bacteria nearest the teeth produce acids. These acids demineralize the enamel and cause cavities. Plaque also irritates gums and can lead to gingivitis or periodontitis if left unchecked. Dentists can identify plaque using instruments or dye tablets to check if brushing and flossing have effectively removed it.
Cytokines are a diverse group of proteins that act as intercellular messengers to regulate immune and inflammatory responses. They are classified based on the cells that produce them and include monokines, lymphokines, interleukins, and chemokines. Cytokines bind to specific cell surface receptors and influence cell growth, differentiation, and synthesis of other cytokines. They are involved in innate immunity, acquired immunity, and hematopoiesis.
Dental plaque is a biofilm that forms on teeth. It is made up of bacteria, salivary components, and food debris embedded in an extracellular matrix. Plaque forms in stages - first, a protein pellicle forms on the tooth surface. Bacteria then attach to the pellicle and begin to colonize. As the bacteria multiply, they produce a matrix material between them made of carbohydrates, proteins, and lipids. Over time this leads to the development of a mature dental plaque biofilm.
La gingivitis es la inflamación de las encías causada por depósitos de placa y sarro en los dientes. Los síntomas incluyen encías sangrantes, encías de apariencia roja brillante y ulceras bucales. El tratamiento consiste en limpiezas dentales profesionales para remover la placa y el sarro, así como una buena higiene oral diaria para prevenir la reaparición de la gingivitis.
The document discusses gingivitis, which is a mild gum disease caused by plaque and bacteria that can irritate the gums. It explains the causes and symptoms of gingivitis, as well as the treatment which involves removing plaque through brushing and flossing daily. Proper oral hygiene and regular dental cleanings are important to prevent gingivitis from worsening and potentially leading to more serious gum disease.
The document discusses the mechanisms behind fever development after infection. When germs infect the body, white blood cells are produced to fight the infection. This causes the body to heat up. The hypothalamus, which regulates body temperature, then raises the temperature set point. Cytokines like interleukin are released, signaling the hypothalamus and activating the arachidonic acid pathway. This leads to prostaglandin E2 release, maintaining the elevated temperature until the infection is fought off. Fever helps the immune system but can become dangerous at very high levels.
This document discusses dental plaque formation at the ultrastructural level. It begins by describing how a saliva-derived acquired pellicle forms on the tooth surface within nanoseconds. Bacteria then initially adhere reversibly to this pellicle via molecular interactions. They can then irreversibly attach through specific adhesins. Once attached, the bacteria begin colonizing the surface and forming a biofilm through multiplication and sequential adsorption of organisms.
The document discusses cytokines, which are proteins that mediate communication between cells of the immune system. It describes the different types of cytokines, including interleukins produced by T-helper cells, lymphokines produced by lymphocytes, and monokines produced by monocytes. The document outlines the roles and functions of specific cytokines like IL-1, IL-2, TNF, IFN-γ and GM-CSF. It also discusses how cytokines are classified based on their structure and roles in innate versus adaptive immunity.
El documento presenta diferentes opciones de compra de oro con sus precios y porcentajes de descuento. La opción Standard cuesta 1,400€ con un descuento del 25% de 350€. La opción Multicard cuesta 3,500€ con un descuento del 7% de 245€. La opción Goldline cuesta 3,000€ con un descuento del 15% de 450€. Se ofrece un paquete de oro de 7,000€ que puede formalizarse obteniendo recompensas por iniciar nuevos pedidos.
El documento habla sobre cómo calcular el monto que se debe ahorrar para generar un ingreso mensual determinado basado en la tasa de interés. Explica que para obtener un ingreso de 10,000 unidades monetarias al mes se necesita tener ahorrado 2 millones de unidades monetarias debido a que la tasa de interés mensual es del 0.5%. También menciona que recibir un ingreso adicional de 100 unidades monetarias al mes es equivalente a tener 20,000 unidades monetarias ahorradas en el banco.
Bill Britt describió su experiencia en redes de mercadeo, mostrando que aunque invirtió tiempo en 1200 personas, solo 300 estuvieron interesadas y de ellas solo 85 lo hicieron de manera seria, resultando en que 11 se hicieron millonarios. Su experiencia ilustra la "Ley de los promedios", donde a pesar de esfuerzos amplios, solo una pequeña fracción tendrá éxito significativo.
Nuestro mundo en 100 personas (De Juan Sánchez Gómez)Rumbo Norte GIG
El documento describe una hipotética aldea global de 100 personas que representa proporcionalmente la distribución mundial actual de la población, la riqueza y otros factores. En esta aldea, 57 personas serían asiáticas, 21 europeas y 8 africanas, y solo 4 serían estadounidenses. Además, 6 personas poseerían el 59% de la riqueza total y la mayoría no tendrían acceso a la educación, la salud y otras necesidades básicas. El propósito es generar conciencia sobre la desigualdad global y la neces
Este documento describe un nuevo sistema educativo piloto en Japón llamado "Cambio Valiente" que forma a los estudiantes como "ciudadanos del mundo" en lugar de japoneses. Los estudiantes aprenden 4 idiomas, culturas, alfabetos y religiones, y se enfocan en aritmética comercial, lectura, civismo y computación. Contrasta esto con los hijos y nietos actuales, quienes pasan más tiempo viendo televisión que estudiando, y son expertos en distracciones como redes sociales pero no en materias académic
Este documento describe el Programa de Incentivos GoldSet de una tienda online de lingotes de oro. El programa ofrece a los clientes la oportunidad de generar ingresos promocionando la compra de lingotes de oro. Los clientes pueden comprar lingotes por un valor mínimo de EUR 7,000 e iniciar nuevos pedidos para recibir unidades de recompensa que pueden usar para pagar el saldo de su compra. El sistema contabiliza los pedidos en una tabla para calcular las unidades de recompensa basadas en el número de niveles y pedidos completados
Global InterGold is an online gold shop that sells physical gold bars from 1 to 100 grams. It aims to make gold investing accessible to more people as a hedge against inflation. The company has operated for over 5 years in more than 200 countries and has sold gold to over 1 million clients. It offers various order options and incentives programs that allow clients to offset payment for gold purchases through promotional activities.
The document provides information on trauma from occlusion and coronoplasty. It defines trauma from occlusion as damage to the periodontium caused by excessive occlusal forces. Coronoplasty involves selective reduction of occlusal surfaces to influence mechanical contact conditions and sensory input, with the aim of reducing excessive tooth mobility and providing functional stimulation for periodontal health. The document discusses the diagnosis, classification, and clinical features of trauma from occlusion, as well as the objectives, methods, and techniques used in performing coronoplasty.
Interleukins are a group of cytokines that were first seen to be expressed by white blood cells and act as signaling molecules between immune cells. They promote the development and differentiation of T and B lymphocytes. The majority of interleukins are synthesized by helper T cells, monocytes, macrophages, and endothelial cells. There are several common families of interleukins that play various roles, such as interleukin 1 which participates in immune responses and inflammation, interleukin 2 which induces T cell proliferation, and interleukin 6 which stimulates antibody production.
This document discusses the microbiology of periodontal diseases. It describes the typical microbiota found in healthy sites, gingivitis sites, and chronic or aggressive periodontitis sites. The microbiota shifts from mostly gram-positive facultative bacteria in health to include more gram-negative anaerobic bacteria in disease. Key pathogenic bacteria associated with periodontitis include Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, Aggregatibacter actinomycetemcomitans, and Prevotella intermedia. These bacteria produce virulence factors like proteases, lipopolysaccharides, and leukotoxins that promote tissue destruction.
Cytokines are small secreted proteins that mediate and regulate immunity, inflammation, and hematopoiesis. They are produced in response to an immune stimulus and act as signaling molecules between cells during immune responses. There are several main classes of cytokines, including interleukins, interferons, tumor necrosis factors, growth factors, colony stimulating factors, and chemokines. Cytokines bind to specific cell surface receptors and influence cellular processes like proliferation, differentiation, and activation.
The document discusses cytokines, which are low-molecular-weight regulatory proteins or glycoproteins secreted by immune cells and other cells. Cytokines play major roles in immune, inflammatory, and hematopoietic systems by binding to specific cell receptors and altering gene expression. They have pleiotropic, redundant, synergistic, antagonistic, and cascading properties. Cytokines are classified into families based on structure and receptors. They signal through receptor families like immunoglobulin, class I and II cytokine receptors, TNF receptor, and chemokine receptors to regulate the immune response.
Dental plaque is a sticky biofilm that forms on teeth daily. It is made up of bacteria and other microorganisms from saliva. If plaque is not removed regularly through brushing, it can build up and the bacteria nearest the teeth produce acids. These acids demineralize the enamel and cause cavities. Plaque also irritates gums and can lead to gingivitis or periodontitis if left unchecked. Dentists can identify plaque using instruments or dye tablets to check if brushing and flossing have effectively removed it.
Cytokines are a diverse group of proteins that act as intercellular messengers to regulate immune and inflammatory responses. They are classified based on the cells that produce them and include monokines, lymphokines, interleukins, and chemokines. Cytokines bind to specific cell surface receptors and influence cell growth, differentiation, and synthesis of other cytokines. They are involved in innate immunity, acquired immunity, and hematopoiesis.
Dental plaque is a biofilm that forms on teeth. It is made up of bacteria, salivary components, and food debris embedded in an extracellular matrix. Plaque forms in stages - first, a protein pellicle forms on the tooth surface. Bacteria then attach to the pellicle and begin to colonize. As the bacteria multiply, they produce a matrix material between them made of carbohydrates, proteins, and lipids. Over time this leads to the development of a mature dental plaque biofilm.
La gingivitis es la inflamación de las encías causada por depósitos de placa y sarro en los dientes. Los síntomas incluyen encías sangrantes, encías de apariencia roja brillante y ulceras bucales. El tratamiento consiste en limpiezas dentales profesionales para remover la placa y el sarro, así como una buena higiene oral diaria para prevenir la reaparición de la gingivitis.
The document discusses gingivitis, which is a mild gum disease caused by plaque and bacteria that can irritate the gums. It explains the causes and symptoms of gingivitis, as well as the treatment which involves removing plaque through brushing and flossing daily. Proper oral hygiene and regular dental cleanings are important to prevent gingivitis from worsening and potentially leading to more serious gum disease.
The document discusses the mechanisms behind fever development after infection. When germs infect the body, white blood cells are produced to fight the infection. This causes the body to heat up. The hypothalamus, which regulates body temperature, then raises the temperature set point. Cytokines like interleukin are released, signaling the hypothalamus and activating the arachidonic acid pathway. This leads to prostaglandin E2 release, maintaining the elevated temperature until the infection is fought off. Fever helps the immune system but can become dangerous at very high levels.
This document discusses dental plaque formation at the ultrastructural level. It begins by describing how a saliva-derived acquired pellicle forms on the tooth surface within nanoseconds. Bacteria then initially adhere reversibly to this pellicle via molecular interactions. They can then irreversibly attach through specific adhesins. Once attached, the bacteria begin colonizing the surface and forming a biofilm through multiplication and sequential adsorption of organisms.
The document discusses cytokines, which are proteins that mediate communication between cells of the immune system. It describes the different types of cytokines, including interleukins produced by T-helper cells, lymphokines produced by lymphocytes, and monokines produced by monocytes. The document outlines the roles and functions of specific cytokines like IL-1, IL-2, TNF, IFN-γ and GM-CSF. It also discusses how cytokines are classified based on their structure and roles in innate versus adaptive immunity.
El documento presenta diferentes opciones de compra de oro con sus precios y porcentajes de descuento. La opción Standard cuesta 1,400€ con un descuento del 25% de 350€. La opción Multicard cuesta 3,500€ con un descuento del 7% de 245€. La opción Goldline cuesta 3,000€ con un descuento del 15% de 450€. Se ofrece un paquete de oro de 7,000€ que puede formalizarse obteniendo recompensas por iniciar nuevos pedidos.
El documento habla sobre cómo calcular el monto que se debe ahorrar para generar un ingreso mensual determinado basado en la tasa de interés. Explica que para obtener un ingreso de 10,000 unidades monetarias al mes se necesita tener ahorrado 2 millones de unidades monetarias debido a que la tasa de interés mensual es del 0.5%. También menciona que recibir un ingreso adicional de 100 unidades monetarias al mes es equivalente a tener 20,000 unidades monetarias ahorradas en el banco.
Bill Britt describió su experiencia en redes de mercadeo, mostrando que aunque invirtió tiempo en 1200 personas, solo 300 estuvieron interesadas y de ellas solo 85 lo hicieron de manera seria, resultando en que 11 se hicieron millonarios. Su experiencia ilustra la "Ley de los promedios", donde a pesar de esfuerzos amplios, solo una pequeña fracción tendrá éxito significativo.
Nuestro mundo en 100 personas (De Juan Sánchez Gómez)Rumbo Norte GIG
El documento describe una hipotética aldea global de 100 personas que representa proporcionalmente la distribución mundial actual de la población, la riqueza y otros factores. En esta aldea, 57 personas serían asiáticas, 21 europeas y 8 africanas, y solo 4 serían estadounidenses. Además, 6 personas poseerían el 59% de la riqueza total y la mayoría no tendrían acceso a la educación, la salud y otras necesidades básicas. El propósito es generar conciencia sobre la desigualdad global y la neces
Este documento describe un nuevo sistema educativo piloto en Japón llamado "Cambio Valiente" que forma a los estudiantes como "ciudadanos del mundo" en lugar de japoneses. Los estudiantes aprenden 4 idiomas, culturas, alfabetos y religiones, y se enfocan en aritmética comercial, lectura, civismo y computación. Contrasta esto con los hijos y nietos actuales, quienes pasan más tiempo viendo televisión que estudiando, y son expertos en distracciones como redes sociales pero no en materias académic
Este documento describe el Programa de Incentivos GoldSet de una tienda online de lingotes de oro. El programa ofrece a los clientes la oportunidad de generar ingresos promocionando la compra de lingotes de oro. Los clientes pueden comprar lingotes por un valor mínimo de EUR 7,000 e iniciar nuevos pedidos para recibir unidades de recompensa que pueden usar para pagar el saldo de su compra. El sistema contabiliza los pedidos en una tabla para calcular las unidades de recompensa basadas en el número de niveles y pedidos completados
Global InterGold is an online gold shop that sells physical gold bars from 1 to 100 grams. It aims to make gold investing accessible to more people as a hedge against inflation. The company has operated for over 5 years in more than 200 countries and has sold gold to over 1 million clients. It offers various order options and incentives programs that allow clients to offset payment for gold purchases through promotional activities.