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NHase_1
1) Boronic acids were shown to be potent competitive inhibitors of the nitrile hydratase enzyme from Pseudonocardia thermophila (PtNHase).
2) X-ray crystallography revealed that the sulfenic acid ligand of the active site cysteine attacks and forms a covalent bond with the boron atom of bound boronic acid inhibitors, representing a potential reaction intermediate.
3) A new mechanism is proposed for nitrile hydration by nitrile hydratases wherein the sulfenic acid ligand acts as the catalytic nucleophile.
Exercícios hibridização
O documento apresenta 10 questões sobre hibridização de átomos em compostos orgânicos. As questões abordam tópicos como estrutura eletrônica, tipos de ligação, ângulos de ligação e hibridização de carbono, nitrogênio e silício em moléculas como CF4, SiH4, C2H2, propeno e resina ureia-formaldeído.
Periodico diario de cadiz
El documento habla sobre los periódicos digitales que informan detalladamente sobre la petición de Javier Arenas para un cambio en Andalucía.
Oscar BH Race
Este documento apresenta indicações de atletas da equipe BH Race para concorrer a diversas categorias do Oscar BH Race, incluindo Atleta Mais Engraçado, Atleta Fashion, Atleta Kodak, Atleta Mais Disciplinado, Atleta Revelação, BH Race no Sangue e Casal BH Race. Muitos atletas são destacados por sua dedicação aos treinos, superação de desafios pessoais e por levarem o espírito da equipe para outros ambientes.
Publicacion no. 3.1
Este documento presenta las metas y aspiraciones de una persona en varias áreas de su vida, incluyendo la religión, la familia, la educación, la salud y lo profesional. Algunas de sus metas son perseverar en las reuniones religiosas, graduarse como ingeniera de la Universidad de San Carlos de Guatemala, ayudar a los necesitados en su comunidad, y ser una maestra ejemplar.
Recomendados
NHase_1
1) Boronic acids were shown to be potent competitive inhibitors of the nitrile hydratase enzyme from Pseudonocardia thermophila (PtNHase).
2) X-ray crystallography revealed that the sulfenic acid ligand of the active site cysteine attacks and forms a covalent bond with the boron atom of bound boronic acid inhibitors, representing a potential reaction intermediate.
3) A new mechanism is proposed for nitrile hydration by nitrile hydratases wherein the sulfenic acid ligand acts as the catalytic nucleophile.
Exercícios hibridização
O documento apresenta 10 questões sobre hibridização de átomos em compostos orgânicos. As questões abordam tópicos como estrutura eletrônica, tipos de ligação, ângulos de ligação e hibridização de carbono, nitrogênio e silício em moléculas como CF4, SiH4, C2H2, propeno e resina ureia-formaldeído.
Periodico diario de cadiz
El documento habla sobre los periódicos digitales que informan detalladamente sobre la petición de Javier Arenas para un cambio en Andalucía.
Oscar BH Race
Este documento apresenta indicações de atletas da equipe BH Race para concorrer a diversas categorias do Oscar BH Race, incluindo Atleta Mais Engraçado, Atleta Fashion, Atleta Kodak, Atleta Mais Disciplinado, Atleta Revelação, BH Race no Sangue e Casal BH Race. Muitos atletas são destacados por sua dedicação aos treinos, superação de desafios pessoais e por levarem o espírito da equipe para outros ambientes.
Publicacion no. 3.1
Este documento presenta las metas y aspiraciones de una persona en varias áreas de su vida, incluyendo la religión, la familia, la educación, la salud y lo profesional. Algunas de sus metas son perseverar en las reuniones religiosas, graduarse como ingeniera de la Universidad de San Carlos de Guatemala, ayudar a los necesitados en su comunidad, y ser una maestra ejemplar.
Ex. micro
Este documento contiene preguntas sobre conceptos básicos de microbiología, como las características de bacterias y virus, técnicas de tinción y microscopía, y procesos celulares como la respiración y síntesis de proteínas. Algunas de las preguntas se refieren a las diferencias entre procariotas y eucariotas, la localización de ribosomas y mitocondrias, y los mecanismos de entrada de nutrientes en bacterias.
Special Counsel
This document proposes creating a Special Counsel position to serve as a liaison between the Legal Aid Society of Westchester County and the Westchester County Department of Correction. The Special Counsel would help address clients' issues and concerns, improve communication between the two agencies, and enhance the quality of care and services for inmates. The author argues they are well-qualified for the role due to their experience representing clients at the jail and coordinating with correctional staff on mental health accommodations and educational programs. As Special Counsel, they would directly field issues from Legal Aid clients and facilitate resolving matters between the agencies to benefit inmates.
Design de Interação - SECOMP 2011 - Segundo dia
O documento discute técnicas de prototipagem para desenvolvedores projetarem artefatos tecnológicos mais humanos, incluindo diferentes níveis de prototipagem desde esboços em papel até protótipos funcionais e a importância da avaliação com usuários.
GABA-AT_1
CPP-115 is a potent mechanism-based inactivator of the enzyme γ-aminobutyric acid aminotransferase (GABA-AT) that was developed to treat seizures and other neurological disorders. This study investigated CPP-115's inactivation mechanism of GABA-AT. It was found that CPP-115 undergoes enzyme-catalyzed hydrolysis of its difluoromethylene group, releasing two fluoride ions. This causes a conformational change in the enzyme, forming a tightly bound complex and inactivating the enzyme. Unexpectedly, CPP-115 does not follow the anticipated Michael addition pathway but instead utilizes a novel catalytic mechanism. This new mechanism of inactivation provides insights for
Science and advancements in psychology
Psychology is the science that studies the behavior and mental functions. Technological advances have proved useful in many areas of science. Like other sciences, Psychology has taken advantage of this technological advance to perfect your research techniques and thus the practices that guide its professionals. It was from the advent of imaging techniques it became possible to observe the brain in action, and so, call the 1990s the "Decade of the Brain" with research in neurosciences with a leading character in the scientific revolution. The Psychology of the future will have greater emphasis on science, more emphasis on social issues, theories and use of mathematical models, work on complex problems, greater professionalism and specialization and integration of psychology around a unifying paradigm. The future of Psychology is associated with the future of technology.
pvdq_1
Rational design of transition state analogue inhibitor for PvdQ enzyme.
PvdQ enzyme plays a key role in biosynthesis of siderophore pyoverdine in Pseudomonas aeruginosa and shows substrate preference for acyl chains 12-14 carbons. A series of alkylboronic acids were designed and found to be reversible, competitive inhibitors with picomolar affinity. X-ray crystal structure showed 1-tridecylboronic acid forms covalent bond with active site serine, mimicking substrate transition state. This inhibitor blocked bacterial growth in iron-limited conditions, reproducing genetic pvdQ disruption phenotype.
Inteligencia [modo de compatibilidad]
Este documento discute diferentes definiciones e interpretaciones de la inteligencia propuestas por psicólogos a lo largo de la historia. También describe brevemente las teorías, pruebas y tipos de inteligencia, incluyendo las pruebas verbales y no verbales utilizadas para medirla.
Caroline wright - HR CV
Caroline Wright has over 10 years of experience in human resources consulting and management. She has worked for several large companies, including T-Systems and Accenture, and provided HR support to a variety of industries. Her experience includes training needs analysis, managing learning systems, supporting international projects, and delivering initiatives related to performance management, talent development, and career progression. She enjoys collaborative work and driving best practices.
Capstone_Project
This design report summarizes a project to design a composting toilet facility for the Learning Garden Lab. Three alternatives were considered: a three-stall composting toilet shelter, a two-stall composting toilet shelter with space for portable toilets, and a three-stall traditional flush toilet shelter. The preferred alternative is a three-stall composting toilet shelter using three Phoenix Model 200 composting toilets. The proposed two-story structure will house the toilets above the composting chambers. Regulatory requirements for composting toilets and a preliminary geotechnical report are also included. Drawings, cost estimates, and an operations and maintenance manual are provided in the appendices
27062016 mat
Este documento presenta los siguientes puntos:
1) Informa sobre la recaudación federal participable de mayo de 2016 y el ajuste definitivo de participaciones de 2015.
2) Da a conocer los coeficientes de participación utilizados para distribuir las participaciones de mayo de 2016 y el ajuste de 2015.
3) Presenta la distribución e integración del Fondo General de Participaciones y otros fondos entre entidades federativas.
Announcements Mon. June 27th
This document contains announcements from ICPS on June 27th, 2016. It announces that there are no birthdays to celebrate today. The Green Team will be assisting at the Recycling Depot. It also notes an upcoming Grade 8 graduation celebration and a yearbook committee meeting. Several students are recognized for character traits like responsibility and caring. The daily message provides an eco tip for a plant bug repellent.
24 25 Sector Al Dia 125 V
1) La industria aeronáutica se enfrenta a problemas de liquidez debido a la crisis económica, lo que dificulta la financiación de las entregas de aviones previstas para este año.
2) Las agencias de crédito a la exportación están jugando un papel importante en la financiación, aunque no favorecen por igual a todas las compañías.
3) Se espera que Airbus y Boeing entreguen alrededor de 1.100 aviones este año, por un valor de 95.000 millones de dólares, aunque
Ple definitivo
El documento describe el uso de un Entorno Personal de Aprendizaje (PLE) por parte de un grupo de estudiantes de pedagogía en inglés. Explica que un PLE permite a los estudiantes dirigir su propio aprendizaje mediante la organización y gestión de contenidos e información de diversas fuentes web. El grupo utilizó la plataforma Symbaloo para crear su PLE, agregando sitios web frecuentes y personalizando la interfaz para facilitar su aprendizaje de manera más rápida y eficaz.
Más contenido relacionado
Destacado
Ex. micro
Este documento contiene preguntas sobre conceptos básicos de microbiología, como las características de bacterias y virus, técnicas de tinción y microscopía, y procesos celulares como la respiración y síntesis de proteínas. Algunas de las preguntas se refieren a las diferencias entre procariotas y eucariotas, la localización de ribosomas y mitocondrias, y los mecanismos de entrada de nutrientes en bacterias.
Special Counsel
This document proposes creating a Special Counsel position to serve as a liaison between the Legal Aid Society of Westchester County and the Westchester County Department of Correction. The Special Counsel would help address clients' issues and concerns, improve communication between the two agencies, and enhance the quality of care and services for inmates. The author argues they are well-qualified for the role due to their experience representing clients at the jail and coordinating with correctional staff on mental health accommodations and educational programs. As Special Counsel, they would directly field issues from Legal Aid clients and facilitate resolving matters between the agencies to benefit inmates.
Design de Interação - SECOMP 2011 - Segundo dia
O documento discute técnicas de prototipagem para desenvolvedores projetarem artefatos tecnológicos mais humanos, incluindo diferentes níveis de prototipagem desde esboços em papel até protótipos funcionais e a importância da avaliação com usuários.
GABA-AT_1
CPP-115 is a potent mechanism-based inactivator of the enzyme γ-aminobutyric acid aminotransferase (GABA-AT) that was developed to treat seizures and other neurological disorders. This study investigated CPP-115's inactivation mechanism of GABA-AT. It was found that CPP-115 undergoes enzyme-catalyzed hydrolysis of its difluoromethylene group, releasing two fluoride ions. This causes a conformational change in the enzyme, forming a tightly bound complex and inactivating the enzyme. Unexpectedly, CPP-115 does not follow the anticipated Michael addition pathway but instead utilizes a novel catalytic mechanism. This new mechanism of inactivation provides insights for
Science and advancements in psychology
Psychology is the science that studies the behavior and mental functions. Technological advances have proved useful in many areas of science. Like other sciences, Psychology has taken advantage of this technological advance to perfect your research techniques and thus the practices that guide its professionals. It was from the advent of imaging techniques it became possible to observe the brain in action, and so, call the 1990s the "Decade of the Brain" with research in neurosciences with a leading character in the scientific revolution. The Psychology of the future will have greater emphasis on science, more emphasis on social issues, theories and use of mathematical models, work on complex problems, greater professionalism and specialization and integration of psychology around a unifying paradigm. The future of Psychology is associated with the future of technology.
pvdq_1
Rational design of transition state analogue inhibitor for PvdQ enzyme.
PvdQ enzyme plays a key role in biosynthesis of siderophore pyoverdine in Pseudomonas aeruginosa and shows substrate preference for acyl chains 12-14 carbons. A series of alkylboronic acids were designed and found to be reversible, competitive inhibitors with picomolar affinity. X-ray crystal structure showed 1-tridecylboronic acid forms covalent bond with active site serine, mimicking substrate transition state. This inhibitor blocked bacterial growth in iron-limited conditions, reproducing genetic pvdQ disruption phenotype.
Inteligencia [modo de compatibilidad]
Este documento discute diferentes definiciones e interpretaciones de la inteligencia propuestas por psicólogos a lo largo de la historia. También describe brevemente las teorías, pruebas y tipos de inteligencia, incluyendo las pruebas verbales y no verbales utilizadas para medirla.
Caroline wright - HR CV
Caroline Wright has over 10 years of experience in human resources consulting and management. She has worked for several large companies, including T-Systems and Accenture, and provided HR support to a variety of industries. Her experience includes training needs analysis, managing learning systems, supporting international projects, and delivering initiatives related to performance management, talent development, and career progression. She enjoys collaborative work and driving best practices.
Capstone_Project
This design report summarizes a project to design a composting toilet facility for the Learning Garden Lab. Three alternatives were considered: a three-stall composting toilet shelter, a two-stall composting toilet shelter with space for portable toilets, and a three-stall traditional flush toilet shelter. The preferred alternative is a three-stall composting toilet shelter using three Phoenix Model 200 composting toilets. The proposed two-story structure will house the toilets above the composting chambers. Regulatory requirements for composting toilets and a preliminary geotechnical report are also included. Drawings, cost estimates, and an operations and maintenance manual are provided in the appendices
27062016 mat
Este documento presenta los siguientes puntos:
1) Informa sobre la recaudación federal participable de mayo de 2016 y el ajuste definitivo de participaciones de 2015.
2) Da a conocer los coeficientes de participación utilizados para distribuir las participaciones de mayo de 2016 y el ajuste de 2015.
3) Presenta la distribución e integración del Fondo General de Participaciones y otros fondos entre entidades federativas.
Announcements Mon. June 27th
This document contains announcements from ICPS on June 27th, 2016. It announces that there are no birthdays to celebrate today. The Green Team will be assisting at the Recycling Depot. It also notes an upcoming Grade 8 graduation celebration and a yearbook committee meeting. Several students are recognized for character traits like responsibility and caring. The daily message provides an eco tip for a plant bug repellent.
24 25 Sector Al Dia 125 V
1) La industria aeronáutica se enfrenta a problemas de liquidez debido a la crisis económica, lo que dificulta la financiación de las entregas de aviones previstas para este año.
2) Las agencias de crédito a la exportación están jugando un papel importante en la financiación, aunque no favorecen por igual a todas las compañías.
3) Se espera que Airbus y Boeing entreguen alrededor de 1.100 aviones este año, por un valor de 95.000 millones de dólares, aunque
Ple definitivo
El documento describe el uso de un Entorno Personal de Aprendizaje (PLE) por parte de un grupo de estudiantes de pedagogía en inglés. Explica que un PLE permite a los estudiantes dirigir su propio aprendizaje mediante la organización y gestión de contenidos e información de diversas fuentes web. El grupo utilizó la plataforma Symbaloo para crear su PLE, agregando sitios web frecuentes y personalizando la interfaz para facilitar su aprendizaje de manera más rápida y eficaz.